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Takahashi Hideyuki Last modified date：2024.04.19

Associate Professor / Animal and Marine Bioresource Sciences
University Farm,Kyushu University
Faculty of Agriculture




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Homepage
https://kyushu-u.elsevierpure.com/en/persons/hideyuki-takahashi
　Reseacher Profiling Tool　Kyushu University Pure
http://www.agr.kyushu-u.ac.jp/lab/kuju_hp/
Phone
０９７４-76-1377
Fax
0974-76-1218
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Physiology
Total Priod of education and research career in the foreign country
00years09months
Research
Research Interests
  • The improvement of meat production performance in Japanese Black Cattle
    keyword : Meat production performance
    2016.04～2017.03.
  • Mechanism of epigenetic control in Japanese Black cattle
    keyword : Japanese Black cattle epigenetics
    2016.04～2019.03.
  • Effect of constituents in colostrum on the subsequent metabolism and physiology in Japanese Black cattle
    keyword : Japanese Black cattle colostrum
    2015.04～2016.03.
  • Effects of myostatin control of the initial growth period is to provide meat quality of Japanese Black cattle
    keyword : Myostatin
    2014.04～2016.03.
  • Basic research aimed at feeding management system development of the initial growth phase that target myostatin of Japanese beef
    keyword : Myostatin
    2014.05～2015.03.
  • The effect of myostatin on energy metabolism
    keyword : myostatin insulin
    2012.04～2014.03.
  • The initial nourishment control is influence to give internal secretion and nutrient metabolism of the skeletal muscle in the black-haired Japanese cow
    keyword : Japanese cattle internal secretion skeletal muscle nutrient metabolism
    2012.04～2016.03.
Academic Activities
Papers
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1. Haruki Yamano, Hiroshi Horike, Yutaka Taguchi, Yudai Inabu, Toshihisa Sugino, Nonomi Suzuki, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Hideyuki Takahashi, Effect of Ca-octanoate supplementation on concentrations of ghrelin and ghrelin-related hormones in plasma and milk of beef cattle, Heliyon, doi.org/10.1016/j.heliyon.2023.e16795, 9, e16795, 2023.06.
2. Shunnosuke Okada, Yudai Inabu, Hirokuni Miyamoto, Kenta Suzuki, Tamotsu Kato, Atsushi Kurotani, Yutaka Taguchi, Ryoichi Fujino, Yuji Shiotsuka, Tetsuji Etoh, Naoko Tsuji, Makiko Matsuura, Arisa Tsuboi, Akira Saito, Hiroshi Masuya, Jun Kikuchi, Yuya Nagasawa, Aya Hirose, Tomohito Hayashi, Hiroshi Ohno, Hideyuki Takahashi, Estimation of silent phenotypes of calf antibiotic dysbiosis, Scientific Reports, 10.1038/s41598-023-33444-0, 2023.04, [URL], 抗菌薬耐性を防ぐために家畜における抗生物質の使用を減らすことは、世界中で緊急の課題となっている。 本研究では、抗菌剤であるクロルテトラサイクリン (CTC) の投与が子牛の成績、血液成分、糞便微生物叢、および有機酸濃度に及ぼす影響を評価した。 黒毛和種子牛には、CTC を 10 g/kg (CON 群) または 0 g/kg (EXP 群) 含む代替乳を与えた。 増体は CTC 投与の影響を受けなかった。 しかし、CTC の投与により、糞便中の有機酸と細菌属との相関関係が変化した。 エネルギーランドスケープ分析などの機械学習 (ML) 手法により、CTC 投与がさまざまな種類の糞便細菌の集団に影響を与えることが明らかとなった。 興味深いことに、生後 60 日のいくつかのメタン生成細菌の存在量は CON グループで高く、酪酸生成細菌であるラクノスピラ科の存在量は EXP グループで高かった。 さらに、統計的因果推論に基づくML データにでは、CTC 給与は腸内環境全体に影響を及ぼし、糞便中のメタン生成菌に起因する可能性のある酪酸生成を抑制する可能性があると推定された。 したがって、これらの結果は、子牛の腸の健康に対する抗生物質の複数の有害な影響と、子牛による温室効果ガスの生成経路が明らかとなった。.
3. Yudai Inabu, Yutaka Taguchi, Hirokuni Miyamoto, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Toru Okada, Motoaki Udagawa,Naoko Tsuji, Makiko Matsuura, Arisa Tsuboi, Tamotsu Kato, Hiroaki Kodama, Hiroshi Ohno, Hideyuki Takahashi, Development of a novel feeding method for Japanese black calves with thermophile probiotics at postweaning, Journal of Applied Microbiology, https://doi.org/10.1111/jam.15519, 2022.03, 仔牛は離乳期は給与飼料の変化や母子分離によるストレスのため、成長が停滞し生産性が低下する。この問題を解決するため、腸内細菌叢を改変し家畜の成長を促すC.hisashiiに着目し検討を行った。その結果、離乳時の発育停滞は起こらず、飼料効率の向上が認められた。また、メタン産生菌であるMethanobrevibacter属の構成割合が減少することを明らかにした。これらのことは、C.hisashiiが腸内細菌叢に影響を及ぼすことで、飼料の利用効率を向上させること、糞からのメタン産生を低下させる可能性があることを示している。.
4. Yudai Inabu, Hiroshi Yamamoto, Haruki Yamano, Yutaka Taguchi, Shunnosuke Okada, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Hideyuki Takahashi, Glucagon-like peptide 2 (GLP-2) in bovine colostrum and transition milk, Heliyon, https://doi.org/10.1016/j.heliyon.2021.e07046, 2021.05.
5. Yutaka Taguchi, Yudai Inabu, Koki Hayasaki, Noriyuki Maeda, Yoshiro Kanmera, Seiji Yamasaki, Noboru Ota, Kenji Mukawa, Arisa Tsuboi, Hirokuni Miyamoto, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Christopher D. McMahon, Hideyuki Takahashi, Effects of feeding high volumes of milk replacer on reproductive performance and on concentrations of metabolites and hormones in blood of Japanese black heifer calves, Animal Science Journal, https://doi.org/10.1111/asj.13505, 2021.01, 肉牛生産現場では仔牛の減少に伴う仔牛取引価格の高騰が問題になっている。この問題を解決するためには母牛の生涯産仔数を増やすことが必須である。そのためには早期に人工授精(AI:Artificial insemination)が可能な体格を獲得させて初産分娩月齢を早める必要がある。これまでの研究成果より哺乳期の代用乳多給がメス仔牛の発育(特に体高)を向上させることが明らかとなり、代用乳多給によって初産分娩月齢を早期化できる可能性が考えられた。しかし、代用乳多給は標準的なプランが確立されておらず、増体および繁殖成績に及ぼす影響は不明である。
　そこで本研究は、生後3日齢の黒毛和種メス仔牛51頭を3種の異なる代用乳多給プランで飼養管理し、増体および繁殖成績を検討した。試験の結果、AIが可能な体格は体重270kg以上、体高116cm以上であることが明らかとなった。また、試験に供試した51頭のうち7割以上のメス仔牛が代用乳多給により10か月齢時に上記のAIに必要な体格の条件を満たし、51頭の初産分娩月齢平均は22.1か月齢となった。これは令和2年度の全国平均である24.5か月齢より2か月以上短い結果となった。また、３種類の代用乳の多給プランの違いによる初産分娩月齢の比較では、最も早期化できたプランでは21.5か月齢となり、代用乳の多給プランによっては全国平均よりも3か月短くできる可能性も示唆され、新生仔牛にも問題はなかった。一方で、農林水産省が提言している初産分娩月齢の数値目標である23.5か月齢よりも早期化できたことから、新規繁殖技術による畜産業改善ならびに政策形成へも寄与する成果である。.
6. Toru Asahina, Kosuke Nakagiri, Yuji Shiotsuka, Tetsuji Etoh, Ryoichi Fujino, Nonomi Suzuki, Christopher D. McMahon, Hideyuki Takahashi, Physiological Responses of Japanese Black Calves to Supplementation with Sodium Butyrate in Milk Replacer, Food & Nutrition Journal, 10.29011/2575-7091. 100083, 2018.06, Genetic factors are important for meat quality in cattle and gene expression may be determined by epigenetic control. This may involve Histone Deacetylases (HDACs), which suppress or enhance gene expression, and beta-hydroxybutyric acid (BHBA, produced from butyric acid), which inhibits HDAC activity and increases gene expression. This study aimed to determine how supplementing Japanese Black calves with sodium butyrate in milk replacer affects the relationship between plasma BHBA, HDAC activity in tissues, and blood metabolites. Eight Japanese Black female calves were randomly assigned to two groups of four animals each (control group, and supplementation with sodium butyrate group; NaB). Calves in both groups were fed milk replacer containing 26% Crude Protein (CP), 25.5% Crude Fat (CF), and 116% Total Digestible Nutrients (TDNs), and all calves received calf starter and hay ad libitum. Sodium butyrate was administered to the calves in the NaB group at daily doses of 3 g (from 3 to 30 days of age), 5 g (from 31 to 60 days of age), and 7 g (from 61 to 90 days of age). The supplementation of Japanese Black calves with sodium butyrate in milk replacer decreased plasma concentrations of BHBA..
7. H Takahashi, Y Suzuki, JS Mohamed, T Gotoh, SL Pereira, SE Alway, Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats, Experimental Gerontology, http://doi.org/10.1016/j.exger.2017.02.075, 92, 56-66, 2017.06, We have previously found that Epigallocatechin-3-gallate (EGCg), an abundant catechin in green tea, reduced apoptotic signaling and improved muscle recovery in response to reloading after hindlimb suspension (HS). In this study, we investigated if EGCg altered autophagy signaling in skeletal muscle of old rats in response to HS or reloading after HS. Fischer 344 x Brown Norway inbred rats (age 34 months) were given 1 ml/day of purified EGCg (50 mg/kg body weight), or the same sample volume of the vehicle by gavage. One group of animals received HS for 14 days and the second group of rats received 14 days of HS, then the HS was removed and they were allowed to recover by ambulating normally around the cage for two weeks. EGCg decreased a small number of autophagy genes in control muscles, but it increased the expression of other autophagy genes (e.g., ATG16L2, SNCA, TM9SF1, Pink1, PIM-2) and HS did not attenuate these increases. HS increased Beclinl, ATG7 and LC3-II/I protein abundance in hindlimb muscles. Relative to vehicle treatment, EGCg treatment had greater ATG12 protein abundance (35.8%, P
8. P Ouanh, ＠H Takahashi, H Ma, Y Shiotsuka, A Matsubara, T Sugino, C McMahon, T Etoh, R Fujino, M Furuse, T Gotoh, Effects of nutritional status on hormone concentrations of the somatotropin axis and metabolites in plasma and colostrum of Japanese Black cows, Animal Science Journal, 10.1111/asj.12686, 88, 4, 643-652, 2017.04, We aimed to determine the effects of nutritional status on concentrations of somatotropic axis hormones (growth hormone (GH) and insulin-like growth factor 1 (IGF-1)), insulin and metabolites (glucose, total protein and nonesterified fatty acids (NEFA)) in the plasma and colostrum in late antepartum cows. Eight pregnant Japanese Black cows were randomly assigned to two experimental groups (n=4 per group). Control cows (CON) received 100% of their nutritional requirements until parturition, whereas restricted group cows (RES) received 60% of their nutritional requirements. Blood samples were taken during the antepartum period, and blood and colostrum samples were collected on days 0, 1, and 3 after calving. Compared to the CON group, the RES group had higher concentrations of GH and NEFA in plasma, but significantly lower concentrations of glucose and insulin in plasma. The concentrations of GH in plasma after calving were significantly higher, but total plasma protein was significantly lower in RES than in CON cows. Compared to the CON group, the RES group had significantly higher concentrations of GH in colostrum, but significantly lower total concentrations of protein in colostrum. Concentrations of IGF-1 were not different between the two groups. These findings suggest that maternal nutritional status during late gestation influences concentrations of GH and total protein in the blood and colostrum of Japanese Black cows.
9. Hideyuki Takahashi, Atsuko Matsubara, Akira Saito, Ouanh Phomvisith, Akari Shiga, Ha T Mai, Toshihisa Sugino, Christopher D McMahon, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, M Furuse, T Gotoh, Higher intake of milk-replacer pre-weaning enhances post-weaning insulin-like growth factor 1 levels in Japanese Black cattle, Journal of Veterinary Science & Technology, 10.4172/2157-7579.1000409, 8, 1, 409, 2017.01, Alterations in early pre-natal nutrition of Japanese Black calves influence the glucose and lipid metabolism after weaning. However, the effects of early nutritional status on the endocrine system in later life stages in Japanese Black cattle are unknown. This study examined how post-weaning plasma levels of growth hormone (GH), insulin-like growth factor 1 (IGF-1), and blood insulin, which are hormones affecting growth and meat quality, and metabolites were affected by feeding 1800 g versus 500 g of milk replacer to Japanese Black cattle (5 per group) during nursing. Up to weaning (90 days post-birth), all calves received calf starter and hay ad libitum, and post-weaning, they received a concentrate feed and hay ad libitum. Plasma concentrations of GH and IGF-1 were greater at weaning in the high-milk-replacer group (P<0.1 and P<0.01, respectively), and elevated IGF-1 concentrations persisted until the study end (210 d) (P<0.05), suggesting that the levels were sustained independent of the influences of both GH and nutrient intake. Blood insulin and metabolites (plasma glucose, beta hydroxybutyric acid, and non-esterified fatty acids) were not significantly different between the two groups. The results of this study suggest that feeding calves a high volume of milk replacer during nursing will increase IGF-1 secretion well beyond weaning..
10. A Matsubara, H Takahashi, A Saito, A Nomura, K Sithyphone, CD McMahon, R Fujino, Y Shiotsuka, T Etoh, M Furuse, T Gotoh, Effects of a high milk intake during the pre-weaning period on nutrient metabolism and growth rate in Japanese Black cattle, Animal Science Journal, 10.1111/asj.12547, 87, 9, 1130-1136, 2016.09, This study aimed to determine the effects of feeding an increased volume of high-fat milk during the early post-natal life on metabolite concentrations in the blood, the expression of key genes regulating intermediary metabolism in the skeletal muscles, and the rate of growth of Japanese Black cattle. All calves were fed a high-fat milk replacer (crude protein, 26%; crude fat, 25.5%; total dissolved nitrogen, 116%). Control calves (n = 4) were nursed with 500 g milk replacer until 3 months of age (mo), whereas calves in the experimental group (n = 4) were nursed with 1,800 g milk replacer until 3 mo, and then the volume was gradually reduced until 5 mo. Body weight was significantly higher in the experimental group than in the control group at 7 mo. Plasma glucose concentrations were significantly lower in the experimental group. Expression of glucose-transporter-4 mRNA was lower, whereas that of glucose transporter 1, cluster of differentiation 36, and carnitine palmitoyltransferase-1b mRNA was significantly higher in the M. longissimus thoracis of the experimental group. Nutritional status during early post-natal life appears to strongly influence the growth rate and glucose and lipid metabolism in Japanese Black cattle..
11. H Takahashi, K Sato, T Yamaguchi, M Miyake, H Watanabe, Y Nagasawa, E Kitagawa, S Terada, M Urakawa, M. T. Rose, C. D. MacMahon, K Watanabe, S Ohwada, T Gotoh, H Aso, Myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese shorthorn cattle, Domestic Animal Endocrinology, 48, 62-68, 2014.02, ミオスタチンのエネルギー代謝に及ぼす影響を明らかにするため、ミオスタチンを欠損した草原短角牛ならびにミオスタチンが発現している日本短角種牛の骨格筋を用いて、グルコース輸送担体であるGLUT1、GLUT4のmRNA発現、グルコース取り込みに関与するインスリン受容体mRNA発現ならびに脂肪酸輸送担体であるCD36、CPT-1 mRNA発現をリアルタイムPCR法により解析をした。その結果、ミオスタチン欠損した草原短角牛の骨格筋では、インスリン依存型グルコース輸送担体であるGLUT4mRNA発現が上昇していることが明らかとなった。また、脂質代謝については、血中の遊離脂肪酸濃度が草原短角牛で低いことが明らかとなった。
　次に、草原短角牛ならびに日本短角種牛骨格筋筋芽細胞を用いて、筋管への分化誘導後0時、24時ならびに72時間後に同様の遺伝子発現を解析した。その結果、草原短角牛筋芽細胞では、筋分化後72時間においてGLUT4mRNA発現が上昇することが明らかとなり、　一方で、インスリン受容体、GLUT1mRNA発現は両種の間に差はなかった。　以上のことより、ミオスタチンはGLUT4発現を介してグルコース代謝を亢進することが考えられ、さらにその作用はインスリン感受性を上昇させることにより行われる可能性が示唆された。.
12. Takahashi H., Kurose Y., Suzuki Y., Kojima M., Yamaguchi T., Yoshida Y., Azuma Y., Sugino T., Kojima M., Kangawa K., Hasegawa Y and Kobayashi S., Changes in blood pancreatic polypeptide and ghrelin levels in response to feeding in sheep., Journal of Animal Science, 2010.06.
13. Takahashi H., Kurose Y., Suzuki Y., Kojima M., Yamaguchi T., Yoshida Y., Ogino M., Hodate K., Azuma Y., Sugino T., Kojima M., Kangawa K., Hasegawa Y and Kobayashi S., Ghrelin differentially modulates the GH secretory response to GHRH between the fed and fasted state in sheep., Domestic Animal Endocrinology, 2009.12.
14. Takahashi H., Kurose Y., Sakaida M., Suzuki Y., Kobayashi S., Sugino T., Kojima M., Kangawa K., Hasegawa Y and Terashima Y., Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep., Journal of Endocrinology, 2007.09.
15. Takahashi H., Kurose Y., Kobayashi S., Sugino T., Kojima M., Kangawa K., Hasegawa Y and Terashima Y., Ghrelin enhances glucose-induced insulin secretion in scheduled meal-fed sheep., Journal of Endocrinology, 2006.04.
Presentations
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1. Haruichi Kanaya, Mohamed M. Mansour, Shuya Yamamoto, Osamu Takiguchi, Moeka Ikedo,Koji Hori, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Hideyuki Takahashi, Battery-less vital sensor platform for cattle, International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS & Applications, 2019.12.


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