Kyushu University Academic Staff Educational and Research Activities Database
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Eikichi Ihara Last modified date:2019.06.19

Assistant Professor / Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Department of Hepatology and Pancreatology
Kyushu University Hospital


Graduate School
Undergraduate School


Academic Degree
MD, PhD
Field of Specialization
Gastroenterology, Gastrointestinal motility
Outline Activities
Outline of research:
Coordinated regulation of gastrointestinal (GI) motility contributes to general health and wellness when functioning normally but is also associated with morbidity and mortality when dysfunctional. Alterations in GI motility with resultant changes in transit can contribute to abdominal pain, intestinal cramping, diarrhea, constipation and urgency to defecate.The GI smooth muscle itself plays an important role in gastrointestinal (GI) motility. In overt inflammatory conditions of the bowel, such as infectious colitis and inflammatory bowel disease (IBD), there have been longstanding observations of altered motility and impaired function of the GI smooth muscle. While the inflammatory mediators are known to affect GI smooth muscle and impaired gastrointestinal motility, it still remains to be investigated how the inflammatory mediators affects GI smooth muscle. The research goals are to those mechanisms which possibly lead to generation of novel therapeutics for patients with GI motility disorders.
Education:
I give lectures on gastroenterology to medical students in kyushu university. I also instruct, supervise and evaluate their clinical trainings. Alternatively, I teach gastroenterological endoscopy and radiology to gastroenterology trainees.
Research
Research Interests
  • Etiology and pathogenesis of esophageal motility disorders and their novel treatments
    keyword : Esophageal motility disorder, high-resolution manometry
    2016.04~2021.03.
  • The underlying mechanisms of regulation of lower esophageal sphincter tone.
    keyword : Lower esophageal sphincter、Mechanism of smooth muscle contraction、Myogenic tone regulation、Rho kinase
    2016.04~2021.03.
  • To elucidate the pathogenesis of Gastroesophageal reflux disease and Esophageal motility disorders
    keyword : High resolution manometry、Esophageal impedance-pH monitoring、Gastroesophageal reflux disease、Esophageal motility disorders
    2016.04~2021.03.
  • The underlying mechanisms by which intestinal inflammation associated with various gastrointestinal (GI) disorders impairs contractile function of intestinal smooth muscle and GI motility.
    keyword : altered GI motility, intestinal smooth muscle, intestinal inflammation
    2016.04~2021.03.
Academic Activities
Reports
1. Ihara E, Akiho H, Nakamura K, Turner SR, MacDonald JA, MAPK signaling pathways represent a possible ideal target for generation of novel therapeutics for patients with gastrointestinal motility disorders. , World J Gastrointest Pathophysiol 2:19-25, 2011.07.
2. Akiho H, Ihara E, Nakamura. K, Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. , World J Gastrointest Pathophysiol 1:97-105, 2010.07.
3. Ihara E and MacDonald JA, The regulation of smooth muscle contractility by zipper-interacting protein kinase. , Can J Physiol Pharmacol 85: 79-87., 2007.07.
Papers
1. Takashi Osoegawa, Yosuke Minoda, Eikichi Ihara, Keishi Komori, Aso Akira, Ayako Goto, Soichi Itaba, Haruei Ogino, Kazuhiko Nakamura, Naohiko Harada, Kosuke Makihara, Shinichi Tsuruta, Hidetaka Yamamoto, Yoshihiro Ogawa, Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions
A randomized cross-over study, Digestive Endoscopy, 10.1111/den.13367, 2019.01.
2. Keishi Komori, Eikichi Ihara, Yosuke Minoda, Haruei Ogino, Taisuke Sasaki, Minako Fujiwara, Yoshinao Oda, Yoshihiro Ogawa, The Altered Mucosal Barrier Function in the Duodenum Plays a Role in the Pathogenesis of Functional Dyspepsia, Digestive Diseases and Sciences, 10.1007/s10620-019-5470-8, 2019.01.
3. Keita Fukaura, Eikichi Ihara, Haruei Ogino, Yoichiro Iboshi, Kazumasa Muta, Bai Xiaopeng, Shohei Hamada, Yoshitaka Hata, tsutomu iwasa, Akira Aso, Kazuhiko Nakamura, Yoshihiro Ogawa, Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function, Digestion, 10.1159/000487708, 95-103, 2018.04.
4. Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa, Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger, CMGH Cellular and Molecular Gastroenterology and Hepatology, 10.1016/j.jcmgh.2017.11.004, 5, 3, 209-221, 2018.03.
5. Bai Xiaopeng, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Kayoko Nakano, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body, European Journal of Pharmacology, 10.1016/j.ejphar.2017.01.004, 797, 65-74, 2017.01.
6. Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Yoshimasa Tanaka, Xiaopeng Bai, Akira Aso, tsutomu iwasa, Kazuhiko Nakamura, New Approach to Diagnosis and Treatment of Esophageal Motility Disorders by High-Resolution manometry, Fukuoka Acta Medica, 107, 7, 121-130, 2016.07.
7. Tanaka Y, Ihara E, Nakamura K, Muta K, Fukaura K, Mukai K, Bai X, Takayanagi R, Clinical characteristics associated with esophageal motility function., J Gastroenterol Hepatol, 10.1111/jgh.13262., 31, 1133-1140, 2016.06.
8. Muta K, Ihara E, Fukaura K, Nakamura K, Tsuchida O, Ochiai T, Effects of acotiamide on esophageal motility function in patients with esophageal motility disorders:a pilot study., Digestion, 94, 1, 9-16, 2016.06.
9. Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Shunsuke Takahashi, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Yoshinao Oda, Ryoichi Takayanagi, Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter, European Journal of Pharmacology, 10.1016/j.ejphar.2015.02.008, 752, 97-105, 2015.04.
10. Ihara E, Yu Q, Chappellaz M, MacDonald JA, ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction, NEUROGASTROENTEROLOGY AND MOTILITY, 10.1111/nmo.12491, 27, 1, 135-146, 2015.01.
11. Iboshi Y, Kazuhiko Nakamura, Ihara E, Iwasa T, AKiho H, Harada N, Makamuta M, Ryoichi Takayanagi, Multigene analysis unveils distinctive expression profiles of helper T-cell-related genes in the intestinal mucosa that discriminate between Ulcerative colitis and Crohn's disease, Inflamm Bowel Dis, 20, 967-977, 2014.06.
12. Aso A, Ihara E, Osoegawa T, Nakamura K, Itaba S, Igarashi H, Ito T, Aishima S, Oda Y, Tanaka M, Takayanagi R, Key endoscopic features of pancreatic ductal adenocarcinoma smaller than 20 mm, Scand J Gastroenterol, 49, 332-338, 2014.03.
13. Ihara E, Matsuzaka H, Honda K, Hata Y, Sumida Y, Akiho H, Misawa T, Toyoshima S, Chijiiwa Y, Nakamura K, Takayanagi R, Mucosal-incision assisted biopsy for suspected gastric gastrointestinal stromal tumors., World J Gastrointest Endosc, doi: 10.4253/wjge.v5.i4.191., 5, 191-196, 2013.04.
14. Higuchi N, Nakamura K, Ihara E, Akahoshi K, Akiho H, Sumida Y, Motomura Y, Kubokawa M, Ito T, Takayanagi R, Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection., J Gastroenterol Hepatol, doi: 10.1111/jgh.12086., 28, 494-498, 2013.03.
15. Ihara E, Chappellaz M, Turner SR, MacDonald JA, Contribution of Protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. , Neurogastroenterol Motil, 24, e15-26, 2012.01.
16. Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R, CD4+CD25+ Regulatory T Cells Suppress Th17-Responses in an Experimental Colitis Model. , Dig Dis Sci , 57, 497-500, 2011.01.
17. Beck, P. L., Ihara, E., Hirota, S. A., Macdonald, J. A., Meng, D., Nanthakumar, N. N., Podolsky, D. K. & Xavier, R. J, Exploring the Interplay of Barrier Function and Leukocyte Recruitment in Intestinal Inflammation by Targeting Fucosyltransferase VII and Trefoil Factor 3. , Am J Physiol Gastrointest Liver Physiol, 299, G43-53, 2010.07.
18. Ihara E, Moffat L, Borman MA, Amon JE, Walsh MP and MacDonald JA, Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide. , Am J Physiol Gastrointest Liver Physiol, 297, G361-370, 2009.07.
19. Ihara E, Beck PL, Chappellaz M, Wong J, Medlicott SA and MacDonald JA, Mitogen-activated protein kinase pathways conribute to hypercontractility and increased Ca2+-sensitization in murine experimental colitis. , Mol Pharmacol, 75, 1031-1041, 2009.07.
20. Ihara E, Edwards E, Borman MA, Wilson DP, Walsh MP and MacDonald JA, Inhibition of zipper-interacting protein kinase function in smooth muscle by a myosin light chain kinase pseudosubstrate peptide. , Am J Physiol Cell Physiol, 292, C1951-1959, 2007.07.
21. Ihara E, Moffat L, Ostrander J, Walsh MP and MacDonald JA, Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle. , Am J Physiol Gastrointest Liver Physiol, 293, G699-710, 2007.07.
22. Ihara E, Hirano K, Derkach DN, Nishimura J, Nawata H, Kanaide H, The mechanism of bradykinin-induced endothelium-dependent contraction and relaxation in the porcine interlobar renal artery. , Br J Pharmacol, 10.1038/sj.bjp.0703141, 129, 5, 943-952, 2000.07.
23. Ihara E, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H, Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta. , J Cell Biochem, 10.1002/jcb.10295, 87, 2, 242-251, 2002.07.
24. Derkach DN, Ihara E, Hirano K, Nishimura J, Takahashi S, Kanaide H, Thrombin causes endothelium-dependent biphasic regulation of vascular tone in the porcine renal interlobar artery. , Br J Pharmacol 2000;131, 10.1038/sj.bjp.0703737, 131, 8, 1635-1642, 2000.07.
25. Ihara E, Hirano K, Nishimura J, Nawata H, Kanaide H, Thapsigargin-induced endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery. , Br J Pharmacol, 10.1038/sj.bjp.0702821, 128, 3, 689-699, 1999.07.
Presentations
1. Hamada S, Ihara E, Muta K, Ikeda H, Mukai K, Otsuka Y, Hata Y, Ogino H, Takatoshi Chinen and Ogawa Y., Significant difference in the proportion of underlying diseases between conventional proton pump inhibitors and vonoprazan refractory gastroesophageal refluc disease., Digestive Disease Week, 2019.05.
2. Ikeda H, Ihara E, Hamada S, Muta K, Fukaura K, Otsuka Y, Hata Y, Mukai K, Komori K, Ogino, H Chinen T and Ogawa Y., Impaired esophagogastric junction recessive relaxation plays a central role in esophageal motility disorders associated with systemic scleroderma., Digestive Disease Week, 2019.05.
3. Ihara E, Muta K, Bai X, Hamada S, Ikeda H, Komori K, Ogino H, Chinen T, and Ogawa Y., Elevation of basal EGJ pressure is associated with low-efficacy of acotiamide for the patients with EGJ outflow obstruction., Digestive Disease Week, 2019.05.
4. Muta K, Ihara E, Fukaura K, Bai X, Hata Y, Ogino H, Ochiai T, Nakamura K and Ogawa Y., Both incomplete LES relaxation and premature contraction of esophageal body are characteristics of dry swallow., Digestive Disease Week, 2018.06.
5. Muta K, Ihara E, Hamada S, Fukaura K, Bai X, Otsuka Y, Ogino H, Bai X, Mukai K, Komori K, Hata Y, Mukai K, Komori K, Iwasa T, Akiho H, Nakamura K and Ogawa Y., Mucosally expressed protease-activated receptor2 and transient receptor potential vanilloid1 are associated with functional heartburn., Digestive Disease Week, 2018.06.
6. Minoda Y, Osoegawa T, Itaba S, Aso A, Iwasa T, Ogino H, Harada N, Ihara E, Nakamura K and Ogawa Y., Endoscopic ultrasound-guided fine needle aspiration v.s. a mucosal incision-assisted biopsy for gastric submucosal tumors: a randomized comparative study., Digestive Disease Week, 2018.06.
7. Hamada S, Ihara E, Muta K, Fukaura K, Ogino H, Bai X, Mukai K, Otsuka Y, Komori K, Hata Y, Aso A, Iwasa T, Ochiai T, Akiho H, Nakamura K and Ogawa Y., The esophageal intraluminal baseline impedance differentiates reflux hypersensitivity from NERD., Digestive Disease Week, 2018.06.
8. Bai X, Ihara E, Otsuka Y, Ogino H, Akiho H, Nakamura K and Ogawa Y., Nicotine caused the dual regulation of tone in the porcine lower esophageal sphincter through excitatory and inhibitory enteric innervation., Digestive Disease Week, 2018.06.
9. Muta K, Ihara E, Fukaura K, Bai X, Ochiai T, Tsutomu Iwasa, Aso A, Kazuhiko Nakamura, Lower esophageal sphincter (LES) receptive relaxation is indispensable for successful LES relaxation in wet swallowing., Digestive Disease Week 2017, 2017.05.
10. Otsuka Y, Bai X, Ihara E, Kazuhiko Nakamura, Ogawa Yoshihiro, Rho kinase-associated myogenic contraction compensates for reduced force induced by release after stretching in the porcine lower esophageal sphincter., Digestive Disease Week 2017, 2017.05.
11. Hata Y, Ihara E, Fukaura K, Muta K, Bai X, Tsutomu Iwasa, Aso A, Kazuhiko Nakamura, Ogawa Yoshihiro, Esophagogastric junction outflow obstruction is discriminated from achalasia by esophageally expressed cytokine profiles using linear discriminant analysis., Digestive Disease Week 2017, 2017.05.
12. Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Kazuhiko Nakamura, Akiho H, Trypsin induced a transient contraction via a PAR2/TRPV1/neurokinin receptors pathway in circular smooth muscle of porcine esophageal body., Digestive Disease Week 2016, 2016.05.
13. Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Kazuhiko Nakamura, Involvement of different subtypes of receptor in prostaglandin E2-induced motile function in lower esophageal sphincter and esophageal body smooth muscle. , Digestive Disease Week 2016, 2016.05.
14. Muta K, Ihara E, Fukaura K, Bai X, Tanaka Y, Iwasa T, Aso A, Tsuchida O, Ochiai T, Kazuhiko Nakamura, Mechanisms of acotiamde-sensitive impaired lower esophageal sphincter accommodation in patients with esophagogastric junction outflow obstruction. , Digestive Disease Week 2016, 2016.05.
15. Ihara E, Fukaura K, Muta K, Tanaka Y, Bai X, Iwasa T, Aso A, Akiho H, Kazuhiko Nakamura, Protease-activated receptor expression in the esophagus is associated with esophageal mucosal integrity and esophageal motility function., Digestive Disease Week 2016, 2016.05.
16. Fukaura K, Ihara E, Muta K, Tanaka Y, Bai X, Nakamura K, Takayanagi R, The cytokine expression patterns of esophageal mucosa are associated with esophageal motility function in human., Digestive Disease Week 2015, 2015.05.
17. Tanaka Y, Ihara E, Muta K, Fukaura K, Mukai K, Bai X, Nakamura K, Akiho H, Takayanagi R, Clinical characteristics associated with function of esophageal motility: A retrospective analysis of 97 patients., Digestive Disease Week 2015, 2015.05.
18. Muta K, Ihara E, Fukaura K, Bai X, Tanaka Y, Nakamura K, Ochiai T, Tsuchida O, Akiho H, Takayanagi R, Actiamide has the potential to become a promising treatment for patients with esophagogastric junction outflow obstruction., Digestive Disease Week 2015, 2015.05.
19. Bai X, Ihara E, Tanaka Y, Hirano K, Hirano M, Akiho H, Nakamura K, Takayanagi R, Endogenous H2S contributes to myogenic tone generation in lower esophageal sphincter: Possible involvement of Na+/Ca2+ exchanger., Digestive Disease Week 2015, 2015.05.
20. Ihara E, Fukaura K, Muta K, Tanaka Y, Bai X, Kazuhiko Nakamura, Ryoichi Takayanagi, Expression levels of cytokines, including IL-23, IL-1β, and IFN-γ, in esophageal mucosa are strongly predictive of esophageal body contractility in human., Canadian Digestive Disease Week, 2015.03.
21. Osoegawa T, Ihara E, Kazuhiko Nakamura, Kubo H, Aso A, Niina Y, Sawamura N, Hijioka M, Igarashi H, Ito T, Tanaka M, Ryoichi Takayanagi, Usefulness and safety of endoscopic ultrasonography-guided drainage for postoperative pancreatic fistulas., 22nd United European Gastroenterology Week, 2014.10.
22. Kazumasa Muta, Eikichi Ihara, Xiaopeng Bai, Yoshimasa Tanaka, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Acotiamide, a novel prokinetic drug reduces both esophageal body contractility and the tone of the lower esophageal sphincter., Digestive Disease Week, 2014.05.
23. Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Different contractile and relaxant effects of trypsin in phasic smooth muscle of the esophageal body and the tonic lower esophageal sphincter., Digestive Disease Week, 2014.05.
24. Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, mayumi hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Trypsin induced biphasic contraction and relaxation in the porcine lower esophageal sphincter., Digestive Disease Week, 2013.05.
25. Ihara E, Honda K, Hata Y, Sumida Y, Akiho H, Nakamura K and Takayanagi R., Preoperative tissue sampling of suspected gastric gastrointestinal stromal tumors by mucosal incision assisted biopsy., Digestive Disease Week,, 2012.05.
26. Kazuko Stoh, Yohei Tokita, Mitsue Nishiyama, Hirotada Akiho, Kazuhiko Nakamura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto, IL-17 is critically involved in post-inflammatory gut hypermotility., Digestive Disease Week 2012, 2012.05.
27. Hirotada Akiho, Mitsue Nishiyama, Yohei Tokita, Kazuko Satoh, Hirotada Akiho, Kazuhiko Nakamura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto, IL-17 suppresses RGS4 translocation in primary cultured intestinal smooth muscle cells via IκBζ signaling: an indication of a mechanism of IL-17-induced gut hypermotility., Digestive Disease Week 2012, 2012.05.
28. ERK and p38MAPK regulate myosin light chain phosphatase and contribute to carbachol-induced contraction in rat intestinal smooth muscle. .
29. Hypoxia Inducible Factor (HIF-1alpha) Plays a Critical Innate Protective Role in Clostridium Difficile (Cdif) Toxin-Induced Intestinal Injury and Inflammation..
30. Protein kinase signaling pathways contribute to hypercontractility in murine experimental colitis..
31. Pharmacological stabilization of HIF-1a is protective in a mouse model of clostridium difficile-associated intestinal inflammation..
32. Up-regulation of HIF-1alpha is associated with augmented Rho-kinase-mediated contraction of ileal smooth muscle following exposure to Clostridium difficile toxins in a mouse ileal loop model. .
33. Alterations in the contractile properties of ileal smooth muscle exposed to Clostridium difficile toxins: the involvemen.
34. Ca2+-sensitization of colonic smooth muscle is altered in a murine experimental colitis model. .
35. Colonic smooth muscle contractile dysfunction in experimental colitis and its underlying mechanisms. .
36. Protein kinases responsible for Ca2+-independent contraction of intestinal smooth muscle..
37. Exploration of protein kinases responsible for Ca2+-independent, microcystin-induced contraction in intestinal smooth muscle. .
38. The Useful Approach to Obstructing or Stenotic Lesions in the Distal Ileum by Retrograde Ileography. .
39. Endothelium-dependent triphasic regulation of vascular tone induced by bradykinin in the porcine renal artery. .
Membership in Academic Society
  • Japanese Society of Internal Medicine
  • Japanese Society of Gastroenterology
  • Japanese Gastroenterological Endoscopy Society
  • Japanese Gastroenterological Association
  • Japanese Society of Smooth Muscle Research
  • The Japan Esophageal Society
  • American Gastroenterological Association
  • Canadian Association of Gastroenterology
Awards
  • I received an Fukuoka Rinsho Kenkyu Igaku award due to excellent research entitled "Esophageal motility disorders causing non-cardiac chest pain".
  • I was certified as scientific accomplishment of early stage investigator by American Gastroenterological Association at Digestive Disease Week 2016 held in San Diego, U.S.A.
  • Award for the excellent presentation in 52nd annual meeting of Japan Society of Smooth Muscle Research
  • The Pfizer/Smooth Muscle Research Group Post-Doctoral Fellow Research Achievement Award at University of Calgary
  • Post-doctoral award of BMB (Department of Biochemistry & Molecular Biology) at University of Calgary
  • Candadian Association of Gastroenterology/CIHR/AstraZeneca research initiative award
    (C$ 45,000/year for the salary and C$15,000/year for research allowance, for 3 years)
  • Uehara Memorial Foundation research fellowship (¥3,000,000)
  • Visiting Speaker & Postdoctoral Recruitment Travel Award from Alberta Heritage Foundation for Medical Research (AHFMR)
Educational
Educational Activities
I give lectures on "gastroduodenal ulcer disease" and "functional gastrointestinal disorders and gastroduodenal dysfunction associated with chronic inflammation" to medical students in the third year in Kyushu University. I also give a lecture on "symptomatology of internal medicine including hematemesis, melena, diarrhea, constipation" to medical students in the fourth year in Kyushu University. I am an examiner for medical students for physical examination of abdomen in the fourth year. I instruct, supervise and evaluate the clinical training of medical students in the fourth and fifth year.