Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Shinobu Yasuo Last modified date:2019.05.30

Associate Professor / Animal & Marine Bioresource Sciences / Department of Bioresource Sciences / Faculty of Agriculture


Papers
1. Naho Morisaki, Chie Nagata, Shinobu Yasuo, Seiichi Morokuma, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Ayako Senju, Toshihiro Kawamoto, Shoichi Ohga, Koichi Kusuhara, Optimal protein intake during pregnancy for reducing the risk of fetal growth restriction
The Japan Environment and Children's Study, British Journal of Nutrition, 10.1017/S000711451800291X, 120, 12, 1432-1440, 2018.12, Clinical trials show that protein supplement increases infant size in malnourished populations; however, epidemiological studies in high-income countries have reported mixed results. Although these findings suggest a non-linear relationship between maternal macronutrient intake and fetal growth, this relationship has not been closely examined. We assessed the association between maternal protein intake and fetal growth among 91 637 Japanese women with singletons in a nation-wide cohort study using validated FFQ. The respondents answered the FFQ twice, once during early pregnancy (FFQ1; 16·3 (sd 6·0) weeks), and second during mid-pregnancy (FFQ2, 28·1 (sd 4·1) weeks). Daily energy intake and percentage energy from protein, fats and carbohydrates were 7477 (sd 2577) kJ and 13·5 (sd 2·0), 29·5 (sd 6·5) and 55·3 (sd 7·8) %, respectively, for FFQ1, and 7184 (sd 2506) kJ and 13·6 (sd 2·1), 29·8 (sd 6·6) and 55·3 (sd 7·9) %, respectively, for FFQ2. The average birth weight was 3028 (sd 406) g, and 6350 infants (6·9 %) were small for gestational age (SGA). In both phases of the survey, birth weight was highest and the risk of SGA was lowest when the percentage energy from protein was 12 %, regardless of whether isoenergetic replacement was with fat or carbohydrates. Furthermore, when protein density in the maternal diet was held constant, birth weight was highest when 25 % of energy intake came from fat and 61 % came from carbohydrates during early pregnancy. We found maternal protein intake to have an inverse U-curve relationship with fetal growth. Our results strongly suggest that the effect of protein on birth weight is non-linear, and that a balanced diet fulfilling the minimum requirement for all macronutrients was ideal for avoiding fetal growth restriction..
2. Yusuke Takaia, Misato Kawaia, Tadashi Ogob, Takashi Ichinoseb, Shigeki Furuyab, Nozomu Takakia, Yukihiro Tonea, Hiroshi Udoc, Mitsuhiro Furusea, Shinobu Yasuoa, Early-life photoperiod influences depression-like behavior, prepulse inhibition of the acoustic startle response, and hippocampal astrogenesis in mice, Neuroscience, 10.1016/j.neuroscience.2018.01.038, 374, 133-143, 2018.03.
3. Shinobu Yasuo, Ayaka Iwamoto, Sang-il Lee, Shotaro Ochiai, Rina Hitachi, Satomi Shibata, Nobuo Uotsu, Chie Tarumizu, Sayuri Matsuoka, Mitsuhiro Furuse, Shigekazu Higuchi, L-Serine enhances light-induced circadian phase resetting in mice and humans, Journal of Nutrition, 10.3945/jn.117.255380, 147, 12, 2347-2355, 2017.12,  約24時間のリズムを刻む概日時計(体内時計)は食事の時刻や内容により調節される。しかし、特定の栄養素が概日時計に及ぼす影響については不明な点が多い。本研究では、概日時計に影響を及ぼすアミノ酸を同定することを目的とした。
 CBA/Nマウスにおいて、回転輪活動リズムの位相変化量を指標として解析を行った。20種類のアミノ酸のうち、L-セリンを投与したマウスでは、光による概日時計の位相変化が強まることが判明した。この効果はGABA-A受容体アンタゴニストであるピクロトキシンにより阻害された。また、明暗周期を6時間前進させてL-セリンを経口投与したところ、新しい明暗周期に対する再同調が早まった。
 L-セリンの効果をヒトで実証するため、L-セリンが光による概日時計の位相前進に及ぼす影響について、男子大学生を対象として解析した。L-セリンを就寝前に摂取して翌朝に強い光を浴びると、概日時計の位相の指標であるメラトニン分泌開始時刻が有意に大きく前進した。
 以上の結果から、光による概日時計のリセットがL-セリンの摂取により強まることが解明された。本成果により、概日時計の乱れや時差ぼけの改善にL-セリンが有用である可能性が示唆された。.
4. Ayako Tashiro, Satomi Shibata, Yusuke Takai, Tatsuhiro Uchiwa, Mitsuhiro Furuse, Shinobu Yasuo, Changes in photoperiod alter Glut4 expression in skeletal muscle of C57BL/6J mice, Biochemical and Biophysical Research Communications, 485, 82-88, 2017.03.
5. Tatsuhiro Uchiwa, Yusuke Takai, Ayako Tashiro, Mitsuhiro Furuse, Yasuo Shinobu, Exposure of C57BL/6J mice to long photoperiod during early life stages increases body weight and alters plasma metabolomic profiles in adulthood, Physiological Reports, 4, e12974, 2016.09.
6. Shoko Furuta, Rika Kuwahara, Eri Hiraki, Koichiro Ohnuki, Shinobu Yasuo, Kuniyoshi Shimizu, Hericium erinaceus extracts alter behavioral rhythm in mice, Biomedical Research, 37, 227-232, 2016.03.
7. Tsuyoshi Otsuka, Ryosei Goda, Ayaka Iwamoto, Misato Kawai, Satori Shibata, Yoshiaki Oka, Wataru Mizunoya, Mitsuhiro Furuse, Yasuo Shinobu, Dietary protein ingested before and during short photoperiods makes an impact on affect-related behaviours and plasma composition of amino acids in mice, British Journal of Nutrition, 114, 1734-1743, 2015.11.
8. Misato Kawai, Ryosei Goda, Tsuyoshi Otsuka, Ayaka Iwamoto, Nobuo Uotsu, Mitsuhiro Furuse, Yasuo Shinobu, Antidepressant-like effect of bright light is potentiated by L-serine administration in a mouse model of seasonal affective disorder, Brain Research Bulletin, 118, 25-33, 2015.09.
9. Ryosei Goda, Tsuyoshi Otsuka, Ayaka Iwamoto, Misato Kawai, Satomi Shibata, Mitsuhiro Furuse, Yasuo Shinobu, Serotonin levels in the dorsal raphe nuclei of both chipmunks and mice are enhanced by long photoperiod, but brain dopamine level response to photoperiod is species-specific, Neuroscience Letters, 593, 95-100, 2015.04.
10. Andras D. Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Yasuo Shinobu, Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder, Chronobiology International, 32, 447-457, 2015.05.
11. Haruka Matsuo, Ayaka Iwamoto, Tsuyoshi Otsuka, Yukihiro Hishida, Saori Akiduki, Mami Aoki, Shozo Tomonaga, Mitsuhiro Furuse, Yasuo Shinobu, Effects of time of l-ornithine administration on the diurnal rhythms of plasma growth hormone, melatonin, and corticosterone levels in mice, Chronobiology International, 32, 225-234, 2015.03.
12. Yasuo Shinobu, Claudia Fischer, Joerg Bojunga, Masayuki Iigo, Horst-Werner Korf, 2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters, Chronobiology International, 31, 337-342, 2014.04.
13. Tsuyoshi Otsuka, Misato Kawai, Yuki Togo, Ryosei Goda, Takahiro Kawase, Haruka Matsuo, Ayaka Iwamoto, Mao Nagasawa, Furuse Mitsuhiro, Yasuo Shinobu, Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice, Psychoneuroendocrinology, 40, 37-47, 2014.02.
14. Ayaka Iwamoto, Misato Kawai, Furuse Mitsuhiro, Yasuo Shinobu, Effects of chronic jet lag on the central and peripheral circadian clocks in CBA/N mice, Chronobiology International, 31, 189-198, 2014.03.
15. Goto Mariko, Matsuo Haruka, Iigo Masayuki, Furuse Mitsuhiro, Horst-Werner Korf, Yasuo Shinobu, Melatonin-induced changes in the expression of thyroid hormone-converting enzymes in hypothalamus depend on the timing of melatonin injections and genetic background in mice., General and Comparative Endocrinology, 10.1016/j.ygcen.2013.02.028, 186C, 33-40, 2013.03.
16. Togo Yuki, Otsuka Tsuyoshi, Goto Mariko, Furuse Mitsuhiro, Yasuo Shinobu, Photoperiod regulates dietary preferences and energy metabolism in young developing Fischer 344 rats but not in same-age Wistar rats, American Journal of Physiology-Endocrinology and Metabolism, 10.1152/ajpendo.00209.2012, 303, 6, E777-E786, 2012.09.
17. Otsuka Tsuyoshi, Goto Mariko, Kawai Misato, Togo Yuki, Sato Katsuyoshi, Katoh Kazuo, Furuse Mitsuhiro, Yasuo Shinobu, Photoperiod regulates corticosterone rhythms by altered adrenal sensitivity via melatonin-independent mechanisms in Fischer 344 rats and C57BL/6J mice, PLoS ONE, 10.1371/journal.pone.0039090, 7, 6, e39090, 2012.06.
18. Shinobu Yasuo, Claudia Unfried, Matthias Kettner, Gerd Geisslinger, Horst-Werner Korf, Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man, Cell and Tissue Research, 342: 273-281, 2010.11.
19. Shinobu Yasuo, Marco Koch, Helmut Schmidt, Simone Ziebell, Joerg Bojung, Gerd Geisslinger, Horst-Werner Korf, An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes, Cell and Tissue Research, 340:127-136, 2010.04.
20. Shinobu Yasuo, Takashi Yoshimura, Shizufumi Ebihara, Horst-Werner Korf, Photoperiodic control of TSH-b expression in the mammalian pars tuberalis has different impact on the induction and suppression of hypothalamo-hypophysial gonadal axis, Journal of Neuroendocrinology, 22: 43-50, 2010.01.
21. Hiroko Ono, Hoshino Yuta, Shinobu Yasuo, Miwa Watanabe, Nakane Yusuke, Atsushi Murai, Shizufumi Ebihara, Horst-Werner Korf, Takashi Yoshimura, Involvement of thyrotropin in photoperiodic signal transduction in mice, Proceedings of the National Academy of Sciences of the United States of America, 105, 18238-18242 , 2009.11.
22. Claudia Unfried, Nariman Ansari, Shinobu Yasuo, Horst-Werner Korf, Charlotte von Gall, Impact of melatonin and molecular clockwork components on the expression of thyrotropin-beta chain (Tshb) and the Tsh receptor in the mouse pars tuberalis, Endocrinology, 150, 4653-4662, 2009.10.
23. Shinobu Yasuo, Takashi Yoshimura, Shizufumi Ebihara, Horst-Werner Korf, Melatonin transmits photoperiodic signals through the MT1 melatonin receptor, Journal of Neuroscience, 29, 2885-2889 , 2009.03.
24. Tsuyoshi Watanabe, Suzuki Tohru, Akira Ishikawa, Yuki Yokota, Hiroki R. Ueda, Rikuhiro G. Yamada, Hajime Tei, Saki Imai, Shigeru Tomida, Junya Kobayashi, Emiko Naito, Shinobu Yasuo, Nobuhiro Nakao, Takao Namikawa, Takashi Yoshimura, Shizufumi Ebihara, Genetic and Molecular Analysis of wild-derived arrhythmic mice, PLoS ONE, e4301, 2009.01.
25. Shinobu Yasuo, Charlotte von Gall, David R Weaver, Horst-Werner Korf, Rhythmic expression of clock genes in the ependymal cell layer of the third ventricle of rodents is independent of melatonin signaling, European Journal of Neuroscience, 28, 2443-2450 , 2008.12.
26. Nobuhiro Nakao, Hiroko Ono, Takashi Yamamura, Tsubasa Anraku, Tsuyoshi Takagi, Kumiko Higashi, Shinobu Yasuo, Yasuhiro Katou, Saburo Kageyama, Yumiko Uno, Takeya Kasukawa, Masayuki Iigo, Peter J. Sharp, Atsushi Iwasawa, Yutaka Suzuki, Sumio Sugano, Teruyuki Niimi, Makoto Mizutani, Takao Namikawa, Shizufumi Ebihara, Hiroki R. Ueda, Takashi Yoshimura, Thyrotrophin in the pars tuberalis triggers photoperiodic response, Nature, 452, 317-322, 2008.03.
27. Shinobu Yasuo, Takashi Yoshimura, Shizufumi Ebihara, Horst-Werner Korf, Temporal dynamics of type 2 deiodinase expression after melatonin injections in Syrian hamsters, Endocrinology, 148, 4385-4392, 2007.09.
28. Tsubasa Anraku, Tsuyoshi Takagi, Nobuhiro Nakao, Miwa Watanabe, Shinobu Yasuo, Yasuhiro Katou, Yukihiro Ueda, Atsushi Murai, Masayuki Iigo, Shizufumi Ebihara, Takashi Yoshimura, Photoperiodic changes in hypothalamic insulin receptor gene expression are regulated by gonadal testosterone, Brain Research, 1163, 86-90 , 2007.08.
29. Nobuhiro Nakao, Shinobu Yasuo, Atsuko Nishimura, Takashi Yamamura, Tuyoshi Watanabe, Tubasa Anraku, Toshiyuki Okano, Yoshitaka Fukada, Peter J. Sharp, Shizufumi Ebihara, Takashi Yoshimura, Circadian clock gene regulation of steroidogenic acute regulatory protein gene expression in pre-ovulatory ovarian follicles, Endocrinology, 148, 3031-3038
Selected as News & Views: Ball GF, The ovary knows more than you think! New views on clock genes and the positive feedback control of luteinizing hormone. Endocrinology 148, 3029-3030 (2007), 2007.07.
30. Yasuhiro Aoki, Hiroko Ono, Shinobu Yasuo, Tomohiro Masuda, Takashi Yoshimura, Shizufumi Ebihara, Masayuki Iigo, Tadashi Yanagisawa, Molecular evolution of prepro-thyrotropin-releasing hormone in the chicken (Gallus gallus) and its expression in the brain, Zoological Science, 24, 686-692 , 2007.07.
31. Tsuyoshi Takagi, Takashi Yamamura, Tubasa Anraku, Shinobu Yasuo, Nobuhiro Nakao, Miwa Watanabe, Masayuki Iigo, Shizufumi Ebihara, Takashi Yoshimura, Involvement of Transforming Growth Factor {alpha} in the Photoperiodic Regulation of Reproduction in Birds, Endocrinology, 148, 2788-2792, 2007.06.
32. Shinobu Yasuo, Miwa Watanabe, Masayuki Iigo, Takahiro J. Nakamura, Tsuyoshi Watanabe, Tsuyoshi Takagi, Hiroko Ono, Shizufumi Ebihara, Takashi Yoshimura, Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic Fischer 344 and nonphotoperiodic Wistar rats, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 292, R1315-1319, 2007.03.
33. Tsuyoshi Watanabe, Takashi Yamamura, Miwa Watanabe, Shinobu Yasuo, Nobuhiro Nakao, Alistair Dawson, Shizufumi Ebihara, Takashi Yoshimura, Hypothalamic expression of thyroid hormone-activating and –inactivating enzyme genes in relation to photorefractoriness in birds and mammals, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 292, R568-572, 2007.01.
34. Takahi Yamamura, Shinobu Yasuo, Kanjun Hirunagi, Shizufumi Ebihara, Takashi Yoshimura, T3 implantation mimics photoperiodically reduced encasement of nerve terminals by glial processed in the median eminence of Japanese quail, Cell and Tissue Reserch , 324, 175-179 , 2006.04.
35. Tsuyoshi Watanabe, Hitomi Kojima, Shigeru Tomida, Takahiro J Nakamura, Nobuhiro Nakao, Shinobu Yasuo, Takashi Yoshimura, Shizufumi Ebihara, Peripheral clock gene expression in CS mice with bimodal locomotor rhythms, Neuroscience Research, 54, 295-301, 2006.04.
36. Nobuhiro Nakao, Tsuyoshi Takagi, Masayuki Iigo, Toshiro Tsukamoto, Shinobu Yasuo, Tomohiro Masuda, Tadashi Yanagisawa, Shizufumi Ebihara, Takashi Yoshimura, Possible involvement of organic anion transporting polypeptide (Oatp) 1c1 in the photoperiodic response of gonads in birds, Endocrinology, 147, 1067-1073
Selected as News & Views: Ball GF, Thyroid hormone transport and photoperiodism: feeling one's oatps. Endocrinology 147, 1065-1066 (2003), 2006.03.
37. Shinobu Yasuo, Nobuhiro Nakao, Satoshi Ohkura, Masayuki Iigo, Satoko Hagiwara, Akemitsu Goto, Hiroshi Ando, Takashi Yamamura, Miwa atanabe, Tsuyoshi Watanabe, Sen-ichi Oda, Kei-ichiro Maeda, Gerald Lincoln, Hiroaki Okamura, Shizuhumi Ebihara, Takashi Yoshimura, Long day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the Saanen goat, a short day breeder: Implication for seasonal window of thyroid hormone action on reproductive neuroendocrine axis, Endocrinology, 147, 432-440 , 2006.01.
38. Shinobu Yasuo, Miwa Watanabe, Nobuhiro Nakao, Tsuyoshi Takagi, Brian K. Follett, Shizufumi Ebihara, Takashi Yoshimura, The reciprocal switching of two thyroid hormone-activating and –inactivating enzyme genes is involved in the photoperiodic gonadal response of Japanese quail, Endocrinology, 146, 2551-2554 , 2005.06.
39. Shinobu Yasuo, Shizuhumi Ebihara, Takashi Yoshimura, Oral thyroxine administration mimics photoperiodically induced gonadal growth in Japanese quail, Animal Science Journal , 75, 407-410 , 2004.10.
40. Miwa Watanabe, Shinobu Yasuo, Takashi Yamamura, Nobuhiro Nakao, Shizufumi Ebihara, Takashi Yoshimura , Photoperiodic regulation of type 2 deiodinase gene in Djungarian hamster: possible homologies between avian and mammalian photoperiodic regulation of reproduction, Endocrinology, 145, 1546-1549, 2004.04.
41. Shinobu Yasuo, Miwa Watanabe, Akira Tsukada, Tsuyoshi Takagi, Kiyoshi Shimada, Shizufumi Ebihara, Takashi Yoshimura, Photoinducible phase specific light induction of Cry1 gene in the pars tuberalis of Japanese quail, Endocrinology, 145, 1612-1616, 2004.04.
42. Takashi Yoshimura, Yuki Yokota, Akira Ishikawa, Shinobu Yasuo, Noriko Hayashi, Tohru Suzuki, Naritoshi Okabayashi, Takao Namikawa, Shizufumi Ebihara, Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice, Journal of Biological Rhythms, 17, 512-519 , 2002.12.
43. Shinobu Yasuo, Miwa Watanabe, Naritoshi Okabayashi, Shizufumi Ebihara, Takashi Yoshimura, Circadian clock genes and photoperiodism: Comprehensive analysis of clock genes expression in the mediobasal hypothalamus, the suprachiasmatic nucleus and the pineal gland of Japanese quail under various light schedules, Endocrinology, 144, 3742-3748
Selected as News & Views: Ball GF and Balthazart J, Birds return every spring like clockwork, but where is the clock? Endocrinology 144, 3739-3741(2003), 2003.09.
44. Takashi Yoshimura, Shinobu Yasuo, Miwa Watanabe, Masayuki Iigo, Takashi Yamamura, Kanjun Hirunagi, Shizufumi Ebihara, Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds, Nature, 426, 178-181, 2003.11.
45. Naritoshi Okabayashi, Shinobu Yasuo, Miwa Watanabe, Takao Namikawa, Shizufumi Ebihara, Takashi Yoshimura, Ontogeny of circadian clock gene expression in the pineal and the suprachiasmatic nucleus of chick embryo, Brain Research, 990, 231-234 , 2003.11.
46. Noriko Hayashi, Shinobu Yasuo, Shizufumi Ebihara, Takashi Yoshimura , Expression of IKKalpha mRNA in the suprachiasmatic nucleus and circadian rhythms of mice lacking IKKalpha, Brain Research, 993, 217-221, 2003.12.
47. Masahiro Funada, Shinobu Yasuo, Takashi Yoshimura,, Shizuhumi Ebihara, Hiromi Sasagawa, Yasuo Kitagawa, Tatsuhiko Kadowaki, Characterization of the two distinct subtypes of metabotropic glutamate receptors from honeybee, Apis mellifera, Neuroscience Letters, 359, 190-104 , 2004.04.
48. Shinobu Yasuo, Shizufumi Ebihara, Takashi Yoshimura, Circadian expression of clock gene in the optic tectum of Japanese quail, Brain Research, 1005, 193-196 , 2004.04.
49. Shinobu Yasuo, Takashi Yoshimura, Paul A. Bartell, Masayuki Iigo, Eri Makino, Naritoshi Okabayashi, Shizufumi Ebihara, Effect of melatonin administration on qPer2, qPer3, and qClock gene expression in the suprachiasmatic nucleus of Japanese quail, European Journal of Neuroscience, 16, 1541-1546 , 2002.10.
50. Takashi Yoshimura, Shinobu Yasuo, Yoshikazu Suzuki, Eri Makino, Yuki Yokota, Shizufumi Ebihara, Identification of the suprachiasmatic nucleus in birds, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 292, R1185-1189, 2001.04.