Kyushu University Academic Staff Educational and Research Activities Database
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masaki kato Last modified date:2019.06.14

Associate Professor / Department of Medicine and Bioregulatory Science
Department of Clinical Medicine
Faculty of Medical Sciences


Graduate School


Homepage
http://www.intmed3.med.kyushu-u.ac.jp/
Home page of Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
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Academic Degree
MD
Country of degree conferring institution (Overseas)
No
Field of Specialization
hepatology
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
We treat outpatients suffered from chronic liver diseases including viral hepatitis, autoimmune hepatitis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. In research field, our main project is to analyze the detailed mechanisms involved in the onset and progression of NAFLD and NASH. Also, evaluation of the effects of sinusoidal circulatory disturbance in pathogenesis of acute liver failure is another featured research theme. We assist graduate school students to unravel our basic and clinical questions. We are also involved in the multi-facility joint clinical research aimed to analyze the pathophysiology of liver diseases.
Research
Research Interests
  • Analyses of the clinical features of non-accoholic fatty liver disease (NAFLD) patients, forcusing on the gender difference and pre/post menopausal stage.
    keyword : NAFLD, women, menopause.
    2018.03~2021.03.
  • Analysis for the improving effects of cell-death inhibitor on acetaminophen induced acute liver failure in mice.
    keyword : acute liver failure, acetamionophen, apoptosis, necrosis, cell death
    2018.04~2021.03.
  • The role of sinusoidal microcirculatory disturbance in the mechanism of acute liver failure.
    keyword : acute liver failure, hepatic micricirculation, hypoxia, LDH, HIF-1
    2016.04~2021.03.
  • Analysis of the effect of menopause by ovariectomy on fructose induced fatty liver disease in female mice.
    keyword : ovariectomy, menopause, fattly liver, fructose
    2014.04~2021.03.
  • Development of treatment for acute liver failure via the improvement of sinusoidal coagulopathy using thrombomoduilin.
    keyword : hepatic microcirculation, acute liver failure
    2018.05~2021.03.
  • Evaluation of the distuebance of intrahepatic microcirculation in the patients with acute liver failure using peripheral blood mononuclear cells.
    keyword : acute liver failure, microcirculatory disturbance, PBMC
    2015.04~2018.03.
  • Analysis of the involvement of Toll-like receptor family in the development of acute liver failure.
    keyword : Toll-like receptor, TLR, acute liver failure
    2014.04~2021.03.
  • Analysis of the involvement of hypoxia induced hepatic stellate cell activation in the formation of liver cirrhosis.
    keyword : liver fibrosis, stellate cell, hypoxia
    2013.04~2016.03.
  • The effects of Antithrombin III administration via the portal vein in the animal models of acute liver failure
    keyword : antithrombinIII, acute liver failure, portal vein
    2009.06~2014.06.
  • Analyses of therapeutic effects of GLP-1 on non-alcoholic fatty liver disease and steatoheptitis.
    keyword : NAFLD, NASH, GLP-1
    2011.04~2016.03.
  • The effects of Branched-chain amino acids on the glucose metabolism through the improved hepatic utility in the liver
    keyword : Branched chain amino acids, glucose metabolism, liver cirrhosis
    2008.07~2013.10.
Academic Activities
Papers
1. Kosuke Tanaka, Yuko Masaki, Masatake Tanaka, Masayuki Miyazaki, masaki kato, Masatoshi Nomura, Toyoshi Inoguchi, Kazuhiro Kotoh, Ryoichi Takayanagi, Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats, World J Gastroenterol, 10.3748/wjg.v20.i10.2653 [doi], 20, 10, 2653-2663, 2014.03.
2. Miyazaki, M.Kato, M.Tanaka, M.Tanaka, K.Takao, S.Kohjima, M.Ito, T.Enjoji, M.Nakamuta, M.Kotoh, K.Takayanagi, R., Antithrombin III injection via the portal vein suppresses liver damage., World J Gastroenterol, 10.3748/wjg.v18.i16.1884 [doi], 2012.05, AIM: To investigate the effects of antithrombin III (AT III) injection via the portal vein in acute liver failure. METHODS: Thirty rats were intraperitoneally challenged with lipopolysaccharide (LPS) and D-galactosamine (GalN) and divided into three groups: a control group; a group injected with AT III via the tail vein; and a group injected with AT III via the portal vein. AT III (50 U/kg body weight) was administrated 1 h after challenge with LPS and GalN. Serum levels of inflammatory cytokines and fibrin degradation products, hepatic fibrin deposition, and hepatic mRNA expression of hypoxia-related genes were analyzed. RESULTS: Serum levels of alanine aminotransferase, tumor necrosis factor-alpha and interleukin-6 decreased significantly following portal vein AT III injection compared with tail vein injection, and control rats. Portal vein AT III injection reduced liver cell destruction and decreased hepatic fibrin deposition. This treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme oxygenase-1. CONCLUSION: A clinically acceptable dose of AT III injection into the portal vein suppressed liver damage, probably through its enhanced anticoagulant and anti-inflammatory activities..
3. Miyazaki, M.Kato, M.Tanaka, M.Tanaka, K.Takao, S.Kohjima, M.Ito, T.Enjoji, M.Nakamuta, M.Kotoh, K.Takayanagi, R., Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury. , J Gastroenterol Hepatol, 26, 12, 1749-56, 2011.12.
4. Higuchi, N.Kato, M.Miyazaki, M.Tanaka, M.Kohjima, M.Ito, T.Nakamuta, M.Enjoji, M.Kotoh, K.Takayanagi, R., Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver., J Cell Biochem, 112, 1, 30-38, 2011.01.
5. M. Miyazaki, M. Kato, M. Tanaka and R. Takayanagi, High-density lipoprotein cholesterol improves the model for end-stage liver disease scoring system for prognostic prediction of acute liver failure, Scand J Gastroenterol, 2010.04.
6. Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, Kohjima M, Kotoh K, Nakamuta M, Takayanagi R, Enjoji M., Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease., Hepatol Res., 2008.11.
7. Kato M, Higuchi N, Enjoji M., Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance., Scand J Gastroenterol. , 2008.08.
8. Nobito Higuchi, Masaki Kato, Kazuhiro Kotoh, Motoyuki Kohjima, Shinichi Aishima, Makoto Nakamuta, Yoshinori Fukui, Ryoichi Takayanagi, and Munechika Enjoji, Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by LPS and D-Galactosamine. , Liver International, 2007年8月アクセプト、現在in press, 2007.08.
9. Kato M, Sasaki T, Imazumi K, Takahashi K, Araki K, Shirataki H, Matsuura Y, Ishida A, Fujisawa H, T, Phosphorylation of Rabphilin-3A by calmodulin-dependent protein kinase II. , Biochem Biophys Res Commun. , 1994 Dec 30;205(3):1776-84, 1994.12.
Presentations
1. Analyses in the mechanism of improving effect of GLP-1 on hepatic steatosis in NAFLD. .
2. The oxygen concentration in hepatic vein suggests the disturbance of hepatic microcirculation in fulminant hepatitis and severe acute hepatitis. .
3. Quantification of the disturbance of hepatic microcirculation by contrast-enhanced ultrasonography using Sonazoid in the patients with acute liver failure. .
4. Trans-arterial high dose of steroid infusion therapy for fulminant hepatitis. .
Membership in Academic Society
  • Japan Acute Liver Failure Scociety
  • Liver Cancer Study Group of Japan
  • Japan Society for the Study of Obesity (JASSO)
  • The Japan Society of Hepatology
  • The Japanise Society of Gastroenterology
  • The Japanese Society of Internal Medicine
  • Japanese Society of Medical Oncology
Educational
Educational Activities
I lecture the basic structure and functions of the liver, prevalent diseases and representative treatments to medical, dental, and pharmaceutical students. I also lecture basic lipid metabolism to medical students. For students in Department of Health Sciences, School of Medicine, I show and demonstrate the practical methods and images for ultrasonography examination. For graduate school students, I assist their works to progress and discuss to figure out the problems.