Kyushu University Academic Staff Educational and Research Activities Database
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Hiroyuki Sasaki Last modified date:2016.05.23

Graduate School
Undergraduate School
Other Organization
Administration Post
Vice President
Director of the Medical Institute of Bioregulation

Academic Degree
Doctor of Medical Science (MD, PhD)
Field of Specialization
Molecular Biology, Human Genetics
Outline Activities
My research interest is on epigenetics and epigenomics in mammals. Epigenetics refers to the regulation of gene activity based on modifications of chromatin: it stably maintains the cellular identity (differentiation state) and serves as a cellular memory. The epigenetic profile of a cell is called the epigenome, and elucidation of various epigenomes and their regulation is thought to be the key to the understanding of induction of pluripotential stem cells and formation of cancers. I investigate the epigenomic regulatory mechanisms in mammals including humans and their relevance to development, disease, phenotypic variation and evolution. I particularly focus on genomic imprinting, which is a good model system to study epigenomic regulation in mammals. I am a program leader of a Grant-in Aid for Scientific Research on Priority Areas supported by the MEXT, titled “The Germline: Its Developmental Cycle and Epigenome Network”, from 2007 to 2012. I mainly teach molecular biology and genetics and supervise graduate students. I was on newspapers and TV programs several times.
Research Interests
  • Epigenomics in Mammals
    keyword : epigenetics、genomic imprinting、small RNA
Current and Past Project
  • Grant-in-Aid for Scientific Research on Innovative Areas by MEXT, 2013.7~2018.3
  • Epigenome analysis of cells in the placenta and endometrium forming the fetal-maternal interface, Strategic Basic Research Programs (CREST) supported by Japan Science and Technology Agency, 2012.10~2018.3
  • Grant-in-Aid for Scientific Research on Priority Areas by MEXT, 2007.10~2013.3
Academic Activities
1. Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H., Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus., Science 332, 848-852, 2011.05.
1. Sasaki, H., Inoue, K., Fukuda, K., Glinka, M., Ichiyanagi, K., Switching from post-transcriptional to transcriptional silencing of retrotransposons during male germ-cell development, The 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription, Suzhou, China, 2016.05.09.
2. Hiroyuki Sasaki, Dynamic changes in DNA methylation and gene expression in spermatogonial stem cell differentiation in neonatal mouse testis, Epigenetics, chromatine & transcription, Cold Spring Harbor Conferences Asia, Suzhou, China, 2014.05.06.
3. Hiroyuki Sasaki, Epigenetic events in mammalian germ-cell development, Gordon Research Conference on Germinal Stem Cell Biology, Hong Kong, 2013.07.16.
4. Gordon Research Conference on Epigenetics: Mechanisms, Development and Disease.
Membership in Academic Society
  • The Japanese Society for Epigenetics
  • The Japan Society of Human Genetics
  • The Molecular Biology Society of Japan
  • The Genetics Society of Japan
  • Japan Society for Reproductive Regeneration
  • Society of Evolutionary Studies, Japan