Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Yasuyuki Ohkawa Last modified date:2018.06.13

Professor / Division of Medical Molecular Cell Biology / Research Center for Transomics Medicine / Medical Institute of Bioregulation


Presentations
1. Ohkawa Yasuyuki, Tissue-specific Chromatin Structures According to Histone H3 Variants ., 研究セミナー, 2017.10.
2. Ohkawa Yasuyuki, Myogenic chromatin structure is formed with the novel histone H3 variant., EMBO Workshop Histone Vriants, 2017.09.
3. Ohkawa Yasuyuki, ChILT - an Immunoprecipitation-free Epigenome Profiling Technology., 1st München-Japan Mini Symposium “Chromatin Structure and Function”, 2017.09.
4. Ohkawa Yasuyuki, Myogenic Chromatin Structure Is Formed with the Histone H3 Variant H3mm7, Gordon Research Conference, 2017.06.
5. Ohkawa Yasuyuki, ChiLT-an Immunoprecipitation-free Epigenome Profiling Technology, Single Cell Omics (E3), 2017.05.
6. 大川 恭行, The baselines of transcription levels are determined by selective incorporation of histone H3 variants., Transcriptional and Epigenetic Control in Stem Cells (J1), 2017.01, Selective gene expression in cell differentiation is initiated by the binding of tissue-specific transcription factors (TFs).
Chromatin structure is known to tune the function of bound TFs by nucleosome positioning, histone modification, and the
incorporation of histone variants [1]. However the specific contribution of each component of chromatin has been
unclear.
We recently reported that we identified hitherto unknown fourteen histone H3 variants and that they were detected in a
variety of tissues [2]. Our functional analysis revealed that H3mm7, one of the newly discovered histone H3 variants, was
required for skeletal muscle differentiation. H3mm7 knockout in C2C12 myoblasts resulted in rigid chromatin structure
and in the reduction of transcription levels of a subset of the genes into which H3mm7 was incorporated. The data
suggest that H3mm7 and other variants contribute to set the baselines of transcription levels. I will discuss other recent
advances in understanding the novel histone H3 variants.
[1] Harada, A. et al. (2015) Nucleic Acids Res. 43, 775. Incorporation of histone H3.1 suppresses the lineage potential of
skeletal muscle.
[2] Maehara, K. et al. (2016) Epigenetics Chromatin. 8, 35. Tissue-specific expression of histone H3 variants diversified
after species separation..
7. 大川 恭行, N6-methyladenosine is required for the processing of MyoD pre-mRNA for maintaining skeletal muscle differentiation potential., Keystone Symposia Chromatin and Epigenetics (C2), 2016.03.
8. 大川 恭行, Cell fate decision on chromatin by MyoD, BMB2010(第38回日本分子生物学会年会・第88回日本生化学会大会合同大会), 2015.12.
9. 大川 恭行, The Diversity of Mouse Histone H3 Variants, International Symposium on Chromatin Structure, Dynamics, and Function, 2015.08.
10. 原田 哲仁, 前原 一満, 佐藤 優子, 木村 宏, 大川 恭行, Incorporation of Histone H3 Variants Dictates the Lineage Potential of Skeletal Muscle, FASEB;Science Research Conferences, 2014.07.
11. 前原 一満, 大川 恭行, Exploring nucleosome positioning patterns act as a functional component of chromatin structure, ENBO Workshop Histone varisnts, 2014.06.
12. 原田 哲仁, 前原 一満, 大川 恭行, Incorporation of Histone H3 Variants Dictates Myogenesis, ENBO Workshop Histone varisnts, 2014.06.
13. 大川 恭行, Diversity of histone H3 variants on mouse genome, ENBO Workshop Histone varisnts, 2014.06.
14. 原田 哲仁, 前原 一満, 大川 恭行, The balance of histone H3 variants around transcription start sites dictates cell differential potential, Keystone Symposia , 2014.02.
15. 前原 一満, 大川 恭行, The formation of nucleosome positioning patterns flanked by transcription factor binding site, Keystone Symposia , 2014.02.
16. 大川 恭行, Epigenomic approach unveils cell fate decision, 日本遺伝学会第85回大会, 2013.09.
17. 大川 恭行, High order chromatin regulation in skeletal muscle differentiation, 第86回日本生化学会大会, 2013.09.
18. 大川 恭行, Histone bariants determine the lineage potential of skeletal muscle, Fukuoka Internasional Symposium on Genomics & Epigenomics 2013, 2013.09.
19. Genomic clustering accompanies cellular differentiation to temporally control gene expression.