| Akira Ito | Last modified date：2013.4.26 |
Associate Professor /
Molecular and Biochemical Systems Engineering
Department of Chemical Engineering
Faculty of Engineering
Department of Chemical Engineering
Faculty of Engineering
Graduate School
Undergraduate School
E-Mail
Homepage
[URL].
Phone
092-802-2753
Fax
092-802-2753
Academic Degree
D. Eng.
Field of Specialization
Medical Biotechnology
Outline Activities
Medical application of functionarized magnetic nanoparticles
Since magnetic particles have unique features, the development of a variety of medical applications has been possible. The most unique feature of magnetic particles is their reaction to a magnetic force, and this feature has been utilized in applications such as drug targeting and bioseparation including cell sorting. Recently, magnetic nanoparticles have attracted attention because of their potential as contrast agents for magnetic resonance imaging (MRI) and heating mediators for cancer therapy (hyperthermia). Magnetite cationic liposomes (MCLs)–one of the groups of cationic magnetic particles-can be used as carriers to introduce magnetite nanoparticles into target cells since their positively charged surface interacts with the negatively charged cell surface; furthermore, they find applications to hyperthermic treatments. Magnetite nanoparticles conjugated with antibodies (antibody-conjugated magnetoliposomes, AMLs) are also applid to hyperthermia and have enabled tumor-specific contrast enhancement in MRI via systemic administration. Since magnetic nanoparticles are attracted to a high magnetic flux density, it is possible to manipulate cells labeled with magnetic nanoparticles using magnets; this feature has been applied in tissue engineering. Magnetic force and MCLs were used to construct multilayered cell structures and a heterotypic layered 3D coculture system. Thus, the applications of these functionalized magnetic nanoparticles with their unique features will further improve medical techniques.
Since magnetic particles have unique features, the development of a variety of medical applications has been possible. The most unique feature of magnetic particles is their reaction to a magnetic force, and this feature has been utilized in applications such as drug targeting and bioseparation including cell sorting. Recently, magnetic nanoparticles have attracted attention because of their potential as contrast agents for magnetic resonance imaging (MRI) and heating mediators for cancer therapy (hyperthermia). Magnetite cationic liposomes (MCLs)–one of the groups of cationic magnetic particles-can be used as carriers to introduce magnetite nanoparticles into target cells since their positively charged surface interacts with the negatively charged cell surface; furthermore, they find applications to hyperthermic treatments. Magnetite nanoparticles conjugated with antibodies (antibody-conjugated magnetoliposomes, AMLs) are also applid to hyperthermia and have enabled tumor-specific contrast enhancement in MRI via systemic administration. Since magnetic nanoparticles are attracted to a high magnetic flux density, it is possible to manipulate cells labeled with magnetic nanoparticles using magnets; this feature has been applied in tissue engineering. Magnetic force and MCLs were used to construct multilayered cell structures and a heterotypic layered 3D coculture system. Thus, the applications of these functionalized magnetic nanoparticles with their unique features will further improve medical techniques.
Research
Research Interests
Membership in Academic Society
- Tissue engineering using functional magnetite nanoparticles
keyword : Tissue engineering, Magnetic nanoparticle, Liposome, Cell culture
2003.04. - Hyperthermia using functional magnetite nanoparticles
keyword : Hyperthermia, Cancer immunotherapy, Magnetic nanoparticle, Liposome, Heat shock protein
2000.04.
- Heat-Immunotherapy for malignant melanoma by using melanoma-targeted nanoparticles (NPrCAP/ML).
Books
| 1. | Ito A, Kamihira M,Tissue engineering using magnetite nanoparticles.,Elsevir,Prog Mol Biol Transl Sci. 104:355-395,2011.11. |
| 2. | Ito A, Honda H,New Research on Biomaterials,Nova Science Publishers,2006.01. |
| 3. | Ito A, Honda H,Nanotechnologies for Tissue, Cell and Organ Engineering,Wiley-VCH,2006.01. |
| 4. | Shinkai M, Ito A,Recent Progress of Biochemical and Biomedical Engineering in Japan II,Springer,Vol. 91, pp191-220,2004.05. |
Papers
| 1. | Yasunori Yamamoto, Akira Ito, Hideaki Fujita, Eiji Nagamori, Yoshinori Kawabe, Masamichi Kamihira,Functional evaluation of artificial skeletal muscle tissue constructs fabricated by a magnetic force-based tissue engineering technique. ,Tissue Engineering Part A,Vol.17,No.1-2,pp.107-114,2011.01. |
| 2. | Ito A, Honda H, Kobayashi T,Cancer Immunotherapy Based on Intracellular Hyperthermia Using Magnetite Nanoparticles: a Novel Concept of “Heat-Controlled Necrosis” with Heat Shock Protein Expression,Cancer Immunology and Immunotherapy,55(3):320-8, review,2006.03. |
| 3. | Tanaka K, Ito A, Kobayashi T, Kawamura T, Shimada S, Matsumoto K, Saida T, Honda H.,Intratumoral Injection of Immature Dendritic Cells Enhances Antitumor Effect of Hyperthermia Using Magnetic Nanoparticles,International Journal of Cancer,116(4):624-33.,2005.09. |
| 4. | Ito A, Ino K, Hayashida M, Kobayashi T, Matsunuma H, Kagami H, Ueda M, Honda H.,A Novel Methodology for Fabrication of Tissue-Engineered Tubular Constructs Using Magnetite Nanoparticles and Magnetic Force,Tissue Engineering,11(9-10):1553-61,2005.09. |
| 5. | Ito A, Shinkai M, Honda H, Kobayashi T.,Medical Application of Functionalized Magnetic Nanoparticles,Journal of Bioscience and Bioengineering,100(1):1-11. Review,2005.07. |
| 6. | Ito A, Takizawa Y, Honda H, Hata K, Kagami H, Ueda M, Kobayashi T.,Tissue Engineering Using Magnetite Nanoparticles and Magnetic Force: Heterotypic Layers of Co-Cultured Hepatocytes and Endothelial cells.,Tissue Engineering,10(5-6):833-40.,2005.05. |
| 7. | Ito A, Hayashida M, Honda H, Hata K, Kagami H, Ueda M, Kobayashi T.,Construction and Harvest of Multilayered Keratinocyte Sheets Using Magnetite Nanoparticles and Magnetic Force.,Tissue Engineering,10(5-6):873-80.,2004.05. |
| 8. | Ito A, Tanaka K, Kondo K, Shinkai M, Honda H, Matsumoto K, Saida T, Kobayashi T.,Tumor Regression by Combined Immunotherapy and Hyperthermia Using Magnetic Nanoparticles in an Experimental Subcutaneous Murine Melanoma,Cancer Science,94(3):308-13.,2003.03. |
| 9. | Ito A, Shinkai M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T.,Augmentation of MHC Class I Antigen Presentation via Heat Shock Protein Expression by Hyperthermia,Cancer Immunology and Immunotherapy,50(10):515-22.,2001.12. |
| 10. | Ito A, Shinkai M, Honda H, Kobayashi T.,Heat-Inducible TNF-Alpha Gene Therapy Combined with Hyperthermia Using Magnetic Nanoparticles as a Novel Tumor-Targeted Therapy,Cancer Gene Therapy,8(9):649-54.,2001.09. |
- JAACT
- Incorporation of Capillary-Like Structures into Dermal Cell Sheets Constructed by Magnetic Force-Based Tissue Engineering
- Effective Cell-Seeding Technique Using Magnetite Nanoparticles and Magnetic Force onto Decellularized Blood Vessels for Vascular Tissue Engineering
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