| Hisato Igarashi | Last modified date：2012.9.15 |
Graduate School
Undergraduate School
Administration Post
Other
E-Mail
Homepage
http://www.med.kyushu-u.ac.jp/intmed3/index.html
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
Phone
092-642-5285
Fax
092-642-5287
Academic Degree
MD, Ph. D
Field of Specialization
Pancreatology
Outline Activities
The core of my clinical research is developing new strategy for pancreatic cancer and islet cell carcinoma, and analysis of the clinical features for autoimmune pancreatitis and chronic pancreatitis. Also as a routine work, I am working on endoscopic therapy and diagnosis for the panceratobiliary diseases, using ERCP technique. At the lab, with graduate school student, we are investigating the protective effect of VIP (vasoactive intestinal peptide) against pancreatic damage.
Research
Research Interests
- Vasoactive intestinal peptide reduces oxidative stress in pancreatic acinar cells through the inhibition of NADPH oxidase.
keyword : acute pancreatitis, exacerbation, oxidative stress
2011.04～2012.03. - Analysis of the involvement of oxidative stress on severe acute pancreatitis and Evaluation of the therapeutic effect of vasoactive intestinal peptideVIP
keyword : acute pancreatitis, exacerbation, oxidative stress
2009.04～2011.03.
Papers
| 1. | Ito T, Nakamura T, Fujimori N, Niina Y, Igarashi H, Oono T, Uchida M, Kawabe K, Takayanagi R, Nishimori I, Otsuki M, Shimosegawa T.,Characteristics of Pancreatic Diabetes in Patients with Autoimmune Pancreatitis,2011.06. |
| 2. | Igarashi H, Fujimori N, Ito T, Nakamura T, Oono T, Nakamura K, Suzuki K, Jensen RT, Takayanagi R.,Vasoactive intestinal peptide (VIP) and VIP Receptors -Elucidation of Structure and Function for Therapeutic Applications-.,Int J Clin Med, 2011; 2(4):500-8.,2011.10. |
| 3. | Fujimori N, Oono T, Igarashi H, Ito T, Nakamura T, Uchida M, Coy DH, Jensen RT, Takayanagi R,Vasoactive intestinal peptide reduces oxidative stress in pancreatic acinar cells through the inhibition of NADPH oxidase.,Peptides,2011;32:2067–2076,2011.10. |
| 4. | Itaba S, Sumida Y, Aso A, Iboshi Y, Iwasa T, Ogino H, Igarashi H, Akiho H, Nakamura K, Ito T, Takayanagi R.,Endoscopic ultrasound-guided transmural drainage of inflammatory peripancreatic fluid collections with a wire-guided triple-lumen needle knife.,Dig Endosc. ,2011 Jul;23(3):269,2011.07. |
| 5. | Igarashi H, Ito T, Hisano T, Fujimor N, Niina Y, Yasuda M, Kaku T, Matsuo S, Oono T, Yoshinaga M, Sakai H, Takayanagi R,Paclitaxel-Based Chemotherapy for Advanced Pancreatic Cancer after Gemcitabine-Based Therapy Failure: A case series of 5 patients.,Case Rep Oncol,2011:4:534-541.,2011.09. |
| 6. | Igarashi H, Ito T, Takayanagi R,The new concept of therapeutic strategy for neuroendocrine tumors: important information from a case report of gastrinoma,Intern Med,Vol.49,No.17,pp.1839-1840,2010.09. |
| 7. | Ito T, Otsuki M, Igarashi H, Kihara Y, Kawabe K, Nakamura T, Fujimori N, Oono T, Takayanagi R, Shimosegawa T; Research Committee of Intractable Diseases of the Pancreas.,Epidemiological study of pancreatic diabetes in Japan in 2005: a nationwide study.,Pancreas,Vol.39,No.6,pp.829-835,2010.08. |
| 8. | ）Kawabe K, Ito T, Igarashi H, Takayanagi R.,The current managements of pancreatic diabetes in Japan.,Clin J Gastroenterol ,2:1–8,2009.04. |
| 9. | Igarashi H, Ito T, Kuwano-Kojima M, Takayanagi R, Coy DH, Jensen RT, Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats ,Pancreas ,37(2): 236-8 ,2008.05. |
| 10. | Igarashi H, Ito T, Yoshinaga M, Kodama M, Hayashi H, Sakai H, Kawabe K, Takayanagi R.,Successful management of multiple liver metastases from pancreatic neuroendocrine tumor by hepatic arterial administration of cisplatin powder.,Pancreas,35(3):288-90,2007.10. |
| 11. | Igarashi H, Ito T, Mantey SA, Pradhan TK, Hou W, Coy DH, Jensen RT.,Development of simplified vasoactive intestinal peptide analogs with receptor selectivity and stability for human vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide receptors.,J Pharmacol Exp Ther,315(1):370-81,2005.10. |
| 12. | Kojima M, Ito T, Oono T, Hisano T, Igarashi H, Arita Y, Kawabe K, Coy DH, Jensen RT, Nawata H.,VIP attenuation of the severity of experimental pancreatitis is due to VPAC1 receptor-mediated inhibition of cytokine production.,Pancreas,30(1):62-70,2005.01. |
| 13. | Igarashi H, Ito T, Pradhan TK, Mantey SA, Hou W, Coy DH, Jensen RT,Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors, Pharmacol Exp Ther,03(2):445-60,2002.11. |
| 14. | Igarashi H, Ito T, Hou W, Mantey SA, Pradhan TK, Ulrich CD 2nd, Hocart SJ, Coy DH, Jensen RT,Elucidation of vasoactive intestinal peptide pharmacophore for VPAC(1) receptors in human, rat, and guinea pig.,J Pharmacol Exp Ther,301(1):37-50,2002.04. |
| 15. | Tsuzuki T, Egashira A, Igarashi H, Iwakuma T, Nakatsuru Y, Tominaga Y, Kawate H, Nakao K, Nakamura K, Ide F, Kura S, Nakabeppu Y, Katsuki M, Ishikawa T, Sekiguchi M,Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase,Proc Natl Acad Sci U S A,98(20):11456-61,2001.09. |
| 16. | Igarashi H, Tsuzuki T, Kakuma T, Tominaga Y, Sekiguchi M,Organization and expression of the mouse MTH1 gene for preventing transversion mutation,J Biol Chem,272(6):3766-72,1997.02. |
Educational
Educational Activities
For the medical school students: lecture of the diagnosis and therapies for pancreatic tumors.
For the medical students and clinical residents:clinical lectures of essential physical examination, data analysis, and medical treatment for pancreatic diseases.
For the graduate school students: evaluation and discussion of the results of the experiments, summarizing the results, and making the paper.
For the medical students and clinical residents:clinical lectures of essential physical examination, data analysis, and medical treatment for pancreatic diseases.
For the graduate school students: evaluation and discussion of the results of the experiments, summarizing the results, and making the paper.
The fact that no permission it reprints contents of this data base is prohibitted.