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Ikeda Yasuhiro Last modified date:2018.10.02

Associate Professor / Department of Ocular Pathology and Imaging Science
Department of Clinical Medicine
Faculty of Medical Sciences




E-Mail
Phone
092-642-5648
Fax
092-642-5663
Academic Degree
M.D. , Ph.D. "Recombinant Sendai Virus-Mediated Gene Transfer into Adult Rat Retinal Tissue: Efficient Gene Transfer by Brief Exposure"
Country of degree conferring institution (Overseas)
No
Field of Specialization
ophthalmology, pathology, molecular biology, gene therapy
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Clinical trial of neuroprotective gene therapy for patients with glaucoma
    keyword : Glaucoma, Gene therapy, Neuroprotection
    2001.04~2021.03.
  • Clinical trial of neuroprotective gene therapy for patients with retinitis pigmentosa
    keyword : Retinitis pigmentosa, Gene therapy, Neuroprotection
    1999.04~2021.03.
  • Development of the night-vision aid
    keyword : night blindness, retinitis pigmentosa, glaucoma
    2008.04~2020.05.
  • To breed novel cynomolgus monkeys with retinitis pigmentosa
    keyword : retinitis pigmenosa, cynomolgus monkey, disease model
    2016.04~2020.05.
Academic Activities
Papers
1. Fujiwara K, Ikeda Y, Murakami Y, Tachibana T, Funatsu J, Koyanagi Y, Nakatake S, Yoshida N, Nakao S, Hisatomi T, Yoshida S, Yoshitomi T, Ishibashi T, Sonoda KH, Assessment of Central Visual Function in Patients with Retinitis Pigmentosa, Scientific Reports, 8, 8070, 2018.05.
2. Murakami Y, Ikeda Y, Nakatake S, Fujiwara K, Tachibana T, Yoshida N, Notomi S, Hisatomi T, Yoshida S, Ishibashi T, Sonoda KH, C-Reactive protein and progression of vision loss in retinitis pigmentosa, Acta Ophthalmologica, 96, e174-e179, 2018.03.
3. Ikeda Y, Nishiguchi KM, Miya F, Shimozawa N, Funatsu J, Nakatake S, Fujiwara K, Tachibana T, Murakami Y, Hisatomi T, Yoshida S, Yasutomi Y, Tsunoda T, Nakazawa T, Ishibashi T, Sonoda KH, Discovery of a cynomolgus monkey family with retinitis pigmentosa, Investigative Ophthalmology and Visual Science, 59, 826-830, 2018.02.
4. Koyanagi Y, Murakami Y, Funatsu J, Akiyama M, Nakatake S, Fujiwara K, Tachibana T, Nakao S, Hisatomi T, Yoshida S, Ishibashi T, Sonoda KH, Ikeda Y, Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa, Acta Ophthalmologica, 96, e59-e67, 2018.02.
5. Murakami Y, Funatsu J, Nakatake S, Fujiwara K, Tachibana T, Koyanagi Y, Hisatomi T, Yoshida S, Sonoda S, Sakamoto T, Sonoda KH, Ikeda Y, Relations among foveal blood flow, retinal-choroidal structure, and visual function in retinitis pigmentosa, Investigative Ophthalmology and Visual Science, 59, 1134-1143, 2018.02.
6. Fujiwara K, Ikeda Y, Murakami Y, Funatsu J, Nakatake S, Tachibana T, Yoshida N, Nakao S, Hisatomi T, Yoshida S, Yoshitomi T, Ishibashi T, Sonoda KH, Risk factors for posterior subcapsular cataract in retinitis pigmentosa, Investigative Ophthalmology and Visual Science, 58, 2534-2537, 2017.05.
7. Nakatake S, Murakami Y, Ikeda Y, Morioka N, Tachibana T, Fujiwara K, Yoshida N, Notomi S, Hisatomi T, Yoshida S, Ishibashi T, Nakabeppu Y, Sonoda KH, MUTYH promotes oxidative microglial activation and inherited retinal degeneration, JCI Insight, 1, e87781, 2016.09.
8. Fujiwara K, Ikeda Y, Murakami Y, Nakatake S, Tachibana T, Yoshida N, Nakao S, Hisatomi T, Yoshida S, Yoshitomi T, Sonoda KH, Ishibashi T, Association between aqueous flare and epiretinal membrane in retinitis pigmentosa, Investigative Ophthalmology and Visual Science, 57, 4282-4286, 2016.08.
9. Murakami Y, Ikeda Y, Akiyama M, Fujiwara K, Yoshida N, Nakatake S, Notomi S, Nabeshima T, Hisatomi T, Enaida H, Ishibashi T, Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa, Acta Ophthalmologica, 93, e644-e648, 2015.12.
10. Yoshida N, Ikeda Y, Murakami Y, Nakatake S, Takashi T, Notomi S, Hisatomi T, Ishibashi T, Vitreous cysts in patients with retinitis pigmentosa, Japanese Journal of Ophthalmology, 59, 373-377, 2015.11.
11. Ikeda Y, Yoshida N (equal contribution), Murakami Y, Nakatake S, Notomi S, Hisatomi T, Enaida H, Ishibashi T, Long-term surgical outcomes of epiretinal membrane in patients with retinitis pigmentosa, Scientific Reports, 5, 13078, 2015.08.
12. Ikeda Y, Suzuki E, Kuramata T, Kozaki T, Koyama T, Kato Y, Enaida H, Ishibashi T, Development and evaluation of a visual aid using see-through display for patients with retinitis pigmentosa, Japanese Journal of Ophthalmology, 59, 43-47, 2015.01.
13. Yoshida N, Ikeda Y, Murakami Y, Nakatake S, Fujiwara K, Notomi S, Hisatomi T, Ishibashi T, Factors affecting visual acuity after cataract surgery in patients with retinitis pigmentosa, Ophthalmology, 122, 903-908, 2015.01.
14. Murakami Y, Yoshida N, Ikeda Y, Nakatake S, Fujiwara K, Notomi S, Nabeshima T, Nakao S, Hisatomi T, Enaida H, Ishibashi T, Relationship between aqueous flare and visual function in retinitis pigmentosa, American Journal of Ophthalmology, 159, 958-963, 2015.01.
15. Akiyama M, Ikeda Y (equal contribution), Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T, Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa, Acta Ophthalmologica, 92, e229-e234, 2014.01.
16. Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T, Therapeutic effect of prolonged treatment with topical dorzolamide for cystoid macular oedema in patients with retinitis pigmentosa, British Journal of Ophthalmology, 97, 1187-1191, 2013.09.
17. Yoshida N, Ikeda Y, Notomi S, Ishikawa K, Murakami Y, Hisatomi T, Enaida H, Ishibashi T, Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa, Ophthalmology, 120, 100-105, 2013.01.
18. Yoshida N, Ikeda Y, Notomi S, Ishikawa K, Murakami Y, Hisatomi T, Enaida H, Ishibashi T., Laboratory evidence of sustained chronic inflammatory reaction in retinitis pigmentosa, Ophthalmology, 120, e5, e12, 2013.01.
19. Murakami Y, Ikeda Y (equal contribution), Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T, MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration, American Journal of Pathology, 181, 1378-1386, 2012.10.
20. Ikeda Y, Hisatomi T, Yoshida N, Notomi S, Murakami Y, Enaida H, and Ishibashi T, The clinical efficacy of a topical dorzolamide in the management of cystoid macular edema in patients with retinitis pigmentosa, Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie, 250, 809-814, 2012.06.
21. Yoshida N, Hisatomi T, Ikeda Y, Kohno R, Murakami Y, Imaki H, Ueno A, Fujisawa K, Ishibashi T, Intravitreal bevacizumab treatment for neovascular glaucoma
Histopathological analysis of trabeculectomy specimens, Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie, 249, 1547-1552, 2011.10.
22. Miyazaki M, Ikeda Y (equal contribution), Yonemitsu Y, Goto Y, Murakami Y, Yoshida N, Tabata T, Hasegawa M, Tobimatsu S, Sueishi K, Ishibashi T, Pigment epithelium-derived factor gene therapy targeting retinal ganglion cell injuries: neuroprotection against loss of function in two animal models, Human Gene Therapy, 22, 559-565, 2011.05.
23. Ikeda Y, Hisatomi T, Miyazaki M, Kohno RI, Murakami Y, Takahashi H, Hata Y, Ishibashi T, Retinitis pigmentosa associated with asteroid hyalosis, Retina, 30, 1278-1281, 2010.09.
24. Murakami Y, Ikeda Y, Yonemitsu Y, Miyazaki M, Inoue M, Hasegawa M, Sueishi K, Ishibashi T, Inhibition of choroidal neovascularization via brief subretinal exposure to a newly developed lentiviral vector pseudotyped with sendai viral envelope proteins, Human Gene Therapy, 21, 199-209, 2010.02.
25. Ikeda Y, Yonemitsu Y, Miyazaki M, Kohno RI, Murakami Y, Murata T, Goto Y, Tabata T, Ueda Y, Ono F, Suzuki T, Ageyama N, Terao K, Hasegawa M, Sueishi K, Ishibashi T, Acute toxicity study of a simian immunodeficiency virus-based lentiviral vector for retinal gene transfer in nonhuman primates, Human Gene Therapy, 20, 943-954, 2009.09.
26. Ikeda Y, Yonemitsu Y, Miyazaki M, Kohno RI, Murakami Y, Murata T, Tabata T, Ueda Y, Ono F, Suzuki T, Ageyama N, Terao K, Hasegawa M, Sueishi K, Ishibashi T, Stable retinal gene expression in nonhuman primates via subretinal injection of SIVagm-based lentiviral vectors, Human Gene Therapy, 20, 573-579, 2009.06.
27. Miyazaki M, Ikeda Y, Yonemitsu Y, Goto Y, Kohno RI, Murakami Y, Inoue M, Ueda Y, Hasegawa M, Tobimatsu S, Sueishi K, Ishibashi T, Synergistic neuroprotective effect via simian lentiviral vector-mediated simultaneous gene transfer of human pigment epithelium-derived factor and human fibroblast growth factor-2 in rodent models of retinitis pigmentosa, Journal of Gene Medicine, 10, 1273-1281, 2008.12.
28. Murakami Y, Ikeda Y, Yonemitsu Y, Tanaka S, Kondo H, Okano S, Kohno RI, Miyazaki M, Inoue M, Hasegawa M, Ishibashi T, Sueishi K, Newly-developed Sendai virus vector for retinal gene transfer
Reduction of innate immune response via deletion of all envelope-related genes, Journal of Gene Medicine, 10, 165-176, 2008.02.
29. Ikeda Y, Yonemitsu Y, Onimaru M, Nakano T, Miyazaki M, Kohno R, Nakagawa K, Ueno A, Sueishi K, Ishibashi T, The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium, Experimental Eye Research, 83, 1031-1040, 2006.11.
30. Miyazaki M, Ikeda Y, Yonemitsu Y, Goto Y. Sakamoto T, Tabata T, Ueda Y, Hasegawa M, Tobimatsu S, Ishibashi T, Sueishi K, Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats, Gene Therapy, 10, 1503-1511, 2003.08.
31. Ikeda Y, Goto Y, Yonemitsu Y, Miyazaki M, Sakamoto T, Ishibashi T, Ueda Y, Hasegawa M, Tobimatsu S, Sueishi K, Simian immunodeficiency virus-based lentivirus vector for retinal gene transfer: a preclinical safety study in adult rats, Gene Therapy, 10, 1161-1169, 2003.07.
32. Ikeda Y, Yonemitsu Y, Kataoka C, Kitamoto S, Yamaoka T, Nishida S, Takeshita A, Egashira K, Sueishi K, Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats, American Journal of Physiology - Heart and Circulatory Physiology, 283, H2021-H2028, 2002.11.
33. Ikeda Y, Yonemitsu Y, Sakamoto T, Ishibashi T, Ueno H, Kato A, Nagai Y, Fukumura M, Inomata H, Hasegawa M, Sueishi K, Recombinant Sendai virus-mediated gene transfer into adult rat retinal tissue: Efficient gene transfer by brief exposure, Experimental Eye Research, 75, 39-48, 2002.01.
Presentations
1. Ikeda Y, Gene Therapy for Inherited Retinal Degenerations, 22nd Annual Meeting of Japan Society of Gene and Cell Therapy, 2016.07.
2. Ikeda Y, Neuroprotective gene therapy for patients with retinitis pigmentosa: interim report of low-titer group, 第6回国際協力遺伝病遺伝子治療フォーラム, 2016.01.
3. Ikeda Y, Role of Inflammation in Retinitis Pigmentosa, Asia-ARVO (Association for Research in Vision and Ophthalmology) 2105, 2015.02.
4. Ikeda Y, Phase I clinical study for patients with retinitis pigmentosa.: interim report of initial 5 subjects (low-titer group), 第5回国際協力遺伝病遺伝子治療フォーラム, 2015.01.
5. Ikeda Y, Phase I clinical study of a third-generation simian immunodeficiency virus (SIV)-based lentiviral vector carrying human PEDF gene for patients with retinitis pigmentosa, 2014 Annual Meeting of Association for Research in Vision and Ophthalmology, 2014.05.
6. Ikeda Y, Clinical trial of gene therapy for retinitis pigmentosa, The World Ophthalmology Congress (WOC) 2014, 2014.04.
7. Ikeda Y, Phase I clinical study of a third-generation simian immunodeficiency virus (SIV)-based lentiviral vector carrying human PEDF gene for patients with retinitis pigmentosa, 第4回国際協力遺伝病遺伝子治療フォーラム, 2014.01.
8. Ikeda Y, Phase I clinical study of a third-generation simian immunodeficiency virus (SIV)-based lentiviral vector carrying human PEDF gene for patients with retinitis pigmentosa, 19th Annual Meeting of Japan Society of Gene Therapy, 2013.07.
9. Ikeda Y, Neuroprotective Gene Therapy to Treat Patients with Retinitis Pigmentosa, 18th Annual Meeting of Japan Society of Gene Therapy, 2012.06.
10. Ikeda Y, Lentivirus vector-mediated gene therapy for retinitis pigmentosa, The World Ophthalmology Congress (WOC) 2012, 2012.02.
11. Ikeda Y, 網膜色素変性に対する視細胞保護遺伝子治療, 第2回国際協力遺伝病遺伝子治療フォーラム, 2012.01.