Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Takeshi Nakahara Last modified date:2024.04.12

Professor / Department of Clinical Medicine / Faculty of Medical Sciences


Papers
1. Tanaka Y, Ito T, Kaku-Ito Y, Tanegashima K, Tsuji G, Kido-Nakahara M, Oda Y, Nakahara T., Human epidermal growth factor receptor 3 serves as a novel therapeutic target for acral melanoma., Cell Death Discov. 2023 Feb 10;9(1):54., 2023.02.
2. Tsuji G, Hashimoto-Hachiya A, Yumine A, Takemura M, Kido-Nakahara M, Ito T, Yamamura K, Nakahara T., PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes., J Dermatol Sci. 2023 May;110(2):61-68., 2023.05.
3. Ichiki T, Yamada Y, Ito T, Nakahara T, Nakashima Y, Nakamura M, Yoshizumi T, Shiose A, Akashi K, Oda Y., Histological and immunohistochemical prognostic factors of primary angiosarcoma., Virchows Arch. 2023 Jul;483(1):59-69., 2023.07.
4. Ito T, Tanaka Y, Ichiki T, Kaku-Ito Y, Nakahara T., KS-EMPD-1: a novel cell line of primary extramammary Paget's disease., Hum Cell. 2023 Sep;36(5):1813-1829. doi: 10.1007/s13577-023-00951-1., 10.1007/s13577-023-00951-1, 2023.09.
5. Nakahara T, Fujita H, Tajima Y, Arima K., Evaluating the usefulness of the Atopic Dermatitis Control Tool for assessing disease control among individuals with atopic dermatitis in Japan., Br J Dermatol. 2023 Sep 15:ljad344. doi: 10.1093/bjd/ljad344., 10.1093/bjd/ljad344, 2023.09.
6. Tsuji G, Yumine A, Yamamura K, Takemura M, Kido-Nakahara M, Ito T, Nakahara T., SEMA3A Expression in Human Keratinocytes through NRF2., J Invest Dermatol. 2023 Oct 12:S0022-202X(23)02952-4. doi: 10.1016/j.jid.2023.10.002., 10.1016/j.jid.2023.10.002, 2023.10.
7. Sugiyama A, Murakami Y, Okamoto K, Nakano H, Wakatsuki M, Kawano T, Akamine Y, Iwata M, Motomura C, Kojima K, Oda M, Honjo S, Odajima H, Nakahara T, Furue M, Ikoma A., Nocturnal Scratching and Quality of Sleep in Children with Atopic Dermatitis., Acta Derm Venereol. 2023 Oct 23;103:adv12345. doi: 10.2340/actadv.v103.12345., 10.2340/actadv.v103.12345, 2023.10.
8. Nakahara T, Onozuka D, Nunomura S, Saeki H, Takenaka M, Matsumoto M, Kataoka Y, Fujimoto R, Kaneko S, Morita E, Tanaka A, Saito R, Okano T, Miyagaki T, Aoki N, Nakajima K, Ichiyama S, Kido-Nakahara M, Tonomura K, Nakagawa Y, Tamagawa-Mineoka R, Masuda K, Takeichi T, Akiyama M, Ishiuji Y, Katsuta M, Kinoshita Y, Tateishi C, Yamamoto A, Morita A, Matsuda-Hirose H, Hatano Y, Kawasaki H, Fukushima-Nomura A, Ohtsuki M, Kamiya K, Kabata Y, Abe R, Mitsui H, Kawamura T, Tsuji G, Katoh N, Furue M, Izuhara K., The ability of biomarkers to assess the severity of atopic dermatitis., J Allergy Clin Immunol Glob. 2023 Sep 27;3(1):100175. doi: 10.1016/j.jacig, 10.1016/j.jacig, 2023.09.
9. Ulzii D, Nakahara T, Furue M, Byamba K, Kido-Nakahara M., Severity strata of patient-oriented eczema measure scores in patients with atopic dermatitis in Mongolia., Int J Dermatol. 2022 Dec;61(12):e469-e472. doi: 10.1111/ijd.16181., 10.1111/ijd.16181, 2024.04.
10. Zeze N, Kido-Nakahara M, Tsuji G, Maehara E, Sato Y, Sakai S, Fujishima K, Hashimoto-Hachiya A, Furue M, Nakahara T., Role of ERK Pathway in the Pathogenesis of Atopic Dermatitis and Its Potential as a Therapeutic Target., Int J Mol Sci. 2022 Mar 23;23(7):3467. doi: 10.3390/ijms23073467., 10.3390/ijms23073467, 2024.04.
11. Nakahara T, Takemoto S, Houzawa H, Nakayama M., Desire for Alternative Treatment Options in Patients with Atopic Dermatitis in Japan: Results of a Web-Based Cross-Sectional Study (AD-JOIN Study)., Dermatol Ther (Heidelb). , 10.1007/s13555-022-00738-6, 2022.06.
12. Kunimura K, Yamamura K, Nakahara T, Kido-Nakahara M, Uruno T, Fukui Y., Identification of a functional DOCK8 gene polymorphism associated with atopic dermatitis., Allergy. 2022 Dec;77(12):3670-3672. doi: 10.1111/all.15429., 10.1111/all.15429, 2022.12.
13. Tsuji G, Hashimoto-Hachiya A, Matsuda-Taniguchi T, Takai-Yumine A, Takemura M, Yan X, Furue M, Nakahara T., Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes., Front Immunol. 2022 May 19;13:745997. doi: 10.3389/fimmu.2022.745997., 10.3389/fimmu.2022.745997, 2022.05.
14. Nakahara T, Izuhara K, Onozuka D, Saeki H, Nunomura S, Takenaka M, Matsumoto M, Kataoka Y, Fujimoto R, Kaneko S, Morita E, Tanaka A, Hide M, Okano T, Miyagaki T, Aoki N, Nakajima K, Ichiyama S, Kido-Nakahara M, Tonomura K, Nakagawa Y, Tamagawa-Mineoka R, Masuda K, Takeichi T, Akiyama M, Ishiuji Y, Katsuta M, Kinoshita Y, Tateishi C, Yamamoto A, Morita A, Matsuda-Hirose H, Hatano Y, Kawasaki H, Tanese K, Ohtsuki M, Kamiya K, Kabata Y, Abe R, Mitsui H, Kawamura T, Tsuji G, Katoh N, Furue M., Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study)., Clin Exp Allergy. 2022 Dec 16. doi: 10.1111/cea.14267., 10.1111/cea.14267, 2024.12.
15. Takechi T, Hirota T, Fujii K, Nakahara T, Sakai T, Maeda N, Furue M, Ieiri I., Effect of Genetic Polymorphisms of Human SLC22A3 in the 5'-flanking Region on OCT3 Expression and Sebum Levels in Human Skin., J Dermatol Sci. 2021 Jan;101(1):4-13., 2021.01.
16. Kamikaseda Y, Uruno T, Kunimura K, Harada A, Saiki K, Oisaki K, Sakata D, Nakahara T, Kido-Nakahara M, Kanai M, Nakamura S, Ohkawa Y, Furue M, Fukui Y., Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound., J Allergy Clin Immunol. 2021 Aug;148(2):633-638., 2021.08.
17. Wollenberg A, Nakahara T, Maari C, Peris K, Lio P, Augustin M, Silverberg JI, Rueda MJ, DeLozier AM, Pierce E, Yang FE, Sun L, Ball S, Tauber M, Paul C., Impact of baricitinib in combination with topical steroids on atopic dermatitis symptoms, quality of life and functioning in adult patients with moderate-to-severe atopic dermatitis from the BREEZE-AD7 Phase 3 randomized trial., J Eur Acad Dermatol Venereol. 2021 Jul;35(7):1543-1552. , 2021.07.
18. Kido-Nakahara M, Yokote G, Yoshida M, Furue M, Nakahara T., Atopic Dermatitis Control Tool (ADCT): A useful tool for self-evaluation in patients with atopic dermatitis., J Dermatol. 2021 Dec;48(12):1951-1952., 2021.12.
19. Nakahara T, Kido-Nakahara M, Onozuka D, Sakai S, Hirose T, Take N, Sugiyama A, Harada K, Tsuji G, Kikuchi S, Kohda F., Efficacy of Dupilumab for Atopic Dermatitis According to Clinical Course and Clinical Findings: A Multicentre Retrospective Study., Acta Derm Venereol. 2021 Nov 10;101(11):adv00586. doi: 10.2340/actadv.v101.369., 2021.11.
20. Matsuda-Taniguchi T, Takemura M, Nakahara T, Hashimoto-Hachiya A, Takai-Yumine A, Furue M, Tsuji G., The Antidiabetic Agent Metformin Inhibits IL-23 Production in Murine Bone-Marrow-Derived Dendritic Cells., J Clin Med. 2021 Nov 29;10(23):5610. doi: 10.3390/jcm10235610., 2021.11.
21. Kido-Nakahara M, Wang B, Ohno F, Tsuji G, Ulzii D, Takemura M, Furue M, Nakahara T, Inhibition of mite-induced dermatitis, pruritus, and nerve sprouting in mice by the endothelin receptor antagonist bosentan, Allergy 76(1):291-301, 2021, 2021.04.
22. Nakahara T, Kido-Nakahara M, Ulzii D, Miake S, Fujishima K, Sakai S, Chiba T, Tsuji G, Furue M, Topical application of endothelin receptor A antagonist attenuates imiquimod-induced psoriasiform skin inflammation., Sci Rep. 10(1):9510. doi: 10.1038/s41598-020-66490-z, 2020, 2020.04.
23. Kido-Nakahara M, Nakahara T, Yasukochi Y, Ulzii D, Furue M, Patient-oriented Eczema Measure score: A Useful Tool for Web-Based Surveys in Patients
with Atopic Dermatitis.
, Acta Derm Venereol doi: 10.2340/00015555-3530, 2020, 2020.04.
24. Eto A, Nakahara T, Kido-Nakahara M, Tsuji G, Furue M, Acrosyringeal endothelin-1 expression: Potential for fostering melanocytes in volar sites., J Dermatol 47(8):924-925, 2020, 2020.04.
25. Tsuji G, Hashimoto-Hachiya A, Yen VH, Miake S, Takemura M, Mitamura Y, Ito T, Murata M, Furue M, Nakahara T, Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in
Keratinocytes via Ovo-Like 1.
, J Clin Med. 9(3).pii: E891, 2020, 2021.04.
26. Tsuji G, Hashimoto-Hachiya A, Yen VH, Takemura M, Yumine A, Furue K, Furue M, Nakahara T, Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in
keratinocytes: implications for preventing the development of psoriasis.
, Cell Death Discov. 6:11. doi: 10.1038/s41420-020-0245-8. eCollection, 2020 , 2020.04.
27. Miake S, Tsuji G, Takemura M, Hashimoto-Hachiya A, Vu YH, Furue M, Nakahara T, IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis. , Int J Mol Sci 20(16). pii: E4053, 2019 , 2019.04.
28. Ohno F, Nakahara T, Kido-Nakahara M, Ito T, Nunomura S, Izuhara K, Furue M, Periostin Links Skin Inflammation to Melanoma Progression in Humans and Mice. , Int J Mol Sci 20(1). pii: E169, 2019, 2019.04.
29. Chiba T, Nakahara T, Kohda F, Ichiki T, Manabe M, Furue M, Measurement of rihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible
biomarker of barrier function in atopic dermatitis.
, PLoS One 14(1):e0210013, 2019 , 2019.04.
30. Nakahara T, Fujita H, Arima K, Taguchi Y, Motoyama S, Furue M, Treatment satisfaction in atopic dermatitis relates to patient-reported severity: A cross-
sectional study.
, Allergy 74(6):1179-1181, 2019, 2021.04.
31. Kido-Nakahara M, Nakahara T, Furusyo N, Shimoda S, Kotoh K, Kato M, Hayashi J, Koyanagi T, Furue M, Pruritus in Chronic Liver Disease: A Questionnaire Survey on 216 Patients., Acta Derm Venereol 99(2):220-221, 2019, 2019.04.
32. Furue M, Iida K, Imaji M, Nakahara T, Microbiome analysis of forehead skin in patients with atopic dermatitis and healthy subjects: Implication of Staphylococcus and Corynebacterium., J Dermatol 45:876-877, 2018, 2018.04.
33. Chiba T, Nakahara T, Fujishima K, Hashimoto-Hachiya A, Furue M, Epidermal barrier disruption by 9-hydroxy-10E,12Z-octadecadienoic acid in human keratinocytes., J Dermatol 45:746-747, 2018 , 2018.04.
34. Takemura M, Nakahara T, Hashimoto-Hachiya A, Furue M, Tsuji G, Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis., Int J Mol Sci. 19(4). pii: E1169. doi: 10.3390/ijms19041169, 2018, 2018.04.
35. Nakahara T, Kido-Nakahara M, Ohno F, Ulzii D, Chiba T, Tsuji G, Furue M, The pruritogenic mediator endothelin-1 shifts the dendritic cell-T-cell response toward Th17/Th1 polarization., Allergy. 73:511-515, 2018, 2018.04.
36. Yasukochi Y, Kido-Nakahara M, Nakahara T, Kuroki R, Koga T, Mashino T, Kurihara Y, Furue M:, Clinical bandings of Patient-Oriented Eczema Measure scores among Japanese patients with atopic eczema., Br J Dermatol. 177(5):e211-e212, 2017, 2017.04.
37. Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y, The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction., Nat Commun. 8:13946, 2017, 2017.04.
38. Itoh E, Nakahara T, Murata M, Ito T, Onozuka D, Furumura M, Hagihara A, Furue M, Chronic spontaneous urticaria: Implications of subcutaneous inflammatory cell infiltration in an intractable clinical course., J Allergy Clin Immunol 139(1):363-366, 2017, 2017.04.
39. Chiba T, Nakahara T, Hashimoto-Hachiya A, Yokomizo T, Uchi H, Furue M, The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes., Exp Dermatol 25(7):532-6, 2016, 2016.04.
40. Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M, STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch., Nat Med 21(8):927-31, 2015, 2015.01.
41. Zhu L, Kohda F, Nakahara T, Chiba T, Tsuji G, Hachisuka J, Ito T, Tu Y, Moroi Y, Uchi H, Furue M, Aberrant expression of S100A6 and matrix metalloproteinase 9, but not S100A2, S100A4, and S100A7, is associated with epidermal carcinogenesis., 72, 3, 311-319, 2013.12.
42. Zhu L, Kohda F, Nakahara T, Chiba T, Tsuji G, Hachisuka J, Ito T, Tu Y, Moroi Y, Uchi H, Furue M, Aberrant expression of S100A6 and matrix metalloproteinase 9, but not S100A2, S100A4, and S100A7, is associated with epidermal carcinogenesis., 72, 3, 311-319, 2013.12.
43. Chen H, Takahara M, Xie L, Takeuchi S, Tu Y, Nakahara T, Uchi h, Moroi Y, Furue M, Levels of the EMT-related protein Snail/Slug are not correlated with p53/p63 in cutaneous squamous cell carcinoma., J Cutan Pathol, 40, 7, 651-656, 2013.06.
44. Kyoko Kudo, Takeshi Nakahara, Junichi Hachisuka, Teiichi Masuda, Sho Miake, Yoichi Moroi, Hiromaro Kiryu, Masutaka Furue, Congenital benign mesenchymoma on the palm, EUROPEAN JOURNAL OF DERMATOLOGY, 10.1684/ejd.2011.1621, 22, 2, 256-257, 2012.04.
45. Sho Miake, Takeshi Nakahara, Yuichi Kurihara, Junnichi Hachisuka, Yoichi Moroi, Masutaka Furue, Verruciform xanthoma of the glans penis mimicking squamous cell carcinoma - role of scavenger receptor positive macrophages., 22, 3, 391-392, 2012.05.
46. Takamichi Ito, Yoichi Moroi, Junna Oba, Takeshi Nakahara, Uchi Hiroshi, Satoshi Takeuchi, Masakazu Takahara, Teiichi Masuda, Masutaka Furue, The prognostic value of a reverse transcriptase-PCR assay of sentinel lymph node biopsy for patients with cutaneous melanoma: a single-center analysis in Japan, MELANOMA RESEARCH, 10.1097/CMR.0b013e32834dcfdf, 22, 1, 38-44, 2012.02.
47. Yukihiro Mizote, Takeshi Nakahara, Chikage Mitoma, Masayoshi Nakao, Hiroki Mitoma, Yoichi Moroi, Masutaka Furue, Differential effect of etanercept on cutaneous and joint lesions in psoriatic arthritis, JOURNAL OF DERMATOLOGY, 10.1111/j.1346-8138.2011.01267.x, 39, 3, 284-285, 2012.03.
48. Oba J, Nakahara T, Hayashida S, Kido M, Xie L, Takahara M, Uchi H, Miyazaki S, Abe T, Hagihara A, Moroi Y, Furue M., Expression of CD10 predicts tumor progression and unfavorable prognosis in malignant melanoma., J Am Acad Dermatol., 65, 6, 1152-60, 2011.12.
49. Oba J, Moroi Y, Nakahara T, Abe T, Hagihara A, Furue M., Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma., Br J Dermatol., 165, 3, 506-12, 2011.11.
50. Oba J, Nakahara T, Abe T, Hagihara A, Moroi Y, Furue M. , Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: an immunohistochemical study and analysis of prognostic value., J Dermatol Sci. , 62, 2, 116-23, 2011.03.
51. Tashiro A, Takeuchi S, Nakahara T, Oba J, Tsujita J, Fukushi J, Kiryu H, Oda Y, Xie L, Yan X, Takahara M, Moroi Y, Furue M., Aberrant expression of CD10 in ground-glass-like multinucleated giant cells of multicentric reticulohistiocytosis., J Dermatol. , 37, 11, 995-7, 2010.11.
52. Nakahara T, Moroi Y, Tashiro A, Kiryu H, Furue M., The interaction of inflammatory cells in granuloma faciale. , Dermatology Reports 2(2)45-46, 2010.11.
53. Nakahara T, Uchi H, Lesokhin AM, Avogadri F, Rizzuto GA, Hirschhorn-Cymerman D, Panageas KS, Merghoub T, Wolchok JD, Houghton AN., Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs., Blood. 2010 Jun 3;115(22):4384-92., 2010.06.
54. Lining X, Uchi H, Hayashida S, Tsuji G, Kido M, Nakahara T, Takeuchi S, Takahara M, Moroi Y, Furue M. , Expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasms, J Dermatol Sci. 2009 Nov;56(2):135-6. , 2009.11.
55. Chen S, Nakahara T, Uchi H, Takeuchi S, Takahara M, Kido M, Dugu L, Tu Y, Moroi Y, Furue M. , Immunohistochemical analysis of the mammalian target of rapamycin signalling pathway in extramammary Paget's disease.
, Br J Dermatol, 2009.08.
56. Chen SJ, Nakahara T, Takahara M, Kido M, Dugu L, Uchi H, Takeuchi S, Tu YT, Moroi Y, Furue M, Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2., British Journal of Dermatology, 160(2):442-5, 2009.02.
57. Chen SJ, Nakahara T, Kido M, Takahara M, Uchi H, Takeuchi S, Dugu L, Tu YT, Moroi Y, Furue M, Stromal cell-derived factor 1 expression in various skin tumours, British Journal of dermatology, Mar;160(3):710-3. Epub 2008 Jan 10, 2009.03.
58. Nakahara T, Uchi H, Urabe K, Chen Q, Furue M, Moroi Y. , Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. Int Immunol. , INTERNATIONAL IMMUNOLOGY, 10.1093/intimm/dxh171, 16, 12, 1701-1709, 16(12):1701-9., 2004.12.
59. Nakahara T, Koga T, Fukagawa S, Uchi H, Furue M, Intermittent topical corticosteroid/tacrolimus sequential therapy improves lichenification and chronic papules more efficiently than intermittent topical corticosteroid/emollient sequential therapy in patients with atopic dermatitis., J Dermatol, 31, 7, 524-528, 31(7):524-8., 2004.07.
60. Nakahara T, Urabe K, Fukagawa S, Uchi H, Inaba K, Furue M, Moroi Y., Engagement of human monocyte-derived dendritic cells into interleukin (IL)-12 producers by IL-1beta + interferon (IFN)-gamma., Clin Exp Immunol, 10.1111/j.1365-2249.2005.02709.x, 139, 3, 476-482, 139(3):476-82, 2005.03.