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Kosuke Teshima Last modified date:2019.06.20

Assistant Professor / Dynamic biology
Department of Biology
Faculty of Sciences


Graduate School
Undergraduate School


E-Mail
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Population Genetics
Total Priod of education and research career in the foreign country
04years00months
Research
Research Interests
  • population genetics for continuously distributing species
    keyword : population genetics, simulation, continuous distribution
    2019.04~2021.06.
  • My research interest is to make inferences on evolutionary history of organisms based on genome sequence data.
    keyword : population genetics, molecular evolution, genomics, evolution
    2011.08~2012.06.
Academic Activities
Papers
1. Teshima KM, Innan H, The coalescent with selection on copy number variants, Genetics, 190, 3, 1077-86, 2012.05, We develop a coalescent-based simulation tool to generate patterns of single nucleotide polymorphisms (SNPs) in a wide region encompassing both the original and duplicated genes. Selection on the new duplicated copy and interlocus gene conversion between the two copies are incorporated. This simulation enables us to explore how selection on duplicated copies affects the pattern of SNPs. The fixation of an advantageous duplicated copy causes a strong reduction in polymorphism not only in the duplicated copy but also in its flanking regions, which is a typical signature of a selective sweep by positive selection. After fixation, polymorphism gradually increases by accumulating neutral mutations and eventually reaches the equilibrium value if there is no gene conversion. When gene conversion is active, the number of SNPs in the duplicated copy quickly increases by transferring SNPs from the original copy; therefore, the time when we can recognize the signature of selection is decreased. Because this effect of gene conversion is restricted only to the duplicated region, more power to detect selection is expected if a flanking region to the duplicated copy is used..
Works, Software and Database
1.
[URL].
Membership in Academic Society
  • Society of Evolutionary Studies, Japan
  • The genetics society of Japan