九州大学-研究者情報 [髙橋淳 (准教授) 生体防御医学研究所 ]

髙橋淳（たかはしあつし）

データ更新日：2013.3.13

准教授　／　生体防御医学研究所悪性腫瘍に対する新規免疫・遺伝子治療薬開発研究部門（寄附研究部門）

原著論文

1.	土方康基, 村橋(伊賀)睦了, 岡崎利彦, 田中芳浩, 大平公亮, 岡野慎士, 久野晃聖, 高橋淳, 丸本朋稔, 井上博之, 谷憲三朗,固形腫瘍に対する新規免疫療法の開発～当科における第Ⅰ相臨床研究の現状～,臨床血液,53,5,487-492,2012.05 https://www.jstage.jst.go.jp/article/rinketsu/53/5/53_487/_pdf.
2.	Shohei Miyamoto, Hiroyuki Inoue, Takafumi Nakamura, Meiko Yamada, Chika Sakamoto, Yasuo Urata, Toshihiko Okazaki, Tomotoshi Marumoto, Atsushi Takahashi, Koichi Takayama, Yoichi Nakanishi, Hiroyuki Shimizu, Kenzaburo Tani,Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma,Cancer Research,72,10,2609-2621,2012.05 http://cancerres.aacrjournals.org/content/72/10/2609.full.pdf.
3.	Atsushi Takahashi, Hisashi Tokita, Kenzo Takahashi, Tomoharu Takeoka, Kosho Murayama, Daihachiro Tomotsune, Miki Ohira, Akihiro Iwamatsu, Kazuaki Ohara, Kazufumi Yazaki, Tadayuki Koda, Akira Nakagawara, Kenzaburo Tani,A novel potent tumour promoter aberrantly overexpressed in most human cancers,Scientific Reports,1,15,2011.06 http://www.nature.com/srep/2011/110614/srep00015/pdf/srep00015.pdf.
4.	Inoue T, Sugiyama D, Kurita R, Oikawa T, Kulkeaw K, Kawano H, Miura Y, Okada M, Suehiro Y, Takahashi A, Marumoto T, Inoue H, Komatsu N, Tani K,APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans. ,Stem Cell Rev and Rep,7,1,43-52,2011.03 http://www.springerlink.com/content/x74050556j4117g1/fulltext.pdf.
5.	Meng X, Nakamura T, Okazaki T, Inoue H, Takahashi A, Miyamoto S, Sakaguchi G, Eto M, Naito S, Takeda M, Yanagi Y, Tani K,Enhanced Antitumor Effects of an Engineered Measles Virus Edmonston Strain Expressing the Wild-type N, P, L Genes on Human Renal Cell Carcinoma.,Mol. Ther.,18,3,544-551,2010.03 http://www.nature.com/mt/journal/v18/n3/pdf/mt2009296a.pdf.
6.	Takahashi M, Ozaki T, Takahashi A, Miyauchi M, Ono S, Takada N, Koda T, Todo S, Kamijo T, Nakagawara A ,DFF45/ICAD restores cisplatin-induced nuclear fragmentation but not DNA cleavage in DFF45-deficient neuroblastoma cells.,Oncogene,26,5669-5673,2007.08 http://www.nature.com/onc/journal/v26/n38/pdf/1210352a.pdf.
7.	Kotone-Miyahara Y, Yamashita K, Lee KK, Yonehara S, Uchiyama T, Sasada M, Takahashi A,Short-term delay of Fas-stimulated apoptosis by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating phosphatidylinositol 3-kinase and MEK1-ERK1/2 pathways downstream of protein kinase C,J. Leukoc. Biol. ,76,1047-1056,2004.11 http://www.jleukbio.org/cgi/reprint/76/5/1047.
8.	Kotani A, Takahashi A, Koga H, Morita R, Fukuyama H, Ichinohe T, Ishikawa T, Hori T, Uchiyama T,Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells.,Eur. J. Haematol.,69,5-6,318-320,2002.11 http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0609.2002.02789.x/pdf.
9.	Kobayashi S, Yamashita K, Takeoka T, Ohtsuki T, Suzuki Y, Takahashi R, Yamamoto K, Kaufmann SH, Uchiyama T, Sasada M, Takahashi A,Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia,J. Biol. Chem. ,277,33968-33977,2002.09 http://www.jbc.org/cgi/reprint/277/37/33968.
10.	Yoshinaga-Ohara N, Takahashi A, Uchiyama T, Sasada M,Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration.,Exp. Cell Res.,278,112-122,2002.08 http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WFC-46952F6-D-1&_cdi=6791&_user=131115&_orig=browse&_coverDate=08%2F01%2F2002&_sk=997219998&view=c&wchp=dGLbVlz-zSkWz&md5=102b782c88645686f9fa4e3c3f26a29a&ie=/sdarticle.pdf.
11.	Nakajima K, Takahashi A, Yaoita Y,Structure, expression and function of the Xenopus laevis caspase family.,J. Biol. Chem.,275,14,10484-10491,2000.04 http://www.jbc.org/content/275/14/10484.full.pdf+html.
12.	Yamashita K, Takahashi A, Kobayashi S, Hirata H, Mesner PW, Kaufmann SH, Yonehara S, Yamamoto K, Uchiyama T, Sasada M,Caspases mediate TNF-alpha-induced neutrophil apoptosis and downregulation of reactive oxygen production.,Blood,93,2,674-685,1999.01 http://bloodjournal.hematologylibrary.org/content/93/2/674.full.pdf+html.
13.	Macen J, Takahashi A, Moon KB, Nathaniel R, Turner PC, Moyer RW,Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses.,J. Virol.,72,5,3524-3533,1998.05 http://jvi.asm.org/cgi/reprint/72/5/3524.
14.	Hirata H, Takahashi A, Kobayashi S, Yonehara S, Sawai H, Okazaki T, Yamamoto K, Sasada M,Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis.,J. Exp. Med.,187,4,587-600,1998.02 http://jem.rupress.org/content/187/4/587.full.pdf+html.
15.	Takahashi A, Hirata H, Yonehara S, Imai Y, Lee KK, Moyer RW, Turner PC, Mesner PW, Okazaki T, Sawai H, Kishi S, Yamamoto K, Okuma M, Sasada M,Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8.,Oncogene,14,23,2741-2752,1997.06 http://www.nature.com/onc/journal/v14/n23/pdf/1201131a.pdf.
16.	Takahashi A, Goldschmidt-Clermont PJ, Alnemri ES, Fernandes-Alnemri T, Yoshizawa-Kumagaya K, Nakajima K, Sasada M, Poirier GG, Earnshaw WC,Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide.,Exp. Cell Res.,231,1,123-131,1997.02 http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WFC-45M8T32-19-1&_cdi=6791&_user=131115&_pii=S001448279693459X&_origin=gateway&_coverDate=02%2F25%2F1997&_sk=997689998&view=c&wchp=dGLzVzb-zSkzV&md5=9527c98001cc5d877c19d26845d09b73&ie=/sdarticle.p.
17.	Takahashi A, Musy P-Y, Martins LM, Poirier GG, Moyer RW, Earnshaw WC,CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation.,J. Biol. Chem.,271,51,32487-32490,1996.12 http://www.jbc.org/content/271/51/32487.full.pdf+html.
18.	Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC,Cleavage of lamin A by Mch2 alpha but not CPP32: Multiple ICE-related proteases with distinct substrate recognition properties are active in apoptosis.,Proc. Natl. Acad. Sci. USA,93,16,8395-8400,1996.08 http://www.pnas.org/content/93/16/8395.full.pdf+html.
19.	Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, Earnshaw WC, Litwack G, Alnemri ES,Mch3, a novel human apoptotic cysteine protease highly related to CPP32.,Cancer Res.,55,24,6045-6052,1995.12 6045-6052.
20.	Lazebnik YA, Takahashi A, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC,Studies of the lamin protease reveal multiple parallel biochemical pathways during apoptotic execution.,Proc. Natl. Acad. Sci. USA,92,20,9042-9046,1995.09 http://www.pnas.org/content/92/20/9042.full.pdf+html.
21.	Takahashi A, Satake M, Yamaguchi-Iwai Y, Bae S-C, Lu J, Maruyama M, Zhang YW, Oka H, Arai N, Arai K-I, Ito Y,Positive and negative regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter activity by AML1-related transcription factor, PEBP2.,Blood,86,2,607-616,1995.07 http://bloodjournal.hematologylibrary.org/content/86/2/607.full.pdf+html.
22.	Takahashi A, Yamamoto K, Okuma M, Sasada M,Transient calcium elevation in polymorphonuclear leukocytes triggered by thrombin-activated platelets.,Eur. J. Haematol.,48,4,196-201,1992.04 http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.1992.tb01585.x/abstract.

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