Kyushu University Academic Staff Educational and Research Activities Database
List of Presentations
Ando Koji Last modified date:2019.05.30

Assistant Professor / Gastrointestinal Surgery (2) / Kyushu University Hospital


Presentations
1. Koji Ando, Qingjian Hu, Yasuo Tsuda, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki and Masaki Mori, Experience of Side-to-Side Anastomosis, Circular Side-Stapling Technique During Laparoscopic Anterior Resection in Our Institute: Experience of Over One Hundred Cases, SSO 2019, 2019.03.
2. 安藤 幸滋, 沖 英次, 佐伯 浩司, Significance of mortalin expression in gastric cancer with normal p53, 2012 ASCO GI, [Background] Gastric cancer still has the highest morbidity rate and the second highest mortality rate. As chemotherapy confers only a minimal survival advantage, the prognosis of patients with advanced or recurrent gastric cancer remains poor. Studying the mechanisms and underlying molecules that drives gastric cancer malignant, could contribute to finding a remedy for gastric cancer. Mortalin is a heat non-inducible member of the heat shock protein 70 family. Mortalin binds to p53 and prevents p53 from entering the nucleus, as well as cell stress. To understand the significance of mortalin in gastric cancer, we investigated the expression of mortalin and p53.
[Methods] The expression of mortalin and p53 were examined by immunohistochemical staining of 182 clinical samples of gastric cancer.
[Results] Mortalin-positive and aberrant-p53-positive samples were found in 75.2% and 62.6% of cases, respectively. Mortalin-positive tumors were deeper in invasion and had more lymph node and liver metastases compared with mortalin-negative tumors (p < 0.01, p < 0.05, respectively). Mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (p = 0.035). Moreover, in tumors with normal p53 expression, mortalin-positive tumors had especially worse prognosis compared with mortalin-negative tumors (p = 0.013). With multivariate analysis, mortalin expression appeared to be an independent prognostic factor in gastric cancer with expression of normal p53 (p = 0.0174).
[Conclusions] Mortalin has a great impact on gastric cancer with normal p53. Therefore, mortalin is a target molecule for treatment of gastric cancer, as well as a promising prognostic factor, especially in tumors with normal p53. .
3. 安藤 幸滋, 沖 英次, 池田 哲夫, 佐伯 浩司, 山下 洋市, 池上 徹, 吉住 朋晴, Evaluation of “Pure laparoscopic simultaneous resection of colorectal cancer and liver metastases” –a comparative study to open surgery-, 60th International College of Surgeons Japan Section, Introduction Laparoscopic surgery is an accepted choice for resecting colorectal cancers and liver metastases. However, there are few reports on simultaneous resection of primary colorectal cancer and synchronous liver metastases. In this study, we report the feasibility of simultaneous resection of colorectal cancer and liver metastases under laparoscopic surgery.
Method 15 patients underwent simultaneous resection by either open surgery or pure laparoscopic simultaneous resection; PULSAR-CL, between 2007 and 2012 in our institute. The perioperative outcomes; duration of surgery, blood loss, complication and hospital stay were compared.
Results Six cases underwent open surgery and nine cases underwent PULSAR-CL. There was no significant difference in duration of surgery between open surgery and PULAR-CL. PULSAR-CL had less blood loss and tend to have shorter hospital stay compared to open surgery (P=0.019 and P=0.11, respectively). Open surgery had postoperative complication in five cases (83.3%) and PULSAR-CL in one case (11.1%).
Discussion PULSAR-CL had better perioperative outcomes compared to open surgery in resecting both primary colorectal cancer and synchronous liver metastases. PULSAR-CL may be one choice for multidisciplinary treatment in colorectal cancer cases with liver metastases..