Kyushu University Academic Staff Educational and Research Activities Database
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Zhou Wu Last modified date:2019.12.26

Associate Professor / Department of Aging Science and Pharmacology
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School
Administration Post

Academic Degree
PhD of Detal sciences, Master of Medical sciences
Country of degree conferring institution (Overseas)
Field of Specialization
Neuronimmunity, aging
Total Priod of education and research career in the foreign country
Outline Activities
It was carried out that involvement of chronic systemic inflammation in bone remodeling. Recently years, the researches are going on the impacts of chronic systemic inflammation (including periodontal disease) on brain. We mainly focus on brain and systemic immune organs.
Research Interests
  • The roles of phagocytes in aging
    keyword :  aging phagocytes
  • Impact ofchronic systemic brain inflammation on brain functions
    keyword : systemic inflammation, neuroinflammation, neuroimmunity, leptomeningeal cell, brain aging
Academic Activities
1. Wu Z, Nakanishi H, TNF-a signaling and cathepsin B, In: Tumor Necrosis Factor: Structure. Enzyme Regulation and Role in Health and Disease, Nova Science Publisher Inc, pp. 113-128, 2013.06.
2. Nakanishi H, Wu Z, Microglia-aging and pain: Microglial cathepsin B-dependent IL-1 production, In: Interleukin-1: Genetics, Inflammatory Mechanisms and Role in Disease, Nova Science Publishers, pp. 143-156, 2013.06.
3. Zhou Wu and Hiroshi Nakanishi, Neuroimmunology Research Focus
Chapter 4
Age-Dependent Differential Activation Profiles of Glial Cell by the Leptomeninges During Systemic Inflammation
, Nova Science Pulishers, Inc., pp. 101-118., 2007.09.
1. Wu Z, Yu J, Zhu A, Nakanishi H, Nutrients, Microglia Aging, and Brain Aging, Oxid Med Cell Longev, 2016:7498528, 2016.06.
1. Zhu A, Wu Z, Zhong X, Ni J, Li Y, Meng J, Du C, Zhao X, Nakanishi H, Wu S, Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude, J. Alzheimer's Dis, 63(2), 551-560, 2018.06, BACKGROUND:
Systemic inflammation is known as a risk factor of cognitive decline.
To investigate the effects of propolis on cognitive decline and systemic inflammation in elderly people living at high altitude.
Sixty participants (average 72.8 years) living at altitude (2,260 meters) were randomized to receive propolis (0.83 g, n = 30) or placebo (n = 30) for 24 months. Cognitive outcomes were assessed using MMSE and serum cytokine levels were measured for 24 months in a double-blind study.
MMSE scores were 26.17 at baseline and 23.87 at 24 months in placebo group. Compared to placebo group, improvements of MMSE scores were significant in propolis-treated subjects (p = 0.007) with a response emerging over time (time points×group interaction, p = 0.016). In addition, the serum IL-1β and IL-6 levels were significantly different across treatments (p < 0.0001) showing upward and downward trends in placebo- and propolis-treated subjects, respectively (p < 0.0001). Serum levels of TNF-α were not significantly different across treatment (p = 0.0528) but with a response emerging over time (time points×group interaction, p = 0.016). In contrast, serum levels of TGFβ1 were significantly different across treatments (p < 0.0001) showing downward and upward trends in placebo- and propolis-treated subjects, respectively. Serum levels of IL-10 were significant for the effect of groups (p = 0.0411). Furthermore, MMSE scores correlated with the decrease in IL-1β and the increase in TGFβ1 in serum.
Elderly people living at high altitude developed to MCI in 24 months with exacerbation of systemic inflammation. Ingestion of propolis (>12 months) protected against cognitive decline after systemic inflammation was reduced..
2. Wu, Z., Tokuda, Y., Zhang, X-W., Nakanishi, H., Age-dependent responses of glial cells and leptomeninges during sytemic inflammation., Neurobiology of Disease, 32, 543-551, 2008.10.
1. Yebo Gu, Junjun Ni, Zhou Wu, Ichiro Takahashi, Chronic systemic exposure of PgLPS induces long bone loss and cognitive decline in middle-aged mice, 第78回日本矯正歯科学会, 2019.11.
2. Yebo Gu, Junjun Ni, Zhou Wu, Ichiro Takahashi, Chronic systemic exposure of Lipopolysaccharide from Porphyromonas gingivalis induces memory decline through the upregulation of the bone loss promotion molecule IL-17 in middle-aged mice, 第72回日本薬理学会西南部会, 2019.11.
3. Muzhou Jiang, Junjun Ni, Yebo Gu, Zhou Wu, Microglia induces tau hyperphosphorylation of cultured neurons after exposure to Porphyromonas gingivalis LPS, 6th Congress of ASCNP, 2019.10.
4. Wanyi Huang, Junjun Ni, Zhou Wu,, Porphyromonas gingivalis infected Leptomeningeal Cells Reduces Synapses Proteins in Primary Cultured Neurons, 6th Congress of AsCNP, 2019.10.
5. Fan Zeng, Junjun Ni, Zhou Wu , Porphyromonas gingivalis infection increases RAGE production in
hCMEC/D3 cell line, 6th Congress of ASCNP, 2019.10.
6. Yebo Gu, Junjun Ni, Muzhou Jiang, Zhou Wu, Ichiro Takahashi, Chronic systemic exposure of Lipopolysaccharide from Porphyromonas gingivalis
induces Memory decline and Bone loss in Middle-aged Mice, 6th Congress of ASCNP, 2019.10.
7. Zhou WU, Inflammation and Lysosomal Enzymes: Prevention Approach of Cognitive Decline, Neurology Conference , 2019.06.
Membership in Academic Society
  • Asian College of Neuropsychopharmacology
  • Society of Neuroscience
  • Involvement of brain pericyte damage in neuropathological
    changes associated with lysosomal storage
Educational Activities
Enforce the lectures for undergraduate and graduate students school as a faculty member, conducte research guidance for undergraduates and graduate studentsand write the research papers as PI (principle investigator).
Other Educational Activities
  • 2019.03.
  • 2018.06.