Kyushu University Academic Staff Educational and Research Activities Database
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Ryo Yazaki Last modified date:2019.07.22

Assistant Professor / Department of Pharmaceutical Health Care and Sciences Faculty of Pharmaceutical Sciences
Department of Chemo-Pharmaceutical Sciences
Faculty of Pharmaceutical Sciences

Graduate School
Undergraduate School

Academic Degree
Field of Specialization
Synthetic Organic Chemistry
ORCID(Open Researcher and Contributor ID)
Research Interests
  • Drug Synthesis through Environmentally Benign Reaction
    keyword : green chemistry, catalysis
Academic Activities
1. Takafumi Tanaka, Tsukushi Tanaka, Taro Tsuji, Ryo Yazaki, Takashi Ohshima, Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer, Organic Letters, 10.1021/acs.orglett.8b01313, 20, 12, 3541-3544, 2018.06, A new strategy, a transient homocoupling dimer strategy, for direct catalytic oxidative cross-enolate coupling reactions is developed. Cross-enolate coupling products bearing a (contiguous) tetrasubstituted carbon center were obtained chemoselectively without the need for stoichiometric amounts of strong bases/metal oxidants, and thus, the present catalysis provides a general method for the synthesis of unnatural α,α-disubstituted amino acid motifs. The distinct transformation of azlactone and 2-acylimidazole units highlighted the synthetic utility of the present catalysis..
Membership in Academic Society
  • The Pharmaceutical Society of Japan