| 1. |
Tsuda Makoto, Microglia in the CNS and neuropathic pain, Springer New York LLC, 10.1007/978-981-13-1756-9_7, 77-91, 2018.01, Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system function. Over the past decades, a body of literature has provided evidence for the necessity and sufficiency of microglia, the tissue-resident macrophages of the central nervous system, for nerve injury-induced alterations in synaptic function. Recent studies have also revealed active roles for microglia in brain regions important for emotion and memory. In this chapter, I highlight recent advances in our understanding of the mechanisms that underlie the role of spinal and brain microglia in neuropathic pain, with a focus on how microglia are activated and alter synaptic function. I also discuss the therapeutic potential of microglia from recent advances in the development of new drugs targeting microglia, which may facilitate translation from the bench to bedside.. |
| 2. |
Masuda Takahiro et al., Intrathecal infusion of microglia cells., Springer, 2013.09. |
| 3. |
Masuda Takahiro et al., Lentiviral transduction of cultured microglia., Springer, 2013.09. |
| 4. |
Toulme E, Tsuda M, Khakh BS, Inoue K, On the role of ATP-gated P2X receptors in acute, inflammatory and neuropathic pain, CRC Press, 2009.11. |
| 5. |
M. Tsuda, K. Inoue, The nociceptive membrane, Current Topics in Membrane 57, Chapter 9. P2X receptors in sensory neurons., Elsevier, pp277-310, (2006), 2006.09. |
| 6. |
Inoue K, Tsuda M, Koizumi S., Chronic pain and microglia: the role of ATP., Novartis Found Symp. 261, 55-64; discussion 64-67, 149-54 (2004)., 2004.05. |
