Kyushu University [Ken-ichirou Morohashi (Professor) Faculty of Medical Sciences, Department of Molecular Biology]

Last modified date：2011.6.30

Ken-ichirou Morohashi

Professor

Biology of sex differences
Department of Molecular Biology
Faculty of Medical Sciences

Papers

1.	Erling A. Hoivik, Trine E. Bjanesoy, Oliver Mai, Shiki Okamoto, Yasuhiko Minokoshi, Yuichi Shima, Ken-ichirou Morohashi, Ulrich Boehm, and Marit Bakke,DNA methylation of intronic enhancers directs tissue-specific expression of Steroidogenic Factor 1/Adrenal 4 Binding Protein (SF-1/Ad4BP).,Endocrinology ,Vol.152,pp.2100-2110,2011.04.
2.	Hidesato Ogawa, Tomoko Komatsu, Yasushi Hiraoka, and Ken-ichirou Morohashi,Transcriptional suppression by transient recruitment of ARIP4 to sumoylated nuclear receptor Ad4BP/SF-1.,Mol Biol Cell,20, 4235-4245,2009.10.
3.	Mohamad Zubair, Sanae Oka, Keith L. Parker, and Ken-ichirou Morohashi,Transgenic expression of Ad4BP/SF-1 in fetal adrenal progenitor cells leads to ectopic adrenal formation.,Mol Endocrinol,23, 1657-1667,2009.10.
4.	Chikako Yokoyama, Tomoko Komatsu, Hidesato Ogawa, Ken-ichirou Morohashi, Masayuki Azuma, and Taro Tachibana,Generation of rat monoclonal antibodies specific for Ad4BP/SF-1.,Hybridoma ,28, 113-119,2009.10.
5.	Ryuji Hiramatsu, Shogo Matoba, Masahiko Fujisawa, Masami Kanai-Azuma, Naoki Tsunekawa, Masamichi Kurohmaru, Ken-ichirou Morohashi, Dagmar Wilhelm, Peter Koopman, Yoshiakira Kanai,A critical time window of Sry action in gonadal sex determination.,Development,136, 129-138,2009.01.
6.	Mohamad Zubair, Keith L. Parker, and Ken-ichirou Morohashi,Developmental links between fetal and adult adrenal cortex revealed by lineage tracing. ,Mol Cell Biol ,28, 7030-7040,2008.10.
7.	Yuko Sato, Takashi Baba, Mohamad Zubair, Kanako Miyabayashi, Yoshiro Toyama, Mamiko Maekawa, Akiko Owaki, Hirofumi Mizusaki1, Tatsuya Sawamura, Kiyotaka Toshimori, Ken-ichirou Morohashi, and Yuko Katoh-Fukui,Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature,Mol. Repro. Dev. ,Vol.75 , in press,2008.08.
8.	Yuichi Shima, Mohamad Zubair, Tomoko Komatsu, Sanae Oka, Chikako Yokoyama, Taro Tachibana, Tord A Hjalt, and Ken-ichirou Morohashi,Pitx2 directly regulates Ad4BP/SF-1 gene transcription in the pituitary gonadotrope via interaction with the intronic enhancer,Mol. Endocrinol. ,Vol. 22, in press,2008.08.
9.	Noriko Sakai, Hiromi Terami, Shinobu Suzuki, Megumi Haga, Ken Nomoto, Nobuko Tsuchida, Ken-ichirou Morohashi, Naoaki Saito, Maki Asada, Megumi Hashimoto, Daisuke Harada, Hiroshi Asahara, Tetsuya Ishikawa, Fumiki Shimada, Kazuhiro Sakurada,Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. ,J Endocrinol 198, 489-497,2008.07.
10.	Takashi Baba, Yuichi Shima, Junsei Mimura, Motohiko Oshima, Yoshiaki Fujii-Kuriyama, and Ken-ichirou Morohashi ,Involvement of aryl hydrocarbon receptor (AhR) in maintenance of seminal vesicle through sexually different target gene expression,Sex Dev ,Vol. 2, No. 1, 1-11,2008.04.
11.	Yoshiyasu Ishimaru, Tomoko Komatsu, Megumi Kasahara, Yuko Katoh-Fukui, Yoshiro Toyama, Mamiko Maekawa, Kiyotaka Toshimori, Roshantha A. S. Chandraratna, Ken-ichirou Morohashi, and Hidefumi Yoshioka,Mechanism of asymmetric ovarian development in chick embryos,Development,Vol. 135, No. 4, 677-685,2008.02.
12.	Maki Fukami, Yuka, Wada, Michiyo Okada, Fumiko Kato, Noriyuki Katsumata, Takashi Baba, Ken-ichirou Morohashi, Jocelyn Laporte, Motoo Kitagawa, and Tsutomu Ogata,Mastermind-like domain containing 1 (MAMLD1 or Cxorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence,J. Biol. Chem.,Vol. 283, No. 9, 5525-5532,2008.02.
13.	Hiromi Kurokawa, Daisuke Saito, Yuko Katoh-Fukui, Kohei Ohta, Takashi Baba, Ken-ichirou Morohashi, Minoru Tanaka,Germ cells are essential for sexual dimorphism in the medaka gonad,PNAS,104, (42), 16958-16963,2007.10.
14.	Yuki Ohmuro-Matsuyama, Kataaki Okubo, Masaru Matsuda, Shigeho Ijiri, Deshou Wang, Guijun Guan, Taiga Suzuki, Makoto Matsuyama, Ken-ichirou Morohashi, and Yoshitaka Nagahama,Liver receptor homologue-1 (LRH-1) activates the promoter of brain aromatase (cyp19a2) in a teleost fish, the medaka, Oryzias latipes,Mol. Repro. Dev. ,Vol. 74, No.9 , 1065-1071,2007.09.
15.	WuQiang Fan, Toshihiko Yanase, Hidetaka Morinaga, Shigeki Gondo, Taijiro Okabe, Masatoshi Nomura, Tomoko Komatsu, Ken-Ichirou Morohashi, Tyrone B. Hayes, Ryoichi Takayanagi and Hajime Nawata,Atrazine-induced aromatase expression is SF-1-dependent: Implications for endocrine disruption in wildlife and reproductive cancers in humans,Environmental Health Perspectives ,115(5), 720-727,2007.05.
16.	Yoshiyuki Kojima, Yutaro Hayashi, Kentaro Mizuno, Shoichi Sasaki, Yuko Fukui, Peter Koopman, Ken-Ichiro Morohashi and Kenjiro Kohri,Up-regulation of SOX9 in human sex-determining region on the Y chromosome (SRY)-negative XX males,Clin. Endocrinol.,Vol. 68, No. 5, 791-799,2007.05.
17.	De-Shou Wang, Tohru Kobayashi, Lin-Yan Shou, Yuki Ohmuro-Matsuyama, Gui-Jun Guan, Shigeho Ijiri, Funie Sakai, Masaru Matsuda, Yasushi Shibata, Kataaki Okubo, Ken-chirou Morohashi, and Yoshitaka Nagahama,Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with Ad4BP/SF-1,Mol. Endocrinol. ,21(3), 712-725,2007.03.
18.	Naoko Sato, Yusuke Kamachi, Hisato Kondoh, Yuichi Shima, Ken-ichirou Morohashi, Reiko Horikawa and Tsutomu Ogata,Hypogonadotropic hypogonadism in an adult female with a heterozygous hypomorphic mutation of SOX2,Eur. J. Endocrinol. ,156(2), 169-173,2007.02.

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