Kyushu University Academic Staff Educational and Research Activities Database
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Masako Hosoi Last modified date:2018.06.24

Graduate School
Undergraduate School
Administration Post

Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Psychosomatic Medicine, Argology, Neuroscience
Total Priod of education and research career in the foreign country
Outline Activities
Psychosomatic Research on Pain, Psychosomatic epidemiological study in Hisamaya, Translational Research on Pain and Micloglia, Development of Assessment Methods for Pain, Development of Multidisciplinary Approach of Chronic Pain, Clinical Research on Psychosomatic Digestive Diseases, Neuroscience Research on the Effects of Opioids on the NMDA receptors
Research Interests
  • Translational research on chronic pain: Elucidation of the pathology and the development of the evaluation methods from the aspects of psycho-neuro-immunology
    keyword : chronic pain, psychology, microglia
  • The cohort study on chronic pain
    keyword : prospective study, pain questionnaire
  • Brain imaging study on chronic pain
    keyword : Default mode network, VBM
  • Clinical and epidemiological research on the relationship between life-style diseases and alexithymia, nurturing style and positive feelings
    keyword : epidemiology; nurturing; life-style disease; alexithymia
  • Study of catastrophizing and alexithymia on chronic pain
    keyword : chronic pain, catastrophizing, alexithymia
  • The development of the assessment of chronic pain
    keyword : pain, questionnaire
    2003.04Development of the Assessment Methods of Chronic Pain.
Academic Activities
1. Hosoi, M.: Recent advance of molecular genetics in the psychosomatic medicine. In Modern Psycosomatic Medicine. Kubo C., Nakai, Y. and Nozoe, S. (Eds). Nagai-shoten, Tokyo, in press.
2. Hori T, Oka T, Hosoi M, Abe M, Oka K, Biphasic modulation of pain by hypothalamic cytokines.
In: Saade, NE, Apkarian, AV, and Jabbur, SJ (ed) : Pain and Neuroimmune Interactions
, Kluwer Academic/Plenum Publishers, New York, pp. 171-189, 2000.01.
3. Komiyama, H. and Hosoi, M.: Chronic pain. In Kubo, C. (ed) :Standard textbook of psychosomatic medicine. Igakusyoin, Tokyo: 178-185, 1996..
4. Hosoi, M.: Psychopharamcotherapy. In Luban-Plozza B, Pöldinger W, Kröger F (ed) :Practice in Psychosomatic Medicine, Schpringer-Verlag, Tokyo: 243-279, 1995 (Translation).
1. Pain and disbelief: the importance in the care of affective component of pain.
2. Psychosomatic approach for difficult cases of patients with chronic pain.
3. Chronic Pain-in the borderline between somatic disorder and psychiatric disorder-
4. Psychosomatic Treatment for Chronic Pain and Cingulate Cortex
-from Bench to Bed-.
5. Muraoka M, Komiyama H, Hosoi M, Mine K, Kubo C, Psychosomatic treatment of phantom limb pain with post-traumatic stress disorder: a case report, Pain 66 (2,3), 385-388, 1996.01.
1. Chie Hayaki, Kozo Anno, Mao Shibata, Rie Iwaki, Hiroshi Kawata, Nobuyuki Sudo, Masako Hosoi, Family dysfunction A comparison of chronic widespread pain and chronic localized pain, MEDICINE, 10.1097/MD.0000000000005495, 95, 49, 2016.12.
2. Anno K, Shibata M, Ninomiya T, Iwaki R, Kawata H, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M, Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population: the Hisayama Study, BMC PSYCHIATRY, 10.1186/s12888-015-0574-y, 15, 2015.07.
3. Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Hosoi M, Sudo N, Alexithymia is Associated with Greater Risk of Chronic Pain and Negative Affect and with Lower Life Satisfaction in a General Population: The Hisayama Study, PLOS ONE, 10.1371/journal.pone.0090984, 9, 3, 2014.03.
4. Makino Seiko, Jensen Mark P., Arimura Tatsuyuki, Obata Tetsuji, Anno Kozo, Iwaki Rie, Kubo Chiharu, SUDO Nobuyuki, Hosoi Masako, Alexithymia and Chronic Pain The Role of Negative Affectivity, The Clinical Journal of Pain, 10.1097/AJP.0b013e3182579c63, 29, 4, 354-361, 2013.04.
5. Iwaki R, Arimura T, Jensen MP, Nakamura T, Yamashiro K, Makino S, Obata T, Sudo N, Kubo C, Hosoi M, Global catastrophizing versus catastrophizing subdomains: Assessment and associations with patient functioning., Pain Medicine, doi: 10.1111/j.1526-4637.2012.01353.x. Epub 2012 Apr 4., 13, 5, 677-87, 2012.05, Objective.  The primary objectives of the current study were to 1) confirm the three-factor model of the Pain Catastrophizing Scale (PCS) items in a Japanese sample and 2) identify the catastrophizing subdomain(s) most closely associated with measures of pain and functioning in a sample of individuals with chronic pain. Design.  This was based on a cross-sectional observational study. Setting.  This study was conducted in a university-based clinic. Patients.  One hundred and sixty outpatients with chronic pain participated in this study. Outcome Measures.  Patients completed the PCS, the Brief Pain Inventory, and the Hospital Anxiety and Depression Scale; 30 patients completed the PCS again between 1 and 4 weeks later. Results.  Confirmatory factor analysis supported a three-factor structure of the Japanese version of the PCS, and univariate and multivariate associations with validity criterion supported the validity of the measure. Catastrophic helplessness was shown to make a unique contribution to the prediction of pain intensity, pain interference and depression, and catastrophic magnification made a unique contribution to the prediction of anxiety. Conclusions.  The findings support the cross-cultural generalizability of the three-factor structure of the PCS and indicate that the PCS-assessed catastrophizing subdomains provide greater explanatory power than the PCS total score for understanding pain-related functioning.
Wiley Periodicals, Inc..
6. Arimura T, Hosoi M, Tsukiyama Y, Yoshida T, Fujiwara D, Tanaka M, Tamura R, Nakashima Y, Sudo N, Kubo C, Pain questionnaire development focusing on cross-cultural equivalence to original questionnaire: the Japanese version of the Short-Form McGill Pain Questionnaire., Pain Medicine , 10.1111/j.1526-4637.2012.01333.x., 13, 4, 541-551, 2012.04, OBJECTIVES:
The present study aimed to develop a Japanese version of the Short-Form McGill Pain Questionnaire (SF-MPQ-J) that focuses on cross-culturally equivalence to the original English version and to test its reliability and validity.
Cross-sectional design.
In study 1, SF-MPQ was translated and adapted into Japanese. It included construction of response scales equivalent to the original using a variation of the Thurstone method of equal-appearing intervals. A total of 147 undergraduate students and 44 pain patients participated in the development of the Japanese response scales. To measure the equivalence of pain descriptors, 62 pain patients in four diagnostic groups were asked to choose pain descriptors that described their pain. In study 2, chronic pain patients (N=126) completed the SF-MPQ-J, the Long-Form McGill Pain Questionnaire Japanese version (LF-MPQ-J), and the 11-point numerical rating scale of pain intensity. Correlation analysis examined the construct validity of the SF-MPQ-J.
The results from study 1 were used to develop SF-MPQ-J, which is linguistically equivalent to the original questionnaire. Response scales from SF-MPQ-J represented the original scale values. All pain descriptors, except one, were used by >33% in at least one of the four diagnostic groups. Study 2 exhibited adequate internal consistency and test-retest reliability, with the construct validity of SF-MPQ-J comparable to the original.
These findings suggested that SF-MPQ-J is reliable, valid, and cross-culturally equivalent to the original questionnaire. Researchers might consider using this scale in multicenter, multi-ethnical trials or cross-cultural studies that include Japanese-speaking patients.
Wiley Periodicals, Inc..
7. Yamashiro K, Arimura T, Iwaki R, Jensen MP, Kubo C, Hosoi M. , A multidimensional measure of pain interference: reliability and validity of the pain disability assessment scale.
, Clinical Journal of Pain, 27, 4, 338-343, 2011.05.
8. Hosoi M, Molton IR, Jensen MP, Ehde DM, Amtmann S, O’Brien S, Arimura T, Kubo C, Relationships among alexithymia and pain intensity, pain interference, and vitality in persons with neuromuscular disease: considering the effect of negative affectivity., Pain, DOI information: 10.1016/j.pain.2010.02.012, 149, 273-277 , 2010.05.
9. Xiong W, Hosoi M, Koo BN, Zhang L. , Anandamide inhibition of 5-HT3A receptors varies with receptor density and
, Molecular Pharmacology, 73(2):314-22. Epub 2007 Nov 9.
, 2008.02.
10. Kanemitsu Y, Hosoi M, Zhu PJ, Weight FF, McLaughlin JS, Zhang, L, Dynorphin A inhibits NMDA receptors through a pH dependent mechanism, Journal of Molecular and Cellular Neuroscience, 24 (3) : 525-537, 2003.11.
11. Hayashi H, Mine K, Hosoi M, Tsuchida O, Handa M, Kinukawa N, Andou K, Kubo C, Comparison of the esophageal manometric characteristics of idiopathic and reflux-associated esophageal spasm: evaluation by 24-hour ambulatory esophageal motility and pH monitoring., Digestive Diseases and Sciences, 10.1023/B:DDAS.0000004514.91064.7f, 48, 11, 2124-2131, 48 (11) : 2124-2131, 2003.11.
12. Zhang L, Hosoi M, Fukuzawa M, Sun H, Rawlings RR, Weight FF, Distinct molecular basis for differential sensitivity of the serotonin type 3A receptor to ethanol in the absence and presence of agonist, Journal of Biological Chemistry, 2002.11.
13. Hosoi M, Oka T, Abe M, Hori T, Yamamoto H, Mine K, Kubo C, Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats, Pain, 10.1016/S0304-3959(99)00105-0, 83, 2, 221-227, 83 (4) : 221-227, 1999.11.
14. Hosoi M, Oka T, Hori T, Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca, Pain, 10.1016/S0304-3959(97)03380-0, 71, 3, 303-311, 71 : 303-311, 1997.07.
1. Masako Hosoi, Masahiro Ohgitani, Takahiro A. Kato, Rie Iwaki, Chie Hayaki, Nobuyuki Sudo, Kanba S, TNFα-Response is Associated with the Clinical Pain Outcomes of Fibromyalgia Patients: An Evaluation Done with Human Blood-Induced MicrogliaLike Cells(iMG), 16th World Congress on Pain(第16回世界疼痛学会), 2016.09.
2. Chronic pain and Alexithymia : the Research History and Future.
3. Abdominal pain and emotion-the role of insular cortex-.
4. Nociception and pain-Alexithymia and pain experience-
5. Psychosomatic approach for difficult cases of patients with chronic pain.
Membership in Academic Society
  • Japanese Society of Pain Clinicians
  • Japanese Association for Study of Pain
Educational Activities
Clinical Teaching for Medical Students to see Outpatients,
Clinical Teaching for Medical Students to see Inpatients,
Teaching in the Clinical Clerkship and Basic Research,
Lecturer in Medical Seminar and Orientation Lecture on Psychosoamtic Medicine held in the Dept.of Psychosomatic Medicine in Kyushu University Hospital
Professional and Outreach Activities
Colaboratory Study with researchers of Department of Psychiatrics in the University of Vienna, Vienna, Austria (2006-)

Colaboratory Study with researchers of Department of Rehabilitation in the University of Washington, Seattle, USA (2005-)

Colaboratory Study with researchers of National Institute on Alcohol Abuse and Alcoholism (NIAAA),
National Institutes of Health (NIH), USA (1997-)

Engagement of the study on psychosomatic diseases funded by Japanese Ministry of Health, Welfare and Labor.