Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Takeshi Yokoyama Last modified date:2019.07.09

Professor / Maxillofacial Diagnostic and Surgical Sciences / Department of Dental Science / Faculty of Dental Science

1. Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Comparison of recovery in pediatric patients: a retrospective study, Clinical Oral Investigations, 10.1007/s00784-019-02993-y, 2019.07, Objective The recovery after general anesthesia is influenced by the choice of inhalational agent. Stimulations might make patient’s agitate. However, the recovery using no touch technique might be safer. In this study, we compared the recovery time, awakening end-tidal concentration, and respiratory complications among inhalational anesthetics in pediatric patients using no touch technique, retrospectively.
Material and methods The subjectswere pediatric patients aged 3 months to 11 years under general anesthesia using sevoflurane, isoflurane, or desflurane. Background, awakening end-tidal concentration, respiratory complications, the time of eye open, body movement, and extubation were recorded.
Results A total of 170 patients were included in the study. There were no respiratory complications during emergence. Awakening end-tidal concentration in desflurane was 0.98%, sevoflurane (0.39%), and isoflurane (0.25%). In patients received
desflurane, the time of body movement, eye open, and extubation were significantly shorter than patients who received other anesthetics (p < 0.05).
Conclusions The recovery from desflurane was significantly shorter among three inhalational anesthetics with no touch technique. In addition, no airway-related complication occurred.
Clinical relevance The recovery from desflurane might be useful to predict emergence by end-tidal inhalational concentration..
2. Tsukamoto M, Yamanaka H, Yokoyama T., Predicting the appropriate size of the uncuffed nasotracheal tube for pediatric patients: a retrospective study., Clin Oral Investig. , 23, 1, 493-495, 2019.01.
3. Tsukamoto M, Yamanaka H, Yokoyama T., Age-related differences in recovery from inhalational anesthesia: a retrospective study., Aging Clin Exp Res., doi: 10.1007/s40520-018-0924-y., 30, 12, 1523-1527, 2018.12, INTRODUCTION:

It is important to understand the anesthetic requirements of elderly patients. However, little is known about age-related recovery from inhalational anesthetics. In this retrospective study, we compared age-related differences in recovery from three inhalational anesthetics in elderly subjects.

Patients were investigated as three age groups which can be defined as age ranges pediatric (< 15 years), adult (15-64 years), and elderly patients ( > 65 years) under general anesthesia using inhalational anesthetics. Anesthesia and surgery times, drug end-tidal concentrations, the time to first movement, time to eye opening, body movement, extubation, and discharge were recorded. The data were analyzed using a Kruskal-Wallis test and Steel-Dwass multiple comparisons.

A total of 594 patients were included in the study. In inhalational anesthetics such as sevoflurane, isoflurane, or desflurane, recovery from general anesthesia was not significantly different among age groups (P > 0.05). In inhalational group, recovery was significantly 5-40% faster in desflurane group than in other inhalational anesthetics groups (P < 0.05). There were 20% faster recovery in pediatric and adult groups with desflurane than in elderly with desflurane group. Drug end-tidal inhalational concentrations in pediatric group were significantly higher than that in adult and elderly groups of all inhalational anesthetics, respectively (P < 0.05).

In the current study, we have found that recovery from desflurane was faster in younger patients than in other inhalational anesthetics and aged patients..
4. Yamanaka H, Tsukamoto M, Hitosugi T, Yokoyama T., Changes in nasotracheal tube depth in response to head and neck movement in children., Acta Anaesthesiol Scand. , doi: 10.1111/aas.13207. , 62, 10, 1383-1388, 2018.11.
5. Kanako Esaki, Masanori Tsukamoto, Eiji Sakamoto, Takeshi Yokoyama, Effect of preoperative oral carbohydrate therapy on perioperative glucose metabolism during oral–maxillofacial surgery: randomised clinical trial, Asia Pacific Journal of Clinical Nutrition, Asia Pacific Journal of Clinical Nutrition, 2017.11.
6. Masanori Tsukamoto, Jun Hirokawa, T Yokoyama, Intraoperative fluid management in pediatric patients using bioelectrical impedance analysis during oral surgery, Pediatric Anesthesia and Critical Care Journal, 2017.11.
7. Azusa Nakashima, Nakano Hiroyuki, Tomohiro Yamada, Tomoki Sumida, T Yokoyama, Katsuaki Mishima, Yoshihide Mori, The relationship between lateral displacement of the mandible and scoliosis, Journal of Oral and Maxillofacial Surgery, DOI 10.1007/s10006-016-0607-9, in press, 2017.11.
8. I Morita, H Oyama, M Yasuo, M Toyot, Yoshinori Hayashi, T Yokoyama, N Kobayashi, Enantioselective Monoclonal Antibodies for Detecting Ketamine to Crack Down on Illicit Use, Biological and Pharmaceutical Bulletin, in press, 2017.11.
9. S Sako, S Tokunaga, M Tsukamoto, J Yoshino, N Fujimura, T Yokoyama, Swallowing action immediately before intravenous fentanyl at induction of anesthesia prevents fentanyl-induced cough: a randomized controlled study, Journal of Anesthesia, DOI: 10.1007/s00540-016-2300-4, vol 31, No 2, 212-218, 2017.04.
10. T Yokoyama, Takashi Hitosugi, Saori Koyama, Masanori Tsukamoto, Kanako Esaki, Low-dose carperitide (α-human A-type natriuretic peptide) alleviates hemoglobin concentration decrease during prolonged oral surgery: a randomized controlled study, Journal of Anesthesia, 325-329, 2017.03.
11. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, Risk Factors for Postoperative Shivering After Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, 74, 12, 2359-2362, 2016.12.
12. Y Hayashi, S Morinaga, X Liu, J Zang, Wu Z, T Yokoyama, H Nakanishi, An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons., Mediators of Inflammation, 2016.11.
13. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, Body composition and hemodynamics changes in special needs patients, J Dent Anesth Pain Med, 16, 3, 193-197, 2016.03.
14. T Yokoyama, S Fujiwara, A Noguchi, U Imaizumi, Y Morimoto, KI Yoshida, S Ito, Masanori Tsukamoto, The effect of adrenaline or noradrenaline with or without lidocaine on the contractile response of lipopolysaccharide-treated rat thoracic aortas, Biomedical Research, 27, 2, 453-457, 2016.02.
15. SJFujiwara, K Tachihara, S Mori, K Ouchi, S Itakura, M Yasuda, Takashi Hitosugi, U Imaizumi, Y Miki, Toyoguchi I, Yoshida KI, T Yokoyama, Influence of the marvelous™ three-way stopcock on the natural frequency and damping coefficient in blood pressure transducer kits., Journal of Clinical Monitoring and Computing, 2016.12.
16. S Fujiwara, K Tachihara, S Mori, K Ouchi, C Yokoe, U Imaizumi, Y Morimoto, Y Miki, I Toyoguchi, KI Yoshida, T Yokoyama, Effect of using a Planecta™ port with a three-way stopcock on the natural frequency of blood pressure transducer kits., J Clin Monit Comput.
17. Fujiwara S, Tachihara K, Mori S, Yamamoto T, Yokoe C, Imaizumi U, Morimoto Y, Miki Y, Toyoguchi I, Yoshida KI, Yokoyama T, Frequency characteristics of pressure transducer kits with inserted pressure-resistant extension tubes., Journal of Clinical Monitoring and Computing, 2017.11.
18. Ju Mizuno, Mikiya Otsuji, Takeshi Yokoyama, Hideko Arita, Kazuo Hanaoka, Half-logistic function model for first half of descending phase of cardiomyocyte cytoplasmic Ca2+ concentration ([Ca2+]i)-time curve(CaTCIII) in isolated Aeqorin-injected mouse left vantricular papillary muscle, Acta Cardiologica Sinica, 32, 1, 65-74, 2016.01.
19. Fujiwara S, Kawakubo, Yokoyama T, Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits., Journal of Clinical Monitoring and Computing, 10.1007/s10877-014-9650-y., 29, 6, 681-689, 2015.12.
20. Hiroko Fujino, Shoko Itoda, Kanako Esaki, Masanori Tsukamoto, Saori Sako, Kazuki Matsuo, Eiji Sakamoto, Kunio Suwa, Takeshi Yokoyama, Intra-operative administration of low-dose IV glucose attenuates post-operative insulin resistance, Asia Pac J Clin Nutr , 10.6133/apjcn.2014.23.3.10, 23, 3, 400-407, 2014.09, Background & Aims: Insulin sensitivity often decreases after surgery in spite of normal insulin secretion, and may worsen the outcome. This post-operative insulin resistance increases according to the magnitude of surgical invasion. However, supplementation of carbohydrates before surgery attenuates the post-operative insulin re- sistance. This study aimed to investigate the effect of intra-operative administration of low-dose glucose on the post-operative insulin resistance. Methods: Patients undergoing maxillofacial surgery were randomly assigned to two groups throughout the surgical procedure: The glucose group receiving acetated Ringer solution with 1.5% glucose and the control group receiving acetated Ringer solution without glucose. Insulin resistance quantified by the mean glucose infusion rate (the glucose infusion rate) was evaluated by glucose clamp using the STG-22TM instrument on the previous day and on the next day of surgery. Blood glucose level was monitored continuously during surgery. In addition, serum insulin, ketone bodies and 3-methylhistidine were measured during periopera- tive period. Results: Patients in the glucose group (n=11) received 0.15±0.06 g/kg/h of glucose during surgery, while patients in the control group (n=11) received no glucose. In both groups, however, the mean blood glucose levels were maintained stable at less than 150 mg/dL during and after surgery. The serum ketone bodies signifi- cantly increased after surgery in the control group (p=0.0035), while it decreased significantly in the glucose group (p=0.043). The reduction rate in the glucose infusion rate was significantly lower in the glucose group, 43.320.7%, than that in the control group, 57.79.3% (p=0.041). Conclusions: Intra-operative small-dose of glucose administration may suppress ketogenesis and attenuate the post-operative insulin resistance without caus- ing hyperglycemia..
21. 林 良憲, 古賀由佳, Xinwen Zhang, Christoph Peters, Yuchio Yanagawa, 武 洲, 横山 武志, 中西 博, Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance., Neuroscience, 10.1016/j.neuroscience.2014.06.037., 275, 384-394, 2014.09, Opioids are the most widely used analgesics in the treatment of severe acute and chronic pain. However, opioids have many adverse side effects, including the development of antinociceptive tolerance after long-term use. The antinociceptive tolerance of opioids has limited their clinical use. A recent study has reported that autophagy is responsible for morphine-induced neuronal injury. However, little is known about the role of autophagy in morphine antinociceptive tolerance. In the present study, chronic morphine administration was found to induce the expression of autophagy-related proteins, including Beclin1 and microtubule-associated protein light chain 3 (LC3)-II, in GABAergic interneurons in the superficial layer (lamina I-II) of the spinal cord. A single intrathecal administration of autophagy inhibitors, 3-methyladenine (3MA) or wortmannin, inhibited the development of antinociceptive tolerance in a dose-dependent manner. Autophagy in the lamina I-II neurons was associated with increased level of cathepsin B (CatB), a lysosomal cysteine protease. The pharmacological blockade or gene deletion of CatB markedly prevented the development of morphine antinociceptive tolerance. Furthermore, the intrathecal administration of 3MA suppressed the upregulation of CatB 5 days after morphine administration. Finally, CatB deficiency inhibited the increased release probability of glutamate in the lamina I neurons after chronic morphine treatment. These observations suggest that the dysfunction of spinal GABAergic system induced by CatB-dependent excessive autophagy is partly responsible for morphine antinociceptive tolerance following chronic treatment..
22. Takeshi Yokoyama, Eiji Sakamoto, Fumiyasu Yamasaki, Koichi Yamashita, Tomoaki Yatabe, KunioSuwa, Remifentanil Has Sufficient Hypnotic and Amnesic Effect for Induction of Anesthesia by Itself, Open Journal of Anesthesiology, 4, 1, 8-12, 2014.01.
23. Mizuno J, Otsuji M, Hanaoka K, Arita H, Yokoyama T, Intracellular Ca2+ transient Phase II can be assessed by half-Logistic function model in isolated aequorin-injected mouse left ventricular papillary muscle., Journal of Acta Cardiologica Sinica, in press, 2013.05.
24. Yamanaka W, Takeshita T, Shibata Y, Matsuo K, Eshima N, Yokoyama T, Yamashita Y., Compositional stability of a salivary bacterial population against supragingival microbiota shift following periodontal therapy., PLoS One. , 2012;7(8):e42806., 2012.08.
25. Hayashi Y, Kawaji K, Sun L, Zhang X, Koyano K, Yokoyama T, Kohsaka S, Inoue K, Nakanishi H., Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain., J Neurosci. , 31, 48, 17370-82, 2011.11.
26. Akihiro Mori, Peter Lee, Takeshi Yokoyama, Hitomi Oda, Kaori Saeki, Yohei Miki, Satoshi Nozawa, Daigo Azakami, Yutaka Momota, Yuki Makino, Takako Matsubara, Motohisa Osaka, Katsumi Ishioka, Toshiro Arai, Toshinori Sako, Evaluation of artificial pancreas technology for continuous blood glucose monitoring in dogs, J Artif Organs, 14, 2, 133-9, 2011.02.
27. Takashi Furuno, Fumiyasu Yamasaki, Takeshi Yokoyama, Kyoko Sato, Takayuki Sato, Yoshinori Doi, Tetsuro Sugiura, Effects of various doses of aspirin on platelet activity and endothelial function, Heart and Vessels, in press, 2010.07.
28. Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, Nakayama KI, Yokoyama T, Nabekura J, Kanematsu T, Hirata M, GABAA receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice, Journal of Neurochemistry 2010;114:302-10, 2010.05.
29. Akinobu Imoto, Takeshi Yokoyama, Kunio Suwa, Fumiyasu Yamasaki, Tomoaki Yatabe, Reiko Yokoyama, Koichi Yamashita, Eva Sellden, Bolus oral or continuous enteral amino acids reduces hypothermia during anesthesia in rats
, Journal of Nutrition Science Vitaminology, 56, 2, 104-108, 2010.04.
30. Ushida T, Yokoyama T, Kishida Y, Hosokawa M, Taniguchi S, Inoue S, Takemasa R, Suetomi K, Arai Y-CP, McLaughlin M, Tani T, Incidence and risk factors of postoperative delirium in cervical spine surgery, Spine , 34, 23, 2500-2504, 2009.11.
31. Takeshi Yokoyama, Reiko Yokoyama, Satoshi Nomura, Satoshi Matsumoto, Ryoji Fujiyama, Syun-ichi Kiyooka, Synthesis of (S)-Ketamine via [1,3]-Chirality Transfer of a Stereocenter Created by Enantioselective Aldol Reaction, Bull. Chem. Soc. Jpn. , 82, 12, 1528-1532, 2009.09.
32. Reiko Yokoyama, Satoshi Matsumoto, Satoshi Nomura, Takafumi Higaki, Takeshi Yokoyama, Syun-ichi Kiyooka, Enantioselective construction of nitrogen-substituted quaternary carbon centers adjacent to the carbonyl group in the cyclohexane ring: first asymmetric synthesis
of anesthetic (S)-ketamine with high selectivity, Tetrahedron, 65, 5, 5181-5191, 2009.05.