Kyushu University Academic Staff Educational and Research Activities Database
List of Books
Yuichi Tsukada Last modified date:2018.06.23

Professor / Division of Medical Molecular Cell Biology, Graduate School of Systems Life Sciences / Advanced Biological Information Research Division / Inamori Frontier Research Center


Books
1. Kaneda, A., Tsukada, Y. (Editor), DNA and Histone Methylation as Cancer Targets, Springer Nature, 2017.09, Epigenetics is a novel dogma that regulates gene expression profiles in the cells and
is known to be involved in cancer. Among numerous epigenetic factors, DNA and
histone methylation has a unique feature that this covalent modification is stable
compared to other covalent modifications, thereby its reversibility had been
unknown until recently. The significant advance of epigenetics has also occurred in
methylation. Histone methylation was revealed to be reversible by the discoveries of
histone demethylases, and DNA demethylation pathway was elucidated by the discovery
of DNA oxidases.
This book focuses on DNA and histone methylation in epigenetics and describes
how it is involved in the molecular mechanisms responsible for the development of
cancer. Each chapter summarizes the current knowledge of the molecular basis of
DNA and histone methylation to explain its involvement in cancer, and describes
the features of DNA and histone methylation associated with a particular type of
cancer, the current diagnostic/therapeutic applications, and future directions of
study on DNA and histone methylation as cancer targets..
2. Yuichi Tsukada, Yujiang Geno Shi, Epigenetics 2nd edition "The discovery of histone demethylases", Cold Spring Harbor Press, pp13-15, 2015.02.
3. Yuichi Tsukada, Yujiang Geno Shi, Cold Spring Harbor Perspective in Biology "The discovery of histone demethylases", Cold Spring Harbor Laboratory Press, 2013.09.
4. Yu-ichi Tsukada, Keiichi I, Nakayama, Cold Spring Harbor Protocol "In vitro histone demethylase assay", Cold Spring Harbor Laboratory Press, 10, 2010.10.
5. Tsukada, Y., Zhang, Y., Methods "Purification of histone demethylases from HeLa cells", 40: 318-326, 2006.12.