Kyushu University Academic Staff Educational and Research Activities Database
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Takeshi Mori Last modified date:2019.06.21

Associate Professor / laboratory of functional organization chemistry
Department of Applied Chemistry
Faculty of Engineering


Graduate School
Undergraduate School
Other Organization


Homepage
http://www.chem.kyushu-u.ac.jp/~katayama/english/
Academic Degree
Ph.D.
Field of Specialization
Polymer Science
Outline Activities
I am trying to understand biological phenomena in chemistry viewpoint (molecular aggregate, chemical reaction) and apply them to medical field. Now I am creating immunomodulatory molecules, efficient therapy of tumor, and a highly accurate diagnostic technique based on the fluorescence method.
Research
Research Interests
  • Oral delivery of antibiotics via protecting intestinal microbiome
    keyword : Oral delivery, antibiotics, intestinal microbiome
    2016.10~2018.06.
  • Drug delivery system by targeting MHC
    keyword : MHC, drug delivery
    2013.04~2018.06.
  • Therapy of inflammatory diseases by using vitamin containing lipid nanoparticles
    keyword : viamin, lipid, inflammatory bowel disease, asthma
    2015.10~2018.06.
  • minimal mimetic of transmembrane protein
    keyword : transmembrane protein
    2015.04.
  • endogenous IgG-recruting molecule for cancer therapy
    keyword : antibody medicine, cancer
    2014.04~2020.05.
  • Efficeint delivery of nanomedicine to cancer by using nitric oxide
    keyword : nitric oxide, cancer, nanomedicine
    2014.04~2020.05.
  • Functionalization of immune cells via chemical transformation
    keyword : immune cell, macrophage, circulating tumor cell
    2012.04~2013.03.
  • co-receptor
    keyword : cell surface engineering
    2011.04~2012.05.
  • Co-endocytosis
    keyword : cell surface engineering
    2011.04~2012.05.
  • Polymeric material for protein delivery
    keyword : delivery, nano-machine
    2010.09~2011.05.
  • Cell membrane pearmeable polymer
    keyword : cell membrane, polymer
    2011.04~2011.05.
  • Efficient endocytosis based on soft engineering of cell surface
    keyword : cell, endocytosis, polymer
    2011.04~2013.03.
  • Global screening of physiological enviroment responsive peptides and their applications as biomaterials
    keyword : biomaterials, peptide, environment-responsive
    2010.04~2012.03.
  • Gene carrier that can respond to cell signal for cancer-specif gene thrapy
    keyword : gene therapy, siganl transduction
    2006.04.
  • Highly sensitive peptide array for drug screening and diagnosis
    keyword : peptide array, diagnosis, drug screening
    2006.04.
  • temperature-responsive polymer with large hysteresis for biomedical application
    keyword : biomedical polymer, drug delivery system
    2005.04.
Academic Activities
Papers
1. K. Zai, M. Hirota, T. Yamada, N. Ishihara, T. Mori, A. Kishimura, K. Suzuki, K. Hase, Y. Katayama, Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease, J. Controlled Release, 286, 94-102, 2018.11.
2. K. Sasaki, Y. Miyashita, D. Asai, D. Funamoto, K. Sato, Y. Yamaguchi, Y. Mishima, T. Iino, S. Takaishi, J. Nagano, A. Kishimura, T. Mori, Y. Katayama, A Peptide Inhibitor of Antibody-Dependent Cell-Mediated Cytotoxicity against EGFR/Folate Receptor-α Double Positive Cells, Med. Chem. Commun., 9, 783-788, 2018.03.
3. E. K. Lee, C. W. Kim, H. Kawanami, Akihiro Kishimura, T. Niidome, Takeshi Mori, Yoshiki Katayama, Utilization of a PNA-peptide Conjugate to Induce a Cancer Protease-Responsive RNAi Effect, RSC Adv., 5, 85816, 2015.11, PNA-peptideコンジュゲートにより、腫瘍において選択的にRNAiを生じるシステムを開発した。腫瘍で高活性化しているcathepsin Bを標的にしたシステムであるが、一般性が高く、望みのプロテアーゼに対して設計可能である。.
4. D. Funamoto, D. Asai, K. Sato, Y. Yamaguchi, C. W. Kim, H. Sato, E. Nakhaei, S. Matsumoto, T. Yoshikawa, K. Sasaki, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Antibody Internalization into Living Cell via Crosslinker-mediated Endocytosis, Chem. Lett., 44, 468, 2015.02.
5. K Tobinaga, C Li, M Takeo, T Niidome, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Rapid and serum-insensitive endocytotic delivery of proteins using biotinylated polymers attached via multivalent hydrophobic anchors, J. Controlled Release, 177, 27, 2014.08.
6. M. Matsuda, W. Hatanaka, M. Takeo, C. W. Kim, T. Niidome, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Short Peptide Motifs for Long-Lasting Anchoring to the Cell Surface, Bioconjugate Chem., 25, 2134, 2014.08.
7. GX Zhao, H Tanaka, CW Kim, K Li, D Funamoto, T Nobori, Y Nakamura, T Niidome, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Histidinylated poly-L-lysine-based vectors for cancer-specific gene expression via enhancing the endosomal escape, J. Biomater. Sci. Polym. Ed., 25, 519, 2014.07.
8. Takeshi Mori, H. Tang, H. Kobayashi, Y. Niidome, Yoshiki Katayama, T. Niidome, CW/pulsed NIR irradiation of gold nanorods: Effect on transdermal protein delivery mediated by photothermal ablation, J. Controlled Release, 171, 178-183, 2013.10.
9. C. W. Kim, R. Toita, J.-H. Kang, K. Li, E. K. Lee, G. X. Zhao, D. Funamoto, T. Nobori, Takeshi Mori, T. Niidome, Y. Nakamura, Yoshiki Katayama, Stabilization of Cancer-specific Gene Carrier via Hydrophobic Interaction for a Clear-cut Response to Cancer Signaling, J. Controlled Release, 170, 469-476, 2013.07.
10. J.-H. Kang, Takeshi Mori, H. Kitazaki, T. Niidome, Y. Nakanishi, K. Takayama, Yoshiki Katayama, Serum protein kinase Cα as a diagnostic biomarker of cancers, Cancer Biomarker, 13, 99-103, 2013.07.
11. H. Ikeda, J. Kamimoto, T. Yamamoto, A. Hata, Y. Otsubo, T. Niidome, M. Fukushima, Takeshi Mori, Yoshiki Katayama, A peptide microarray fabricated on a non-fouling phosphatidylcholine-polymer-coated surface for a high-fidelity analysis of a cellular kinome, Current Med. Chem., 20, 4419-25, 2013.06.
12. Y. Nakamura, C. W. Kim, A. Tsuchiya, S. Kushio, K. Li, T. Nobori, E. K. Lee, G. Xi Zhao, D. Funamoto, T. Niidome, Takeshi Mori, Yoshiki Katayama, Branched polyethylenimine-based PKCα-responsive gene carriers, J. Biomater. Sci.-Polym. Ed., 24, 1858-1868, 2013.06.
13. J.-H. Kang, D. Asai, J.-H. Kim, T. Mori, R. Toita, T. Tomiyama, Y. Asami, J. Oishi, Y. T. Sato, T. Niidome, B. Jun, H. Nakashima, Y. Katayama, Design of polymeric carriers for cancer-specific gene targeting: Utilization of abnormal protein kinase Cα activation in cancer cells, J. Am. Chem. Soc, 130, 14906-14907, 2009.10.
14. T. Mori*, T. Hirano, A. Maruyama, Y. Katayama, T. Niidome, Y. Bnado, K. Ute, S. Takaku, Y. Maeda, Syndiotactic poly(N-n-propylacrylamide) shows highly cooperative phase transition, Langmuir, 25, 48-50, 2009.01.
15. J. Oishi, Y. Asami, T. Mori*, J.-H. Kang, M. Tanabe, T. Niidome, Y. Katayama, Measurement of Homogeneous Kinase Activity for Cell Lysates Based on Aggregation of Gold Nanoparticles, ChemBioChem, 8, 875-879, 2007.06.
16. Measurement of homogeneous kinase activityfor cell lysates based on the aggregation of gold nanoparticles, Measurement of homogeneous kinase activityfor cell lysates based on the aggregation of gold nanoparticles, ChemBioChem, 8, 875-879, , 2007.05.