Kyushu University Academic Staff Educational and Research Activities Database
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Ichiro Takahashi Last modified date:2024.04.03

Professor / Division of Oral Health, Growth and Development
Department of Dental Science
Faculty of Dental Science


Graduate School
Undergraduate School


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Homepage
https://kyushu-u.elsevierpure.com/en/persons/ichiro-takahashi
 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
DDS, PhD.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Section of Orthodontics and Dentofacial Orthopedics
Total Priod of education and research career in the foreign country
02years00months
Outline Activities
Managing the research, education and clinical activities of academic and clinical orthodontic field in the Section of Orthodontics and Dentofacial Orthopedics, Kyushu University Faculty of Dental Science.

The basic and clinical research projects are as follows:
1. Molecular biology in maxillofacial, oral and dental development
2. Molecular mechanobiology in cartilage and bone cells
3. Molecular mechanisms of alteration in tissue structure and physiological function during orthodontic tooth movement
4. Integrated analyses of interaction between function and morphology in maxillofacial and oral organs
5. Advanced orthodontics for craniofacial anomalies and jaw deformities
6. Three-dimensional and/or genetic analyses for maxillofacial morphology, growth and development
7. Development of orthodontic appliances and their performance assessment

Dental education course in orthodontics are as follows:
Undergraduate dental education
1. Lecture courses:
(1) Craniofacial growth and development
(2) Orthodontic diagnosis and treatment
(3) Ethics in dentistry
2. Practical courses
(1) Basic practice for orthodontic diagnosis
(2) Basic practice for orthodontic treatment
(3) Clinical practice for orthodontic diagnosis and treatment
Postgraduate dental education
1. Resident course for advanced clinical orthodontics
2. Specialty education for orthodontic specialist
3. PhD course in orthodontics

Clinical activities in orthodontic clinics are as follows:
1. Managing the orthodontic diagnosis and treatment planning
2. Managing the treatment outcome in the orthodontic clinic
3. Clinical trials for advanced orthodontic treatment for jaw deformities and use of implants for orthodontic anchorage
4. Free consultation for orthodontic needs of citizens
Research
Research Interests
  • Development of orthodontic appliances and their performance assessment
    keyword : Friction, Bracket, Orthodontic wire, Multi bracket system
    2009.04Development of orthodontic appliances and their performance assessment.
  • Dynamic/static, esthetic and social, two- and three-dimensional and/or genetic analyses for maxillofacial morphology, growth and development
    keyword : Genetic analysis, Three-dimensional analysis, Facial esthetics, Treatment goal
    2009.04Three-dimensional and/or genetic analyses for maxillofacial morphology, growth and development.
  • Advanced orthodontics for craniofacial anomalies and jaw deformities
    keyword : Distraction osteogenesis, Implant orthodontics, Orthognathic surgery, Bone regeneration, Tissue engineering
    2009.04Advanced orthodontics for craniofacial anomalies and jaw deformities.
  • Integrated dynamic and static analyses of interaction between function and morphology in maxillofacial and oral organs
    keyword : Jaw movement, Masticatory function, EMG, MKG, Occlusal force, Lip pressure, Tongue pressure
    2009.04Integrated analyses of interaction between function and morphology in maxillofacial and oral organs.
  • Molecular mechanisms of alteration in tissue structure and physiological function during orthodontic tooth movement
    keyword : Periodontal ligament, Fibroblast, Osteoblast, Bone formation, Bone resorption, Osteoclast, Distraction osteogenesis, Root resorption, MMPs, TIMPs, Collagens, Cytokines, Growth factors
    2009.04Molecular mechanisms of alteration in tissue structure and physiological function during orthodontic tooth movement .
  • Molecular mechanobiology in cartilage and bone cells
    keyword : Chondrogenesis, Osteogenesis, Chondrocyte, Osteoblast, Mechanical stress, Cell-ECM interaction, Cell-cell interaction, tension, compression, intracellular signaling, MAPK, cytoskeleton
    2009.04Molecular mechanobiology in cartilage and bone cells.
  • Molecular biology in maxillofacial, oral and dental development
    keyword : artilage, Bone, Teeth, Transcriptional control, epitherial -mesenchymal interaction, Growth factor signaling, Mandibular morphogenesis, MicroRNA
    2009.04Molecular biology in maxillofacial, oral and dental development.
Academic Activities
Presentations
1. Ichiro Takahashi, Mechanical stress response of chondrocytes during early development of cartilage, The 9th International Orthodontic Congress /12th Asian Pacific Orthodontic Conference/ the 79th Annual Meeting of the Japanese Orthodontic Society, 2020.10, cientific background of orthodontic-orthopedic treatment for skeletal malocclusion during growing period is one of the important issues to be addressed. Mandibular condylar cartilage (MCC) is the major growing cite of mandible by endochondral bone formation. We have been performing series of experiments to analyze the cellular response of differentiating chondrocyte to compressive and tensional stress loading. In the first experiment, electrical stimulation of lateral pterygoid muscle inhibited the chondrogenic differentiation of mesenchymal cells in the posterior area of MCC in growing rats. Since distribution of mechanicals stress in temporomandibular joints was unclear, we employed midpalatal suture cartilage (MSC) in growing rats to verify the hypothesis that compression enhances chondrogenesis and tension inhibits chondrogenic differentiation in the MSC. As the result, hypertrophy of chondrocytes was enhanced in the MSC compressed by orthopedic force, while the cartilage was replaced by bone under expansive force. Further, integrins are found to be expressed in the MSC and Extracellular Signal-regulated Kinase (ERK) was activated by expansive force. To analyze the cellular mechanisms of mechano-response of differentiating chondrocytes, embryonic limb bud cells were mechanically stimulated in vitro. When mouse limb bud cells were compressed in collagen gel 3-D culture, differentiation of chondrocytes was accelerated with enhanced expression of Sox9, the transcriptional activator for cartilage specific collagen, Col2a1. On the other hand, expansive stress inhibited the chondrogenic differentiation of rat limb bud cells in stretched micromass culture through integrin mediated ERK signaling pathway. Thus, different types of mechanical stress would differentially regulate the differentiation of chondrocytes..
Membership in Academic Society
  • JAPANESE SOCIETY of DEVELOPMENTAL BIOLOGISTS
  • Japan Society of Cranio-Maxillo-Facial Surgery
  • Japanese Dental Education Association
  • Japanese Association for Oral Biology
  • Japanese Society for Bone and Mineral Research
  • The Tohoku Orthodontic Society
  • International Association for Dental Research
  • Japan Orthodontic Society
  • Japanese Cleft Palate Association
  • The Japanese Society for Jaw Deformities
  • The Kyushu Orthodontic Society
Educational
Educational Activities
In charge of lectures for mechanisms of human maxillofacial and dentoalveolar growth and development. Managing lectures and practical training for orthodontic diagnosis and treatment in undergraduate dental education before clinical practical training at 6th grade. Provide a clinical practical training for orthodontic diagnosis and treatment in undergraduate dental education course for 6th grade. Managing immediate postgraduate resident course of orthodontics for general dentist and orthodontic specialty course for postgraduate students for a certified orthodontist of Japanese Orthodontic Society. Opening a wide range of postgraduate PhD course for basic and clinical orthodontics regarding molecular mechanisms of maxillofacial and dentoalveolar growth and development, molecular mechanisms of response of cells to mechanical stimulation, and morphological and functional assessment of maxillofacial and dentoalveolar complex.