| Koyanagi Satoru | Last modified date：2023.11.28 |
Professor /
Medico-Pharmaceutical Sciences /
Department of Pharmaceutical Health Care and Sciences /
Faculty of Pharmaceutical Sciences
Papers
| 1. | Jaballah N, Tsurudome Y, Murakami C, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S., The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells, J Biochem, 10.1093/jb/mvad035, 2023.05. |
| 2. | Hashikawa KI, Tsuruta A, Yamakawa W, Yasukochi S, Koyanagi S, Ohdo S., Senescence-induced alteration of circadian phagocytic activity of retinal pigment epithelium cell line ARPE-19, Biochem Biophys Res Commun, 658, 88-96, 2023.04. |
| 3. | Uchinomiya S, Nagaura T, Weber M, Matsuo Y, Zenmyo N, Yoshida Y, Tsuruta A, Koyanagi S, Ohdo S, Matsunaga N, Ojida A, Fluorescence-based detection of fatty acid β-oxidation in cells and tissues using quinone methide-releasing probes, J Am Chem Soc, 2023.04. |
| 4. | Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S, RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells, J Biol Chem, 298, 102184, 2022.07. |
| 5. | Mine K, Kawashiri T, Inoue M, Kobayashi D, Mori K, Hiromoto S, Kudamatsu H, Uchida M, Egashira N, Koyanagi S, Ohdo S, Shimazoe T, Omeprazole suppresses oxaliplatin-induced peripheral neuropathy in a rodent model and clinical database, Int J Mol Sci, 23, 8859, 2022.04. |
| 6. | Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S., Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice, Mol Cancer Res, 10.1158/1541-7786.MCR-21-0786, Online ahead of print, 2022.04. |
| 7. | Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S., Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells, Elife, 10.7554/eLife.66155, 10, e66155, 2021.06. |
| 8. | Yoshida Y, Matsunaga N, Nakao T, Hamamura K, Kondo H, Ide T, Tsutsui H, Tsuruta A, Kurogi M, Nakaya M, Kurose H, Koyanagi S, Ohdo S., Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis, Nature Commun, 10.1038/s41467-021-23050-x, 12, 2883, 2021.06. |
| 9. | Yasukochi S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S, Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord, Biochem Pharmacol, 10.1016/j.bcp.2021.114411, 185, 114411, 2021.04, [URL]. |
| 10. | Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S, RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene, J Biol Chem, 10.1016/j.jbc.2021.100601, 298, 100601, 2021.04. |
| 11. | Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, Inamori R, Hosokawa K, Watari K, Shibata T, Matsunaga N, Koyanagi S, Ohdo S, Ono M, Ojida A, Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines, ACS Med Chem Lett, 10.1021/acsmedchemlett.9b00574, 11, 1137-1144, 2020.10. |
| 12. | Tokunaga K, Sato M, Kuwata K, Miura C, Fuchida H, Matsunaga N, Koyanagi S, Ohdo S, Shindo N, Ojida A, Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins, J Am Chem Soc, 10.1021/jacs.0c07490, 142, 18522-18531, 2020.10. |
| 13. | Kato M, Tsurudome Y, Kanemitsu T, Yasukochi S, Kanado Y, Ogino T, Matsunaga N, Koyanagi S, Ohdo S, Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity in mice, Sci Rep, 10.1038/s41598-020-70321-6, 10, 13484, 2020.10. |
| 14. | Kusunose N, Tsuruta A, Hamamura K, Tsurudome Y, Yoshida Y, Akamine T, Matsunaga N, Koyanagi S, Ohdo S, Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches, Genes Cells, 10.1111/gtc.12758, 25, 270-278, 2020.03. |
| 15. | Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S Ohdo S, Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs, Biochem Biophys Res Commun, 10.1016/j.bbrc.2019.09.021, 519, 613-619, 2019.10. |
| 16. | Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M, Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes, Br J Pharmacol, 10.1111/bph.14777, 176, 3723-3738, 2019.05. |
| 17. | Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S, Microcurrent stimulation activates the circadian machinery in mice, Biochem Biophys Res Commun, 10.1016/j.bbrc.2019.02.022, 513, 293-299, 2019.05. |
| 18. | Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S, Time-dependent changes in the anti-tumor effect of xCT inhibitor erastin in human breast cancer xenograft mice, Biol Pharm Bull, 10.1248/bpb.b19-00546, 42, 1921-1925, 2019.05. |
| 19. | Katamune C, Koyanagi S, Hashikawa KI, Kusunose N, Akamine T, Matsunaga N, Ohdo S, Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene, J Biol Chem, 294, 547-558, 2019.01. |
| 20. | Shindo N, Fuchida H Sato H, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunag K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A, Selective and Reversible Modification of Kinase Cysteines with Chlorofluoroacetamides, Nature Chem Biol , 15: 250-258, 2019.01. |
| 21. | Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S, Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function, Sci Rep, 8, 9072, 2018.12. |
| 22. | Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S, Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model, Biochem Biophys Res Commun, 503, 181-187, 2018.09. |
| 23. | Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu S, Koyanagi S, Ohdo S, Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system, Biochem Biophys Res Commun, 503:1063-1069, 2018.09. |
| 24. | Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S, Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase inhibitor, Cancer Res, 78: 3698-3708, 2018.08. |
| 25. | Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura K, Koyanagi S, Ohdo S, Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice, Biochem Biophys Res Commun, 498:86-91, 2018.07. |
| 26. | Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga N, Koyanagi S, Ohdo S, Kubota T, Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells, Jpn J Ophthalmol , 62:677-685, 2018.07. |
| 27. | Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S., Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice, J Pharmacol Sci, 136, 228-233, 2018.05. |
| 28. | Kanemitsu K, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S., Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα, J Biol Chem, 292, 21397-21406, 2017.12. |
| 29. | Hashikawa K, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S., Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis, Scientific Reports, 73, 2017.08. |
| 30. | Dilixiati A, Koyanagi S, Kusunose N, Matsunaga N, Ohdo S., Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light–dark cycle in mice, J Pharmacol Sci, 134, 211-217, 2017.08. |
| 31. | Sakamoto Y, Yano T, Hanada Y, Takeshita A, Inagaki F, Masuda S, Matsunaga N, Koyanagi S, Ohdo S., Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells, Eur J Pharmacol, 800, 48-56, 2017.04. |
| 32. | Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Kazutaka T, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Makoto T, Inoue K, Ojida A, Koyanagi S, Ohdo S., Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease, EBioMedicine, 13, 262-273, 2016.11. |
| 33. | Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, Ohdo S, Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia, Nature Commun., 7, 2016.10. |
| 34. | Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S, Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation, J Biol Chem, 291, 2016.05. |
| 35. | Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagi S, Ogawa H, Okumura K, Shibata S, Nakao A, Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock, J Allergy Clin Immun, 4, 2016.04. |
| 36. | Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S, Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction, J Biol Chem, 10, 4913-4927, 2016.03. |
| 37. | Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Hara Y, Tsuruta A, Tsurudome Y, Ogino T, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S, Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression, J Biol Chem, 13, 7017-7028, 2016.03. |
| 38. | Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi M, Izumi T, Ohdo S:, Circadian modulation in the intestinal absorption of p-glycoprotein substrates in monkeys, Mol Pharmacol, 1, 2015.07. |
| 39. | Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguichi M, Matsunaga N, Ohdo S, Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice, J Pharmacol Exp Ther, 2015.05. |
| 40. | Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S;, Modulation of Peroxisome Proliferator-Activated Receptor-alpha Activity by Bile Acids Causes Circadian Changes in the Intestinal Expression of Octn1/Slc22a4 in Mice, Mol Pharmacol, 2, 314-322, 2015.02. |
| 41. | Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S, Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1, J Biol Chem, 36, 2014.09. |
| 42. | Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S., Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice, Mol Pharmacol, 5, 715-722, 2014.05. |
| 43. | Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S., 24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks., J Invest Dermatol, 6, 2014.01. |
| 44. | Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S, Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma, Cancer Res, 2, 543-551, 2014.01. |
| 45. | Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H, The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S, Scientific Reports, 2013.09. |
| 46. | Karakawa S, Miyoshi Y, Konno R, Koyanagi S, Mita M, Ohdo S, Hamase K, Two-dimensional high-performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes, Anal Bioanal Chem, 25, 2013.09. |
| 47. | Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S., Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells, Cancer Res, 8, 2013.04. |
| 48. | Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S., Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatum, Mol Pharmacol, 5, 2013.02, [URL]. |
| 49. | Oishi K, Koyanagi S, Ohkura N, The molecular clock regulates circadian transcription of tissue factor gene, Biochem Biophys Res Commun, 2, 332-335, 2013.02. |
| 50. | Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S., A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease, Neuromolecular Med, 2013.01, [URL]. |
| 51. | Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K., The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis., Hum Immunol., 74, 2012.11. |
| 52. | Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H., Induction of Cardiac Fibrosis by beta-Blocker in G Proteinin-dependent and G Protein-coupled Receptor Kinase 5/beta-Arrestin2-dependent Signaling Pathways, J Biol Chem, 42, 35669-35677, 2012.10. |
| 53. | Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S., Role of Activating Transcription Factor-4 in 24-Hour Rhythm of Serotonin Transporter Expression in the Mouse Midbrain, Mol Pharmacol, 2, 264-270, 2012.08. |
| 54. | Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S., Intestinal Expression of Mouse Abcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway, J Biol Chem, 21, 17224-17231, 2012.05. |
| 55. | Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi A, Yoshimura Y, Sato F, Fujimoto K, Koyanagi S, Ohdo S., Time-dependent Interaction Between DEC2 and C/EBPα Underlies the Circadian Expression of CYP2D6 in Serum-shocked HepG2 Cells., Mol Pharmacol, 5, 739-747, 2012.02. |
| 56. | Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S., Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner., Toxicology, 290, 204-208, 2011.12. |
| 57. | Oishi K, Koyanagi S, Ohkura N., Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice, Exp Gerontol, 12, 994-999, 2011.11. |
| 58. | Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S., Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors, Cancer Res., 72, 395-401, 2011.11. |
| 59. | Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, Ohdo S., cAMP response element-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene., J Biol Chem., 286, 32416-32423, 2011.07. |
| 60. | To H, Yoshimatsu H, Tomonari M, Ida H, Tsurumoto T, Tsuji Y, Sonemoto E, Shimasaki N, Koyanagi S, Sasaki H, Ieiri I, Higuchi S, Kawakami A, Ueki Y, Eguchi K., Methotrexate chronotherapy is effective against rheumatoid arthritis., Chronobiol Int., 3, 267-274, 2011.04. |
| 61. | Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K, JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats, Brain, 4, 1127-1139, 2011.03. |
| 62. | Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S., Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes, Toxicology, 3, 144-151, 2010.12. |
| 63. | Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S., Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain, Mol. Pain, 6, 83, 2010.11. |
| 64. | Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S., Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice, Chronobiol Int., 27, 1735-1753, 2010.11. |
| 65. | Okazaki F, Matsunaga N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo S., Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice, Cancer Res., 15, 6238-6246, 2010.11. |
| 66. | Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S, Hypoxia-Response Plasmid Vector Producing bcl-2 shRNA Enhances the Apoptotic Cell Death of Mouse Rectum Carcinoma, J Pharmacol Sci, 113, 4, 353-361, 2010.08. |
| 67. | Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto Y, Shimeno H, Soeda S, Ohdo S., Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner, Mol Pharmacol, 2010.04. |
| 68. | Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K, Koyanagi S, Ohdo S., Glucocorticoid-dependent expression of O6-methylguanine-DNA methyltransferase gene modulates the dacarbazine-induced hepatotoxicity in mice, J Pharmacol Exp Ther, 3, 782-787, 2010.03. |
| 69. | Kim J, Matsunaga N, Koyanagi S, Ohdo S., Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene., Biochem Pharmacol., 8, 1075-1082, 2009.11. |
| 70. | Burioka N, Koyanagi S, Fukuoka Y, Okazaki F, Fujioka T, Kusunose N, Endo M, Suyama H, Chikumi H, Ohdo S, Shimizu E., Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation, Life Sci., 9, 372-378, 2009.08. |
| 71. | Akagi T, Fukagawa T, Kage Y, To H, Matsunaga N, Koyanagi S, Uchida A, Fujii A, Iba H, Ikemura T, Aramaki H, Higuchi S, Ohdo S., Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride., J Pharmacol Sci, 2, 265-274, 2009.03. |
| 72. | Tojo Y, Hamase K, Konno R, Koyanagi S, Ohdo S, Zaitsu K., Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis., J Sep Sci., 3, 430-436, 2009.02. |
| 73. | Soeda S., Koyanagi S., Kuramoto Y., Kimura M., Oda M., Kozako T., Hayashida S., Shimeno H., Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system, Thromb. Haemost., 100, 1014-1020, 2008.12. |
| 74. | Morikawa A., Hamase K., Miyoshi Y., Koyanagi S., Ohdo S., and Zaitsu K., Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts., J Chromatogr B Analyt Technol Biomed Life Sci., 875, 168-173, 2008.11. |
| 75. | Shinohara A, Koyanagi S, Hamdan AM, Matsunaga N, Aramaki H, Ohdo S., Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function, Life Sci., 83, 574-580, 2008.08. |
| 76. | Nakagawa H, Koyanagi S, Kuramoto Y, Yoshizumi A, Matsunaga N, Shimeno H, Soeda S, Ohdo S., Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling, J. Pharmacol. Sci., 107, 401-407, 2008.08. |
| 77. | Murakami Y, Higashi Y, Matsunaga N, Koyanagi S, Ohdo S, Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice, Gastroenterology, 135, 1636-1644, 2008.08. |
| 78. | Matsunaga N., Ikeda M., Takiguchi T., Koyanagi S., and Ohdo S., The molecular mechanism regulating 24-hr rhythm of CYP2E1 expression in the mouse liver., Hepatology, 48, 240-251, 2008.07. |
| 79. | Burioka N., Koyanagi S., Endo M., Takata M., Fukuoka Y., Miyata M., Takeda K., Chikumi H., Ohdo S., and Shimizu E., Clock gene dysfunction in patients with obstructive sleep apnoea syndrome, Eur. Respir. J., 32, 105-112, 2008.07. |
| 80. | Terazono H., Hamdan A., Matsunaga N., Hayasaka N., Kaji H., Egawa T., Makino K., Shigeyoshi Y., Koyanagi S., and Ohdo S., Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances, Biochem. Pharmacol., 75, 1616-1622, 2008.04. |
| 81. | Sato F., Bhawal U.K., Kawamoto T., Fujimoto K., Imanaka T., Imaizumi T., Kondo J., Noshiro M., Koyanagi S., Kusumi T., Kato Y., and Kijima H., Basic-helix-loop-helix (bHLH) transcription factor DEC2 binds to HIF-1α and negatively regulates the expression of vascular endothelial growth factor., Genes Cells, 13, 131-144, 2008.02. |
| 82. | Takiguchi T., Tomita M., Matsunaga N., Nakagawa H., Koyanagi S., and Ohdo S., Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells, Pharmacogenet. Genomics, 17, 1047-1056, 2007.12. |
| 83. | Nakagawa H., Takiguchi T., Nakamura M., Furuyama A., Koyanagi S., Aramaki H., Higuchi S., Ohdo S., Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice, Biochem. Pharmacol., 72, 2006.11. |
| 84. | Soeda S, Shinomiya K, Ochiai T, Koyanagi S, Toda A, Eyanagi R, Shimeno H, Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways, Neuroscience, 141, 101-108, 2006.08. |
| 85. | Koyanagi S., Suyama H., Kuramoto Y., Matsunaga N., Takane H., Soeda S., Shimeno H., Higuchi S., Ohdo S., Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver, Endocrinology, 147, 5037-5040, 2006.08. |
| 86. | Yamauchi A., Ichimiya T., Inoue K., Taguchi Y., Matsunaga N., Koyanagi S., Fukagawa T., Aramaki H., Higuchi S., Ohdo S., Cell cycle dependent pharmacology of methotrexate in HL-60, J Pharmacol Sci, 99, 335-341, 2006.06. |
| 87. | Yoshida M, Kiyofuji H, Koyanagi S, Matsuo A, Fujioka T, To H, Higuchi S, Ohdo S., Glucocorticoid is involved in food-entrainable rhythm of mu-opioid receptor expression in mouse brainstem and analgesic effect of morphine, J Pharmacol Sci., 101, 77-84, 2006.05. |
| 88. | Hikishima S., Isobe M., Koyanagi S., Soeda S., Shimeno H., Shibuya S., Yokomatsu T., Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors, Bioorg. Med. Chem., 14, 1660-1670, 2006.05. |
| 89. | Koyanagi S., Okazawa S., Kuramoto Y., Ushijima K., Shimeno H., Soeda S., Okamura H., Ohdo S., Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues, Mol. Endocrinol., 20, 573-583, 2006.04. |
| 90. | Kuramoto Y., Hata K., Koyanagi S., Ohdo S., Shimeno H., Soeda S., Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones, Biochem. Pharmacol, 71, 1155-1161, 2006.04. |
| 91. | Yoshida M., Koyanagi S., Matsuo A., Fujioka T., To H., Higuchi S., Ohdo S., Glucocorticoid hormone regulates the circadian coordination of ?-opioid receptor expression in mouse brainstem., J. Pharmacol. Exp. Ther., 3, 1119-1124, 2005.12. |
| 92. | Ushijima K., Sakaguchi H., Sato Y., To H., Koyanagi S., Higuchi S., Ohdo S., Chronopharmacological study of antidepressants in forced swimming test in mice, J. Pharmacol. Exp. Ther., 2, 764-770, 2005.11. |
| 93. | Takimoto M., Hamada A., Tomoda A., Ohdo S., Ohmura T., Sakato H., Kawatani J., Jodoi T., Nakagawa H., Terazono H., Koyanagi S., Higuchi S., Kimura M., Tukikawa H., Irie S., Saito H., Miike T., Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder, Am. J. Physiol. Regul. Integr. Comp. Physiol., 5, 1273-1279, 2005.11. |
| 94. | Soeda S., Imatoh T., Ochiai T., Koyanagi S., Shimeno H., Plasminogen activator inhibitor-1 aids survival of neuritis on neurons derived from pheochromyctoma (PC-12) cells, Neuroreport, 855-858, 2004.04. |
| 95. | Nakagawa H., Koyanagi S., Takiguchi T., Soeda S., Shimeno H., Higuchi S., Ohdo S., 24-hr oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression is regulated by clock gene proteins, Cancer Res., 64, 22, 8328-8333, 2004.01. |
| 96. | Koyanagi S., Kuramoto Y., Nakagawa H., Aramaki H., Ohdo S., Soeda S., Shimeno H., A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells, Cancer Res., 21, 7277-7283, 2003.11. |
| 97. | Koyanagi S., Kuga M., Soeda S., Hosoda Y., Yokomatsu T., Takeuchi H., Akiyama T., Shibuya S., Shimeno H., Elevation of de novo ceramide synthesis in tumor masses and a role of the microsomal dihydroceramide synthase, Int. J. Cancer, 1-6, 2003.05. |
| 98. | Koyanagi S., Nakagawa H., Kuramoto Y., Ohdo S., Soeda S., Shimeno H., Optimizing the dosing schedule of TNP-470 enhances its antitumor and anti-angiogenic efficacies, J. Pharmacol. Exp. Ther., 2, 669-674, 2003.02. |
| 99. | Koyanagi S., Tanigawa N., Nakagawa H., Soeda S., Shimeno H., Oversulfation of fucoidan enhances its anti-angiogenic and anti-tumor activities, Biochem. Pharmacol., 173-179, 2003.01. |
| 100. | Koyanagi S., Ohdo S., Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism, Mol. Pharmacol., 6, 1393-1399, 2002.11. |
| 101. | Soeda S., Shimada T., Koyanagi S., Yokomatsu T., Murano T., Shibuya S., Shimeno H., An attempt to promote neovascularization by employing a newly synthesized inhibitor of protein tyrosine phosphatase, FEBS Lett., 54-58, 2002.07. |
| 102. | Ohdo S., Koyanagi S., Suyama H., Higuchi S., Aramaki H., Changing the dosing schedule minimizes the disruptive effects of interferon on clock function., Nature Medicine, 3, 354-360, 2001.03. |
| 103. | Takane H., Ohdo S., Yamada T., Koyanagi S., Yukawa E., Higuchi S., Relationship between diurnal rhythm of cell cycle and interferon receptor in implanted-tumor cell, Life Sci., 12, 1449-1455, 2001.02. |
| 104. | Wang D.S., Ohdo S., Koyanagi S., Takane H., Aramaki H., Yukawa E., Higuchi S., Effects of dosing schedule on pharmacokinetics of alpha-interferon and anti-alpha interferon neutralizing antibody in mice, Antimicrob. Agents. Chemother., 176-180, 2001.01. |
| 105. | Yokomatsu T., Hayakawa Y., Kihara T., Koyanagi S., Soeda S., Shimeno H., Shibuya S., Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases, Bioorg Med Chem, 11, 2571-2579, 2000.11. |
| 106. | Ohdo S., Wang D.S., Koyanagi S., Takane H., Inoue K., Aramaki H., Yukawa E., Higuchi S., Basis for dosing time-dependent changes in the antiviral activity of interferon-α in mice, J Pharmacol Exp Ther, 2, 488-493, 2000.08. |
| 107. | Takane H., Ohdo S., Baba R., Koyanagi S., Yukawa E., Higuchi S., Relationship between 24-hr rhythm in antiviral effect of interferon-β and interferon-α/β receptor expression in mice, J. Pharmacol. Sci., 304-312, 2000.02. |
| 108. | Koyanagi S., Ohdo S., Yukawa E., Higuchi S., Chronopharmacological study of interferon-α in mice, J Pharmacol Exp Ther, 1, 259-264, 1997.06. |
| 109. | Ohdo S., Koyanagi S., Yukawa E., Higuchi S., Circadian rhythm of fever induced by interferon-alpha in mice, Life Sci., 8, PL95-100, 1997.01. |
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