Kyushu University Academic Staff Educational and Research Activities Database
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Kawabe Yoshinori Last modified date:2017.05.29

Assistant Professor / Molecular and Biochemical Systems Engineering
Department of Chemical Engineering
Faculty of Engineering


Graduate School
Undergraduate School


E-Mail
Homepage
http://www.chem-eng.kyushu-u.ac.jp/lab3/index.html
Phone
092-802-2783
Fax
092-802-2793
Academic Degree
Doctor of Engineering
Field of Specialization
Biochemical Engineering
Research
Research Interests
  • Mass production sysytem for the biopharmaceutical proteins by transgenic avian bioreactor
    keyword : transgenic avian bioreactor, biopharmaceuticals, recombinant proteins, monoclonal antibody, retroviral vector
    2004.04.
  • development of maintainance and efficient derivation for pluripotential stem cells
    keyword : pluripotential stem cells, genetically manipulated animals, feeder layer, tissue engineering
    2008.04.
Academic Activities
Books
1. Kawabe Y, Kamihira M, Antibody Expression and Production - Chapter 6 Production of Antibody by Transgenic Avians Cell Engineering Volume 7 SpringerLink, pp121-141, 2011.04.
Papers
1. Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Guan Huang, Akira Ito, Takeshi Omasa, Masamichi Kamihira, Improved recombinant antibody production by CHO cells using a production enhancer DNA element with repeated transgene integration at a predetermined chromosomal site., J Biosci Bioeng., in press, doi: 10.1016/j.jbiosc.2016.10.011., 2016.11.
2. Yoshinori Kawabe, Takuya Shimomura, Shuohao Huang, Suguru Imanishi, Akira Ito, Masamichi Kamihira, Targeted transgene insertion into the CHO cell genome using Cre recombinase-incorporating integrase-defective retroviral vectors., Biotechnol Bioeng., 113, 7, 2016.01.
3. Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Akira Ito, Masamichi Kamihira, Cre-mediated cellular modification for establishing producer CHO cells of recombinant scFv-Fc, BMC Proceedings, 9(Suppl 9):P5 , 2015.12.
4. Kawabe Y, Hayashida Y, Numata K, Harada S, Hayashida Y, Ito A, Kamihira M , Oral immunotherapy for pollen allergy using T-cell epitope-containing egg white derived from genetically manipulated chickens, PLOS ONE, 7, e48512, 2012.10.
5. Kawabe Yoshinori, Makitsubo H, Kameyama Y, Huang S, Akira Ito, Masamichi Kamihira, Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system., Cytotechnology, 64(3)、267-279, 2012.05.
6. Obayashi H, Kawabe Y, Makitsubo H, Watanabe R, Kameyama Y, Huang S, Takenouchi Y, Ito A, Kamihira M, Accumulative gene integration into a pre-determined site using Cre/loxP., J Biosci Bioeng, 113, 3, 381-388, 2012.05.
7. Huang S, Kawabe Y, Ito A, Kamihira M, Adeno-associated virus Rep-mediated targeting of integrase-defective retroviral vector DNA circles into human chromosome 19., Biochem Biophys Res Commun, 417, 1, 78-83, 2012.01.
8. Yamamoto H, Kawabe Y, Ito A, Kamihira M, Enhanced liver functions in mouse hepatoma cells by induced overexpression of liver-enriched transcription factors., Biochem Eng J, 60, 15, 67-73, 2012.01.
9. Huang S, Kawabe Y, Ito A, Kamihira M , Cre recombinase-mediated site-specific modification of a celluar genome using an integrase-defective retroviral vector, Biotechnol Bioeng, 107: 717-29, 2010.11.
10. Kameyama Y, Kawabe Y, Ito A, Kamihira M., An accumulative site-specific gene integration system using Cre recombinase-mediated cassette exchange., Biotechnol Bioeng. , 105(6):1106-14., 2010.04.
11. Penno CA, Kawabe Y, Ito A, Kamihira M., Production of recombinant human erythropoietin/Fc fusion protein by genetically manipulated chickens, Transgenic Res. , 19(2):187-95., 2010.04.
12. Kamihira M, Kawabe Y, Shindo T, Ono K, Esaka K, Yamashita T, Nishijima K, Iijima S, Production of chimeric monoclonal antibodies by genetically manipulated chickens, J Biotechnol. , 141(1-2):18-25., 2009.04.
13. Kawabe Y, Naka T, Komatsu H, Nishijima K, Iijima S, Kamihira M., Retroviral gene transduction into chicken embryo gonads through blood circulation, J Biosci Bioeng, 106(6):598-601, 2008.12.
14. Kameyama Y, Kawabe Y, Ito A, Kamihira M, Antibody-dependent gene transduction using gammaretroviral and lentiviral vectors pseudotyped with chimeric vesicular stomatitis virus glycoprotein, J Virol Methods, 153, 1, 49-54, 2008.06.
15. Kawabe Y, Kamihira M, Ono K, Kyogoku K, Nishijima K, Iijima S, Production of scFv-Fc Fusion Protein by Genetically Manipulated Quails, J Biosci Bioeng , 102, 4, 297-303, 2006.10.
16. Kawabe Y, Naka T, Ando-Noumi N, Matsumoto H, Ono K, Nishijima K, Kamihira M, Iijima S, Transport of human Immunoglobulin G and Fc-Fusion Proteins to Chicken Egg Yolk, J Biosci Bioen, 102, 6, 518-523, 2006.12.
17. Yoshinori Kawabe, Akitsu Hotta, Ken-ichiro Ono, Kazuhisa Esaka, Ken-ichi Nishijima, Masamichi Kamihira, and Shinji Iijima, Production of chimeric antibodies by transgenic chicken bioreactor, Animal Cell Technology: Basic & Applied Aspects, 14,307-314, 2006.05.
Presentations
1. Yoshinori Kawabe, Takuya Shimomura, Shuohao Huang, Suguru Imanishi, Akira Ito, Masamichi Kamihira, Development of retroviral vectors capable of site-specific gene insertion together with protein delivery, 25th European Society for Animal Cell Technology (ESACT) Meeting , 2017.05.15.
2. Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Guan Huang, Akira Ito, Masamichi Kamihira, Improved scFv-Fc productivity in CHO cells with tandem-repeat expression units flanked by a production enhancer element, The 29th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2016 Kobe), 2016.11.12.
3. Kawabe Yoshinori, Takanori Inao, Shodai Komatsu, Akira Ito, Masamichi Kamihira, Cre-mediated cellular modification for establishing producer CHO cells of recombinant scFv-Fc, ESACT ("European Society for Animal Cell Technology" Meeting) 2015, 2015.06.01.
4. Yoshinori Kawabe, Yuuki Hayashida, Kensaku Numata, Kenta Okuzono, Reina Obata, Akira Ito, Masamichi Kamihira, Egg-based oral immunotherapy with genetically manipulated chickens producing T-cell epitopes against Japanese cedar pollinosis, YABEC2014, 2014.11.07.
Membership in Academic Society
  • The Society of Biotechnology, Japan
  • The Society of Chemical Engineers, Japan
  • Japanese Association for Animal Cell Technology
  • The Molecular Biology Society of Japan
Educational
Other Educational Activities
  • 2010.07.