| Motoko Unoki | Last modified date：2013.5.23 |
Assistant Professor /
Division of Epigenomics
Department of Molecular Genetics
Medical Institute of Bioregulation
Department of Molecular Genetics
Medical Institute of Bioregulation
Graduate School
Other Organization
E-Mail
Phone
092-642-6760
Fax
092-642-6799
Academic Degree
Ph.D.
Field of Specialization
Epigenetics, carcinogenesis
Outline Activities
I'm interested in mechanisms of gene transcriptional regulations through UHRF1, which links DNA methylation status and histone modification status.
Research
Research Interests
Membership in Academic Society
- Analysis of protein-protein interactions involved in epigenetic regulation
keyword : UHRF1, epigenetics, histon modifications, DNA methylation
2010.10～2015.04.
Books
| 1. | Unoki M. et al.,Bladder Cancer Chapter: UHRF1 is a potential molecular marker for diagnosis and prognosis of bladder cancer,INTECH,in press,2011.10. |
Reports
| 1. | Unoki M, Kumamoto K, Takenoshita S, Harris CC.,Reviewing the current classification of inhibitor of growth family proteins.,Cancer Sci.,2009.07 [URL]. |
| 2. | Unoki M, Kumamoto K, Harris CC.,ING proteins as potential anticancer drug targets.,Curr Drug Targets.,2009.05 [URL]. |
| 3. | Unoki M, Brunet J, Mousli M.,Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis.,Biochem Pharmacol.,2009.11 [URL]. |
| 4. | Motoko Unoki,Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers.,Recent Pat Anticancer Drug Discov.,2011.01 [URL]. |
Papers
| 1. | Motoko Unoki, Akiko Masuda, Naoshi Dohmae, Kyohei Arita, Masanori Yoshimatsu, Yukiko Iwai, Yoshinori Fukui, Koji Ueda, Ryuji Hamamoto, Masahiro Shirakawa, Hiroyuki Sasaki, Yusuke Nakamura,Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6),J Biol Chem,Vol.288,No.9,2013.03 [URL]. |
| 2. | Unoki M, Daigo D, Koinuma J, Tsuchiya E, Hamamoto R, Nakamura Y.,UHRF1 is a novel diagnostic marker of lung cancer. ,Br. J. Cancer,Vol.103,No.2,pp.217-22,2010.07 [URL]. |
| 3. | Unoki M, Kelly JD, Neal DE, Ponder BAJ, Nakamura Y, Hamamoto R.,UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.,Br. J. Cancer,Vol.101,No.1,pp.98-106,2009.07 [URL]. |
| 4. | Unoki M, Kumamoto K, Robles AI,Shen JC,Zheng ZM, Harris CC.,A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.,FEBS Letters,Vol.582,No.28,pp.3868-74,2008.11 [URL]. |
| 5. | Unoki M, Bronner C, Mousli M.,A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.,Radiat Res.,Vol.169,No.2,pp.240-4,2008.02 [URL]. |
| 6. | Unoki M, Shen JC, Zheng ZM, Harris, CC.,Novel splice variants of ING4 and their possible roles in regulation of cell growth and motility. ,J Biol Chem.,Vol.281,No.45,pp.34677-86,2006.11 [URL]. |
| 7. | Unoki M, Nishidate T, Nakamura Y.,ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.,Oncogene,Vol.23,No.46,pp.7601-10.,2004.10 [URL]. |
| 8. | Unoki M, Nakamura Y.,Methylation at CpG-islands in intron1 of EGR2 confers enhancer-like activity.,FEBS Lett.,Vol.554,No.1-2,pp.67-72,2003.11 [URL]. |
| 9. | Unoki M, Okutsu J, Nakamura Y. ,Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia.,Int J Oncol.,Vol.22,No.6,pp.1217-23,2003.06 [URL]. |
| 10. | Unoki M, Nakamura Y.,EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK.,Oncogene,Vol.22,No.14,pp.2172-85.,2003.04 [URL]. |
| 11. | Unoki M, Nakamura Y.,Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.,Oncogene,Vol.20,No.33,pp.4457-65,2001.07. |
| 12. | Unoki M, Furuta S, Onouchi Y, Watanabe O, Doi S, Fujiwara H, Miyatake A, Fujita K, Tamari M, Nakamura Y.,Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene.,Hum Genet.,Vol.106,No.４,pp.440-6,2000.04 [URL]. |
Presentations
| 1. | We identified a hydroxylase JMJD6 as a member of the UHRF1 complex, which works around nucleosomes, and found that JMJD6 hydroxylates histone lysine residues in vitro. We also revealed that histones purified from Jmjd6 wild-type mouse embryos include 5-hydroxylysine, but those purified from Jmjd6 knockout mouse embryos do not include it, indicating that Jmjd6 is a hydroxylase, which hydroxylates lysine residues of histones in vivo. Currently, we are studying biological significance of this novel histone modification.. |
- The genetics society of Japan
- The Japan Society of Human Genetics
- The molecular biology society of Japan
- The Japanese Society for Epigenetics
- American Association for Cancer Research
- Japanese Cancer Association
Educational
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