| Eikichi Ihara | Last modified date：2012.5.28 |
Assistant Professor /
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Department of Hepatology and Pancreatology
Kyushu University Hospital
Department of Hepatology and Pancreatology
Kyushu University Hospital
Graduate School
Undergraduate School
Academic Degree
MD, PhD
Field of Specialization
Gastroenterology, Gastrointestinal motility
Outline Activities
Outline of research:
Coordinated regulation of gastrointestinal (GI) motility contributes to general health and wellness when functioning normally but is also associated with morbidity and mortality when dysfunctional. Alterations in GI motility with resultant changes in transit can contribute to abdominal pain, intestinal cramping, diarrhea, constipation and urgency to defecate.The GI smooth muscle itself plays an important role in gastrointestinal (GI) motility. In overt inflammatory conditions of the bowel, such as infectious colitis and inflammatory bowel disease (IBD), there have been longstanding observations of altered motility and impaired function of the GI smooth muscle. While the inflammatory mediators are known to affect GI smooth muscle and impaired gastrointestinal motility, it still remains to be investigated how the inflammatory mediators affects GI smooth muscle. The research goals are to those mechanisms which possibly lead to generation of novel therapeutics for patients with GI motility disorders.
Education:
I give lectures on gastroenterology to medical students in kyushu university. I also instruct, supervise and evaluate their clinical trainings. Alternatively, I teach gastroenterological endoscopy and radiology to gastroenterology trainees.
Coordinated regulation of gastrointestinal (GI) motility contributes to general health and wellness when functioning normally but is also associated with morbidity and mortality when dysfunctional. Alterations in GI motility with resultant changes in transit can contribute to abdominal pain, intestinal cramping, diarrhea, constipation and urgency to defecate.The GI smooth muscle itself plays an important role in gastrointestinal (GI) motility. In overt inflammatory conditions of the bowel, such as infectious colitis and inflammatory bowel disease (IBD), there have been longstanding observations of altered motility and impaired function of the GI smooth muscle. While the inflammatory mediators are known to affect GI smooth muscle and impaired gastrointestinal motility, it still remains to be investigated how the inflammatory mediators affects GI smooth muscle. The research goals are to those mechanisms which possibly lead to generation of novel therapeutics for patients with GI motility disorders.
Education:
I give lectures on gastroenterology to medical students in kyushu university. I also instruct, supervise and evaluate their clinical trainings. Alternatively, I teach gastroenterological endoscopy and radiology to gastroenterology trainees.
Research
Research Interests
Membership in Academic Society
- The underlying mechanisms by which intestinal inflammation associated with various gastrointestinal (GI) disorders impairs contractile function of intestinal smooth muscle and GI motility.
keyword : altered GI motility, intestinal smooth muscle, intestinal inflammation
2011.07～2013.03.
Reports
| 1. | Ihara E, Akiho H, Nakamura K, Turner SR, MacDonald JA,MAPK signaling pathways represent a possible ideal target for generation of novel therapeutics for patients with gastrointestinal motility disorders. ,World J Gastrointest Pathophysiol 2:19-25,2011.07. |
| 2. | Akiho H, Ihara E, Nakamura. K,Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. ,World J Gastrointest Pathophysiol 1:97-105,2010.07. |
| 3. | Ihara E and MacDonald JA,The regulation of smooth muscle contractility by zipper-interacting protein kinase. , Can J Physiol Pharmacol 85: 79-87.,2007.07. |
Papers
| 1. | Ihara E, Chappellaz M, Turner SR, MacDonald JA., Protein kinase C and CPI-17 signaling pathways contribute to hypercontractility in murine experimental colitis. ,Neurogastroenterol Motil,Vol.24,pp.e15-26,2011.10. |
| 2. | Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R, CD4+CD25+ Regulatory T Cells Suppress Th17-Responses in an Experimental Colitis Model. ,Dig Dis Sci ,Vol.57,pp.497-500,2011.01. |
| 3. | Beck, P. L., Ihara, E., Hirota, S. A., Macdonald, J. A., Meng, D., Nanthakumar, N. N., Podolsky, D. K. & Xavier, R. J,Exploring the Interplay of Barrier Function and Leukocyte Recruitment in Intestinal Inflammation by Targeting Fucosyltransferase VII and Trefoil Factor 3. ,Am J Physiol Gastrointest Liver Physiol,Vol.299,pp.G43-53,2010.07. |
| 4. | Ihara E, Moffat L, Borman MA, Amon JE, Walsh MP and MacDonald JA,Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide. ,Am J Physiol Gastrointest Liver Physiol,Vol.297,pp.G361-370,2009.07. |
| 5. | Ihara E, Beck PL, Chappellaz M, Wong J, Medlicott SA and MacDonald JA, Mitogen-activated protein kinase pathways conribute to hypercontractility and increased Ca2+-sensitization in murine experimental colitis. ,Mol Pharmacol,Vol.75,pp.1031-1041,2009.07. |
| 6. | Ihara E, Edwards E, Borman MA, Wilson DP, Walsh MP and MacDonald JA,Inhibition of zipper-interacting protein kinase function in smooth muscle by a myosin light chain kinase pseudosubstrate peptide. ,Am J Physiol Cell Physiol,Vol.292,pp.C1951-1959,2007.07. |
| 7. | Ihara E, Moffat L, Ostrander J, Walsh MP and MacDonald JA,Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle. ,Am J Physiol Gastrointest Liver Physiol,Vol.293,pp.G699-710,2007.07. |
| 8. | Ihara E, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H,Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta. ,J Cell Biochem,Vol.87,pp.242-251,2002.07. |
| 9. | Ihara E, Hirano K, Derkach DN, Nishimura J, Nawata H, Kanaide H,The mechanism of bradykinin-induced endothelium-dependent contraction and relaxation in the porcine interlobar renal artery. ,Br J Pharmacol,Vol.129,pp.943-952,2000.07. |
| 10. | Derkach DN, Ihara E, Hirano K, Nishimura J, Takahashi S, Kanaide H,Thrombin causes endothelium-dependent biphasic regulation of vascular tone in the porcine renal interlobar artery. ,Br J Pharmacol 2000;131,Vol.131,pp.1635-1642,2000.07. |
| 11. | Ihara E, Hirano K, Nishimura J, Nawata H, Kanaide H, Thapsigargin-induced endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery. ,Br J Pharmacol,Vol.128,pp.689-699,1999.07. |
Presentations
| 1. | Background and study aim: Endoscopic submucosal dissection (ESD)-associated techniques have been used in Japan for tissue sampling of suspected gastrointestinal stromal tumors (GISTs) instead of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The aim of the present report was to evaluate the diagnostic yield and sensitivity of this procedure, which we named mucosal incision assisted biopsy (MIAB), for the histological diagnosis of gastric submucosal tumor (SMT). Patients and methods: We performed a retrospective review of the 15 patients with suspected gastric GIST who underwent MIAB in our hospitals between January 2010 and March 2011. This technique involved making a mucosal incision in the same way as the circumferential mucosal incision is made for ESD, followed by careful submucosal dissection until a portion of the lesion was exposed, and taking biopsy specimens under direct vision. Results: Tissue samples obtained by MIAB were sufficient for us to make a histological diagnosis of the gastric SMTs in 13 of the 15 patients. There were no significant differences in age, sex, SMT location or SMT size between diagnostic and non-diagnostic MIAB groups of patients, but there was a significant difference in SMT growth patterns between the groups (p < 0.05). Conclusions: Although it is generally accepted that EUS-FNA is the gold standard for obtaining tissue specimens for histological and cytological analysis of suspected gastric GISTs, MIAB can be used as an alternative method for obtaining biopsy specimens of lesions with an intraluminal growth pattern. . |
| 2. | ERK and p38MAPK regulate myosin light chain phosphatase and contribute to carbachol-induced contraction in rat intestinal smooth muscle. . |
| 3. | Hypoxia Inducible Factor (HIF-1alpha) Plays a Critical Innate Protective Role in Clostridium Difficile (Cdif) Toxin-Induced Intestinal Injury and Inflammation.. |
| 4. | Pharmacological stabilization of HIF-1a is protective in a mouse model of clostridium difficile-associated intestinal inflammation.. |
| 5. | Protein kinase signaling pathways contribute to hypercontractility in murine experimental colitis.. |
| 6. | Up-regulation of HIF-1alpha is associated with augmented Rho-kinase-mediated contraction of ileal smooth muscle following exposure to Clostridium difficile toxins in a mouse ileal loop model. . |
| 7. | Ca2+-sensitization of colonic smooth muscle is altered in a murine experimental colitis model. . |
| 8. | Alterations in the contractile properties of ileal smooth muscle exposed to Clostridium difficile toxins: the involvemen. |
| 9. | Colonic smooth muscle contractile dysfunction in experimental colitis and its underlying mechanisms. . |
| 10. | Protein kinases responsible for Ca2+-independent contraction of intestinal smooth muscle.. |
| 11. | Exploration of protein kinases responsible for Ca2+-independent, microcystin-induced contraction in intestinal smooth muscle. . |
| 12. | The Useful Approach to Obstructing or Stenotic Lesions in the Distal Ileum by Retrograde Ileography. . |
| 13. | Endothelium-dependent triphasic regulation of vascular tone induced by bradykinin in the porcine renal artery. . |
- Canadian Association of Gastroenterology
- Japanese Gastroenterological Endoscopy Society
- Japanese Society of Gastroenterology
- Japanese Society of Internal Medicine
- Award for the excellent presentation in 52nd annual meeting of Japan Society of Smooth Muscle Research
- The Pfizer/Smooth Muscle Research Group Post-Doctoral Fellow Research Achievement Award at University of Calgary
- Post-doctoral award of BMB (Department of Biochemistry & Molecular Biology) at University of Calgary
- Candadian Association of Gastroenterology/CIHR/AstraZeneca research initiative award (C$ 45,000/year for the salary and C$15,000/year for research allowance, for 3 years)
- Uehara Memorial Foundation research fellowship (￥3,000,000)
- Visiting Speaker & Postdoctoral Recruitment Travel Award from Alberta Heritage Foundation for Medical Research (AHFMR)
Educational
Educational Activities
I give lectures on "gastroduodenal ulcer disease" and "gastroduodenal dysfunction with inflammation" to medical students in the third year in Kyushu University. I also give a lecture on "methods of physical examination of abdomen and extremities" to medical students in the fourth year in Kyushu University. I will be an examiner for medical students with physical examination of abdomen in the fourth year. I instruct, supervise and evaluate the clinical training of medical students in the fourth and fifth years.
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