Kyushu University Academic Staff Educational and Research Activities Database
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Kazuhide Inoue Last modified date:2017.10.06

Executive Vice President(Senior Vice President) / Clinical Pharmaceuticals
Trustee(Vice President)


Undergraduate School
Administration Post
Vice President


Homepage
http://yakkou.phar.kyushu-u.ac.jp/
Department of Molecular and System Pharmacology .
Phone
092-642-6566
Fax
092-642-6566
Academic Degree
Ph.D.
Field of Specialization
Neuropharmacology
Research
Research Interests
  • Research for the functions of purinergic receptors on neuropathic pain sugnalling
    keyword : ATP, purine, pain
    2004.04.
  • The function of glia-neuron interaction for the mechanism of neuropathic pain through purinergic receptors.
    keyword : pain, ATP receptors
    2003.04.
  • Finding the machanism of the regulation of the function of astrocyte-neuron interaction through extracellular ATP.
    keyword : ATP, astrocytes
    2003.04.
Current and Past Project
  • To examine the mechanism of neuropathic pain.
Academic Activities
Books
1. 井上和秀, 生理活性ヌクレオチド・ヌクレオシド In New薬理学, 南江堂, 田中千賀子、加藤隆一編、p.147-149, 2007.12.
2. Tsuda M and Inoue K., P2X receptors in Sensory Neurons. In The Nociceptive Membrane (Current Topics in Membrane, vol.57) ed.by Uhtaek Oh., Academic Press, London, p.277-310, 2006.04.
3. Inoue K, ATP receptors of microglia involved in pain. In Purinergic signaling in neuron-glia interaction (Novartis Foundation Symposium 276), John Wiley & Sons, Ltd, Chichester, p.263-281, 2006.04.
4. Inoue K., Chronic pain and microglia: the role of ATP. In Pathological pain:From molecular to clinical aspects (Novartis Foundation Symposium 261), John Wiley & Sons, Ltd, Chichester, p.263-281, 2004.01.
Reports
1. Inoue K, Purinergic systems in microglia., Cell Mol Life Sci, 65, 3074-3080, 2008.06.
Papers
1. Masuda Takahiro, Nao Nishimoto, Daisuke Tomiyama, Tsuyoshi Matsuda, Hidetoshi Saitoh, Tomohiko Tamura, Shinichi Kohsaka, TSUDA MAKOTO, Kazuhide Inoue, IRF8 is a transcriptional determinant for microglial motility. , Purinergic Signal., [Epub ahead of print], 2014.05.
2. Masuda Takahiro, Shosuke Iwamoto, Ryohei Yoshinaga, Hidetoshi Saitoh, A. Nishiyama, T. W. Mak, T. Tamura, TSUDA MAKOTO, Kazuhide Inoue, Transcription factor IRF5 drives P2X4R+ reactive microglia gating neuropathic pain. , Nat Commun., 13;5:3771. , 2014.05.
3. Katsuyuki Matsushita, Chinami Kojima, Hidetoshi Saitoh, TSUDA MAKOTO, Kazuhide Inoue, Sumio Hoka, C-C chemokine receptor type 5 is an important pathological regulator in the development and maintenance of neuropathic pain. , Anesthesiology, 120, 6, [Epub ahead of print], 2014.02.
4. Nakaya Michio, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K, Nishihara H, Ohba M, Komiya S, Tani N, Motohiro Nishida, Taniguchi H, Sato Y, Matsumoto M, TSUDA MAKOTO, Kuroda M, Kazuhide Inoue, Hitoshi Kurose, GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance., Nat Commun., 4:1532., 2013.02.
5. Sun L, Wu Z, Yoshinori Hayashi, Peters C, TSUDA MAKOTO, Kazuhide Inoue, Hiroshi Nakanishi, Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain., J Neurosci, 32(33):11330-42., 2012.08.
6. Masuda Takahiro, TSUDA MAKOTO, Ryohei Yoshinaga, Hidetoshi Saitoh, K. Ozato, T. Tamura, Kazuhide Inoue, IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype., Cell Rep., 1(4):334-40, 2012.04.
7. Y. Hayashi, K. Kawaji, L. Sun, X. Zhang, K. Koyano, T. Yokoyama, S.Kohsaka, K. Inoue, and H. Nakanishi., Microglial Ca2+-activated K+ Channels Are Possible Molecular Targets for the Analgesic Effects of S-ketamine on Neuropathic Pain., J.Neurosci, 31, 48, 17370-17382, 2011.11.
8. Biber K, Tsuda M, Saitoh-Tozaki H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K., Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development., EMBO J, 30:1864-73, 2011.05.
9. M. Nishida, M. Ogushi, R. Suda, M. Toyotaka, S. Saiki, N. Kitajima, M. Nakaya, K.-M. Kim, T. Ide, Y. Sato, K. Inoue, and H. Kurose., Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-κB, PNAS, 108(16):6662-7, 2011.04.
10. M. Tsuda, Y. Kohro, T. Yano, T. Tsujikawa, J. Kitano, H. Tozaki-Saitoh, S. Koyanagi, S. Ohdo, R-R Ji, M. W. Salter, K. Inoue., JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. , Brain, 134(4): 1127-1139, 2011.04.
11. M. Tsuda*, T. Masuda*, J. Kitano, H. Shimoyama, H. Tozaki-Saitoh, K. Inoue. *equally contributed., IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain. , Pro.Natl.Acad.Sci.USA , 106(19):8032-7, 2009.05.
12. Y. Shinozaki, K. Sumitomo, M. Tsuda, S. Koizumi, K. Inoue and K. Torimitsu. , Direct observation of ATP-induced conformational changes in single P2X4 receptors.
, PLoS Biology , 2009 May 5;7(5):e103. [Epub ahead of print]
, 2009.05.
13. H. Tozaki-Saitoh1, M. Tsuda, H. Miyata, K. Ueda, S. Kohsaka, K. Inoue. , P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. , J.Neurosci., 28:4949-56, 2008.05.
14. Coull JAM, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y, BDNF from microglia mediates the shift in neuronal anion gradient that underlies neuropathic pain., Nature, 438, 7070, 438, 1017-1021, 2005.04.
15. Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Kita A, Inoue K., Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures., Pro Nat Acad Sci USA, 100, 19, 100, 11023-11028, 2003.04.
16. Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K., P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury., Nature, 424, 6950, 424, 778-783, 2003.04.
Presentations
1. Kazuhide Inoue, Purinergic Regulation of Microglia in Neuropathic Pain, Keystone Symposia Conference Purinergic Signaling, 2016.01.28.
2. Kazuhide Inoue, The role of microglia in neuropathic pain mechanism., NEA_ASIAHORCsシンポジウム, 2015.11.10.
3. Kazuhide Inoue, Onset Mechanisms of Neuropathic Pain., 第63回国際歯科研究学会日本部会(JADR)学術大会, 2015.10.30.
4. Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hachisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, TSUDA MAKOTO, STAT3-dependent reactive astrocytes in the spinal dorsal horn contribute to the maintenance of chronic itch in mice, Neuroscience 2015, 2015.10.18.
5. Kazuhide Inoue, P2X4 of microglia in neuropathic pain., Purine 2015, 2015.07.25.
6. Kazuhide Inoue, Glial cell implication on pain modulation., The 8th Igakuken International Symposium on “Pain Modulation and Opioid Functions”, 2014.09.05.
7. Kazuhide Inoue, The role of microglia in neuropathic pain., The 12th Asian-Pacific Society for Neurochemistry, 2014.08.24.
8. Kazuhide Inoue, The role of microglial purinergic signaling in neuropathic pain., the 17th World Congress of Basic and Clinical Pharmacology, 2014.07.16.
9. Kazuhide Inoue, Gene regulation in microglia in neuropathic pain., 29th CINP WORLD CONGRESS OF NEUROPSYCHOPHARMACOLOGY, 2014.06.24.
10. Kazuhide Inoue, Activation of spinal microglia causing neuropathic pain., The 22nd International Symposium on Molecular Cell Biology of Macrophages, 2014.06.03.
11. Kazuhide Inoue, The role of microglia in neuropathic pain after nerve injury., the 1st EMBO Workshop -Microglia: Sculptors of the brain, 2014.03.28.
12. Kazuhide Inoue, P2X4 blockers: New drugs for the neuropathic pain., Asian Federation for Pharmaceutical Sciences 2013, 2013.11.21.
13. Kazuhide Inoue, Microglia causing neuropathic pain after nerve injury., the IUPS 2013 Congress, 2013.07.23.
14. Kazuhide Inoue, Role of PAF receptor in pro-inflammatory cytokine expression in the dorsal root ganglion in a neuropathic pain model., The 14th World Congress on Pain., 2012.08.31.
15. Kazuhide Inoue, Microglia in pain signalling., The 29th Naito Conference: Glia World, 2010.10.05.