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Shingo Baba Last modified date:2018.06.15

Lecturer / Department of Radiology
Radiology Center
Kyushu University Hospital


Graduate School
Undergraduate School


Academic Degree
MD、PhD
Field of Specialization
Radiology
Research
Research Interests
  • Assessment of malignancy and prognosis of tumor using volume-metric parameter of the PET
    keyword : PROGNOSIS PET MTV TLG
    2015.04~2017.05.
  • development of novel receptor imaging using 64Cu labeled antibody
    keyword : Cu64 PET Antibody imaging
    2015.04~2017.05.
  • Variability of size-collected pretreatment FDG uptake predicts prognosis of patients with diffuse large cell lymphoma.

    keyword : lymphoma FDG-PET
    2013.05~2013.05.
  • Extrahippocampal benzodiazepin receptor density of hippocampal sclerosis correlates with surgical outcome.
    keyword : BZR receptor density, Epilepsy
    2010.03~2012.01.
  • Assessment of the FDG-PET findings and CT Hounsfield unit in the cases of lung nodules with GGO.
    keyword : FDG-PET Lung cancer
    2010.05~2012.05.
  • Usefulness of dynamic FDG PET/CT for the evaluation of liver tumor

    keyword : PET/CT
    2013.05~2013.05.
  • Diagnostic and Prognostic value of pretreatment SUV in 18F-FDG/PET in breast cancer; comparison with ADC form diffusion weighted MRI.
    keyword : FDG-PET PET/CT
    2007.10~2013.03.
Current and Past Project
  • To demonstrate the usefulness of FDG-PET/CT for the diagnosis of fever of unknown origin (FUO), we will compare the sensitivity of FDG-PET/CT and that of gallium SPECT for the detection of fever origin.
  • The purpose of this study is to evaluate the usefulness of 11C-PIB PET in the differential diagnosis of Alzheimer's type dementia. We evaluate the relationship between 11C-PIB PET avidity and change of cognitive function.
  • Inclusion criteria: 1.Newly diagnosed NHL by tissue biopsy; DLBCL, listed under mature B-cell neoplasms according to the WHO classification (diffuse large B-cell lymphoma/NOS, primary mediastinal large B-cell lymphoma, excluding intravascular large B-cell lymphoma). 2.Histologically proven CD20 positive DLBCL. 3.Patients with measurable disease by CT scan. 4.Age: 15-65. 5.Ann Arbor stage: 2-4. 6.Performance status (ECOG): 0-3. 7.Age-adjusted International Prognostic Index (aaIPI): High or High-intermediate. 8.Adequate hematological, hepatic, renal, cardiac, or pulmonary function (Neutrophil count >=1000/mm3, Platelet count >=7.5X104/mm3, AST<=3 X upper limit of normal, ALT<=3 X upper limit of normal, T. Bil<=2.0mg/dL, Cr<=2.0mg/dL, EF>=50%, PaO2>=60 mmHg or SaO2>=90%). 9.Patients without severe complications. 10.The patient must sign the consent form prior to registration. If the patient is under age, both the guardian and the patient must sign the consent form.
    Exclusion criteria: 1.Patients with a history of prior or concurrent malignancies. 2.Patients who are on any medication for diabetes. 3.Patients who have severe complications such as active systematic infection, heart failure, respiratory failure, pulmonary disease, hepatic failure, liver cirrhosis, acute or chronic hepatitis, renal failure, active tuberculosis. 4.Patients with a history of angina or cardiac infarction. Patients with cardiomyopathy. Patients taking anti-arrhythmic drugs. 5.Patients with a history of drug anaphylaxis. 6.Patients with severe mental illness. 7.Patients with a history of lymphoma, leukemia, or MDS. 8.Patients with a history of chemotherapy, cytokine therapy, or antibody therapy for present DLBCL. 9.Patients with primary central nervous system lymphoma or with central nervous system involvement of DLBCL 10.Pregnancy or lactation. 11.Known hepatitis B or C virus infection 12.Known HIV or HTLV-1 infection 13.Patients with any medical condition that in the opinion of the investigator would compromise treatment delivery.

Academic Activities
Papers
1. TAKURO ISODA, Shingo Baba, Yasuhiro Maruoka, Kitamura Yoshiyuki, Keiichiro Tahara, Masayuki Sasaki, Hiroshi Honda, Influence of the Different Primary Cancers and Different Types of Bone Metastasis on the Lesion-based Artificial Neural Network Value Calculated by a Computer-aided Diagnostic System,BONENAVI, on Bone Scintigraphy Images, Asia Ocean J Nucl Med Biol., 8, 1, 49-55, 2017.12.
2. Kitamura Yoshiyuki, Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Satoshi Kawanami, Kazuhiko Himuro, Masayuki Sasaki, Hiroshi Honda, The Efficiency of Respiratory-gated 18F-FDG PET/CT in Lung
Adenocarcinoma: Amplitude-gating Versus Phase-gating Methods
, Asia Ocean J Nucl Med Biol., 5, 1, 30-36, 2017.12.
3. Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Horoshi Honda, A functional scoring system based on salivary gland scintigraphy for evaluating salivary gland dysfunction secondary to 131I therapy in patients with differentiated thyroid carcinoma, Journal of Clinical and Diagnostic Research, https://doi.org/10.7860/JCDR/2017/27340.10431, 11, 8, TC23-TC28, 2017.08, Introduction: Radioiodine therapy with 131I (131I therapy) after total or near-total thyroidectomy has been established as an effective treatment for Differentiated Thyroid Carcinoma (DTC), but can induce dry mouth symptoms by salivary gland damage and impair the patients’ quality of life. Aim: To propose a functional scoring system based on Salivary Gland Scintigraphy (SGS) findings that evaluates development of salivary gland dysfunction secondary to 131I therapy in patients with DTC. Materials and Methods: This retrospective study evaluated the records of 279 DTC patients who underwent SGS after one or more round(s) of 131I therapy, using 370 MBqof 99mTc-pertechnetate. The SGS results were assessed using a novel functional scoring system in the Parotid Glands (PGs) and Submandibular Glands (SMGs) according to visual evaluations based on a three-point uptake score, Washout Rate (%WR) score after lemon-juice stimulation, and functional score. The scores were compared among pretreatment, low-dose (<10 GBq), and high-dose (>10 GBq) groups and among pretreatment, symptom-positive, and symptom-negative groups. Risk factors for dry mouth were analyzed by univariate and multivariate logistic regression analyses. Results: Dry mouth symptoms developed in 15.4% of the DTC patients after 131I therapy. The three-point uptake, %WR, and functional scores in both the PG and SMG were statistically significant between low-dose and high-dose groups, and between symptom-positive and symptom-negative groups. The PG/SMG functional scores were independent risk factors for dry mouth (odds ratio, 0.03 and 0.0007 respectively). Conclusion: SGS-based PG and SMG functional scores were effective biomarkers to objectively evaluate salivary gland dysfunction, with the high strength of association with dry mouth symptoms..
4. Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Hiroshi Honda, Association between volumetric analysis of lung metastases on F-18-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography and short-term progression after i-131 therapy for differentiated thyroid carcinoma, Indian Journal of Nuclear Medicine, https://doi.org/10.4103/ijnm.IJNM_43_17, 32, 3, 167-172, 2017.07, Purpose: Lung metastases (LMs) and their radioiodine uptake affect prognosis in patients with differentiated thyroid carcinoma (DTC). We herein investigate the value of metabolic tumor volume (MTV) in LMs on positron emission tomography/computed tomography (PET/CT) using 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18 FDG PET/CT) in predicting short-term progression after initial I-131 therapy in DTC patients. Materials and Methods: We retrospectively evaluated 111 DTC patients with LMs. Diagnostic CT and I-131 scintigraphy were performed within 1 week of I-131 therapy. Maximum standardized uptake value (SUVmax) and total MTV (MTVtotal) were compared between patients with I-131-positive and I-131-negative LMs and between patients with and without short-term progression. Correlation analyses were performed between F-18 FDG PET/CT parameters and thyroglobulin (TG) level, and predictive factors for short-term progression were analyzed by logistic regression and receiver operating characteristic curve analysis.Results: Patients with short-term progression had significantly higher SUVmax and MTVtotal than those without. TG levels were significantly correlated with SUVmax (r = 0.21) and MTVtotal (r = 0.51) after I-131 therapy. MTVtotal showed significant association (χ2 = 16.5, odds ratio = 0.02) with short-term progression after initial I-131 therapy and had the highest predictive value of all the putative risk factors. Conclusions: MTVtotal in LMs on F-18 FDG PET/CT is an independent predictive factor with a high predictive value for short-term progression of DTC after initial I-131 therapy. It is recommended that F-18 FDG PET/CT be performed before planning therapy during the evaluation of DTC patients with LM..
5. TAKURO ISODA, Shingo Baba, Yasuhiro Maruoka, Kitamura Yoshiyuki, Keiichiro Tahara, Masayuki Sasaki, Hiroshi Honda, Impact of patient age on the iodine/FDG "flip-flop" phenomenon in lung metastasis from thyroid cancer., Ann Nucl Med. , 30, 8, 518-524, 2016.10.
6. Michinobu Nagao, Shingo Baba, Masato Yonezawa, Yuzo Yamasaki, Takeshi Kamitani, Takuro Isoda, Satoshi Kawanami, Yasuhiro Maruoka, Yoshiyuki Kitamura, Abe Kohtaro, Taiki Higo, Kenji Sunagawa, Hiroshi Honda, Prediction of adverse cardiac events in dilated cardiomyopathy using cardiac T2* MRI and MIBG scintigraphy., The International Journal of Cardiovascular Imaging , 31, 2, 399-407, 2015.02.
7. Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Akihiro Nishie, Hiroshi Honda, Nabothian Cyst a Predominant Cause of False-Positive Iodine Uptake in Uterus:Comparison of SPECT/CT and Pelvic MRI
, Clin Nucl Med, 39, 8, 680-684, 2014.08.
8. Akira Monji, Keisuke Motomura, Yoshito Mizoguchi, Tomoyuki Ohara, Shingo Baba, Takashi Yoshiura, Shigenobu Kanba, A Case of Late-Onset Bipolar Disorder With Severely Abnormal Behavior and Neuroimaging Observations Very Similar to Those of Frontotemporal Dementia , J Neuropsychiatry Clin Neurosci, 26, 1, pp e35-pp e35, 2014.04.
9. Shingo Baba, Takuro Isoda, Yasuhiro Maruoka, Yoshiyuki Kitamura, Tuyoshi Yoshida, Masayuki Sasaki, Hiroshi Honda, Diagnostic and prognostic value of pretreatment SUV in 18F-FDG/PET in breast cancer: comparison with ADC from diffusion-weighted MRI, J Nucl Med, 55, 5, 736-742, 2014.03.
10. Yasuhiro Maruoka, Koichiro Abe, Shingo Baba, Takuro Isoda, Yoshiyuki Kiramura, Go Akamatsu, Masayuki Sasaki, Hiroshi Honda, Usefulness of partial volume effect-corrected F-18 FDG PET/CT for predicting I-131 accumulation in the metastatic lymph nodes of patients with thyroid carcinoma., Ann Nucl Med, 27, 10, 873-879, 2013.12, PURPOSE:
The purpose of this study was to evaluate the clinical usefulness of partial volume effect (PVE)-corrected F-18 FDG PET/CT for predicting I-131 accumulation in metastatic lymph nodes (mLNs) during I-131 therapy for papillary thyroid carcinoma (PTC).

METHODS:
Sixty-five mLNs in 31 PTC patients who underwent F-18 FDG PET/CT in an initial radioiodine therapy (RIT) were retrospectively evaluated. Of these, 25 mLNs were I-131-positive and 40 were I-131-negative. SUVmax and SUVmax with PVE correction (cSUVmax) were measured for each mLN, where PVE correction was performed utilizing a simple table lookup correction method. Then, SUVmax/cSUVmax was compared between I-131-positive and I-131-negative mLNs, including the analyses for the mLNs with small-sized (<1 cm) and weak FDG accumulation (SUVmax <3.5). The predictability for I-131 accumulation with SUVmax/cSUVmax was also compared.

RESULTS:
For all 65 mLNs, SUVmax/cSUVmax was significantly higher in I-131-negative than I-131-positive mLNs (p < 0.0001). Only in cSUVmax, I-131-negative mLNs were significantly higher than I-131-positive, in terms of the 30 small-sized mLNs (p = 0.0001) and 14 mLNs with weak FDG uptake (p = 0.007). The highest accuracy in predictability for I-131 accumulation was significantly better with cSUVmax (92 %) than SUVmax (62 %) (p < 0.0001).

CONCLUSION:
PVE-corrected F-18 FDG PET/CT is a valuable predictor of I-131 accumulation in mLNs during RIT..
11. Go Akamatsu, Katsuhiko Mitsumoto, Takahumi Taniguchi, Shingo Baba, Masayuki Sasaki, Influences of point-spread function and time-of-flight reconstructions on standardized uptake value of lymph node metastases in FDG-PET., Eur J Radiol., 83, 1, 226-230, 2013.01, Purpose
The purpose of this study was to investigate the effects of point-spread function (PSF) and time-of-flight (TOF) on the standardized uptake value (SUV) of lymph node metastasis in FDG-PET/CT.

Materials and methods
This study evaluated 41 lymph node metastases in 15 patients who had undergone 18F-FDG PET/CT. The lesion diameters were 2.5 cm or less. The mean short-axis diameter of the lymph nodes was 10.5 ± 3.7 mm (range 4.6–22.8 mm). The PET data were reconstructed with baseline OSEM algorithm, with OSEM + PSF, with OSEM + TOF and with OSEM + PSF + TOF. A semi-quantitative analysis was performed using the maximum and mean SUV of lymph node metastases (SUVmax and SUVmean) and mean SUV of normal lung tissue (SUVlung). We also evaluated image quality using the signal-to-noise ratio in the liver (SNRliver).

Results
Both PSF and TOF increased the SUV of lymph node metastases. The combination of PSF and TOF increased the SUVmax by 43.3% and the SUVmean by 31.6% compared with conventional OSEM. By contrast, the SUVlung was not influenced by PSF and TOF. TOF significantly improved the SNRliver.

Conclusion
PSF and TOF both increased the SUV of lymph node metastases. Although PSF and TOF are considered to improve small-lesion detectability, it is important to be aware that PSF and TOF influence the accuracy of quantitative measurements..
12. Shingo Baba, Heather A. Jacene, James M. Engles, Hiroshi Honda, Richard L. Wahl, CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies, J Nucl Med. , vol51, 2, 246-25-, 2010.02.
13. Jespersgaard C, Larsen LA, Baba S, Kukita Y, Tahira T, Christiansen M, Vuust J, Hayashi K, Andersen PS., Optimization of capillary array electrophoresis single-strand conformation polymorphism analysis for routine molecular diagnostics., Electrophoresis., 2006 Oct;27(19):3816-22., 2006.10.
14. Shingo Baba, Mitsuaki Tatsumi, Takayoshi Ishimori, David Lilien, James M Engles, and Richard L Wahl, Effect of Nicotine and Ephedrine on the Accumulation of FDG in Brown Adipose Fat Tissue, J Nucl Med. , 2007 Jun;48(6):981-6, 2007.06.
15. Shingo Baba, Steve Y. Cho, Zhaohui Ye, Linzhao Cheng, James M. Engles, Richard L. Wahl, How Reproducible is Bioluminescent Imaging of Tumor Cell Growth? : Single Time Point v.s. Dynamic Measurement Approach, Molecular Imaging. , 2007 Sep-Oct;6(5):315-22., 2007.09.
16. Shingo Baba, James M. Engles, David L. Huso, Takayoshi Takayoshi, and Richard L. Wahl, Comparative Uptake of Multiple Clinical Radiotracers into Brown Adipose Fat Tissue under Cold Stimulated and Non- stimulated Conditions, J Nucl Med., Oct;48(10):1715-23., 2007.10.
Presentations
1. Yasuhiro Maruoka, Shingo Baba, Michinobu Nagao, Takuro Isoda, Kitamura Yoshiyuki, Keiichiro Tahara, Akihiro Nishie, Satoshi Kawanami, Abe Kohtaro, Kazuya Hosokawa, Masayuki Sasaki, Hiroshi Honda, Evaluation of Balloon Pulmonary Angioplasty Response for Chronic Thromboembolic Pulmonary Hypertension Using Fractal Analysis of 99mTc-MAA SPECT, 第56回日本核医学会学術総会, 2016.11.
2. Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Kitamura Yoshiyuki, Keiichiro Tahara, Masayuki Sasaki, Hiroshi Honda, Use of recombinant human thyroid-stimulating hormone (rhTSH) reduces the damage to salivary glands after radioiodine therapy for thyroid cancer, 63th Annual Meeting, Society of Nuclear Medicine, 2016.06.
3. Yasuhiro Maruoka, Shingo Baba, Michinobu Nagao, Takuro Isoda, Kitamura Yoshiyuki, Keiichiro Tahara, Akihiro Nishie, Satoshi Kawanami, Abe Kohtaro, Kazuya Hosokawa, Masayuki Sasaki, Hiroshi Honda, Evaluation of Balloon Pulmonary Angioplasty Response for Chronic Thromboembolic Pulmonary Hypertension Using Fractal Analysis of 99mTc-MAA SPECT, 63th Annual Meeting, Society of Nuclear Medicine, 2016.06.
4. Kitamura Yoshiyuki, Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Keiichiro Tahara, Masayuki Sasaki, Akihiro Nishie, Hiroshi Honda, Relationship of the I-123 Metaiodobenzylguanidine (MIBG) Uptake and Early Relapse of Neuroblastoma Using Semi-quantitative Analysis of SPECT/CT., 63th Annual Meeting, Society of Nuclear Medicine, 2016.06.
5. Shingo Baba, Yuji Watanabe, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, Keiichiro Tahara, Koji Sagiyama, Ryotaro Kamei, Hiroshi Honda, Evaluation of the novel method for the measurement of brain amyloid burden using PET/MRI, 第55回日本核医学会学術総会, 2015.10.
6. TAKURO ISODA, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Impact of the patient age on flip-flop phenomenon in lung metastasis from thyroid cancer, 27th European Congress of Radiology, 2015.05.
7. Akifumi Yamada, Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Effective synthesis of Pittsburg Compound B (11C-PIB) for clinical application by on-column 11C-methylation, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.
8. TAKURO ISODA, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Use of recombinant human thyroid-stimulating hormone (rhTSH) reduces the damage to salivary glands after radioiodine therapy for thyroid cancer, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.
9. Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, KojI Kato, Masayuki Sasaki, Hiroshi Honda, Usefulness of FDG-PET/CT in the diagnosis of acute transformation of Adult T-cell Lymphoma, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.
10. Shingo Baba, TAKURO ISODA, Yasuhiro Maruoka, Yoshiyuki Kitamura, Koji Sagiyama, Ryotaro Kamei, Yuji Watanabe, Hiroshi Honda, Evaluation of cortical uptake of amyloid PET tracer with hybrid PET/MRI; comparison with PET/CT, 62th Annual Meeting, Society of Nuclear Medicine, 2015.06.
11. Shingo Baba, Takuro Isoda, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Hiroshi Honda, Usefulness of myocardial 123I-MIBG-SPECT for the differential diagnosis of Parkinson's syndrome, 61th Annual Meeting, Society of Nuclear Medicine, 2014.06.
12. Shingo Baba, Koichiro Abe, Takuro Isoda, Yasuhiro Maruoka, Masayuki Sasaki, Hiroshi Honda, Variability of size-collected pretreatment FDG uptake predicts prognosis of patients with diffuse large cell lymphoma., 59th Annual Meeting, Society of Nuclear Medicine, 2012.06, Purpose: To evaluate the usefulness of recovery-collected SUVs in the clinical diagnosis of malignant lymphoma patients.
Materials and Methods: Previously reported recovery-collection using simple table look-up method was used in this study. Recovery coefficient was estimated using size and signal-background ratio by phantom experiment. Fifty three patients of malignant lymphoma (DLBCL; 37, FL; 16) were subjected to FDG-PET/CT for initial staging. Recovery-collected SUVs (SUVcor) were calculated and average±SD, coefficient of variation (CV) of SUVcor were compared with those of conventional SUV within the patient and between the groups divided by histology and prognosis.
Result: Average±SD of SUVmax, SUVcor were higher in DLBCL (14.5±9.1, 18.6±9.6) than in FL(8.5±2.6, 11.7±3.24)( p<0.05). With recovery collection, average±SD was increased and CVs within the patient were significantly decreased in both type of histology(p<0.05). CVs of SUVcor was significantly smaller in good responder (20cases) than those of poor responder (17) (p<0.05).
Conclusion: Uptakes of FDG free from partial-volume effect can be measured correctly with this method. Variability of pretreatment SUVs with size-collection is one of the independent predictor of the prognosis of patient with DLBCL.
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13. ariability of size-collected SUV evaluated by FDG-PET/CT predicts prognosis of patients with diffuse large cell lymphoma..
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15. The 18F-FAZA /FDG uptake ratio: Potential Index of tumor hypoxia?.
Membership in Academic Society
  • Society of Nuclear Medicine
Educational
Educational Activities
1) Education in graduate school of medicine (2007~)
2) Education for medical school student. (2007~)
3) Education for the staff in the lab of blood test for radiation protection (2007~2010)