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Ken-ichirou Morohashi Last modified date:2019.12.24

Professor / Biology of sex differences
Department of Molecular Biology
Faculty of Medical Sciences


Graduate School
Undergraduate School
Other Organization


Academic Degree
PhD
Country of degree conferring institution (Overseas)
No
Field of Specialization
Molecular Biology, Biology Sex Differentiation
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
I have conducted research to understand the mechanisms for sex (male and female) differentiation of animals. Based on the functions of nuclear receptors and steroid hormones, I analyze the molecular mechanisms of gonadal sex differentiation and development of the adrenal cortex. Moreover, epigenetic regulation of energy production and metabolism for lipophilic compounds has been studied in relation to functions of nuclear receptors. In addition to organizing international conferences and giving lectures in the international symposium of this research field, I organized a research project to study Molecular Mechanisms of Sex Differentiation as one of the Priority Areas of the Scientific Research by the Ministry of Education, Culture, Sports, Science and Technology, Japan from 2004 to 2009. Moreover, from 2010 to 2014, I organize as the representative researcher the project to study Molecular Basis of Sex Difference.
I supervise PhD students of Graduate School of Systems Life Science and receive PhD students from other universities.
In order to disclose our research observations, I organize open seminar and give a talk in the seminar. Recently, I cooperate with NHK to produce TV program.
Research
Research Interests
  • molecular mechanism of adrenocortical development
    keyword : adrenal cortex
    1998.05~2016.05.
  • Regulation of energy metabolism by Ad4BP
    keyword : energy metabolism
    2012.04~2014.06.
  • Molecular mechanisms of sex differentiation, Transcriptional regulation of steroidogenic genes, Molecular mechanisms of gonad development, Transcriptional regulation by nuclear receptor
    keyword : gonad, sex, transcriptional regulation, steroid hormone, nuclear receptor
    1990.04I have conducted research for understanding mechanisms for sex (male and female) differentiation of animals. The genes responsible for development of the gonad (testis and ovary) have been studied with genetic and biochemical methods. I particularly focused on cell, stage, and sex-specific enhancers of the genes encoding transcription factors expressed in the sexually differentiating gonads. Since the enhancers carries elements responsible for sexually differential gene expression, detailed characterization of the function and chromatin structure will lead to understanding molecular mechanisms underlying sex differentiation..
Academic Activities
Papers
1. Yurina Shishido, Takashi Baba, Tetsuya Sato, Yuichi Shima, Kanako Miyabayashi, Miki Inoue, Haruhiko Akiyama, Hiroshi Kimura, Yoshiakira Kanai, Yasuhiro Ishihara, Shogo Haraguchi, Akira Miyazaki, Damjana Rozman, Takeshi Yamazaki, Man-Ho Choi, Yasuyuki Ohkawa, Mikita Suyama, Ken-ichirou Morohashi, Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

, Scientific Rep, 10.1038/srep41912, 2017, 7, 2017.06.
Presentations
1. Ken-ichirou Morohashi, A Novel Landscape of Target Genes for Ad4BP/SF-1. , Endocrine Society’s 95th Annual Meeting, 2013.06.
2. Ken-ichirou Morohashi, Molecular and Cellular Mechanisms of Testis Differentiation, Gordon Research Conference, 2010 Reproductive Tract Biology, 2010.08.
Membership in Academic Society
  • The Japanese Biochemical Society
  • The Molecular Biology Society of Japan
  • The Japan Endocrine Society
  • Japan Steroid Hormone Society
  • Japan Society of Reproductive Endocrinology
  • The Endocrine Society
Awards
  • ?
  • ?
  • ?
Educational
Educational Activities
I supervise PhD students of Graduate School of Systems Life Science and have classes for undergraduate course of Department of Biomedical Science.