| 1. |
Hirofumi Tomiyama, Keitaro Murayama, Kiyotaka Nemoto, Suguru Hasuzawa, Taro Mizobe, Kenta Kato, Akira Matsuo, Aikana Ohno, Mingi Kang, Osamu Togao, Akio Hiwatashi, Kousei Ishigami, Tomohiro Nakao., Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 10.1016/j.pnpbp.2022.110516, Volume 116, 110516, 2022.06. |
| 2. |
Hasuzawa S, Tomiyama H, Murayama K, Ohno A, Kang M, Mizobe T, Kato K, Matuso A, Kikuchi K, Togao O, Nakao T., Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects., Front Psychiatry. 2022 May 13;13:836965., 10.3389/fpsyt.2022.836965. eCollection 2022., 2022.05. |
| 3. |
Mizobe T, Ikari K, Tomiyama H, Murayama K, Kato K, Hasuzawa S, Togao O, Hiwatashi A, Nakao T, Abnormal white matter structure in hoarding disorder., Journal of Psychiatric Research. 2022 Jan 18;148:1-8., 10.1016/jpsychires.202201031., 2021.01. |
| 4. |
Keitaro Murayama, Tomohiro Nakao, Aikana Ohono, Sae Tsuruta, Hirofumi Tomiyama, Suguru Hasuzawa, Taro Mizobe, Kenta Kato and Sigenobu Kanba, Impacts of Stressful Life Events and Traumatic Experiences on Onset of Obsessive-Compulsive Disorder., Frontiers in Psychiatry, 2020.11. |
| 5. |
Keitaro Murayama, Tomohiro Nakao, Sanematsu Hirokuni, Kayo Okada, Takashi Yoshiura, Mayumi Tomita, Yusuke Masuda, Kayoko Isomura, Akiko Nakagawa, Shigenobu Kanba, Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder., Progess in Neuropsychopharmacolgy & Biological Psychiatry, 10, 40, 160-166, 2013.10, Obsessive-compulsive disorder (OCD) is clinically heterogeneous. The aim of this study was to investigate differential neural responses to a symptom provocation task in drug-free patients who have predominantly aggression/checking symptoms (Checkers) and patients with contamination/washing symptoms (Washers). We compared the Checkers (n=10) and the Washers (n=12) separately to normal controls during the symptom provocation tasks using fMRI (functional magnetic resonance imaging). Moreover, we performed correlative analysis in each OCD group between brain activation and symptom severity. The Checkers showed hypoactivation in the left caudate and left anterior cingulate cortex (ACC) compared to the normal controls and a positive correlation between activated brain areas and symptom severity in the left ACC. The Washers showed hyperactivation in several bilateral cortico-cerebellar regions and a positive correlation between symptom severity and the bilateral fronto-temporal gyrus. We suggest that the caudate and ACC are associated with checking rituals and that large cortical brain regions are related to washing rituals.. |
