| Ryo Yamasaki | Last modified date：2013.6.4 |
Assistant Professor /
Faculty of Medical Sciences
Graduate School
Undergraduate School
Other Organization
Administration Post
Other
Other
E-Mail
Homepage
[URL].
[URL].
Phone
092-642-5340
Fax
092-642-5352
Academic Degree
M.D, Ph.D
Field of Specialization
Neuroscience
Outline Activities
We investigate the model mice of amyotrophic lateral sclerosis, from the view point of the neuroprotective function of non-neuronal cells like microglia, astrocytes, etc. We found the impaired activation ability of microglia harvested from ALS model mice. It indicates the impaired neuroprotective function of ALS model mice microglia.
And also we are now starting the investigation of the white blood cell from the ALS patients.
And also we are now starting the investigation of the white blood cell from the ALS patients.
Research
Research Interests
- I conduct clinical neurology and a neurosciences study.
The mechanism of amyotrophic lateral sclerosis (ALS) still remain unknown, and the therapy is limited, too. The elucidation of the mechanism of ALS is the mission of the university, and the immediate therapy development is urgent business.
The spinal cord of the ALS reveals the colonization of monocytes-based cells, activation with a denaturing dropout of the motor nerve, but the role of these cells is not apparent. It is very likely that it contributes to clinical condition elucidation to analyze the function of these cells in detail.
We are analyzing the effect that a mechanism of the motor nerve degeneration and a non-neuronal cell give to these using an ALS model mouse.
keyword : Amyotrophic lateral sclerosis, microglia, SOD1
2008.01～2009.12.
Papers
| 1. | Ryo Yamasaki, Jian Zhang, Ichiro Koshiishi, Dewi F. Sastradipura Suniarti, Zhou Wu, Christoph Peters, Michael Schwake, Yasuo Uchiyama, Jun-ichi Kira, Paul Saftig, Hideo Utsumi, Hiroshi Nakanishi ,Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in the cathepsin D-deficient mice. ,Molecular and Cellular Neuroscience ,2007.08. |
Presentations
| 1. | The impaired neuroprotective function of microglia in the mutant superoxide dismutase 1 transgenic mice. |
Educational
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