Kyushu University Academic Staff Educational and Research Activities Database
Researcher information (To researchers) Need Help? How to update
Takashi Ohshima Last modified date:2017.11.06

Professor / Department of Pharmaceutical Health Care and Sciences
Department of Chemo-Pharmaceutical Sciences
Faculty of Pharmaceutical Sciences


Graduate School
Undergraduate School
Other Organization
Other
Other


E-Mail
Homepage
http://www.facebook.com/ohshimatakashi
http://green.phar.kyushu-u.ac.jp/index_e.html
Phone
092-642-6650
Academic Degree
Ph. D.
Field of Specialization
Synthetic Organic Chemistry, Catalysis, Green Sustainable Chemistry
Outline Activities
The following topics are currently under investigation in our laboratories:

1. Development of Environmentally Benign Processes Based on the Catalytic Activation of Unreactive Functional Group
2. Synthesis of Biologically Active Natural Products Using One-Pot Multistep Catalysis
3. Development of Molecular-targeted Anticancer Drug
Research
Research Interests
  • Development of Molecular-targeted Anticancer Drug
    keyword : Anticancer Drug
    2011.03~2013.03.
  • Deacylation of Unactivated Amides to Amines
    keyword : transamidation. ammonium salt, microwave
    2011.03~2013.03.
  • Rh-Catalyzed Asymmetric Alkynylation of alpha-Ketoesters and alpha-Ketoimines
    keyword : catalysis, enantioselective, alkynylation, ketone, ketoimine
    2007.04~2013.03.
  • Lewis acid-catalyzed direct substitution of the hydroxy group
    keyword : catalysis, green chemistry, hydroxy group, direct substitution
    2008.04~2011.08.
  • Direct Substitution Reaction of Hydroxyl Group Catalyzed by Platinum Complex
    keyword : catalysis, environmental harmony, platinum, p-allyl complex, allylamines, atom-economy
    2006.04~2013.03.
  • Development of Environmentally Friendly Acylation Reaction using Tetranuclear Zinc Cluster Catalyst
    keyword : catalysis, environmental harmony, transesterification, metal cluster, atom-economy, e-factor
    2005.04~2013.03.
Academic Activities
Books
1. Ohshima, T., Comprehensive Chirality (Yamamoto, H. Carreira, E. Eds.)
Chapter 4.18 Catalytic Asymmetric 1,2-Alkynylation.
, Elsevier, 2011.04.
Reports
1. Shibasaki Masakatsu; Ohshima Takashi, Two-center Chiral Phase Transfer Catalysts for Asymmetric Synthesis, Asymmetric Phase Transfer Catalysis; Maruoka, K. Ed.; WILEY-VCH, Weinheim, 2008.03.
2. Shibasaki, Masakatsu; Ohshima, Takashi, Desymmetrizing Heck Reactions, The Heck Reaction; Oestreich, M. Ed.; WILEY-VCH, Weinheim, 2009.03.
Papers
1. Seiya Taninokuchi, Ryo Yazaki, Takashi Ohshima, Chemoselective α-Oxidation of Acylpyrazoles en Route to α-Hydroxy Acid Derivatives, Org. Lett., 2017, 19 (12), pp 3187–3190, 2017.03.
2. Toru Deguchi, Hai-Long Xin, Hiroyuki Morimoto, Takashi Ohshima, Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides, ACS Catal. 2017, 7, 3157–3161., 2017.03.
3. Kazuhiro Morisaki, Hiroyuki Morimoto, Kazushi Mashima, Takashi Ohshima, DIRECT ENANTIOSELECTIVE ALKYNYLATION OF α-KETOESTERS AND α-KETIMINOESTERS CATALYZED BY [BIS(OXAZOLINE)PHENYL] RHODIUM(III) COMPLEXES, Heterocycles 2017, 95, 637–661., 2017.01.
4. Renshi Li, Tomoki Takeda, Takashi Ohshima, Hideyuki Yamada, Yuji Ishii, Metabolomic profiling of brain tissues of mice chronically exposed to heroin, Drug Metab. Pharmacokinet. 2017, 32, 108–111, 2017.02.
5. Zhao Li, Masamichi Tamura, Ryo Yazaki, Takashi Ohshima, Catalytic Chemoselective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Ester: Hydroxy Group over Amino Group and Conjugate Addition over Transesterification., Chem. Pharm. Bull. 2017, 65, 19–21, 2017.01.
6. Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Takashi Ohshima, Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas, Org. Lett. 2016, 18, 6062–6065, 2016.11.
7. Yumi Yamamoto, Jun Arai, Takuya Hisa, Yohei Saito, Takahiro Mukai, Takashi Ohshima, Minoru Maeda, Isomeric iodinated analogs of nimesulide: synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells, Bioorg. Med. Chem. 2016, 24, 3727–3733., 2016.06.
8. Daiki Nakatake, Ryo Yazaki, Takashi Ohshima, Chemoselective Transesterification of Acrylate Derivatives for Functionalized Monomer Synthesis Using a Hard Zinc Alkoxide Generation Strategy, Eur. J. Org. Chem. 2016, 2016.07.
9. Zhao Li, Ryo Yazaki, Takashi Ohshima, Chemo- and Regioselective Direct Functional Group Installation through Catalytic Hydroxy Group Selective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Sulfonyl Compounds, Org. Lett. 2016, 2016.06.
10. Rikiya Horikawa, Chika Fujimoto, Ryo Yazaki, Takashi Ohshima, μ-Oxo-Dinuclear Iron(III) Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of tert-Alcohols, Chem. Eur. J. 2016, 2016.06.
11. Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Hiroyuki Morimoto, Kazushi Mashima, Takashi Ohshima, Mechanistic Studies and Expansion of the Substrate Scope of Direct Enantioselective Alkynylation of α-Ketiminoesters Catalyzed by Adaptable (Phebox)Rh(III) Complexes, J. Am. Chem. Soc. 2016, 2016.06.
12. Daiki Nakatake, Ryo Yazaki, Yoshimasa Matsushima, Takashi Ohshima, Transesterification Reaction Catalyzed by Recyclable Heterogeneous Zinc/Imidazole Catalyst, Adv. Synth. Catal. 2016, 2016.06.
13. Kazushi Agura, Yukiko Hayashi, Mari Wada, Daiki Nakatake, Kazushi Mashima, Takashi Ohshima, Studies of the Electronic Effects of Zinc Cluster Catalysts and their Application to the Transesterification of β-Keto Esters, Chem. Asian J. 2016, 2016.04.
14. Keisuke Tokumasu, Ryo Yazaki, Takashi Ohshima, Direct Catalytic Chemoselective α-Amination of Acylpyrazoles: A Concise Route to Unnatural α-Amino Acid Derivatives, J. Am. Chem. Soc., 2016, 138, 2664–2669. , 2016.02.
15. Daiki Nakatake, Yuki Yokote, Yoshimasa Matsushima, Ryo Yazaki, Takashi Ohshima, A highly stable but highly reactive zinc catalyst for transesterification supported by a bis(imidazole) ligand, Green Chem., 2016, Advance Article, DOI: 10.1039/C5GC02056E , 2015.10.
16. Ming Zhang, Kenji Watanabe, Masafumi Tsukamoto, Ryozo Shibuya, Hiroyuki Morimoto, Takashi Ohshima, A Short Scalable Route to (−)-α-Kainic Acid Using Pt-Catalyzed Direct Allylic Amination, Chemistry - A European Journal, Volume 21, Issue 10, pages, 3937-3941, 2015.03.
17. Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto, Takashi Ohshima, Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis (Backcover), Chem. Commun. , 50, 2014.05.
18. Ryozo Shibuya, Lu Lin, Yasuhito Nakahara, Kazushi Mashima, Takashi Ohshima, Dual Platinum and Pyrrolidine Catalysis in the Direct Alkylation of Allylic Alcohols: Selective Synthesis of Monoallylation Products, Angew. Chem. Int. Ed., 53, 4377–4381, 2014.04.
19. Hiroyuki Morimoto, Risa Fujiwara, Yuhei Shimizu, Kazuhiro Morisaki, Takashi Ohshima, Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters, Org. Lett., 16, 2018–2021., 2014.03.
20. Shuhei Uesugi, Zhao Li, Ryo Yazaki, Takashi Ohshima, Chemoselective Catalytic Conjugate Addition of Alcohols over Amines., Angew. Chem. Int. Ed., 53, 1611–1615., 2014.02.
21. Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto, Yosuke Takeuchi, Kazushi Mashima, Takashi Ohshima, Rh-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters, Chem. Eur. J. , 19,(26), 8417-8420, 2013.06.
22. Yukiko Hayashi,, Stefano Santoro, Yuki Azuma, Fahmi Himo, Takashi Ohshima, Kazushi Mashima, Enzyme-like Catalysis via Ternary-Complex Mechanism: Alkoxy-bridged Dinuclear Cobalt Complex Mediates Chemoselective O-Esterification over N-Amidation, J. Am. Chem. Soc., 135, 16, 2013.03.
23. Takashi Ohshima, Kazushi Mashima, Platinum-Catalyzed Direct Amination of Allylic Alcohols, Journal of Synthetic Organic Chemistry, Japan , 70, 2012.07.
24. Takashi Ohshima, Junji Ipposhi, Yasuhito Nakahara, Ryozo Shibuya, Kazushi Mashima, Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron-Withdrawing Group-Substituted Benzhydrols, Adv. Synth. Catal., 354, 2012.08.
25. Yuhei Shimizu, Hiroyuki Morimoto, Ming Zhang, Takashi Ohshima, Microwave-Assisted Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation, Angew. Chem. Int. Ed, 51, 2012.07.
26. Takashi Ohshima, Yukiko Hayashi,, Kazushi Agura, Yuka Fujii, Asako Yoshiyama, Kazushi Mashima, Sodium methoxide: a simple but highly efficient catalyst for the direct amidation of esters, Chem. Commun., 48, 2012.04.
27. Das, Kalpataru; Shibuya, Ryozo; Nakahara, Yasuhito; Germain, Nicolas; Ohshima, Takashi; Mashima, Kazushi, Platinum-Catalyzed Direct Amination of Allylic Alcohols with Aqueous Ammonia for Selective Synthesis of Primary Allylamines., Angew. Chem. Int. Ed., 51, 150-154, 2011.11.
28. Takashi Ohshima, Direct substitution of the hydroxy group with highly functionalized nitrogen nucleophiles catalyzed by Au(III)., Chem. Commun., 47, 8322-8234, 2011.06.
29. T. Ohshima, T. Kawabata, Y. Takeuchi, T. Kakinuma, T. Iwasaki, T. Yonezawa, H. Murakami, H. Nishiyama, K. Mashima, C1-Symmetric Rh-Phebox-Catalyzed Asymmetric Alkynylation of α-Keto Ester, Angew. Chem. Int. Ed., accepted, 2011.05.
30. T. Ohshima, T. Iwasaki, Y. Maegawa, A. Yoshiyama, K. Mashima, Enzyme-like Chemoselective Acylation of Alcohols in the presence of Amines Catalyzed by a Tetranuclear Zinc Cluster, J. Am. Chem. Soc., 130, 2945-2946, 130, 2944-2945 (2008), 2008.03.
Presentations
1. Takashi Ohshima, Ryo Yazaki, Keisuke Tokumasu, Direct Catalytic Chemoselective α-Amination of Acylpyrazoles: A Concise Route to Unnatural α-Amino Acid Derivatives, International Symposium on Catalysis and Fine Chemicals (C&FC2016), 2016.11.11.
2. Takashi Ohshima, Kazuhiro Morisaki, Hiroyuki Morimoto, Zn-Catalyzed Direct Alkynylation of N-Unprotected Trifluoromethyl Ketimine, The 11th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-11) & The 2nd Advanced Research Network on Cutting-Edge Organic Chemistry in Asia (ARNCEOCA-2), 2016.10.27.
3. Takashi Ohshima, Catalytic Chemoselective Conjugate Addition of Alcohol over Amine, The 2nd HU-TMU-KU Joint Symposium for Pharmaceutical Sciences, 2016.09.05.
4. Takashi Ohshima, Rhodium-Catalyzed Direct Enantioselective Alkynylation of Ketimines: Mechanistic Studies and Expansion of Substrate Generality, The 3rd International Conference on Organometallics and Catalysis 2016 (OM&Cat-2016), 2016.08.28.
5. Takashi Ohshima, Direct Catalytic Chemoselective α-Amination of Acylpyrazoles:A Concise Route to Unnatural α-Amino Acid Derivatives, International Symposium on Pure & Applied Chemistry (ISPAC2016), 2016.08.16.
6. Takashi Ohshima, Ryo Yazaki, Keisuke Tokumasu, Direct Catalytic Chemoselective α-Amination of Acylpyrazoles, The 27th International Conference on Organometallic Chemistry (ICOMC 2016), 2016.07.18.
7. Takashi Ohshima, Dinuclear Iron(III) Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of tert-Alcohols, The International Symposium on Homogeneous Catalysis (ISHC) 2016, 2016.07.10.
8. Takashi Ohshima, New Zinc and Iron Catalysts for Transesterification, The 2nd International Symposium on Middle Molecular Strategy (ISMMS-2), 2016.07.02.
9. Takashi Ohshima, Rikiya Horikawa, Chika Fujimoto, Ryo Yazaki, μ-Oxo-Dinuclear Iron(III) Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of tert-Alcohols, French-Japanese Society of Medicinal and Fine Chemistry (FJS2016), 2016.05.17.
10. Takashi Ohshima, Ryo Yazaki, Keisuke Tokumasu, Direct Catalytic Chemoselective α-Amination of Acylpyrazoles:A Concise Route to Unnatural α-Amino Acid Derivatives
, The 12th International Symposium on Organic Reactions and The 6th German-Japanese Symposium on Electrosynthesis (ISOR-12 and GJSE-6), 2016.04.22.
11. Takashi Ohshima, Zn-Catalyzed Direct Alkynylation of N-Unprotected Trifluoromethyl Ketimines, The11th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-11), 2016.10.27.
12. Takashi Ohshima, Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Hiroyuki Morimoto, Rhodium-Catalyzed Direct Enantioselective Alkynylation of Ketimines: Mechanistic Studies and Expansion of Substrate Generality, The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem), 2015.12.19.
13. Takashi Ohshima, Rikiya Horikawa, Chika Fujimoto, Ryo Yazaki, Dinuclear iron complex-catalyzed transesterification: Synthesis of tert-butyl esters and unprecedented chemoselectivity, The 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem), 2015.12.18.
14. Takashi Ohshima, Direct Catalytic Chemoselective Amination: A Concise Route to α-Amino Acid Derivatives, The 10th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-10), 2015.11.03.
15. Takashi Ohshima, Catalytic Chemoselective Conjugate Addition of Alcohol over Amine, The 18th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 18), 2015.06.30.
16. Takashi Ohshima, Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Hiroyuki Morimoto, Rhodium-Catalyzed Direct Enantioselective Alkynylation of Ketimines: Mechanistic Studies and Expansion of Substrate Generality, The 7th Spanish-Portuguese- Japanese Organic Chemistry Symposium (7th SPJ-OCS), 2015.06.24.
17. Takashi Ohshima, Direct Catalytic Chemoselective Amination: A Concise Route to α-Amino Acid Derivatives, The 10th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-10), 2015.11.03.
18. Takashi Ohshima, Development of Rhodium-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters, 8th Singapore International Chemical Conference (SICC8), 2014.12.15.
19. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Green Processes, Nanyang Technological University Department Seminar, 2014.12.12.
20. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Asian Core Program Lectureship (Korea), 2014.10.06.
21. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Asian Core Program Lectureship (Korea), 2014.10.02.
22. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Asian Core Program Lectureship (Korea), 2014.09.30.
23. Takashi Ohshima, Platinum-Catalyzed Direct Substitution of Allylic Alcohols with Nitrogen and Carbon Nucleophiles and Its Application to Short Total Synthesis of (–)-α-Kainic Acid, IGER International Symposium on Chemical Science in Asia, 2014.05.27.
24. Takashi Ohshima, Platinum-Catalyzed Direct Substitution of Allylic Alcohols with Nitrogen Nucleophiles and its Application to Short Total Synthesis of (-)-α-Kainic Acid, Vietnam Malaysia International Chemical Congress (VMICC), 2014.11.09.
25. Takashi Ohshima, Catalytic Chemoselective Conjugate Addition of Alcohols over Amines, Malaysian International Chemical Congress (18MICC) , 2014.11.04.
26. Takashi Ohshima, Catalytic Chemoselective Conjugate Addition of Alcohols over Amines, 2014 Pusan-Kyushu International Joint Semina, 2014.08.18.
27. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Dr. Harisingh Gour University, 2014.01.27.
28. Takashi Ohshima, Ryo Yazaki, Shuhei Uesugi, Li Zhao, Catalytic Chemoselectivity Conjugate Addition of Alcohol over Amine, The 8th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-8)/The 4th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-4), 2013.11.26.
29. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, 第23回 光学活性化合物シンポジウム, 2013.11.01.
30. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Lecture at Hangzhou Normal University, 2013.10.28.
31. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Lecture at Fudan University, 2013.10.25.
32. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Lecture at Shanghai Institute of Materia Medica, 2013.10.25.
33. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Lecture at East China Normal University, 2013.10.24.
34. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Lecture at Shanghai Institute of Organic Chemistry, 2013.10.23.
35. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Lecture at University of Science and Technology of China, 2013.10.22.
36. Takashi Ohshima, Catalyst Control of Chemoselectivity for the Development of New Direct Catalyses, Lecture at Nanjing University, 2013.10.21.
37. Takashi Ohshima, Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto, Yosuke Takeuchi, Kazushi Mashima, Rh-Catalyzed Direct Enantioselective Alkylation of α-Ketoiminoesters, OMCOS17, 2013.07.28.
38. Takashi Ohshima, Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto, Yosuke Takeuchi, Kazushi Mashima, Rh-Catalysed Direct Enantioselective Alkynylation of α-Ketiminoesters, Thieme Nagoya Symposium, 2013.05.23.
39. Takashi Ohshima, Development of Direct Transformations, Twenty-third French-Japanese Symposium on Medicinal and Fine Chemistry (FJS-2013), 2013.05.15.
40. Takashi Ohshima, Yuhei Shimizu, Hiroyuki Morimoto, Ming Zhang, Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation, The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7)/The 3rd New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-3), 2012.12.14.
41. Takashi Ohshima, Kazushiro Morisaki, Jun-ya Nomaguchi, Hiroyuki Morimoto, Takahito Kawabata, Yosuke Takeuchi, Kazushi Mashima, Rh-Phebox-Catalyzed Asymmetric Alkynylation of α-Ketoesters and α-Ketoiminoesters, 13th Beligian Organic Synthesis Symposium BOSS 2012, 2012.07.19.
42. C1-Symmetric Rh-Phebox-Catalyzed Asymmetric Alkynylation of α-Keto Ester, The 1st Junior International Conference on Cutting-Edge Organic Chemistry in Asia (1st JACP), China, Dec.2011.
43. Takashi Ohshima, Development of New Direct Catalytic Reactions Using Tetranuclear Zinc Clusters, 14th Asian Chemical Congress (14 ACC), 2011.09.07.
44. Takashi Ohshima, Development of New Direct Catalytic Reactions Using Tetranuclear Zinc Clusters, The International Chemical Congress of Pacific Basin Societies, 2010.12.18.
Membership in Academic Society
  • American Chemical Society
Awards
  • Direct Catalytic Asymmetric Addition to N-Unprotected Ketimines
  • Lanthanum(III) Triflate-Catalyzed Direct Amidation of Esters
  • The Asian Core Program Lectureship Award, The 8th International Conference on Cutting-Edge Organic Chemistry in Asia /The 4th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia, Catalytic Chemoselectivity Conjugate Addition of Alcohol over Amine, Nov. 2013
  • The Asian Core Program Lectureship Award, The 7th International Conference on Cutting-Edge Organic Chemistry in Asia /The 3rd New Phase International Conference on Cutting-Edge Organic Chemistry in Asia, Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation, Dec.2012
  • Development of Environmentally Benign Direct Reactions Using Multinuclear Metal Cluster Catalysts
  • Development of Protecting Free Catalytic O-Selective Acylation of Aminoalcohols, JSPC Award for Excellence 2008, The Japanese Society for Process Chemistry, Dec. 2008