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Takahiro A. Kato Last modified date:2018.07.05

Lecturer / Department of Neuropsychiatry, Graduate School of Medical Sciences
Kyushu University Hospital

Other Organization


Website of "Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University"
Academic Degree
Ph.D. (Medicine)
Country of degree conferring institution (Overseas)
Field of Specialization
Psychiatry, Mood disorders, Hikikomori, Psychoneuroimmunology, Microglia, Psychoanalysis, Transcultural Psychiatry, Sucide Prevention, Inflammation・Oxidative Stress
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Academic Activities
1. Kohei Hayakawa, Takahiro Kato, Motoki Watabe, Alan R. Teo, Hideki Horikawa, Nobuki Kuwano, Norihiro Shimokawa, Mina Sato-Kasai, Hiroaki Kubo, Masahiro Ohgidani, Noriaki Sagata, Hiroyuki Toda, Masaru Tateno, Naotaka Shinfuku, Junji Kishimoto, Shigenobu Kanba, Blood biomarkers of Hikikomori, a severe social withdrawal syndrome, Scientific Reports, 10.1038/s41598-018-21260-w, 8, 1, 2018.02, Hikikomori, a severe form of social withdrawal syndrome, is a growing social issue in Japan and internationally. The pathophysiology of hikikomori has not yet been elucidated and an effective treatment remains to be established. Recently, we revealed that avoidant personality disorder is the most common comorbidity of hikikomori. Thus, we have postulated that avoidant personality is the personality underpinning hikikomori. First, we herein show relationships between avoidant personality traits, blood biomarkers, hikikomori-related psychological features, and behavioural characteristics assessed by a trust game in non-hikikomori volunteers. Avoidant personality traits were negatively associated with high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) in men, and positively associated with fibrin degeneration products (FDP) and high sensitivity C-reactive protein (hsCRP) in women. Next, we recruited actual individuals with hikikomori, and compared avoidant personality traits, blood biomarkers, and psychological features between individuals with hikikomori and age-matched healthy controls. Individuals with hikikomori had higher avoidant personality scores in both sexes, and showed lower serum UA levels in men and lower HDL-C levels in women compared with healthy controls. This is the first report showing possible blood biomarkers for hikikomori, and opens the door to clarify the underlying biological pathophysiology of hikikomori..
2. Nobuki Kuwano, Takahiro Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenobu Kanba, Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder
An exploratory pilot case-control study, Journal of Affective Disorders, 10.1016/j.jad.2018.01.014, 231, 74-82, 2018.04, Background: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. Methods: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis. Results: Plasma tryptophan and kynurenine levels were significantly lower in MDD group (N = 15) compared to healthy controls (HC) group (N = 19), and plasma tryptophan was the significant biomarker to identify MDD group (area under the curve = 0.740). Lower serum high density lipoprotein-cholesterol (HDL-C) was the predictive biomarker for severity of depression in MDD group (R2 = 0.444). Interestingly, depressive symptoms were variously correlated with plasma tryptophan-kynurenine and lipid related metabolites. Moreover, plasma tryptophan-kynurenine metabolites and cholesteryl esters (CEs) were significantly correlated in MDD group, but not in HC group. Limitations: This study had small sample size, and we did not use the multiple test correction. Conclusions: This is the first study to suggest that not only tryptophan-kynurenine metabolites but also HDL-C and CEs are important blood biomarkers for first-episode drug-naïve MDD patients. The present study sheds new light on early intervention in clinical practice in depression, and further clinical studies especially large-scale prospective studies are warranted..
3. Takahiro Kato, Shigenobu Kanba, Alan R. Teo, Hikikomori
experience in Japan and international relevance, World Psychiatry, 10.1002/wps.20497, 17, 1, 105-106, 2018.02, 九州大学を拠点するひきこもり国際共同ネットワークによる成果の概要をまとめた報告である。.
4. Yukako Nakagami, Hiroaki Kubo, Ryoko Katsuki, Tomomichi Sakai, Genichi Sugihara, Chisako Naito, Hiroyuki Oda, Kohei Hayakawa, Yuriko Suzuki, Daisuke Fujisawa, Naoki Hashimoto, Keiji Kobara, Tetsuji Cho, Hironori Kuga, Kiyoshi Takao, Yoko Kawahara, Yumi Matsumura, Toshiya Murai, Koichi Akashi, Shigenobu Kanba, Kotaro Otsuka, Takahiro Kato, Development of a 2-h suicide prevention program for medical staff including nurses and medical residents
A two-center pilot trial, Journal of Affective Disorders, 10.1016/j.jad.2017.08.074, 225, 569-576, 2018.08, Background Suicide is a crucial global health concern and effective suicide prevention has long been warranted. Mental illness, especially depression is the highest risk factor of suicide. Suicidal risk is increased in people not only with mental illness but also with physical illnesses, thus medical staff caring for physically-ill patients are also required to manage people with suicidal risk. In the present study, we evaluated our newly developed suicide intervention program among medical staff. Methods We developed a 2-h suicide intervention program for medical staff, based on the Mental Health First Aid (MHFA), which had originally been developed for the general population. We conducted this program for 74 medical staff members from 2 hospitals. Changes in knowledge, perceived skills, and confidence in early intervention of depression and suicide-prevention were evaluated using self-reported questionnaires at 3 points; pre-program, immediately after the program, and 1 month after program. Results This suicide prevention program had significant effects on improving perceived skills and confidence especially among nurses and medical residents. These significant effects lasted even 1 month after the program. Limitations Design was a single-arm study with relatively small sample size and short-term follow up. Conclusions The present study suggests that the major target of this effective program is nurses and medical residents. Future research is required to validate the effects of the program with control groups, and also to assess long-term effectiveness and actual reduction in suicide rates..
5. Takahiro Kato, Aye M. Myint, Johann Steiner, Editorial: Minding glial cells in the novel understandings of mental illness, Frontiers in Cellular Neuroscience, 10.3389/fncel.2017.00048, 11, 2017.02.
6. Takahiro Kato*, Shigenobu Kanba, Modern-type depression as an "adjustment" disorder in Japan
The intersection of collectivistic society encounteringanindividualisticperformance-basedsystem, American Journal of Psychiatry, 10.1176/appi.ajp.2017.17010059, 174, 11, 1051-1053, 2017.11, うつ病の現代における課題に関して、特に適応の障害という観点から論じた論文である。.
7. Masahiro Ohgidani, Takahiro Kato*, Masako Hosoi, Tsuda Makoto, Kohei Hayakawa, Chie Hayaki, Rie Iwaki, Noriaki Sagata, Ryota Hashimoto, Kazuhide Inoue, Nobuyuki Sudo, Shigenobu Kanba, Fibromyalgia and microglial TNF-α
Translational research using human blood induced microglia-like cells, Scientific Reports, 10.1038/s41598-017-11506-4, 7, 1, 2017.12, Fibromyalgia is a refractory disease characterized by chronic intractable pain and psychological suffering, the cause of which has not yet been elucidated due to its complex pathology. Activation of immune cells in the brain called microglia has attracted attention as a potential underlying pathological mechanism in chronic pain. Until recently, however, technological and ethical considerations have limited the ability to conduct research using human microglia. To overcome this limitation, we have recently developed a technique to create human-induced microglia-like (iMG) cells from human peripheral blood monocytes. In this study, we created the iMG cells from 14 patients with fibromyalgia and 10 healthy individuals, and compared the activation of iMG cells between two groups at the cellular level. The expression of tumor necrosis factor (TNF)-α at mRNA and protein levels significantly increased in ATP-stimulated iMG cells from patients with fibromyalgia compared to cells from healthy individuals. Interestingly, there was a moderate correlation between ATP-induced upregulation of TNF-α expression and clinical parameters of subjective pain and other mental manifestations of fibromyalgia. These findings suggest that microglia in patients with fibromyalgia are hypersensitive to ATP. TNF-α from microglia may be a key factor underlying the complex pathology of fibromyalgia..
8. Noriaki Sagata, Takahiro Kato, Shin Ichi Kano, Masahiro Ohgidani, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Ashley M. Wilson, Koko Ishizuka, Shiori Kato, Takeshi Nakahara, Makiko Nakahara-Kido, Daiki Setoyama, Yasunari Sakai, Shoichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba, Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients
A pilot study, Scientific Reports, 10.1038/s41598-017-14440-7, 7, 1, 2017.12, Direct conversion technique to produce induced-neuronal (iN) cells from human fibroblasts within 2 weeks is expected to discover unknown neuronal phenotypes of neuropsychiatric disorders. Here, we present unique gene expression profiles in iN cells from patients with neurofibromatosis type 1 (NF1), a single-gene multifaceted disorder with comparatively high co-occurrence of autism spectrum disorder (ASD). Microarray-based transcriptomic analysis on iN cells from male healthy controls and male NF1 patients (NF1-iN cells) revealed that 149 genes expressions were significantly different (110 upregulated and 39 downregulated). We validated that mRNA of MEX3D (mex-3 RNA binding family member D) was lower in NF1-iN cells by real-time PCR with 12 sex-mixed samples. In NF1-iN cells on day 14, higher expression of FOS mRNA was observed with lower expression of MEX3D mRNA. Interestingly, BCL2 mRNA was higher in NF1-iN cells on day 5 (early-period) but not on day 14. Our data suggest that aberrant molecular signals due to NF1 mutations may disturb gene expressions, a subset of which defines continuum of the neuronal phenotypes of NF1 with ASD. Further translational studies using induced pluripotent stem (iPS) cell-derived neuronal cells are needed to validate our preliminary findings especially confirming meanings of analysis using early-period iN cells..
9. Masahiro Ohgidani, Takahiro Kato, Yoshinori Haraguchi, Toshio Matsushima, Yoshito Mizoguchi, Toru Murakawa-Hirachi, Noriaki Sagata, Akira Monji, Shigenobu Kanba, Microglial CD206 gene has potential as a state marker of bipolar disorder, Frontiers in Immunology, 10.3389/fimmu.2016.00676, 7, JAN, 2017.01, The pathophysiology of bipolar disorder, especially the underlying mechanisms of the bipolarity between manic and depressive states, has yet to be clarified. Microglia, immune cells in the brain, play important roles in the process of brain inflammation, and recent positron emission tomography studies have indicated microglial overactivation in the brain of patients with bipolar disorder. We have recently developed a technique to induced microglia-like (iMG) cells from peripheral blood (monocytes). We introduce a novel translational approach focusing on bipolar disorder using this iMG technique. We hypothesize that immunological conditional changes in microglia may contribute to the shift between manic and depressive states, and thus we herein analyzed gene profiling patterns of iMG cells from three patients with rapid cycling bipolar disorder during both manic and depressive states, respectively. We revealed that the gene profiling patterns are different between manic and depressive states. The profiling pattern of case 1 showed that M1 microglia is dominant in the manic state compared to the depressive state. However, the patterns of cases 2 and 3 were not consistent with the pattern of case 1. CD206, a mannose receptor known as a typical M2 marker, was significantly downregulated in the manic state among all three patients. This is the first report to indicate the importance of shifting microglial M1/M2 characteristics, especially the CD206 gene expression pattern between depressive and manic states. Further translational studies are needed to dig up the microglial roles in the underlying biological mechanisms of bipolar disorder..
10. Takahiro A. Kato, Can “Pokémon GO” rescue shut-ins (hikikomori) from their isolated world?, Psychiatry and Clinical Neurosciences, 2016.11.
11. Tateno M, Teo AR, Shirasaka T, Tayama M, Watabe M, Kato TA, Internet addiction and self-evaluated ADHD traits among Japanese college students, Psychiatry and Clinical Neurosciences.
12. Haraguchi Y*, Mizoguchi Y, Noguchi T, Arai T, Fukuyaa J, Kato TA, Kawashima T, Monji A*, A patient with Alzheimer’s disease complicated by elderly-onset Cushing’s syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia, Psychogeriatrics , 10.1111/psyg.12146., 16, 4, 274-276, 2016.07.
13. Maruo, J, Haraguchi, Y, Tateishi H, Noguchi T, Mizoguchi Y, Kato TA, Kawashima T, Monji A, Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report, Psychogeriatrics , 10.1111/psyg.12148. , 16, 4, 283-286, 2016.07.
14. Ohgidani M, Kato TA*, Sagata N, Hayakawa K, Shimokawa N, Sato-Kasai M, Kanba S, TNF-α from hippocampal microglia directly induces working memory deficits by acute stress in mice, Brain, Behavior, and Immunity, 10.1016/j.bbi.2015.08.022. , 55, 17-24, 2016.07.
15. Kato TA*, Kanba S, Teo AR*, A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan. Perspectives in Global Mental Health, American Journal of Psychiatry, 10.1176/appi.ajp.2015.15081034., 173, 2, 112-114, 2016.02.
16. Hashimoto N*, Suzuki Y, Kato TA, Fujisawa D, Sato R, Aoyama-Uehara K, Fukasawa M, Asakura S, Kusumi I, Otsuka K, The effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12358. , 70, 1, 62-70, 2016.01.
17. Kato TA*, Hashimoto R, Hayakawa K, Kubo H, Watabe M, Teo AR, Kanba S, The multidimensional anatomy of “modern type depression” in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5. Frontier Review, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12358., 70, 1, 7-23, 2016.01.
18. Kato TA*, Kanba S, Boundless syndromes in modern society – An interconnected world producing novel psychopathology in the 21st century, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12368. , 70, 1, 1-2, 2016.01.
19. Tateishi H, Hirachi T, Maruo J, Haraguchi Y, Noguchi T, Mizoguchi Y, Kato TA, Kawashima T, Monji A, Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review, Psychosomatics, 10.1016/j.psym.2015.07.007., 57, 1, 107-12, 2016.01.
20. Kano S-I, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Horiuchi Y, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O'Donnell P*, Sawa A*, Kai M*, Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy, Current Molecular Medicine, 15, 2, 138-45.
21. Hirachi T, Ishii H, Tada Y, Noguchi T, Haraguchi Y, Tateishi H, Mizoguchi Y, Kato TA, Kawashima T, Monji A*, Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up, Lupus, 10.1177/0961203315570161., 24, 9, 990-993, 2015.08.
22. Teo AR, Stufflebam K, Saha S, Fetters MD, Tateno M, Kanba S, Kato TA, Psychopathology Associated with Social Withdrawal: Idiopathic and Co-Morbid Presentations, Psychiatry Research, 10.1016/j.psychres.2015.04.033., 228, 1, 182-183, 2015.07.
23. Guest PC, Iwata K, Kato TA, Steiner J, Schmitt A, Turck CW, Martins-de-Souza D* (Contributed equally), MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia, Frontiers in Cellular Neuroscience, 10.3389/fncel.2015.00180. , 9, 180, 2015.05.
24. Ohgidani M, Kato TA*, Kanba S, Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders, Frontiers in Cellular Neuroscience, 10.3389/fncel., 9, 184, 2015.05.
25. Watabe M*, Kato TA*, Teo AR, Horikawa H, Tateno M, Hayakawa K, Shimokawa N, Kanba S (: These authors contributed equally to this work), Relationship between trusting behaviors and psychometrics associated with social network and depression among young generation: a pilot study, PLoS ONE, 10.1371/journal.pone.0120183., 10, 4, e0120183, 2015.04.
26. Teo AR*, Kato TA, The prevalence and correlates of severe social withdrawal in Hong Kong. (Letter to the Editor) , International Journal of Social Psychiatry, 10.1177/0020764014554923. , 61, 1, 102, 2015.02.
27. Teo AR*, Fetters MD,Stufflebam S, Tateno M, Balhara YBS, Choi TY, Kanba S, Mathews CA, Kato TA*, Identification of the Hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries, International Journal of Social Psychiatry, 10.1177/0020764014535758. , 61, 1, 64-72, 2015.02.
28. Kato TA, Introducing Hikikomori from multidimensional perspectives. Interview, World Child & Adolescent Psychiatry (WPA, Child and Adolescent Psychiatry Section's Official Journal), 7, 12-16.
29. Mizoguchi Y*, Kato TA, Horikawa H, Monji A, Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia, Frontiers in Cellular Neuroscience, 10.3389/fncel.2014.00370., 8, 370, 2014.11.
30. Yamamura K, Kato S, Kato TA, Mizoguchi Y, Monji A, Kanba S, Furue M, Takeuchi S, Anti-allergic mechanisms of Japanese herbal medicine, yokukansan on mast cells, Journal of Dermatology, 10.1111/1346-8138.12578. , 41, 9, 808-14, 2014.08.
31. Suzuki Y*, Kato TA, Sato R, Fujisawa D, Aoyama-Uehara K, Hashimoto N, Yonemoto N, Fukasawa M, Otsuka K, Effectiveness of brief suicide management training program for medical residents in Japan: A cluster randomized controlled trial. Epidemiology and Psychiatric Sciences, Epidemiology and Psychiatric Sciences, 10.1017/S2045796013000334. , 23, 2, 167-76, 2014.06.
32. Mizoguchi Y*, Kato TA, Seki Y, Ohgidani M, Sagata N, Horikawa H, Yamauchi Y, Sato-Kasai M, Hayakawa K, Inoue R, Kanba S, Monji A, BDNF induces sustained intracellular Ca2+ elevation through the upregulation of surface TRPC3 channels in rodent microglia, Journal of Biological Chemistry, 10.1074/jbc.M114.555334., 289, 26, 18549-18555, 2014.06.
33. Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S, Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease, Scientific Reports, 10.1038/srep04957., 4, 4957, 2014.05.
34. Hayakawa K, Kato TA*, Kojiro M, Monji A, Kanba S, Minocycline, a microglial inhibitor, diminishes terminal patients’ delirium? , American Journal of Geriatric Psychiatry, 10.1016/j.jagp.2013.11.003., 22, 3, 314-315, 2014.03.
35. Farooq K, Lydall GJ, Malik A, Ndetei DM; ISOSCCIP Group (including Kato TA & Kanba S), Bhugra D, ISOSCCIP Group (including Kato TA & Kanba S), Bhugra D: Why medical students choose psychiatry - a 20 country cross-sectional survey, BMC Medical Education, 10.1186/1472-6920-14-12., 14, 12, 2014.01.
36. Kato TA*, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S, Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry, Current Medicinal Chemistry, 20, 3, 331-344.
37. Umene-Nakano W*, Kato TA, Kikuchi S, Tateno M, Fujisawa D, Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan, PLoS ONE, 10.1371/journal.pone.0055189., 8, 2, e55189.
38. Watabe M*, Kato TA*, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S [*Double Corresponding authors who were equally contributed to this work.]: , Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange, Scientific Reports, 10.1038/srep01685., 3, 1685.
39. Isomura S, Monji A, Sasaki K, Baba S, Onitsuka T, Ohara T, Mizoguchi Y, Kato TA, Horikawa H, Seki Y, Kanba S:, A case of FTD with catatonia-like signs that temporarily resolved with zolpidem, Neurology: Clinical Practice, 3, 354-357.
40. Seki Y, Kato TA*, Monji A*, Mizoguchi Y, Horikawa H, Sato-Kasai M, Yoshiga D, Kanba S, Aripiprazole and minocycline, but not haloperidol, suppress oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model, Schizophrenia Research, 151, 1-3, 20-28.
41. Yoshihiro Seki, Kato TA, Monji A, Mizoguchi Y, Horikawa H, Sato-Kasai M, Yoshiga D, Kanba S, Aripiprazole and minocycline, but not haloperidol, suppress oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model., Schizophrenia Research , 151, 1-3, 20-28, 2013.12.
42. Fujisawa D*, Suzuki Y, Kato TA, Hashimoto N, Sato R, Aoyama-Uehara K, Fukasawa M, Tomita M, Kashima H, Otsuka K, Suicide intervention skills among medical residents, Academic Psychiatry, 10.1176/appi.ap.10110154., 37, 6, 402-407, 2013.11.
43. Kato TA*, Watabe M, Kanba S, Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry, Frontiers in Psychiatry (Frontiers in Neuropsychiatric Imaging and Stimulation), 10.3389/fpsyt.2013.00139., 4, 139, 2013.10.
44. Kato TA, Watabe M, Kanba S, Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry., Frontiers in Psychiatry (Frontiers in Neuropsychiatric Imaging and Stimulation), 4, 139, 2013.10.
45. Kato TA, Balhara YPS, Chawla JM, Tateno M, Kanba S, Undergraduate medical students' attitudes toward psychiatry: an international cross-sectional survey between India and Japan., International Review of Psychiatry, 25, 4, 378-384, 2013.09.
46. Kato TA*, Balhara YPS*, Chawla JM, Tateno M, Kanba S, Undergraduate medical students' attitudes toward psychiatry: an international cross-sectional survey between India and Japan, International Review of Psychiatry, 10.3109/09540261.2013.812959., 25, 4, 378-384, 2013.08.
47. Kato TA, Hayakawa K, Monji A, Kanba S, Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders and Microglia., Frontiers in Integrative Neuroscience, 10.3389/fnint.2013.00053, 7, 53, 2013.07.
48. Kato TA*, Hayakawa K, Monji A, Kanba S, Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders and Microglia, Frontiers in Integrative Neuroscience, 10.3389/fnint.2013.00053. , 7, 53, 2013.07.
49. Kato TA*, Kanba S, Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach, Frontiers in Human Neuroscience, 10.3892/or.2013.2354. , 7, 13, 2013.06.
50. Watabe M, Kato TA, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S, Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange., Scientific Reports 3, 1685, 2013, 3, 1683, 2013.04.
51. Monji A*, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M, Yamauchi Y, Yamada S, Kanba S, Neuroinflammation in schizophrenia especially focused on the role of microglia, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 10.1016/j.pnpbp.2011.12.002. , 42, 115-121, 2013.04.
52. Kato A. Takahiro, Kanba Shigenobu, Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach., Frontiers in Human Neuroscience, 10.3389/fnhum.2013.00013, 7, 13, [], 2013.02, The unconscious mind-brain relationship remains unresolved. From the perspective of neuroscience, neuronal networks including synapses have been dominantly believed to play crucial roles in human mental activities, while glial contribution to mental activities has long been ignored. Recently, it has been suggested that microglia, glial cells with immunological/inflammatory functions, play important roles in psychiatric disorders. Newly revealed microglial roles, such as constant direct contact with synapses even in the normal brain, have defied the common traditional belief that microglia do not contribute to neuronal networks. Recent human neuroeconomic investigations with healthy volunteers using minocycline, an antibiotic with inhibitory effects on microglial activation, suggest that microglia may unconsciously modulate human social behaviors as "noise." We herein propose a novel unconscious mind structural system in the brain centering on microglia from a neuropsychoanalytic approach. At least to some extent, microglial activation in the brain may activate unconscious drives as "psychological immune memory/reaction" in the mind, and result in various emotions, traumatic reactions, psychiatric symptoms including suicidal behaviors, and (psychoanalytic) transference during interpersonal relationships. Microglia have the potential to bridge the huge gap between neuroscience, biological psychiatry, psychology and psychoanalysis as a key player to connect the conscious and the unconscious world..
53. Kato TA, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S, Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry, Current Medicinal Chemistry, 20, 3, 331-344, 2013.01.
54. Kato TA*, Watabe M*, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S [* These authors equally contributed to this work.], Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors., PLoS ONE, 7, 7, e40461, 2012.07.
55. Watabe M*, Kato TA*, Monji A, Horikawa H, Kanba S [* These authors equally contributed to this work.], Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?, Psychopharmacology, 220.0, 3.0, 551-557, 2012.04.
56. Kato TA, Shinfuku N, Sartorius N, Kanba S, Are Japan's hikikomori and depression in young people spreading abroad? [Correspondence], The Lancet, 378.0, 9796.0, 1070.0, 2011.08, None..
57. Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S, Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)- stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia., Schizophrenia Research, 129.0, 2−3, 172-182, 2011.07.
58. Kato TA, Shinfuku N, Fujisawa D, Tateno M, Ishida T, Akiyama T, Sartorius N, Teo AR, Choi TY, Wand APF, Balhara YPS, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, Umene-Nakano W, Horikawa H, Matsumoto R, Kuga H, Tanaka M, Kanba S, Introducing the Concept of Modern Depression in Japan; an International Case Vignette Survey., Journal of Affective Disorders, 135.0, 1-3, 66-76, 2011.07.
59. Kato TA, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y, Kasai M, Utsumi H, Kanba S, Anti-inflammatory properties of antipsychotics via microglia modulations; Are antipsychotics a 'fire extinguisher' in the brain of schizophrenia?, Mini-Reviews in Medicinal Chemistry, 11.0, 7.0, 565-574, 2011.06.
60. Kato TA, Tateno M, Shinfuku N, Fujisawa D, Teo AR, Sartorius N, Akiyama T, Ishida T, Choi TY, Balhara YPS, Matsumoto R, Umene-Nakano W, Fujimura Y, Wand A, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, Kanba S, Does the 'hikikomori' syndrome of social withdrawal exist outside Japan?: A preliminary international investigation., Social Psychiatry and Psychiatric Epidemiology, 2011.06.
61. Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Gotoh L, Ohkuri T, Yonaha M, Ueda T, Hashioka S, Kanba S, Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracelluar calcium., Prog Neuropsychopharmacol Biol Psychiatry, 37.0, 12.0, 1306–1316, 2010.10.
62. Kato TA, Suzuki Y, Sato R, Fujisawa D, Uehara K, Hashimoto N, Sawayama Y, Hayashi J, Kanba S, Otsuka K, Development of two-hour suicide intervention program among medical residents: First pilot trial., Psychiatry and Clinical Neurosciences, 64.0, 5.0, 531–540, 2010.10.
63. Kato TA, Tateno M, Nakano Y, Balhara YPS, Teo AR, Fujisawa D, Sasaki R, Ishida T, Kanba S, Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?, Psychiatry and Clinical Neurosciences, 64.0, 5.0, 520–530, 2010.10.
64. Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S, Brain-derived neurotrophic factor (BDNF) induces sustained elevation of intracellular Ca2+ in rodent microglia., Journal of Immunology, 183.0, 12.0, 7778-7786, 2009.12.
65. Monji A, Kato T, Kanba S, Cytokines and Schizophrenia-Microglia Hypothesis of Schizophrenia-., Psychiatry and Clinical Neurosciences, 63.0, 3.0, 257-265, 2009.06.
66. Kato T, Mizoguchi Y, Monji A, Horikawa H, Suzuki S, Seki Y, Iwaki T, Hashioka S, Kanba S, Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro., Journal of Neurochemistry, 106.0, 2.0, 815-825, 2008.07.
67. Kato T, Monji A, Hashioka S, Kanba S, Risperidone significantly inhibits interferon- gamma -induced microglial activation in vitro., Schizophrenia Research, 92.0, 1ー3, 108-115, 2007.05.
68. Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, Horikawa H, Kanba S, The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon- gamma., Prog Neuropsychopharmacol Biol Psychiatry, 32.0, 1.0, 42-48, 2008.01.
69. Kato T, Hanada T, Takano K, Antoku Y, and Nose Y, A Question and Answer E-Mail System for Responding to Query from the General Public with Which the System Manager Can Identify Delayed Replies., J Med Syst, 24.0, 1.0, 21-28, 2000.02.