Kyushu University Academic Staff Educational and Research Activities Database
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Masayuki Ochiai Last modified date:2018.06.18

Associate Professor / Department of Perinatal and Pediatric Medicine
Faculty of Medical Sciences


Graduate School
Undergraduate School


E-Mail
Phone
092-642-5421
Fax
092-642-5435
Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Pediatrics, Neonatology
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
Medical examination of pediatrics
Clinical research of pediatrics and neonatal medicine
Clinical management of perinatal care center
Education for clinical research fellows
Pediatric home care medicine
Clinical genetic counseling
Research
Research Interests
  • Development of noninvasive monitoring method using transcutaneous blood gas analysis
    keyword : monitoring respiration
    2016.01~2018.03.
  • Etiology of hyperferritineia in very low birth weight infants
    keyword : Neonate、NICU、Blood transfusion、Oxygen injury、Susceptibility to infection
    2016.04~2019.03.
  • Investigation of severity factors of neonatal broncopulmonary dysplasia and these inflammatory specific therapeutic strategy
    keyword : neonatal medicine, respiratory
    2014.04~2018.03.
  • Analysis of vitamin K deficiency due to newborn digestive tract allergy
    keyword : neonatal medicine, immunology, nutrition
    2014.04~2016.03.
  • Kyushu University clincal research network of the high-risk infants
    keyword : neonatal medicine multicenter research network
    2013.04~2016.03.
  • Surveillance of predicable factors with feto-maternal immunothorombocytopenia and icterus praecox
    keyword : feto-maternal immunity, thrombocytopenia, hemolysis, jaundice
    2012.04~2015.03.
  • Kyushu University clincal research network of the high-risk infants
    keyword : neonatal medicine multicenter research network
    2010.04~2013.04.
  • Development of a new assessment system in the perinatal-neonatal medicine
    keyword : perinatal neonatal medicine
    2003.04~2015.03.
  • Gene repair using an adeno, adeno-associate virus vector
    keyword : gene therapy
    2003.06~2010.03.
Academic Activities
Papers
1. 落合 正行, Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan., PLoS One, 2016.08.
2. Masayuki Ochiai, BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector., Gene Ther., 2016.04.
3. Masayuki Ochiai, Longitudinal study of very low birth weight infants until 9years of age; attention deficit hyperactivity and autistic features are correlated with their cognitive functions., Early Hum Dev., 2015.12.
4. Masayuki Ochiai, Survival and Neurodevelopmental Outcome of Preterm Infants Born at 22-24 Weeks of Gestational Age, NEONATOLOGY, 10.1159/000355818, 105, 2, 79-84, 2013.11, Background: The limits of viability in extremely premature infants are challenging for any neonatologists in developed countries. On the other hand, tThe neurological development and growth of extremely preterm infants have come to be the emerging issue in the next stage of following the management of in NICU.
Objective: To assess potential associations between changes in practice and survival/neurodevelopmental outcome, and clinical outcomes of extremely preterm infants born at the limit of viability were studied in a tertiary center.  
Study design: A retrospective study enrolled 51 infants who had no congenital disorders, and were born at 22-24 weeks of gestational age (GA) in 2000-2009 in our single institution. Clinical variables and interventions were studied with regard to one-year survival and developmental quotient (DQ) at 3 years of age.  
Results: The one-year survival rate of 24 preterm infants born in 2005-2009 (79%) was higher than that of the 27 those infants born in 2000-2004 (52%) (p=0.04). The iInfants born at or post-2005 underwent less and more frequently tocolysis (54% vs. 94%, p<0.01) and more frequently antenatal steroid therapy (32% vs. 6%, p=0.01) than those born at pre-20045, respectively. The post-2005 survivors (n=19) received more frequently indomethacin therapy (89% vs. 50%, p=0.03) and early parenteral nutrition (95% vs. 36%, p<0.01) than the pre-20045 survivors (n=14). There were no differences in the proportion of infants who attained a DQ of >50 at 3-years of age between pre-20045 (n=9/13=69%) and post-2005 groups (n=10/17=59%) (30% vs. 33%). Multivariate analysis indicated that extremely premature birth ity born at GA<24w was the sole critical factor for the development status with the a DQ of >50 in survivors.  
Conclusions: The perinatal care after 2005 could improved the overall survival rate, but not, the neurological outcomes of preterm survivors at the limit of viability. Neurodevelopmental impairments were associated with the extremely premature birth ity born at GA<24w.
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Presentations
1. 落合 正行, An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis, and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very Low Birth Weight Infants, Asian Society for Pediatric Research, 2017.11.
2. 落合 正行, Blood Reference Intervals for Preterm Low Birth Weight Infants: Multicenter Cohort Study in Japan, THE NEONATE, an International Symposium for Asia, 2017.03.
3. 落合 正行, Hyperferritinemia as a clinical risk factor of sepsis or bronchopulmonary dysplasia in very low birth weight infants, THE NEONATE, an International Symposium for Asia, 2017.03.
4. 落合 正行, Blood chemistry and hematology reference intervals in preterm or low birth weight infants at birth, PAS and ASPR Joint Meeting 2014 May 3-6, 2014 Vancouver, 2014.05.
5. 落合 正行, Survival and neurodevelopmental outcome of preterm infants born at 22-24 weeks of gestational age, The 25th Fukuoka International Symposium on Perinatal/Maternal Medicine, 2014.08.
Membership in Academic Society
  • The Japanese Society of Child Neurology
  • The Japan Society of Obstetrical, Gynecological and Neonatal Hematology
  • The Japan Society of Human Genetics
  • Japan Society for Neonatal Health and Development
  • Japan Society of Perinatal and Neonatal Medicine
  • Japan pediatric society
Educational
Educational Activities
Clincal education for medical students
Clinical reseach education for graduate students and clinical fellows