|Shingo Baba||Last modified date：2019.06.17|
Field of Specialization
Research InterestsMembership in Academic Society
- Assessment of malignancy and prognosis of tumor using volume-metric parameter of the PET
keyword : PROGNOSIS PET MTV TLG
- development of novel receptor imaging using 64Cu labeled antibody
keyword : Cu64 PET Antibody imaging
- Variability of size-collected pretreatment FDG uptake predicts prognosis of patients with diffuse large cell lymphoma.
keyword : lymphoma FDG-PET
- Extrahippocampal benzodiazepin receptor density of hippocampal sclerosis correlates with surgical outcome.
keyword : BZR receptor density, Epilepsy
- Assessment of the FDG-PET findings and CT Hounsfield unit in the cases of lung nodules with GGO.
keyword : FDG-PET Lung cancer
- Usefulness of dynamic FDG PET/CT for the evaluation of liver tumor
keyword : PET/CT
- Diagnostic and Prognostic value of pretreatment SUV in 18F-FDG/PET in breast cancer; comparison with ADC form diffusion weighted MRI.
keyword : FDG-PET PET/CT
- To demonstrate the usefulness of FDG-PET/CT for the diagnosis of fever of unknown origin (FUO), we will compare the sensitivity of FDG-PET/CT and that of gallium SPECT for the detection of fever origin.
- The purpose of this study is to evaluate the usefulness of 11C-PIB PET in the differential diagnosis of Alzheimer's type dementia. We evaluate the relationship between 11C-PIB PET avidity and change of cognitive function.
- Inclusion criteria: 1.Newly diagnosed NHL by tissue biopsy; DLBCL, listed under mature B-cell neoplasms according to the WHO classification (diffuse large B-cell lymphoma/NOS, primary mediastinal large B-cell lymphoma, excluding intravascular large B-cell lymphoma). 2.Histologically proven CD20 positive DLBCL. 3.Patients with measurable disease by CT scan. 4.Age: 15-65. 5.Ann Arbor stage: 2-4. 6.Performance status (ECOG): 0-3. 7.Age-adjusted International Prognostic Index (aaIPI): High or High-intermediate. 8.Adequate hematological, hepatic, renal, cardiac, or pulmonary function (Neutrophil count >=1000/mm3, Platelet count >=7.5X104/mm3, AST<=3 X upper limit of normal, ALT<=3 X upper limit of normal, T. Bil<=2.0mg/dL, Cr<=2.0mg/dL, EF>=50%, PaO2>=60 mmHg or SaO2>=90%). 9.Patients without severe complications. 10.The patient must sign the consent form prior to registration. If the patient is under age, both the guardian and the patient must sign the consent form.
Exclusion criteria: 1.Patients with a history of prior or concurrent malignancies. 2.Patients who are on any medication for diabetes. 3.Patients who have severe complications such as active systematic infection, heart failure, respiratory failure, pulmonary disease, hepatic failure, liver cirrhosis, acute or chronic hepatitis, renal failure, active tuberculosis. 4.Patients with a history of angina or cardiac infarction. Patients with cardiomyopathy. Patients taking anti-arrhythmic drugs. 5.Patients with a history of drug anaphylaxis. 6.Patients with severe mental illness. 7.Patients with a history of lymphoma, leukemia, or MDS. 8.Patients with a history of chemotherapy, cytokine therapy, or antibody therapy for present DLBCL. 9.Patients with primary central nervous system lymphoma or with central nervous system involvement of DLBCL 10.Pregnancy or lactation. 11.Known hepatitis B or C virus infection 12.Known HIV or HTLV-1 infection 13.Patients with any medical condition that in the opinion of the investigator would compromise treatment delivery.
|1.||Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Clinical Impact of radiolabeled amino acid PET for the diagnosis of cerebral gliomas, THE 13TH ASIA OCEANIA CONGRESS OF NUCLEAR MEDICINE AND BIOLOGY, 2019.05, BACKGROUND:
Magnetic resonance imaging (MRI) is the investigation of choice for diagnosing cerebral glioma, but its capacity to differentiate tumor tissue from non-specific tissue changes is limited. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a molecular imaging technique, which provides information on the metabolic behavior of the tumor. However, FDG-PET often leads to several controversies in making clinical decisions due to their high uptake of normal surrounding tissues, and pose difficulty in delineating treatment-induced necrosis, edema, inflammation, and pseudoprogression. Thus, it is imperative to find new approach to demarcate normal and tumor tissues. PET using radiolabeled amino acids is a promising technique and it increases diagnostic accuracy for brain tumor.
PURPOSE: We have provided some cases and literature of 11C methionine-PET (MET-PET) and other amino acid PET for gliomas, along with prognostic and diagnostic significance.
Review based on the authors' own research results and a selective literature review
The use of radiolabeled amino acids allows better delineation of tumor margins and improves targeting of biopsy and radiotherapy, and planning surgery. In addition, amino acid imaging appears useful in distinguishing tumor recurrence from non-specific post-therapeutic necrosis, in predicting prognosis in low grade gliomas, and in monitoring metabolic response during treatment.
Amino acid PET including MET-PET can lead to a better understanding of the existing controversies and can enhance our knowledge for future treatment of GBM patients based on their tumor gene signatures to achieve better prognosis and treatment outcome..
|2.||Effect of spatial resolution on the PET Radiomics parameters of malignant tumors.|
|3.||Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Ryo Somehara , Keiichiro Tahara, Akio Hiwatashi, Saiji Ohga, Koji Yshimoto, Hiroshi Honda, Comparison of F-18 FDG and C-11 Methionine PET/CT for the differentiation of recurrent brain tumors from radiation necrosis after radiotherapy, Society of Nuclear Medicine and Molecular Imaging (SNMMI), 2018.06, Background
C-11Methionine positron emission tomography has reported to be useful to distinguish brain tumor recurrence from radiation necrosis. We undertook this study to directly compare F-18 flurodeoxyglucose (FDG) PET and C-11 methionine (MET) PET for the evaluation of recurrence in brain tumors.
Thirty-seven patients with a history of treated brain tumors (31 primary brain tumor and 6 metastatic tumor) referred for evaluation of recurrent disease were initially included in the study. There were 22 males and 15 females (mean age: 38.7 ± 14.4 years; range: 15 to 65 years). All patients underwent the MET and FDG study within 2 weeks. Visual image interpretation was performed independently by 2 PET physicians for each tracer using the fused PET/CT images. Images were analyzed semiquantitatively using tumor to normal contralateral cortex ratios (T/N). Imaging results were compared with histopathology on tumor excision or biopsy in 10 patients and with clinical follow-up in 27 patients.
The final diagnosis was tumor recurrence in 27 patients and no recurrence/stable disease in 10 patients. On FDG, findings in 23/37 (62.2%) were suggestive of recurrent tumors. On MET, findings in 28/37 (75.7%) cases were suggestive of recurrent tumors. Spatially separated secondary lesions were clearly delineated in 4 cases, 3 were glioblastoma multiforme (GBM) and 1 were anaplastic astrocytoma. Two of the secondary lesions were missed on FDG PET. Using a cutoff for T/N ratio on FDG of >0.90 to differentiate recurrence from no recurrence, sensitivity of FDG was 74.1%, whereas specificity was 70.0%. Area under the curve was 0.86. Using a cutoff for T/N ratio of >2.1 to differentiate recurrence from no recurrence, sensitivity of MET was 92.6%, whereas specificity was 80.0%. Area under the curve was 0.95.
Semiquantitative analysis of MET can provide more informative values than FDG to aid in the differentiation of tumor recurrence from radiation necrosis.
|4.||Takuro Isoda, Shingo Baba, Yoshiyuki Kitamura, Ryo Somehara , Keiichiro Tahara,Taiki Higo, Takeo Fujino, Masayuki Sasaki, Hiroshi Honda, FDG-PET of drive line infection and non-pathological uptake in or around a ventricular assist device, Society of Nuclear Medicine and Molecular Imaging (SNMMI), 2018.06.|
|5.||Yasuhiro Maruoka, Shingo Baba, Michinobu Nagao, Takuro Isoda, Kitamura Yoshiyuki, Keiichiro Tahara, Akihiro Nishie, Satoshi Kawanami, Abe Kohtaro, Kazuya Hosokawa, Masayuki Sasaki, Hiroshi Honda, Evaluation of Balloon Pulmonary Angioplasty Response for Chronic Thromboembolic Pulmonary Hypertension Using Fractal Analysis of 99mTc-MAA SPECT, 第56回日本核医学会学術総会, 2016.11.|
|6.||Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Kitamura Yoshiyuki, Keiichiro Tahara, Masayuki Sasaki, Hiroshi Honda, Use of recombinant human thyroid-stimulating hormone (rhTSH) reduces the damage to salivary glands after radioiodine therapy for thyroid cancer, 63th Annual Meeting, Society of Nuclear Medicine, 2016.06.|
|7.||Kitamura Yoshiyuki, Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Keiichiro Tahara, Masayuki Sasaki, Akihiro Nishie, Hiroshi Honda, Relationship of the I-123 Metaiodobenzylguanidine (MIBG) Uptake and Early Relapse of Neuroblastoma Using Semi-quantitative Analysis of SPECT/CT., 63th Annual Meeting, Society of Nuclear Medicine, 2016.06.|
|8.||Yasuhiro Maruoka, Shingo Baba, Michinobu Nagao, Takuro Isoda, Kitamura Yoshiyuki, Keiichiro Tahara, Akihiro Nishie, Satoshi Kawanami, Abe Kohtaro, Kazuya Hosokawa, Masayuki Sasaki, Hiroshi Honda, Evaluation of Balloon Pulmonary Angioplasty Response for Chronic Thromboembolic Pulmonary Hypertension Using Fractal Analysis of 99mTc-MAA SPECT, 63th Annual Meeting, Society of Nuclear Medicine, 2016.06.|
|9.||Shingo Baba, Yuji Watanabe, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, Keiichiro Tahara, Koji Sagiyama, Ryotaro Kamei, Hiroshi Honda, Evaluation of the novel method for the measurement of brain amyloid burden using PET/MRI, 第55回日本核医学会学術総会, 2015.10.|
|10.||Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, Koji Sagiyama, Ryotaro Kamei, Yuji Watanabe, Hiroshi Honda, Evaluation of cortical uptake of amyloid PET tracer with hybrid PET/MRI; comparison with PET/CT, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.|
|11.||Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, KojI Kato, Masayuki Sasaki, Hiroshi Honda, Usefulness of FDG-PET/CT in the diagnosis of acute transformation of Adult T-cell Lymphoma, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.|
|12.||TAKURO ISODA, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Use of recombinant human thyroid-stimulating hormone (rhTSH) reduces the damage to salivary glands after radioiodine therapy for thyroid cancer, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.|
|13.||Akifumi Yamada, Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Effective synthesis of Pittsburg Compound B (11C-PIB) for clinical application by on-column 11C-methylation, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.|
|14.||TAKURO ISODA, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Impact of the patient age on flip-flop phenomenon in lung metastasis from thyroid cancer, 27th European Congress of Radiology, 2015.05.|
|15.||Shingo Baba, Takuro Isoda, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Usefulness of myocardial 123I-MIBG-SPECT for the differential diagnosis of Parkinson's syndrome, 61th Annual Meeting, Society of Nuclear Medicine, 2014.06.|
|16.||Shingo Baba, Koichiro Abe, Takuro Isoda, Yasuhiro Maruoka, Masayuki Sasaki, Hiroshi Honda, Variability of size-collected pretreatment FDG uptake predicts prognosis of patients with diffuse large cell lymphoma., 59th Annual Meeting, Society of Nuclear Medicine, 2012.06, Purpose: To evaluate the usefulness of recovery-collected SUVs in the clinical diagnosis of malignant lymphoma patients.
Materials and Methods: Previously reported recovery-collection using simple table look-up method was used in this study. Recovery coefficient was estimated using size and signal-background ratio by phantom experiment. Fifty three patients of malignant lymphoma (DLBCL; 37, FL; 16) were subjected to FDG-PET/CT for initial staging. Recovery-collected SUVs (SUVcor) were calculated and average±SD, coefficient of variation (CV) of SUVcor were compared with those of conventional SUV within the patient and between the groups divided by histology and prognosis.
Result: Average±SD of SUVmax, SUVcor were higher in DLBCL (14.5±9.1, 18.6±9.6) than in FL(8.5±2.6, 11.7±3.24)( p<0.05). With recovery collection, average±SD was increased and CVs within the patient were significantly decreased in both type of histology(p<0.05). CVs of SUVcor was significantly smaller in good responder (20cases) than those of poor responder (17) (p<0.05).
Conclusion: Uptakes of FDG free from partial-volume effect can be measured correctly with this method. Variability of pretreatment SUVs with size-collection is one of the independent predictor of the prognosis of patient with DLBCL.
|17.||ariability of size-collected SUV evaluated by FDG-PET/CT predicts prognosis of patients with diffuse large cell lymphoma..|
|19.||The 18F-FAZA /FDG uptake ratio: Potential Index of tumor hypoxia?.|
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