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Genshiro Esumi Last modified date:2018.10.02

Assistant Professor / Reproductive and Developmental Medicine
Pediatric Surgery
Kyushu University Hospital

Academic Degree
Doctor of Medical Science
Field of Specialization
Pediatricsurgery, Neonatalsurgery
Research Interests
  • Fatty acid profile and de novo lipogenesis
    keyword : fatty acid profile, de novo lipogenesis
  • Efficacy of TARC measurement among pediatric liver transplantation recipients.
    keyword : transplantation, CCL17, TARC
  • New treatment strategy for congenital diaphragmatic hernia patients using Insulin-like growth factors
    keyword : congenital diaphragmatic hernia, neonatal surgery, insulin-like growth factors
Academic Activities
1. Genshiro Esumi, Kouji Masumoto, Risa Teshiba, Kouji Nagata, Yoshiaki Kinoshita, Haruyoshi Yamaza, Kazuaki Nonaka and Tomoaki Taguchi, Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model, PEDIATRIC SURGERY INTERNATIONAL, 10.1007/s00383-010-2791-2, 27, 2, 187-192, 2011.02, Purpose
Both the mortality and morbidity associated with congenital diaphragmatic hernia (CDH) are mainly caused by pulmonary hypoplasia and persistent pulmonary hypertension. A previous study revealed that insulin-like growth factors (IGFs) play important roles in fetal lung development. The aim of this study was to investigate the effect of IGF-1 and IGF-2 on tissue cultures of fetal hypoplastic lungs obtained from nitrofen-induced CDH model rats.
Pregnant rats were exposed to nitrofen on day 9 of gestation (D9). Fetuses were harvested on D18 by caesarian section. Lung specimens of the CDH (+) fetus were divided into three groups; control, IGF-1, and IGF-2. The specimens from the control group were cultured in culture medium without IGFs. The IGF-1 group specimens were cultured with IGF-1 (500 ng/ml), and those in the IGF-2 group were cultured with IGF-2 (500 ng/ml). The mRNA expression of TTF-1, T1α and α-SMA were analyzed in each group using real-time RT-PCR after 24 and 48 h of incubation. Immunohistochemical staining of these markers was also assessed for each of the cultured specimens.
There was a significant increase in the expression of both TTF-1 and T1α mRNA in the IGF-2 group, in comparison to the control group after 48 h of culture. Immunohistochemical staining revealed that the cell morphology was changed from cuboidal to squamous type in the IGF-2 group.
An increased mRNA expression of the markers related to type 1 and 2 alveolar epithelial cells, and morphological changes in the epithelial cells were observed in the IGF-2 group. The administration of IGF-2 to nitrofen-induced hypoplastic lungs might lead to alveolar maturation, which thus results in their improved development..
Membership in Academic Society
  • Japanese Society for Parenteral & Enteral Nutrition