| Takashi Ohshima | Last modified date：2013.5.20 |
Professor /
Department of Pharmaceutical Health Care and Sciences
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences
Graduate School
Undergraduate School
E-Mail
Homepage
[URL].
Phone
092-642-6650
Fax
092-642-6650
Academic Degree
Ph. D.
Field of Specialization
Synthetic Organic Chemistry, Catalysis, Green Sustainable Chemistry
Research
Research Interests
Membership in Academic Society
- Development of Molecular-targeted Anticancer Drug
keyword : Anticancer Drug
2011.03～2013.03. - Deacylation of Unactivated Amides to Amines
keyword : transamidation. ammonium salt, microwave
2011.03～2013.03. - Rh-Catalyzed Asymmetric Alkynylation of alpha-Ketoesters and alpha-Ketoimines
keyword : catalysis, enantioselective, alkynylation, ketone, ketoimine
2007.04～2013.03. - Lewis acid-catalyzed direct substitution of the hydroxy group
keyword : catalysis, green chemistry, hydroxy group, direct substitution
2008.04～2011.08. - Direct Substitution Reaction of Hydroxyl Group Catalyzed by Platinum Complex
keyword : catalysis, environmental harmony, platinum, p-allyl complex, allylamines, atom-economy
2006.04～2013.03. - Development of Environmentally Friendly Acylation Reaction using Tetranuclear Zinc Cluster Catalyst
keyword : catalysis, environmental harmony, transesterification, metal cluster, atom-economy, e-factor
2005.04～2013.03.
Books
| 1. | Ohshima, T.,Comprehensive Chirality (Yamamoto, H. Carreira, E. Eds.) Chapter 4.18 Catalytic Asymmetric 1,2-Alkynylation. ,Elsevier,2011.04. |
Reports
| 1. | Shibasaki Masakatsu; Ohshima Takashi,Two-center Chiral Phase Transfer Catalysts for Asymmetric Synthesis,Asymmetric Phase Transfer Catalysis; Maruoka, K. Ed.; WILEY-VCH, Weinheim,2008.03. |
| 2. | Shibasaki, Masakatsu; Ohshima, Takashi,Desymmetrizing Heck Reactions,The Heck Reaction; Oestreich, M. Ed.; WILEY-VCH, Weinheim,2009.03. |
Papers
| 1. | Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto, Yosuke Takeuchi, Kazushi Mashima, Takashi Ohshima,Rh-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters,Chem. Eur. J.,accepted.,2013.05. |
| 2. | Yukiko Hayashi,, Stefano Santoro, Yuki Azuma, Fahmi Himo, Takashi Ohshima, Kazushi Mashima,Enzyme-like Catalysis via Ternary-Complex Mechanism: Alkoxy-bridged Dinuclear Cobalt Complex Mediates Chemoselective O-Esterification over N-Amidation,J. Am. Chem. Soc.,Vol.135,No.16,2013.03. |
| 3. | Takashi Ohshima, Kazushi Mashima,Platinum-Catalyzed Direct Amination of Allylic Alcohols,Journal of Synthetic Organic Chemistry, Japan ,Vol.70,2012.07. |
| 4. | Takashi Ohshima, Junji Ipposhi, Yasuhito Nakahara, Ryozo Shibuya, Kazushi Mashima,Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron-Withdrawing Group-Substituted Benzhydrols,Adv. Synth. Catal.,Vol.354,2012.08. |
| 5. | Takashi Ohshima, Junji Ipposhi, Yasuhito Nakahara, Ryozo Shibuya, Kazushi Mashima,Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron-Withdrawing Group-Substituted Benzhydrols,Adv. Synth. Catal.,Vol.354,2012.08. |
| 6. | Yuhei Shimizu, Hiroyuki Morimoto, Ming Zhang, Takashi Ohshima,Microwave-Assisted Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation,Angew. Chem. Int. Ed,No.51,2012.07. |
| 7. | Nagano, Takuto, Iimuro, Atsuhiro, Takashi Ohshima, Kita, Yusuke, Mashima, Kazushi,Asymmetric Autoinduction in Hydrogenation of 2-Substituted Quinoxalines Catalyzed by Iridium Complexes bearing Chiral Diphosphine Ligand,Chem. Eur. J.,No.18,2012.08. |
| 8. | Cartigny, Damien, Berhal, Farouk, Nagano, Takuto, Phansavath, Phannarath, Ayad, Tahar, Genêt, Jean-Pierre, Takashi Ohshima, Mashima, Kazushi, Ratovelomanana-Vidal Virginie,Highly Efficient and General Asymmetric Hydrogenation of 2-Alkyl- and 2-Aryl-Substituted Quinoxaline Derivatives Catalyzed by Iridium-Difluorphos: Halide Effect and Synthetic Application,J. Org. Chem,Vol.77,2012.04. |
| 9. | Takashi Ohshima, Yukiko Hayashi,, Kazushi Agura, Yuka Fujii, Asako Yoshiyama, Kazushi Mashima,Sodium methoxide: a simple but highly efficient catalyst for the direct amidation of esters,Chem. Commun.,No.48,2012.04. |
| 10. | Das, Kalpataru; Shibuya, Ryozo; Nakahara, Yasuhito; Germain, Nicolas; Ohshima, Takashi; Mashima, Kazushi,Platinum-Catalyzed Direct Amination of Allylic Alcohols with Aqueous Ammonia for Selective Synthesis of Primary Allylamines.,Angew. Chem. Int. Ed.,Vol.51,pp.150-154,2011.11. |
| 11. | T. Ohshima, Y. Nakahara, J. Ipposhi, Y. Miyamoto, K. Mashima,Direct substitution of the hydroxy group with highly functionalized nitrogen nucleophiles catalyzed by Au(III).,Chem. Commun.,Vol.47,pp.8322-8234,2011.06. |
| 12. | T. Ohshima, T. Kawabata, Y. Takeuchi, T. Kakinuma, T. Iwasaki, T. Yonezawa, H. Murakami, H. Nishiyama, K. Mashima,C1-Symmetric Rh-Phebox-Catalyzed Asymmetric Alkynylation of α-Keto Ester,Angew. Chem. Int. Ed.,accepted,2011.05. |
| 13. | T. Ohshima, T. Iwasaki, Y. Maegawa, A. Yoshiyama, K. Mashima,Enzyme-like Chemoselective Acylation of Alcohols in the presence of Amines Catalyzed by a Tetranuclear Zinc Cluster,J. Am. Chem. Soc.,Vol.130,pp.2945-2946,130, 2944-2945 (2008),2008.03. |
- American Chemical Society
- Deacylation of Unactivated Amides to Amines Using Ammonium Salt-Accelerated Transamidation
- Development of Environmentally Benign Direct Reactions Using Multinuclear Metal Cluster Catalysts
- Development of Protecting Free Catalytic O-Selective Acylation of Aminoalcohols
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