| 1. |
Toru Chikui, Masahiro Ohga, Yukiko Kami, Osamu Togao, Shintaro Kawano, Tamotsu Kiyoshima and Kazunori Yoshiura, Correlation between diffusion-weighted image-derived parameters and dynamic contrast-enhanced magnetic resonance imaging-derived parameters in the orofacial region, Acta Radiologica Open, 10.1177/20584601241244777, 13, 3, 1-9, 2024.04. |
| 2. |
Mizuki Sakamoto, Jun Araki, Masafumi Moriyama, Yuka Miyahara, Tatsuya Kawado, Aiko Yano, Risako Koga, Ryuichi Aoyagi, Yuka Murakami, Naoki Kaneko, Shintaro Kawano, Seiji Nakamura, The utility of oral moisture measurement for the diagnosis of Sjo ̈gren’s syndrome: Its potential application as a diagnostic criterion, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, in press, 2024.03. |
| 3. |
Ryoji Kitamura, Masafumi Moriyama, Hiroe Kakehashi, Kenichi Ogata, Naoki Kaneko, Taiki Sakamoto, Ichiro Takahashi, Shintaro Kawano, Unilateral scissors bite treated by posterior segmental maxillary osteotomy and corticotomy-assisted mandibular expansion, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, https://doi.org/10.1016/j.ajoms.2024.01.006, in press, 2024.01. |
| 4. |
Shinsuke Fujii, Kana Hasegawa, Takashi Maehara, Kari J Kurppa,Kristiina Heikinheimo, Kristy A. Warner, Satoshi Maruyama,Yudai Tajiri, Jacques E. Nör, Jun-ichi Tanuma, Shintaro Kawano, Tamotsu Kiyoshima, Wnt/β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication, Pathology - Research and Practice, in press, 2024.01. |
| 5. |
Risako Koga, Takashi Maehara, Ryuichi Aoyagi, Ryusuke Munemura, Yuka Murakami, Atsushi Doi, Michihito Kono, Hidetaka Yamamoto, Hiroaki Niiro, Tamotsu Kiyoshima, Mika Tanabe, Toshiaki Nakano, Yuta Matsukuma, Mitsuhiro Kawano, John H Stone, Shiv Pillai, Seiji Nakamura, Shintaro Kawano
, Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease, Journal of Allergy and Clinical Immunology, 10.1016/j.jaci.2023.11.916, in press, 2023.12. |
| 6. |
Ryoko Nagano, Yusuke Nakako, Shinsuke Fujii, Shintaro Kawano, Hidefumi Maeda and Tamotsu Kiyoshima, The IL-1β-p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF-β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laboratory investigation, International Endodontic Jounrnal, in press, 2023.12. |
| 7. |
Hiroe Kakehashi, Mizuki Sakamoto, Masafumi Moriyama, Yuichi Goto, Ryoji Kitamura, Kenichi Ogata, Seiji Nakamura, Shintaro Kawano, The clinical effectiveness of conservative surgical management in medication-related osteonecrosis of the Jaw, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, https://doi.org/10.1016/j.ajoms.2023.11.001, in press, 2023.12. |
| 8. |
Ogata K, Moriyama M, Kawado T, Yoshioka H, Yano A, Matsumura-Kawashima M, Nakamura S, Kawano S., Extracellular vesicles of iPS cells highly capable of producing HGF and TGF-β1 can attenuate Sjögren's syndrome via innate immunity regulation, Cell Signal, 10.1016/j.cellsig.2023.110980. , in press, 2023.12. |
| 9. |
Yuka Miyahara, Masafumi Moriyama, Chen Hu, Keita Mochizuki, Naoki Kaneko, Rafiul ASM Haque, Akira Chinju, Kazuki Kai, Mizuki Sakamoto, Noriko Kakizoe-Ishiguro, Masaki Yamauchi, Kenichi Ogata, Tamotsu Kiyoshima, Shintaro Kawano, Seiji Nakamura, Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K, Scientific Reports, in press, 2023.11. |
| 10. |
Hu Chen, Junsei Sameshima, Shiho Yokomizo, Tomoki Sueyoshi, Haruki Nagano, Yuka Miyahara, Taiki Sakamoto, Shinsuke Fujii, Tamotsu Kiyoshima, Thomas Guy, Seiji Nakamura, Masafumi Moriyama, Naoki Kaneko, Shintaro Kawano, Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: Single-cell analysis and in vitro experiments, Frontiers in Immunology, in press, 2023.11. |
| 11. |
Aoyagi R, Maehara T, Koga R, Munemura R, Tomonaga T, Murakami Y, Doi A, Yamamoto H, Kiyoshima T, Kawano S, Nakamura S., Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD., J Allergy Clin Immunol., 10.1016/j.jaci.2023.08.019. , in press, 2023.10. |
| 12. |
Naoki Kaneko, Junsei Sameshima, Shintaro Kawano, Toru Chikui, Takeshi Mitsuyasu, Hu Chen, Taiki Sakamoto, Seiji Nakamura, Comparison of computed tomography findings between odontogenic keratocyst and ameloblastoma in the mandible: Criteria for differential diagnosis, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, https://doi.org/10.1016/j.ajoms.2022.07.016, 2022.09. |
| 13. |
Yukiko Kami, Toru Chikui, Osamu Togai, Shintaro Kawano, Shinsuke Fujii, Masahiro Ooga, Tamotsu Kiyoshima, Kazunori Yoshiura, Usefulness of reconstructed images of Gd-enhanced 3D gradient echo sequences with compressed sensing for mandibular cancer diagnosis: comparison with CT images and histopathological findings, European Radiology, 10.1007/s00330-022-09075-w, 2022.09. |
| 14. |
Kazuki Kai, Masafumi Moriyama, A. S. M. Rafiul Haque, Taichi Hattori , Akira Chinju, Chen Hu, Keigo Kubota, Yuka Miyahara, Noriko Kakizoe-Ishiguro, Shintaro Kawano and Seiji Nakamura, Oral squamous cell carcinoma contributes to differentiation of monocyte-derived tumor-associated macrophages via PAI-1 and IL-8 production, International Journal of Molecular Sciences, 10.3390/ijms22179475, 22, 9475, 2021.08. |
| 15. |
Toru Chikui, Kenji Tokumori, Wannakamon Panyarak, Osamu Togao, Yusuo Yamashita, Shintaro Kawano, Takeshi Kamitani, Kazunori Yoshiura., The application of a gamma distribution model to diffusionweighted
images of the orofacial region., Dentmaxillofacial Radiology, in press, 2020.06. |
| 16. |
Wannakamon Panyarak, Toru Chikui, Kenji Tokumori, Yasuo Yamashita, Takeshi Kamitani, Osamu Togao, Shintaro Kawano, Kazunori Yoshiura., A comparison among the diffusion-derived parameters of gamma distribution, intravoxel incoherent motion and mono-exponential models in the differential diagnosis of orofacial lesions, Academic Radiology, 2020.06. |
| 17. |
Shintaro Kawano, Taichi Hattori, Yurie Mikami, Toru Chikui, Toshiyuki Kawazu, Taiki Sakamoto, Yasuyuki Maruse, Shoichi Tanaka, Eiki Hamada, Megumi Hiwatashi, Yurika Shiraishi, Kazunari Oobu, Tamotsu Kiyoshima, and Seiji Nakamura
, Prediction of nodal metastasis based on intraoral sonographic findings of primary lesion in early-stage tongue cancer
, International Journal of Oral and Maxillofacial Surgery, 2020.06. |
| 18. |
Takashi Maehara, Ryusuke Munemura, Mayumi Shimizu, Noriko Kakizoe, Naoki 4 Kaneko, Yuka Murakami, Moriyama Masafumi, Tamotsu Kiyoshima, Shintaro Kawano, and Seiji Nakamura., Tissue-infiltrating immune cells contribute to understanding the pathogenesis of 1 Kimura’s Disease: a case report, Medicine, in press, 2019.07. |
| 19. |
Taichi Hattori, Shintaro Kawano, Shoichi Tanaka, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Yurie Mikami, Masahiko Morioka, Yasuyuki Maruse, Ryoji Kitamura, Eiki Hamada, Megumi Hiwatashi, Kazunari Oobu, Tamotsu Kiyoshima, and Seiji Nakamura, Protease activated receptor 1 in tumor-microenvironment contributes to nodal metastasis poor prognosis of oral squamous cell carcinoma, International Journal of Oral and Maxillofacial Surgery, 10.1016/j.ijom.2020.04.021, 50, 2, 163-170, 2021.02, Protease activated receptor (PAR) 1 is known as thrombin receptor. Recent studies have reported PAR1 expression in the various malignancies, however, the detail role remains unclear in oral squamous cell carcinoma (OSCC). We previously showed that down-regulation of ΔNp63, a homolog of p53, augments PAR1 expression in OSCC. In this study, we retrospectively examined the association of PAR1 expression in OSCC with clinicopathological findings. Expression of PAR1, thrombin, and ΔNp63 was immunohistochemically examined in the OSCC biopsy specimens. The patients were divided into three groups based on the expression pattern of PAR1 at the invasive front as follows: group A; PAR1-negative in both cancer and stromal cells: group B; positive in stromal cells but negative in cancer cells: group C; positive in both cancer and stromal cells. Histologically high-grade tumors were significantly more common in group C. The patients of group C had the highest incidence rate of nodal metastasis and significantly lower survival rate than other groups. At the invasive front, thrombin was expressed but ΔNp63 was faint. These results indicated that increased PAR1 expression in both cancer and stromal cells could be a useful predictive marker of nodal metastasis and ΔNp63 was involved in regulating PAR1 expression.. |
| 20. |
Shoichi Tanaka, Shintaro Kawano, Taichi Hattori, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Yurie Mikami, Masahiko Morioka, Yasuyuki Maruse, Ryoji Kitamura, Eiki Hamada, Megumi Hiwatashi, Kazunari Oobu, Tamotsu Kiyoshima, and Seiji Nakamura, Cytokeratin 19 as a marker of highly invasive oral squamous cell carcinoma with metastatic potential, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, in press, 2019.07, Objective:Cytokeratin (CK) 19 is a member of the acidic type I CK family. Recently, CK19 expression has beenfound in various tumor tissues; however, the significance of this remains unknown. The purpose of this study isto clarify the roles of CK19 in the progression of oral squamous cell carcinoma (OSCC).Methods:A total of 100 patients who had been diagnosed with OSCC at our department between January 2011and December 2016 was included. The patients were divided into three groups based on an optimal cut-offpoints (5% and 77%) of the labeling index (LI) as follows: group A; LI |
| 21. |
Takashi Maehara, Yuka Murakami, Shintaro Kawano, Yurie Miami, Tamotsu Kiyoshima, Noriko Kakizoe, Ryusuke Munemura, and Seiji Nakamura, Osteoid osteoma of mandibular bone: Case report and review of the literature
, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, in press, 2019.06. |
| 22. |
A S M Rafiul Haque, Masafumi Moriyama, Keigo Kubota, Noriko Ishiguro, Mizuki Sakamoto, Akira Chinju, Keita Mochizuki, Taiki Sakamoto, Naoki Knack, Ryusuke Munemura, Akihiko Tanaka, Takashi Maehara, Jun-Nosuke Hayashida, Shintaro Kawano, and Seiji Nakamura, CD206+ tumor-associated macrophages promote oral squamous cell carcinoma cell proliferation and invasion via EGF production, Scientific Reports, in press, 2019.07. |
| 23. |
Yurie Mikami, Shinsuke Fujii, Ken-ichi Kohashi, Yuichi Yamada, Masafumi Moriyama, Shintaro Kawano, Seiji Nakamura, Yoshinao Oda, and Tamotsu Kiyoshima, A case of low-grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A Case Report, Oncology Letters, 10.3892/ol.2018.9115, 16, 3, 3889-3894, 2018.09. |
| 24. |
Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Mai Hazekawa, Atsushi Yasukochi,, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima, miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironmen, Molecular Carcinogenesis, 10.1002/mc.22744., 57, 2, 295-302, 2018.02. |
| 25. |
Syarifah NovaAmiza Zam, Takeshi Mitsuyasu, Shiori Kanda, Shintaro Kawano, Seiji Nakamura, Induction of apoptosis by inhibition of sonic hedgehog signalling pathway in ameloblastoma cell line: a pilot study for novel therapeutic approach, International Journal of Oral and Maxillofacial Surgery, https://doi.org/10.1016/j.ijom.2017.02.748, 46, 221, 2017.07. |
| 26. |
Eiji Mitate, Shintaro Kawano, Yuka Okabe, Oobu, K, Seiji Nakamura, Effect of cepharanthine and Z-100 against complications during preoperative chemoradiotherapy for oral cancer, Journal of Oral and Maxillofacial Surgery, Medicine and Pathology, 2017.08. |
| 27. |
Yasuyuki Maruse, Shintaro Kawano, Teppei Jinno, Ryota Matsubara, Yuichi Goto, Naoki Kaneko, Taiki Sakamoto, Yuma Hashiguchi, Masafumi Moriyama, Takeshi Toyoshima, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura, Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and poor prognosis in oral squamous cell carcinoma, International Journal of Oral and Maxillofacial Surgery, 10.1016/j.ijom.2018.01.004, 47, 7, 836-845, 2018.07. |
| 28. |
Yuma Hashiguchi, Shintaro Kawano, Yuichi Goto, Yasuda Kaori, Naoki Kaneko, Taiki Sakamoto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Hideaki Tanaka, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Tamotsu Kiyoshima, Seiji Nakamura, Tumor-suppressive roles of ΔNp63-miR205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2, Journal of Cellular Physiolosy, 10.1002/jcp.26267, 233, 10, 6565-6577, 2018.10, We previously revealed that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Recent studies have highlighted the involvement of microRNA (miRNA) in EMT of cancer cells, though the mechanism remains unclear. To identify miRNAs responsible for ΔNp63β-mediated EMT, miRNA microarray analyses were performed by ΔNp63β-overexpression in OSCC cells; SQUU-B, which lacks ΔNp63 expression and displays EMT phenotypes. miRNAs microarray analyses revealed miR-205 was the most up-regulated following ΔNp63β-overexpression. In OSCC cells, miR-205 expression was positively associated with ΔNp63 and negatively with zinc-finger E-box binding homeobox (ZEB) 1 and ZEB2, potential targets of miR-205. miR-205 overexpression by miR-205 mimic transfection into SQUU-B cells led to decreasing ZEB1, ZEB2, and mesenchymal markers, increasing epithelial markers, and reducing cell motilities, suggesting inhibition of EMT phenotype. Interestingly, the results opposite to this phenomenon were obtained by transfection of miR-205 inhibitor into OSCC cells, which express ΔNp63 and miR-205. Furthermore, target protector analyses revealed direct regulation by miR-205 of ZEB1 and ZEB2 expression. These results showed tumor-suppressive roles of ΔNp63β and miR-205 by inhibiting EMT thorough modulating ZEB1 and ZEB2 expression in OSCC.. |
| 29. |
Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura, Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma, Oral Oncology, in press, 2017.04, We previously reported that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β in oral squamous cell carcinoma (OSCC). In this study, DNA microarray analyses were performed using ΔNp63β-overexpressing OSCC cells to identify genes associated with ΔNp63β-mediated EMT. Thereby, we focused on kallikrein-related peptidase (KLK) 6, most up-regulated following ΔNp63β-overexpression, that activates protease-activated receptors (PARs). In RT-PCR analyses, ΔNp63 was positively associated with KLK6 and PAR2 and negatively with PAR1 in OSCC cells. By ΔNp63 knockdown, KLK6 and PAR2 expression was decreased and PAR1 was increased. Furthermore, KLK6 knockdown led to enhancing migration and invasion, and inhibiting proliferation, suggesting EMT-phenotypes. Although, in the KLK6 or PAR2 knockdown cells, phosphorylation of ERK was reduced, it was restored in the KLK6 knockdown OSCC cells treated with recombinant KLK6 proteins. Immunohistochemistry showed ΔNp63, KLK6, and PAR2 were more strongly expressed in the epithelial dysplasia and central region of OSCC than normal oral epithelium, whereas PAR1 expression was undetectable. Interestingly, at the invasive front of OSCC, ΔNp63, KLK6, and PAR2 were reduced, but PAR1 was elevated. In addition, the OSCC patients with decreasing KLK6 expression at the invasive front had more unfavourable prognosis. These results suggested differential roles of KLK6 in malignant transformation and EMT; high ΔNp63β expression up-regulates KLK6-PAR2 and down-regulates PAR1, inducing malignant transformation in oral epithelium with stimulating proliferation through ERK signal activation. Moreover, KLK6-PAR2 expression is down-regulated and PAR1 is up-regulated when ΔNp63β expression is decreased, leading to EMT with enhancing migration and invasion through ERK signal reduction at the invasive front.. |
| 30. |
Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei jinno, Yasuyuki Maruse, Kazunari Oobu, Seiji Nakamura, Cytokeratin 17 as a prognostic marker of oral squamous cell carcinoma, Oncology Letters, in press, 2017.04. |
| 31. |
Keigo Kubota, Masafumi Moriyama, Sachiko Furukawa, A S M Rafiul Haque, Yasuyuki Maruse, Teppei Jinno, Akihiko Tanaka, Miho Ohta, Noriko Ishiguro, Masaki Yamauchi, Mizuki Sakamoto, Shintaro Kawano, Takashi Maehara, Hayashida Jun-Nosuke, Shintaro Kawano, Tamotsu Kiyoshima, Seiji Nakamura, CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma, Scientific Reports, 7, 1755, 2017.03. |
| 32. |
Sachiko Furukawa, Kazunari Oobu, Masafumi Moriyama, Shintaro Kawano, Hayashida Jun-Nosuke, Ryota Matsubara, Ken-ichi Ogata, Tamotsu Kiyoshima, Seiji Nakamura, Methotrexate-related lymphoproliferative disorder associated with severe osteonecrosis of the jaw: A case report and literature review, Internal Medicine, in press, 2017.03. |
| 33. |
Taiki Sakamoto, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Taichi Hattori, Shoichi Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura, Critical roles of Wnt5a-Ror2 signaling in aggressiveness of oral squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition, Oral Oncology, 69, 15-25, in press, 2017.01, OBJECTIVES:
We previously showed that ΔNp63β, a splicing variant of ΔNp63, mediated EMT and affected cell motility. DNA microarray was thus performed to elucidate the mechanism that ΔNp63β affects cell motility. As the results, Wnt5a was significantly down-regulated by ΔNp63β overexpression in tongue SCC cell line (SQUU-B) with EMT phenotype.
MATERIALS AND METHODS:
Seven OSCC cell lines were used. Expression of ΔNp63, Wnt5a, its receptor Ror2, and matrix metalloproteinases (MMPs) were analyzed by RT-PCR, real-time PCR, and western blotting, and gelatin zymography. Furthermore, we examined the effects of siRNA for Wnt5a or Ror2 and recombinant human Wnt5a (rhWnt5a) on motility of tongue SCC cells. Biopsy specimens from tongue SCC patients were used for immunohistochemical staining of Wnt5a and Ror2.
RESULTS:
Wnt5a and Ror2 were expressed only in SQUU-B cells without ΔNp63 expression, and negatively associated with ΔNp63 expression in other cells. ΔNp63β overexpression in SQUU-B cells decreased Wnt5a and Ror2 expression. By Wnt5a or Ror2 knockdown, cell motility was remarkably inhibited, but EMT markers expression was unaffected. MMP-2 expression and the activities inversely correlated with ΔNp63 expression, and were inhibited by Wnt5a or Ror2 knockdown. Cell motility and MMP-2 activities were recovered by adding rhWnt5a in the cells with Wnt5a knockdown, but not in those with Ror2 knockdown. Moreover, immunohistochemical analyses in tongue SCC specimens found that high expression of Wnt5a or Ror2 was associated with poorer prognosis.. |
| 34. |
Yurie Mikami, Fujii Shinsuke, Kengo Nagata, Hiroko Wada, Kana Hasegawa, Misaki Abe, ReikoYoshimoto, Shintaro Kawano, Seiji Nakamura, Tamotsu Kiyoshima, GLI-KRT17 axis promotes tumorigenesis through the anti-apoptotic function in oral squamous cell carcinomas, Journal of Cancer Research and Clinical Oncology, 143, 8, 1381-1393, 2017.08. |
| 35. |
Eiji Mitate, Shintaro Kawano, Hayashida Jun-Nosuke, Tamotsu Kiyoshima, Tetsuo Ikebe, Seiji Nakamura, A case of inversely fused tooth of impacted maxillary third molar and supernumerary tooth, International Journal of Case reports and Images, 8, 2, 129-132, 2017.02. |
| 36. |
Masahiko Morioka, Tomoyo Kawakubo-Yasukochi, Yoshikazu Hayashi, Mai Hazekawa, Nishinakagawa Takuya, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima, Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination, Journal of Oral Biosciences, 58, 180-184, 2016.07. |
| 37. |
Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Taiki Sakamoto, Yuma Hashiguchi, Masakazu Iida, Seiji Nakamura, Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factor: a case report and literature review, World Journal of Surgical Oncology, 14, 161, 2016.06. |
| 38. |
Sitti Fadhillah Oemar Mattalitti, Toshiyuki Kawazu, Shintaro Kawano, Tatsuya Ikari, Hiroko Wada, Kazunori Yoshiura, Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography, Oral Radiology, 33, 101-107, 2016.06. |
| 39. |
Miho Ohta, Masafumi Moriyama, Takashi Maehara, Yuka Gion, Sachiko Furukawa, Akihiko Tanaka, Masaki Yamauchi, Noriko Ishiguro, Yurie Mikami, Hiroto Tsuboi, Mana Iizuka-Koga, Jun-Nosuke Hayashida, Shintaro Kawano, Tamotsu Kiyoshima, Seiji Nakamura, DNA microarray analysis of submandibular glands in IgG4-related disease indicates a role for MARCO and other innate immune related proteins, Medicine, 95, 7, e2853, 2016.07. |
| 40. |
Masafumi Moriyama, Miho Ohta, Sachiko Furukawa, Yurie Mikami, Akihiko Tanaka, Takashi Maehara, Masaki Yamauchi, Norriko Ishiguro, Jun-Nosuke Hayashida, Shintaro Kawano, Yukiko Ohyama, Tamotsu Kiyoshima, Seiji Nakamura, The diagnostic utility of labial salivary gland biopsy in IgG4-related disease, Modern Rheumatology, 26, 725-729, 2016.01. |
| 41. |
Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Yoshikazu Hayashi, Takuya Nishinakagawa, Mai Hazekawa, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima, The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes, Journal of Oral Biosciences, 58, 11, 33-38, 2016.02. |
| 42. |
Keiji Masuda, Shintaro Kawano, Haruyoshi Yamaza, Taiki Sakamoto, Tamotsu Kiyoshima, Seiji Nakamura, Kazuaki Nonaka, Complete resolution of a calcifying cystic odontogenic tumor with physiological eruption of a dislocated permanent tooth after marsupialization in a child with a mixed dentition: A case report, World Journal of Surgical Oncology, 13, 277, 2015.09. |
| 43. |
Yoshikazu Hayashi, Masafumi Moriyama, Takashi Maehara, Yuichi Goto, Shintaro Kawano, Miho Ohta, Akihiko Tanaka, Sachiko Furukawa, Jun-Nosuke Hayashida, Tamotsu Kiyoshima, Mayumi Shimizu, Toru Chikui, Seiji Nakamura, A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease, World Journal of Surgical Oncology, 13, 225, 2015.06. |
| 44. |
Toru Chikui, Erina Kitamoto, Yukiko Nishioka Kami, Shintaro Kawano, Kouji Kobayashi, Takeshi Kamitani, Makoto Obara, Kazunori Yoshiura, Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: A preliminary study of the correlations between quantitative parameters and the clinical stage, British Journal of Radiology, 88, 20140814, 2015.01. |
| 45. |
Takashi Maehara, Masafumi Moriyama, Shintaro Kawano, Jun-Nosuke Hayashida, Sachiko Furukawa, Miho Ohta, Akihiko Tanaka, Masaki Yamauchi, Yukiko Ohyama, Tamotsu Kiyoshima, Seiji Nakamura, Cytokine Profiles Contribute to Understanding the Pathogenic Difference between Good Syndrome and Oral Lichen Planus: Two Case Report and Literature Review, Medicine, 94, 14, e704, 2015.04. |
| 46. |
Yasuyuki Maruse, Shintaro Kawano, Tamotsu Kiyoshima, Yuichi Goto, Ryota Matsubara, Toru Chikui, Daigo Yoshiga, Seiji Nakamura, A case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation, Head and Neck, 37, 11, 161-164, 2015.11. |
| 47. |
Teppei Jinno, Shintaro Kawano, Yasuyuki Maruse, Ryota Matsubara, Yuichi Goto, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Hideaki Tanaka, Ryoji Kitamura, Toyoshima Takeshi, Akiko Jinno, Masafumi Moriyama, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura, Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma, Oncology Reports, 10.3892/or.2015.3838, 33, 5, 2161-2168, 2015.03. |
| 48. |
Miho Ohta, Masafumi Moriyama, Yuichi Goto, Shintaro Kawano, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Jun-Nosuke Hayashida, Tamotsu Kiyoshima, Mayumi Shimizu, Yojiro Arinobu, Seiji Nakamura, A case of marginal zone B-cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis, World Journal of Surgical Oncology, 13, 67, in press, 2015.02. |
| 49. |
Shintaro Kawano, Yanqun Zheng, Kazunari Oobu, Ryota Matsubara, Yuichi Goto, Toru Chikui, Tadamasa Yoshitake, Tamotsu Kiyoshima, Teppei Jinno, Yasuyuki Maruse, Eiji Mitate, Ryoji Kitamura, Hideaki Tanaka, Toyoshima Takeshi, Tsuyoshi Sugiura, Seiji Nakamura, Clinicopathological evaluation of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma, Oncology Letters, 11, 5, 3369-3376, 2016.05. |
| 50. |
Erina Kitamoto, Toru Chikui, Shintaro Kawano, Masahiro Oga, Kouji Kobayashi, Yoshio Matsuo, Takashi Yoshiura, Makoto Obara, Hiroshi Honda, Kazunori Yoshiura, The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors, Academic Radiology, 10.1016/j.acra.2014.08.016, 22, 2, 210-216, 2014.02. |
| 51. |
Masafumi Moriyama, Sachiko Furukawa, Shintaro Kawano, Yuichi Goto, Tamotsu Kiyoshima, Akihiko Tanaka, Takashi Maehara, Jun-Nosuke Hayashida, Seiji Nakamura, The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease, International Journal of Oral and Maxillofacial Surgery, 43, 10, 1276-1281, 2014.10. |
| 52. |
Sachiko Furukawa, Masafumi Moriyama, Shintaro Kawano, Takashi Maehara, Jun-Nosuke Hayashida, Yuichi Goto, Tamotsu Kiyoshima, Hideki Shiratsuchi, Yukiko Ohyama, Miho Ohta, Yumi Imabayashi, Seiji Nakamura, Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis, Oral Disease, 10.1111/odi.12259, in press, 2014.05. |
| 53. |
Hideaki Tanaka, Toyoshima Takeshi, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura, Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma , Journal of Translational Medicine, 10.1186/1479-5876-12-112, In press, 2014.05. |
| 54. |
Toru Chikui, Masahiro Ohga, Erina Kitamoto, Shintaro Kawano, Takashi Yoshiura, Kazunori Yoshiura, Quantification of diffusion and permeability of MRI in the head and neck region, Journal of Radiology & Radiation therapy, 2, 2, 1047, 印刷中, 2014.01. |
| 55. |
A case of cervical recurrence of the tongue squamous cell carcinoma successfully treated with superselective intra-arterial chemotherapy concurrent with radiotherapy. |
| 56. |
Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Toyoshima Takeshi, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura, Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype, Clinical & Experimental Metastasis, 214, 289-306, 2014.03. |
| 57. |
Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toshiyuki Kawazu, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura, Carcinoma ex pleomorphic adenoma of the upper lip: A case of an unusual malignant component of squamous cell carcinoma, World Journal of Surgical Oncology, 10.1186/1477-7819-11-234, in press, 2013.09. |
| 58. |
Yu Nakao, Takeshi Mitsuyasu, Shintaro Kawano, Norifumi Nakamura, Shiori Kanda, Seiji Nakamura, Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway, International Journal of Oncology, 43, 5, 1377-1384, 2013.11. |
| 59. |
Shiori Kanda, Takeshi Mitsuyasu, Yu Nakao, Shintaro Kawano, Yuichi Goto, Ryota Matsubara, Seiji Nakamura, Anti-apoptotic role of sonic hedgehog signaling pathway in the proliferation of ameloblastoma, International Journal of Oncology, 43, 3, 695-702, 2013.09. |
| 60. |
Hiroe Kakehashi, Shintaro Kawano, Tamotsu Kiyoshima, Mayumi Shimizu, Ryota Matsubara, Takahiro Kiyosue, Yuichi Goto, Hideki Shiratsuchi, Seiji Nakamura, Parotid gland myoepithelioma with remarkable cystic formation: A case report
, Journal of Oral and Maxillofacial Surgery, Medicine and Pathology, 25, 183-188, 2013.04. |
| 61. |
Toru Chikui, Erina Kitamoto, Shintaro Kawano, Tsuyoshi Sugiura, Makoto Obara, Arjan W. Simonetti, Masamitsu Hatakenaka, Yoshio Matsuo, Syoichi Koga, Masahiro Ohga, Katsumasa Nakamura, Yoshiyuki Shioyama, Kazunori Yoshiura, A pharmacokinetic analysis based on dynamic contrast-enhanced MR imaging for evaluating the tumor response to preoperative therapy for oral cancer, Journal of Magnetic Resonance Imaging , 36, 3, 589-597, 2012.09. |
| 62. |
Eiji Mitate, Shintaro Kawano, Yu Nakao, Yuichi Goto, Ieyoshi Kobayashi, Onozawa K, Takashi Hashimoto, and Seiji Nakamura
, Concurrence of autoantibodies to both the γ2 subunit of laminin 332 and laminin γ1 in a patient with rejection response to the transplanted kidney, Acta Dermato-Venereologica, 93, 1, 114-115, 2013.01. |
| 63. |
Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shintaro Kawano, Kazunari Oobu, Takahiro Kiyosue, Ryota Matsubara, Yuichi Goto, and Seiji Nakamura, Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma, Journal of Cancer Research and Clinical Oncology, 138, 8, 1299-1310, 2012.08. |
| 64. |
Ryota Matsubara, Shintaro Kawano, Toru Chikui, Takahiro Kiyosue, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinnno, Tetsuji Nagata, Kazunari Oobu, Koichiro Abe, and Seiji Nakamura, Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma, Academic Radiology, 19, 6, 708-717, 2012.06. |
| 65. |
Takahiro Kiyosue, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinnno, Takeshi Toyoshima, Ryoji Kitamura, Kazunari Oobu, Seiji Nakamura, Immunohistochemical localization of p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma, International Journal of Clinical Oncology, in press, 2011.11. |
| 66. |
Ryota MATSUBARA, Shintaro KAWANO, Takahiro KIYOSUE, Yuichi GOTO, Mitsuhiro HIRANO, Takeshi TOYOSHIMA, Ryoji KITAMURA, Kazunari OOBU and Seiji NAKAMURA , Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma, International Journal of Oncology, 39, 6, 1391-1399, 2011.12. |
| 67. |
Toru Chikui, Shintaro Kawano, Toshiyuki Kawazu, Masamitsu Hatakenaka, Syouzou Koga, Masahiro Ohga,Yoshio Matsuo, Syunya Sunami, Tsuyoshi Sugiura, Yoshiyuki Shioyama, Makoto Obara, Kazunori Yoshiura, Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings, European Radiology, 21, 8, 1699-708, 2011.03. |
| 68. |
A postoperative case of oral cancer in which widening of esphageal entrance with a balloon catheter enabled oral intake. |
| 69. |
A clinicostatistical study of 151 patients with salivary gland tumors. |
| 70. |
Tetsuji Nagata, Kazuhide Matsunaga, Toshiyuki Kawazu, Shintaro Kawano, Kazunari Oobu, Masamichi Ohishi., Patency assessment of the internal jagular vein after neck dissection., International Journal of Oral and Maxillofacial Surgery, 35: 416-420, 2006.03. |
| 71. |
Shintaro Kawano, Masahiro Saito, Keisuke Handa, Takahiko Morotomi, Takashi Toyono, Yuji Seta, Norifumi Nakamura, Takashi Uchida, Kuniaki Toyoshima, Masamichi Ohishi, Hidemitsu Harada., Characterization of dental epithelial progenitor cells derived from cervical-loop epithelium in a rat lower incisor, Journal Dental Research, 83, 2, 129-133, 83:129-133, 2004.01. |
| 72. |
Norifumi Nakamura, Shintaro Kawano, Yu Nakao, Koichiro Tateishi, Masamichi Ohishi., An alternative method for vermillion reconstruction after resection of hemangioma., Journal of Oral and Maxillofacial Surgery, 10.1016/j.joms.2005.04.017, 63, 8, 1239-1243, 63:1239-43, 2005.01. |
| 73. |
Takahiko Morotomi, Shintaro Kawano, Takashi Toyono, Chiaki Kitamura, Masamichi Terashita, Takashi Uchida, Kuniaki Toyoshima, Hidemitsu Harada., In vitro differentiation of dental epithelial progenitor cells through epithelial-mesenchymal interactions., Archives of Oral Biology, 50:695-705, 2005.01. |
| 74. |
Harada H, Ichimori Y, Yokohama-Tamaki T, Ohshima H, Kawano S, Katsube K, Wakisaka S, Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling., Biochemical and Biophysical Research Communications, 340:611-616, 2006.01. |
| 75. |
Shintaro Kawano, Takashi Uchida, Takashi Toyono, Yuji Seta, Shinji Kataoka, Kuniaki Toyoshima., Immunohistochemical classification of dental epithelium and characterization of dental epithelial (stem-like) cell line, HAT-7, Archives of comparative biology of tooth enamel, 8:50-53, 2003.01. |
| 76. |
Takashi Toyono, Yuji Seta, Shinji Kataoka, Shintaro Kawano, Shigemoto R, Kuniaki Toyoshima., Expression of metabotropic glutamate receptor group I in rat gustatory papillae, Cell Tissue Research, 313:29-35, 2003.01. |
| 77. |
Takashi Toyono, Yuji Seta, Shinji Kataoka, HIdemitsu Harada, Takahiko Morotomi, Shintaro Kawano, Ryuichi Shigemoto, Kuniaki Toyoshima., Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae, Archives of Histology and Cytology, 10.1679/aohc.65.91, 65, 91-96, 2002.01. |
| 78. |
Shintaro Kawano, Takahiko Morotomi, Takashi Toyono, Norifumi Nakamura, Takashi Uchida, Masamichi Ohishi, Kuniaki Toyoshima, HIdemitsu Harda, Establishment of dental epithelial cell line (HAT-7) and the cell differentiation dependent on Notch signaling pathway, Connective Tissue Research, 10.1080/03008200290000637, 43, 2-3, 409-412, 43:409-412, 2002.01. |
