Kyushu University Academic Staff Educational and Research Activities Database
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YOICHIRO OGINO Last modified date:2024.04.18

Associate Professor / Section of Fixed Prosthodontics, Division of Oral Rehabilitation
Department of Dental Science
Faculty of Dental Science


Graduate School
Undergraduate School
Administration Post
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Homepage
https://kyushu-u.elsevierpure.com/en/persons/yoichiro-ogino
 Reseacher Profiling Tool Kyushu University Pure
https://hyoka.ofc.kyushu-u.ac.jp/search/details/K002651/index.html
Researcher information .
Phone
092-642-6371
Fax
092-642-6374
Academic Degree
PhD (Dentistry) (Kyushu University, Japan)
Country of degree conferring institution (Overseas)
No
Field of Specialization
Prosthodontics
Total Priod of education and research career in the foreign country
01years10months
Outline Activities
Education for dental student and post-graduate student
Education for dental residents
Certified prosthodontist
Research for clinical evaluation of prosthodontic treatment (effects of prosthodontic treatment on edentulous patients, maxilloafacial Prosthetic patients,, combination syndrome)
Chief dentist for maxillofacial prosthodontics
Research
Research Interests
  • The association between polypharmacy and oral functions
    keyword : polypharmacy, oral functions
    2021.04~2025.03.
  • Validation of oral sarcopenia
    keyword : oral sarcopenia
    2023.04~2026.03.
  • The effect of dental intervention of cognitive function:systematic review
    keyword : dental intervention, cognitive function
    2021.03~2023.03.
  • Biomechanical Behaviors of Implant-Supported Removable Partial Dentures
    keyword : Implant-Supported Removable Partial Dentures  Biomechanical Behaviors
    2020.10~2021.06.
  • Validation of oral functions in the community-dwelling elderly
    keyword : community-dwelling elderly oral functions
    2020.04~2022.03.
  • Mastication predominance and prosthetic intervention
    keyword : mastication predominance Kennedy classification prosthetic intervention
    2020.04~2022.03.
  • Clinical evaluation of all ceramic crown
    keyword : all ceramic crown
    2020.04~2023.03.
  • Clinical research of GBR membrane
    keyword : GBR
    2020.03~2021.03.
  • Clinical research of monolithic zirconia crown adhesion
    keyword : monolithic zirconia crown
    2020.06~2021.03.
  • Clinical assessment of novel bone substitute
    keyword : bone substitute
    2018.03~2019.12.
  • Oral function and QoL evaluation in Maxillofacial Prosthetic patients
    keyword : Maxillofacial Prostheses
    2018.04~2021.03.
  • Clinical evaluation of monolithic zirconia crowns
    keyword : monolithic zirconia crowns
    2016.05~2018.03.
  • Interaction between proinflammatory cytokine and bone morphogenetic protein
    keyword : proinflammatory cytokine  bone morphogenetic protein
    2016.04~2019.03.
  • Clinical evaluation of novel implant
    keyword : implant
    2014.04~2018.12.
  • Clinical evaluation of CAD/CAM molar crown with hybride resin
    keyword : CAD/CAM、hybride resin、molar crown
    2015.04~2015.12.
  • Clinical Trial of novel bone substitute
    keyword : bone substitute、Implant
    2015.08~2015.08.
  • Prosthetic treatment for an adult oeteopetrosis patient
    keyword : oeteopetrosis, Prosthetic treatment
    2014.04~2014.08.
  • effect of surface topography on cellular functions
    keyword : Ti, implant, Cell
    2014.04~2017.03.
  • Prothsodontic management for combination syndrome patients
    keyword : combination syndrome  dental implants removable denture
    2010.04~2013.03.
  • The effect of osteoporosis on dental implants
    keyword : osteoporosis implant
    2010.06~2012.03.
  • Multicenter research for the prosthodontic treatment for SDA patients
    keyword : SDA
    2008.05~2011.03.
  • Biological study for osseointegration by inhibition of extraction sockets resorption
    keyword : teeth extraction, inhibition of bone resorption
    2008.04~2010.03.
  • Bone Response to Implant Placement Torque
    keyword : Implant, Insertion torque, osseointegration
    2007.04.
  • Clinical Application of Growth Factors in Dntistry
    keyword : growth factor
    2006.04.
  • Biological Approach for Alveolar Bone Regeneration
    keyword : osteoblast, osteoclast
    2000.04~2005.12Research for alveolar bone regeneration.
Current and Past Project
  • Osteoimmunologic approach to titanium disk
  • Clinical assessment of maxillofacial prostheses subjectively and objectively
  • Assessment of the effect of surface topogaphy and hydrothemal teratment on surface chemistry and bone induction
  • Examnination of cellular functions on various Ti surface topography
  • The effect of osteoporosis on stable osseointegrated implants
Academic Activities
Reports
1. Inamochi Y, Ogino Y, Harada K, Fueki K, Ayukawa Y, Nishimura M, Maekawa K, Kang Y, Hirai T, Kuboki T., DO ORAL CARE AND REHABILITATION IMPROVE COGNITIVE FUNCTION? A SYSTEMATIC REVIEW OF CLINICAL STUDIES., J Evid Based Dent Pract. , doi: 10.1016/j.jebdp.2023.101948. , 2024.03, Objectives: An increasing number of studies have identified an association between oral health status and cognitive function. However, the effect of oral interventions, including oral health care, dental treatment and oral motor exercises, on cognitive function remains unclear. This systematic review examined whether oral interventions contribute to the long-term improvement of cognitive status.

Methods: Four databases were searched (MEDLINE, Web of Science, Cochrane Library, and ICHUSHI Web) to identify randomized and nonrandomized controlled trial studies and prospective cohort studies from inception until 1 September 2023, published in English or Japanese. The Cochrane risk of bias tool for randomized controlled trials and the risk of bias assessment tool for nonrandomized studies were used to assess bias risk.

Results: A total of 20 articles were included in the qualitative analysis; 13 articles were published in English, and 7 were published in Japanese. The implemented interventions were oral care in 8 studies, dental treatment in 8 studies, and oral motor exercise in 4 studies. One study found a significant effect on attention following oral care intervention. Some dental treatments influenced cognitive function, although a clear positive effect was not determined. In 1 study, attention and working memory improved in the chewing exercise group.

Conclusions: Several studies verified the improvement effects of oral interventions, such as oral care, dental treatment, and oral motor exercise, on cognitive function or impairment. However, there was still a lack of conclusive evidence that such an intervention clearly improved cognitive function. To clarify the effects of oral interventions on cognitive function, it is necessary to examine participants, interventions, and outcome measures in detail..
2. Ogino Y, Ayukawa Y., Anterior Hyperfunction by Mandibular Anterior Teeth: A Narrative Review., Healthcare (Basel). , 10.3390/healthcare11222967., 2023.11, "Combination syndrome", defined by Kelly in 1972, is a challenging condition observed in a patient with an edentulous maxilla and a partially edentulous mandible with only mandibular anterior teeth. "Anterior hyperfunction syndrome" is regarded as a synonym of combination syndrome and was first described in 1994. Although these terms have been well known, the definition of "anterior hyperfunction" has not been described yet. This narrative review focused on anterior hyperfunction and discussed the etiology and the clinical managements. An electronic bibliographic search for this literature review was conducted in addition to the review of our clinical cases. The previous reports indicated that combination syndrome with all five features was rarely observed. The patients with anterior hyperfunction generally showed the loss of posterior occlusal supports and the loss of vertical dimension of occlusion. To manage anterior hyperfunction, these conditions should be improved using conventional removable prostheses and implant-supported prostheses. Anterior hyperfunction is attributed to mandibular anterior teeth and some interventions for mandibular anterior teeth are required in many cases. Additionally, it must be noted that implant-supported prostheses may lead to anterior hyperfunction. In conclusion, comprehensive approaches for the remaining teeth and the prostheses will be required to manage this complex condition..
Papers
1. Yoshioka K, Ogino Y, Kawasaki M, Ayukawa Y., An observational study of oral functions in patients aged from 20 to 49 years., J Oral Sci., 10.2334/josnusd.23-0311., 66, 1, 75-78, 2024.01, Purpose: The purpose of this study was to analyze oral functions (MOF: maximum occlusal force; MTP: maximum tongue pressure; and MF: masticatory function) in Eichner A subjects aged from 20 to 49 years.

Methods: The data of three oral functions in Eichner A patients aged from 20 to 49 years were extracted. The mean values, subjects with lower values than the thresholds, and the differences among ages, and between sexes were investigated retrospectively.

Results: Although the mean values of these oral functions in 183 subjects were higher than the thresholds, the numbers of the subjects with lower values than the thresholds were 30 in MTP, 19 in MOF, and only three in MF. No significant effects of ages on all oral functions were identified and all functions in males were significantly higher than those in females. The subjects whose two functions were lower than the thresholds were nine females, eight of whom were associated with malalignment.

Conclusion: Although the mean values of oral functions were higher than the thresholds, some patients showed lower values, especially in MOF and MTP, even though they were unaware of any inconvenience. Patients with malalignment might be associated with declined oral functions.

Keywords: malalignment; masticatory function; maximum occlusal force; maximum tongue pressure; middle-aged population; young adulthood..
2. Kawasaki M, Ogino Y, Moroi R, Ayukawa Y., Comprehensive Analyses of Masticatory Function in Maxillectomy Patients with Functioning Removable Prostheses: A Retrospective Cross-Sectional Study.
, J Clin Med. , 10.3390/jcm12155117., 12, 15, 5117-5117, 2023.08, The aim of this retrospective cross-sectional study was to comprehensively assess masticatory function in maxillectomy patients with functioning removable prostheses. Their general and oral profiles, the measurement values of their oral functions, including masticatory function, and the history of tumor therapy were extracted from medical charts. The correlations of masticatory function with numerical data and the effects of tumor therapy-related factors on masticatory function were evaluated. In addition, a stepwise conditional logistic regression analysis was performed to identify the potential predictive factors comprehensively. The data from 55 maxillectomy patients revealed that the median value of masticatory function (138.0 mg/dL) was higher than the threshold (100.0 mg/dL) based on the concept of oral hypofunction. Moderate correlations of masticatory function with the number of remaining teeth, the number of functioning occlusal supports, and maximum occlusal force were found, as well as a weak correlation with maximum tongue pressure. These variables also showed statistically significant coefficients (p
3. Imai M, Ogino Y, Tanaka H, Koyano K, Ayukawa Y, Toyoshima T., Primary stability of different implant macrodesigns in a sinus floor elevation simulated model: an ex vivo study, BMC Oral Health. 2022 Aug 8;22(1):332. , doi: 10.1186/s12903-022-02345-5., 2022.08.
4. Ogino Y, Ayukawa Y, Tachikawa N, Shimogishi M, Miyamoto Y, Kudoh K, Fukuda N, Ishikawa K, Koyano K., Staged Sinus Floor Elevation Using Novel Low-Crystalline Carbonate Apatite Granules: Prospective Results after 3-Year Functional Loading., Materials (Basel)., doi: 10.3390/ma14195760., 14, 19, 5760, 2021.10, The aim of this study was to evaluate clinical outcomes of staged sinus floor elevation (SFE) using novel low-crystalline carbonate apatite (CO3Ap) granules. Patients who needed SFE for implant placement were recruited into this clinical trial. A staged procedure (lateral window technique using CO3Ap granules, followed by implant placement after 7 ± 2 months) was employed in 13 patients. Bone-height increase and insertion torque values (ITVs) were assessed along with histological evaluation. The survival and success rates of 3-year functioning implants were also evaluated. Mean of bone-height increase after SFE using CO3Ap granules was 7.2 ± 2.5 mm and this increase allowed implant placement in all cases (17 implants). Mean of ITV was 25.1 ± 13.2 Ncm and primary stability was achieved successfully in all cases. Histological analyses revealed mature new bone formation (36.8 ± 17.3%) and residual CO3Ap granules (16.2 ± 10.1%) in the compartment after SFE. The survival and success rates after 3-year functional loading were 100% and no complications were found. These results clearly indicate the clinical usefulness of CO3Ap granules for SFE..
5. Ogino Y, Suzuki H, Ayukawa Y, Ueno Y, Jinnouchi A, Koyano K., Masticatory performance and other oral functions in commu, J Oral Sci., doi: 10.2334/josnusd.21-0265., 63, 4, 330-333, 2021.10.
6. Ogino Y, Suzuki H, Ayukawa Y, Jinnouchi A, Koyano K., Analyses of Swallowing Function and Its Related Factors in Community-Dwelling Elderly Patients: A Case-Control Study., J Clin Med., doi: 10.3390/jcm10153437., 10, 15, 3437, 2021.08.
7. Kinoshita K, Ogino Y, Oki K, Yamasaki Y, Tsukiyama Y, Ayukawa Y, Koyano K., A Prospective Comparative Study of Mastication Predominance and Masticatory Performance in Kennedy Class I Patients., Healthcare (Basel). , doi: 10.3390/healthcare9060660., 9, 6, 660, 2021.06.
8. Oki K, Ogino Y, Takamoto Y, Imai M, Takemura Y, Ayukawa Y, Koyano K., The Significance of Posterior Occlusal Support of Teeth and Removable Prostheses in Oral Functions and Standing Motion., Int J Environ Res Public Health. , doi: 10.3390/ijerph18136776., 18, 13, 6776, 2021.06.
9. Ogino Y, Fujikawa N, Koga S, Moroi R, Koyano K. , A retrospective cross-sectional analysis of swallowing and tongue functions in maxillectomy patients., Support Care Cancer., doi: 10.1007/s00520-021-06186-w., 29, 10, 6079-6085, 2021.10, Purpose: To investigate the profiles of swallowing and tongue functions, and to identify factors influencing swallowing in maxillectomy patients.

Methods: Maxillectomy patients whose swallowing function defined by Eating Assessment Tool (EAT-10) score and tongue functions (oral diadochokinesis: ODK, maximum tongue pressure: MTP) with or without obturator prostheses had been evaluated were enrolled in this study. The effects of the history of radiotherapy and soft palate defect on swallowing function were evaluated. The effect of radiotherapy on oral dryness was also evaluated. To examine correlations of swallowing function with continuous variables, Spearman correlation coefficients were calculated.

Results: A total of 47 maxillectomy patients (23 males and 24 females, median age: 71 [IQR: 63-76]) were registered. The median value of EAT-10 scores was 3 [IQR: 0-14]. Patients with the history of radiotherapy, but not with soft palate defect, showed significantly declined swallowing function. ODK and MTP of patients wearing obturator prostheses were significantly improved. No significant effect of radiotherapy on oral dryness was found. A significant correlation was found between EAT-10 score and MTP (P = 0.04).

Conclusions: Swallowing function in maxillectomy patients was relatively impaired and the patients with the history of radiotherapy showed lower swallowing function. Obturator prostheses could contribute to the improvement of MTP and ODK (/ta/). MTP may play a crucial role in swallowing in maxillectomy patients..
10. Ogino Y, Matsushita Y, Sasaki M, Ayukawa Y, Koyano K., A 3-Year Prospective Study on Radiographic Marginal Bone Evaluation Around Platform-Shifting Implants with Internal Conical Connections., Int J Oral Maxillofac Implants. 2021 May-Jun;36(3):574-580. , doi: 10.11607/jomi.8425., 36, 3, 574-580, 2021.06.
11. Kihara M, Ogino Y, Matsushita Y, Morita T, Sawae Y, Ayukawa Y, Koyano K., In Vitro Assessment of the Effect of Implant Position on Biomechanical Behaviors of Implant-Supported Removable Partial Dentures in Kennedy Class II Condition, MATERIALS, 10.3390/ma14092145, 14, 9, 2021.05.
12. Oki K, Ogino Y, Tsukiyama Y, Yamasaki Y, Koyano K, The impacts of prosthetic interventions on mastication predominance in Kennedy Class Ⅱ patients., J Prosthodont Res., doi: 10.2186/jpr.JPR_D_20_00055., 65, 3, 327-331, 2021.08.
13. Koga S, Ogino Y, Fujikawa N, Ueno M, Kotaki Y, Koyano K., Oral health-related quality of life and oral hygiene condition in patients with maxillofacial defects: A retrospective analysis.
, J Prosthodont Res., 10.1016/j.jpor.2019.11.003., 2020.02, Purpose: The purpose of this study was to evaluate the effect of oral rehabilitation (maxillofacial prosthetic intervention and oral hygiene instruction) on oral health-related Quality of Life (OHRQoL) and oral hygiene condition in patients with maxillofacial defects and to explore the correlation between them in these patients.Methods: Twenty-five patients with maxillofacial defects who had been treated since April 2016 to March 2018 were included in this study. The scores of the Oral Health Impact Profile (OHIP) and O’Leary’s Plaque Control Record (PCR) were also identified as the scores of OHRQoL and oral hygiene condition, respectively. Statistical analyses were performed to compare between the scores of “pre” and “post” prosthetic treatment and to evaluate patient-related factors influencing these variables (age, the number of residual teeth and occlusal supports, and occlusal units (OUs)). The effect of combined chemo-radiotherapy (CRT) on each score was also assessed statistically. Furthermore, the correlation of OHIP and PCR scores was explored statistically.Results: Both oral rehabilitations could significantly improve OHIP and PCR scores. Significant correlations of the change of OHIP scores with age and OUs were detected. CRT had no significant effect on OHIP and PCR scores. No correlations between OHIP and PCR were observed. Conclusions: Although oral rehabilitation such as maxillofacial prosthetic treatment and oral hygiene instruction would be highly effective for improvement of OHRQoL and oral hygiene condition in patients with maxillofacial defects, there was no correlation between them..
14. Nishimura T, Ogino Y, Ayukawa Y, Koyano K., Influence of the wettability of different titanium surface topographies on initial cellular behavior., Dent Mater J., 2018.06, This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability..
15. Gunge H, Ogino Y, Kihara M, Tsukiyama Y, Koyano K., Retrospective clinical evaluation of posterior monolithic zirconia restorations after 1 to 3.5 years of clinical service., J Oral Sci., 24, 60, 154-158, 2018.03.
16. Kaku T, Ogino Y, Matsushita Y, Koyano K., Technique for identifying keratinized gingival tissue and soft tissue morphology on 3-dimensional implant-planning software images., J Prosthet Dent., doi: 10.1016/j.prosdent., 116, 1, 21-24, 2016.05.
17. YOICHIRO OGINO, Ruiwei Liang, Daniela Mendonca, Gustavo Mendonca, Masako Nagasawa, kiyoshi koyano, Lyndon F. Cooper, RhoA-Mediated Functions in C3H10T1/2 Osteoprogenitors Are Substrate Topography-Dependent., J Cell Physiol, doi: 10.1002/jcp.25100., 231, 3, 568-575, 2016.03.
18. 荻野 洋一郎, 鮎川 保則, 富田陽子, 古谷野 潔, Prosthetic aspects in adult osteopetrosis., J Prosthet Dent., 2014.10, Osteopetrosis (OP) is a rare condition characterized by skeletal sclerosis caused by dysfunctional osteoclasts. Though many reports have described severe infantile-malignant autosomal recessive OP, few have described the prosthetic management of adult OP. This report discusses the prosthetic treatment of adult OP. Although prosthodontists should try to reconstruct occlusal function as much as possible, a conservative prosthodontic approach may be a reasonable and recommended treatment option for minimizing the risk of further osteomyelitis and osteonecrosis..
19. YOICHIRO OGINO, Kihara Masafumi, Junichi Yamda, Kohei Toriya, kiyoshi koyano, Implant Treatments for Edentulous Maxilla with Anterior Hyperfunction., J Oral Implantol., doi: 10.1563/AAID-JOI-D-13-00123. , 41, 6, 731-735, 2015.12.
20. Daisuke Kondo, YOICHIRO OGINO, Yasunori AYUKAWA, Shinji Sakai, KOEI KAWAKAMI, kiyoshi koyano, Bone Regeneration of Tibial Defects in Rats with Enzymatic Hydrogelation of Gelatin Derivative and Recombinant Human Platelet-Derived Growth Factor-BB Complex, INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 28, 5, 1377-1385, 2013.09.
21. Ogino Y. Ayukawa Y. Kukita T. Atsuta I. Koyano K. , Platelet-rich plasma suppresses osteoclastogenesis by promoting the secretion of osteoprotegerin.

, Journal of Periodontal Research, 44(2):217-24, 2009 Apr. , 2009.04.
22. Yoichiro Ogino, Kohei Toriya, Yasunori Ayukawa, Kiyoshi Koyano, Prosthetic and Surgical Managements of Peri-implantitis at the Flap Reconstruction Site., Prosthodontic Research & Practice Vol.7 No.2, 2008, Vol.7 No.2, 231-233, 2008, 2008.07.
23. Yoichiro Ogino,Yasunori Ayukawa,Toshio Kukita,Kiyoshi Koyano, The contribution of platelet-derived growth factor, transforming growth factor-β1 and insulin-like growth factor-I in platelet-rich plasma (PRP) to the proliferation of osteoblast-like cells., Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics., 2006.05.
24. Yoichiro Ogino, DDS, PhD,a Yasunori Ayukawa, DDS, PhD,b Yoshihiro Tsukiyama, DDS, PhD,c, The effect of platelet-rich plasma on the cellular response of rat bone
marrow cells in vitro, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 10.1016/j.tripleo.2005.03.007, 100, 3, 302-307, Oral Surg Oral Med Oral Pathol Oral Radiol
Endod 2005;100:302-7, 2005.10.
Presentations
1. Ogino Y, Matsushita Y, Koyano K, Clinical and radiological assessment of maxillary sinus floor augmentation using carbonate apatite: A 30-month follow-up study, 18th Biennial Meeting of ICP and 43rd Annual Meeting of the EPA, 2019.09.
2. Ogino Y, Matsushita Y, Koyano K, Maxillary sinus floor augmentation using carbonate apatite granules: A 30-month follow-up study., 6th Biennial Joint Congress of KAP-CPS-JPS, 2019.03.
3. Ogino Y, Koga S, Fujikawa N, Koyano K, Advantages and disadvantages of preoperative-restored implant prostheses after oral tumor resection. , ISMR-AAMP 4th joint meeting, 2017.11.
4. YOICHIRO OGINO, LYNDON F COOPER, 古谷野 潔, Specific acid-treated surface topography alter hydrophilicity and osteogenic cellular responses., 16th biannual meeting of International Collage of Prosthodontics, 2015.09.
5. YOICHIRO OGINO, Lyndon F. Cooper, kiyoshi koyano, Topography influences cellular responses and RhoA activity of titanium surface-adherent cells. , Congress of Asian Academy of Prosthodontincs, 2014.11.
6. YOICHIRO OGINO, Lyndon F. Cooper, kiyoshi koyano, Topography influences cellular responses and RhoA activity of titanium surface-adherent cells. , Congress of Asian Academy of Prosthodontincs, 2014.11.
7. YOICHIRO OGINO, Lyndon F. Cooper, kiyoshi koyano, Topography influences cellular functions and RhoA activity of titanium surface-adherent cells., 9th International Wrokshop on Biomaterials in Interface Science, 2014.08, Purpose: RhoA, one of Rho-family of GTPases, is known to influence cell adhesion and motility through organization of the actin cytoskeleton in response to various stimuli. The aim of this study was to investigate cellular functions and RhoA activities of the adherent cells on titanium substrates with three kinds of topography.
Materials and Methods: Three kinds of surface topography Ti disks were prepared. Smooth (S) surfaces were passivated with 30% HNO3. HCl-treated (H1) surfaces were grit-blasted with 100-μm aluminum oxide (Al2O3) particles, subsequently treated with 5N HCl and passivated with 30% HNO3. H2O2+H2SO4-treated (H2) surfaces grit-blasted with 100-μm Al2O3 particles and subsequently treated with 30% H2O2 and 2N H2SO4. These surfaces were characterized by SEM analysis and the measurement of surface roughness. To evaluate the effect of surface topography and RhoA inactivation on cellular functions, murine mesenchymal stem cells were cultured on each disk and cell morphology, RhoA activity, wound healing rates (cell migration) and osteogenic markers’ expressions were investigated with or without RhoA inhibitor (C3).
Results: Each disk showed a specific surface topography and surface roughness analysis indicated the highest roughness in H1 surfaces (H1>H2>S). Cell morphology was influenced by surface topography and C3. RhoA was activated in a surface roughness-dependent manner. The highest wound healing rate was observed on S surface. RhoA inhibition also enhanced cell migration on S and H1 surfaces, but not H2 surface. The expression of osteogenic markers was inhibited by C3 in S and H1 adherent cells, but not in H2 adherent cells.
Conclusions: Topography influences cellular functions and RhoA activity. However, the effect of RhoA inhibition on cellular functions may be in a surface topography- dependent manner.
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8. KATHARINE AVANESYAN K, YOICHIRO OGINO, Lyndon Cooper, Monocytic Prostaglandin as a Chemotactic Agent for MSC Homing, American Association for Dental Research (AADR) Annual Meeting & Exhibition, 2014.03.
9. YOICHIRO OGINO, Ruiwei Liang, Daniela Mendonca, Gustavo Mendonca, Lyndon F Cooper, Kiyoshi Koyano, Topography and RhoA on Initial Cell Behaviors, the 91st IADR General Session & Exhibition, 2013.03.
Membership in Academic Society
  • Japanese Society of Gerodontology
  • Japanese Academy of Maxillofacial Prosthetics
  • International Association for Dental Research
  • International college of prosthodontists
Awards
  • Maxillary sinus floor augmentation using carbonate apatite granules: A 30-month follow-up study.
Educational
Educational Activities
Education of basic and clinical prosthodontics (crown-fixed partial denture, removable denture)
Education of basic and clinical dental implantology
Education of basic bone regeneration research
Education of oral function