Kyushu University Academic Staff Educational and Research Activities Database
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DAISUKE SUGIYAMA Last modified date:2019.06.19

Professor /


Other Organization
Administration Post
Other
Other
Other


E-Mail
Homepage
http://www.med.kyushu-u.ac.jp/crc/english/index.html
Center for Clinical and Translational Research(CCTR) .
http://wat-new.org/
West Japan Academia Translational Research Network .
http://jisedai.med.kyushu-u.ac.jp/
Department of Research and Development of Next Generation Medicine .
Phone
092-642-6210
Fax
092-642-6146
Academic Degree
PhD
Country of degree conferring institution (Overseas)
No
Field of Specialization
Hematology,Developmental Biology,Stem Cell Biology, Laboratory medicine, Industry-university cooperation, Clinical study
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • 1)Analysis on hematopoietic development (especially on hematopoietic stem cell and erythropoiesis)
    2)Development of medical seeds of medical drugs and diagnostic products.
    keyword : stem cells
    2006.10~2015.03.
Academic Activities
Books
1. Sugiyama D, Sasaki T, Isolation of embryonic hematopoietic niche cells by flow cytometry and laser capture microdissection., Methods Mol Biol, 1035:57-65.
2. Sugiyama D, Inoue T, Kulkeaw K., Stem cell maintenance in embryos and adults., Year Book of SCIENCE & TECHNOLOGY 2011 (McGRAW-HILL) , 258-261.
Reports
1. Sugiyama D, Tanaka Y, Yumine A, and Kojima N., Embryonic regulation of the mouse erythropoietic niche and its clinical application., Rinsho Ketsueki, 57(7):944-950, 2016.07, [URL].
2. Swain A, Inoue T, Tan KS, Nakanishi Y, Sugiyama D., Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver., HISTOLOGY AND HISTOPATHOLOGY, 29(9):1077-82, 2014.09, [URL].
3. Sugiyama D, Inoue-Yokoo T, Fraser ST, Kulkeaw K, Mizuochi C, Horio Y., Embryonic regulation of the mouse hematopoietic niche., ScientificWorldJournal, 11:1770-80, 2011.01, [URL].
4. Sugiyama D, Tsuji K., Definitive hematopoiesis from endothelial cells in the mouse embryo; a simple guide., Trends Cardiovasc Med, 16(2):45-9, 2006.02, [URL].
5. Sugiyama D, Tanaka Y, Yumine A, and Kojima N., Embryonic regulation of the mouse erythropoietic niche and its clinical application., Rinsho Ketsueki, 57(7):944-950, 2016.07, [URL].
6. Swain A, Inoue T, Tan KS, Nakanishi Y, Sugiyama D., Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver., HISTOLOGY AND HISTOPATHOLOGY, 29(9):1077-82, 2014.09, [URL].
7. Sugiyama D, Inoue-Yokoo T, Fraser ST, Kulkeaw K, Mizuochi C, Horio Y., Embryonic regulation of the mouse hematopoietic niche., ScientificWorldJournal, 11:1770-80, 2011.01, [URL].
8. Sugiyama D, Tsuji K., Definitive hematopoiesis from endothelial cells in the mouse embryo; a simple guide., Trends Cardiovasc Med, 16(2):45-9, 2006.02, [URL].
Papers
1. Shigeto J, Ichiki T, Nii T, Konno K, Nakanishi Y, Sugiyama D., Preclinical toxicity studies for regenerative medicines in Japan, Clinical Therapeutics, 2018.12.
2. Kulkeaw K, Tomoko Inoue T, Ishitani T, Nakanishi Y, Zon L.I and Sugiyama D., Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis, Brit J Haematol, 180:420-431, 2018.02.
3. Tan KS, Kulkeaw K, Nakanishi Y, Sugiyama D., Expression of cytokine and extracellular matrix mRNAs in fetal hepatic stellate cells., Genes to Cells, 22(9):836-844, 2017.08.
4. Kulkeaw K, Inoue T, Iino T, Tani K, Akashi K, Speck N, Nakanishi Y, Sugiyama D. , Twist1 regulates embryonic hematopoietic differentiation through binding to Myb and Gata2 promoter regions., Blood Advances, 1(20):1672-1681, 2017.08.
5. Hoong L.K, Mahdzir M.A, Din M.F, Awang K, Tanaka Y, KASEM KULKEAW, Ishitani T, DAISUKE SUGIYAMA, Induction of intrinsic apoptosis in leukaemia stem cells and in vivo zebrafish model by betulonic acid isolated from Walsura pinnata Hassk (Meliaceae), Phytomedicine, 26:11-21, 2017.03.
6. Sugiyama D, Joshi A, Kulkeaw K, Tan K.S, Yokoo-Inoue T, Mizuochi-Yanagi C, Yasuda K, Doi A, Iino T, Itoh M, Nagao-Sato S, Tani K, Akashi K, Hayashizaki Y, Suzuki H, Kawaji H, Carninci P. Forrest A.R., A Transcriptional Switch Point During Hematopoietic Stem and Progenitor Cell Ontogeny., Stem Cells Dev, 26(5):314-327, 2017.03.
7. Sasaki T,Tanaka Y,Kulkeaw K,Yumine A,Tan Keai-Sinn,Nishinakamura R,Ishida J,Fukamizu A,Sugiyama D., Embryonic intra-aortic clusters undergo myeloid differentiation mediated by mesonephros-derived CSF1 in mouse, Stem Cell Reviews and Reports, 12(5):530-542, 2016.10.
8. Swain A, KulkeawK, Tanaka Y, Nakanishi Y, Shirasawa S, Sugiyama D., DBA Lectin Binds to Highly Proliferative Mouse Erythroleukemia Cells, Anticancer Research, 36(7):3625-33., 2016.07.
9. Koide R, Kulkeaw K, Tanaka Y, Swain A, Nakanishi Y, Sugiyama D., Aryl Hydrocarbon Receptor Antagonist StemRegenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4., Anticancer Research, 36(7):3635-3643, 2016.07.
10. Tanaka Y, Inoue-Yokoo T, Kulkeaw K, Yanagi-Mizuochi C, Shirasawa S, Nakanishi Y and Sugiyama D., Embryonic hematopoietic progenitors cells reside in muscle before bone marrow hematopoiesis., PLoS One, 10(9):e0138621, 2015.09.
11. Kojima N, Tanaka Y, Kulkeaw K, Nakanishi Y, Shirasawa S, Sugiyama D., Apoptosis-inducing Factor, Mitochondrion-associated 2, Regulates Klf1 in a Mouse Erythroleukemia Cell Line., Anticancer Res, 35(8):4493-9, 2015.08.
12. Yonehara A, Tanaka Y, Kulkeaw K, Era T, Nakanishi Y, Sugiyama D., Aloe vera Extract Suppresses Proliferation of Neuroblastoma Cells In Vitro., Anticancer Res, 35(8):4479-85, 2015.08.
13. Tan KS, Inoue T, Kulkeaw K, Tanaka Y, Lai MI, Sugiyama D., Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos., Biol Open, 4(5):596-607, 2015.04.
14. Tanaka Y, Kulkeaw K, Inoue T, Tan KS, Nakanishi Y, Shirasawa S, Sugiyama D., Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells., Anticancer Res, 34(8):4561-7, 2014.08.
15. Inoue T, Swain A, Nakanishi Y, Sugiyama D., Multicolor analysis of cell surface marker of human leukemia cell lines using flow cytometry., Anticancer Res, 34(8):4539-50., 2014.08.
16. Inoue T, Kulkeaw K, Muennu K, Tanaka Y, Nakanishi Y, Sugiyama D., Herbal drug ninjin'yoeito accelerates myelopoiesis but not erythropoiesis in vitro., Genes Cells, 19(5):432-40, 2014.05.
17. Sugiyama D, Sasaki T., Isolation of embryonic hematopoietic niche cells by flow cytometry and laser capture microdissection., Methods Mol Biol, 1035:57-65, 2013.06.
18. Sugiyama D, Kulkeaw K, Mizuochi C., TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts., Mech Dev, 130(2-3):195-206, 2013.02.
19. Mizuochi C, Fraser ST, Biasch K, Horio Y, Kikushige Y, Tani K, Akashi K, Tavian M, Sugiyama D., Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis., PLoS One, 7(4):e35763, 2012.04.
20. Kulkeaw K, Inoue T, Mizuochi C, Horio Y, Ishihama Y, Sugiyama D., Ectopic expression of Hmgn2 antagonizes mouse erythroid differentiation in vitro., Cell Biol Int, 36(2):195-202, 2012.02.
21. Inoue T, Kulkeaw K, Okayama S, Tani K, Sugiyama D., Variation in mesodermal and hematopoietic potential of adult skin-derived induced pluripotent stem cell lines in mice., Stem Cell Rev, 7(4):958-68, 2011.11.
22. Sugiyama D, Kulkeaw K, Mizuochi C, Horio Y, Okayama S., Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production., Biochem Biophys Res Commun, 410(2):301-6, 2011.07.
23. Kulkeaw K, Ishitani T, Kanemaru T, Ivanovski O, Nakagawa M, Mizuochi C, Horio Y, Sugiyama D., Cold exposure down-regulates zebrafish pigmentation., Genes Cells, 16(4):358-67, 2011.04.
24. Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D., Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse., Development, 137(23):3941-52, 2010.12.
25. Kulkeaw K, Horio Y, Mizuochi C, Ogawa M, Sugiyama D., Variation in hematopoietic potential of induced pluripotent stem cell lines., Stem Cell Rev, 6(3):381-9, 2010.09.
26. Kulkeaw K, Ishitani T, Kanemaru T, Fucharoen S, Sugiyama D., Cold exposure down-regulates zebrafish hematopoiesis., Biochem Biophys Res Commun, 394(4):859-64, 2010.04.
27. Ivanovski O, Kulkeaw K, Nakagawa M, Sasaki T, Mizuochi Ch, Horio Y, Ishitani T, Sugiyama D., Characterization of kidney marrow in zebrafish (Danio rerio) by using a new surgical technique., Prilozi, 30(2):71-80, 2009.12.
28. Kulkeaw K, Mizuochi C, Horio Y, Osumi N, Tsuji K, Sugiyama D., Application of whole mouse embryo culture system on stem cell research., Stem Cell Rev, 5(2):175-80, 2009.06.
29. Talebian L, Li Z, Guo Y, Gaudet J, Speck ME, Sugiyama D, Kaur P, Pear WS, Maillard I, Speck NA., T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage., Blood, 109(1):11-21, 2007.01.
30. Sugiyama D, Arai K, Tsuji K., Definitive hematopoiesis from acetyl LDL incorporating endothelial cells in the mouse embryo., Stem Cells Dev, 14(6):687-96, 2005.12.
31. Sugiyama D, Ogawa M, Hirose I, Jaffredo T, Arai K, Tsuji K., Erythropoiesis from acetyl LDL incorporating endothelial cells at the preliver stage., Blood, 101(12):4733-8, 2003.06.
Presentations
1. Sugiyama D., Bioactive SL-13R peptide expands human umbilical cord blood hematopoietic stem cells and maintains long-term reconstitution ability, CiRA 2017 International Symposium:Notification of Abstract Acceptance, 2017.11.
2. Daisuke Sugiyama, Ayako Yumine, and Yoichi Nakanishi, Bioactive SL-13R peptide expands human umbilical cord blood hematopoietic stem cells and maintains long-term reconstitution ability, 2nd International Conference on Stem Cells, 2017.09.
3. Sugiyama D., Embryonic regulation of the mouse hematopoietic niche and implications for haematotherapy, TRANSLATIONAL MEDICINE 2017, 2017.09.
4. Sugiyama D., Thoughts on the career paths of researchers; A case study of a bio-active peptide expanding hematopoietic stem cells., knowledge for Growth, 2017.03.
Membership in Academic Society
  • International Society of Clinical Medicine
  • American Physiological Society
  • American Society of Hematology
  • Japan society for Regenerative Medicine
  • Japanese Society of Clinical Pharmacology and Therapeutics
  • Japan Society of Clinical Trials and Research
  • Japanese Society of Laboratory Medicine
  • Physiological Society of Japan
  • Japanese Society of Hematology
  • Japanese Society of Internal Medicine
Educational
Educational Activities
Department of Translational Research Promotion Incubation Center for Advanced Medical Science