Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
YASUKAWA TAKEHIRO Last modified date:2018.06.20

Assistant Professor / Department of Clinical Chemistry and Laboratory Medicine / Department of Basic Medicine / Faculty of Medical Sciences

1. Matsuda S, Yasukawa T*, Sakaguchi S, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D., Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA, Sci. Rep., 8, 5801, [*corresponding author], 2018.04.
2. Mezuki, S., Fukuda, K., Matsushita, T., Fukushima, Y., Matsuo, R., Goto, Y.-i., Yasukawa, T., Uchiumi, T., Kang, D., Kitazono, T., Ago, T., Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report, BMC Neurology, 17:217, 2017.12.
3. Moss, C.F., Dalla Rosa, I., Hunt, L.E., Yasukawa, T., Young, R., Jones, A.W.E., Reddy, K., Desai, R., Virtue, S., Elgar, G., Voshol, P., Taylor, M.S., Holt I.J., Reijns, M.A.M., Spinazzola, A., Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model, Nucleic Acids Res., 45, 22, 12808-12815, 2017.11.
4. Fakruddin, M., Wei, F.Y., Emura, S., Matsuda, S., Yasukawa, T., Kang, D., Tomizawa, K., Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species, Nucleic Acids Res., 45, 20, 11954-11961, 2017.09.
5. Akman, G., Desai, R., Bailey, L.J., Yasukawa, T., Dalla Rosa, I., Durigon, R., Holmes, J.B., Moss, C.F., Mennuni, M., Houlden, H., Crouch, R.J., Hanna, M.G., Pitceathly, R.D., Spinazzola, A., Holt I.J., Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria, Proc. Natl. Acad. Sci. USA., 113, 30, E4276-E4285, 2016.07.
6. Qu, J., Yasukawa, T.*, Kang, D., Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells, J. Biochem., doi:10.1093/jb/mvw010, [*corresponding author], 2016.02, [2017年日本生化学会JB論文賞受賞].
7. Zhang, H., Zhang, Y.W., Yasukawa, T., Dalla Rosa, I., Khiati, S., Pommier, Y., Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria, Nucleic Acids Res., 42, 11, 7259-7267, 2014.05.
8. Reyes, A., Kazak, L., Wood, S.R., Yasukawa, T., Jacobs, H.T., Holt I.J., Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts, Nucleic Acids Res., 10.1093/nar/gkt196, 41(11):5837-5850, 2013.06.
9. Yao Z., Jones A. W. E., Fassone E., Sweeney M. G., Lebiedzinska M., Suski J. M., Wieckowski M. R., Tajeddine N., Hargreaves I. P., Yasukawa T., Tufo G., Brenner C., Kroemer G., Rahman S., Szabadkai G, PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations, Oncogene, 10.1038/onc.2012.259, 32(20):2592-600, 2013.05.
10. Ruhanen, H., Ushakov, K., Yasukawa, T.* [*corresponding author], Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells, Biochim. Biophys. Acta, 1813, 2000-2007, 2011.12.
11. Ruhanen, H., Borrie, S., Szabadkai, G., Tyynismaa, H., Jones, A. W. E., Kang, D., Taanman, J.-W., Yasukawa, T.* [*corresponding author], Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organization, Biochim. Biophys. Acta, 1803, 931-939, 2010.08.
12. Pohjoismäki, J. L. O., Holmes, J. B., Wood, S. R., Yang, M. Y., Yasukawa, T., Reyes, A., Bailey, L. J., Cluett, T. J., Goffart, S., Willcox, S., Rigby, R. E., Jackson, A. P., Spelbrink, J. N., Griffith, J. D., Crouch, R. J., Jacobs, H. T., Holt, I. J., Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid, J. Mol. Biol., 397, 1144-1155, 2010.04.
13. Di Re, M., Sembongi, H., He, J., Reyes, A., Yasukawa, T., Martinsson, P., Bailey, L. J., Goffart, S., Boyd-Kirkup, J. D., Wong, T. S., Fersht, A. R., Spelbrink, J. N., Holt, I. J., The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells, Nucleic Acids Res., 37, 5701-5713, 2009.09.
14. Hyvärinen, A. K., Pohjoismäki, J. L. O., Reyes, A., Wanrooij, S., Yasukawa, T., Karhunen, P. J., Spelbrink, J. N., Holt, I. J., Jacobs, H. T., The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA, Nucleic Acids Res., 35, 6458-6474, 2007.09.
15. Wanrooij, S., Goffart, S., Pohjoismäki, J. L. O., Yasukawa, T., Spelbrink, J. N., Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes, Nucleic Acids Res., 35, 3238-3251, 2007.04.
16. Yasukawa, T., Reyes, A., Cluett, T. J., Yang, M. Y., Bowmaker, M., Jacobs, H. T., Holt, I. J., Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand, EMBO J., 25, 5358-5371, 2006.10.
17. Kirino, Y., Yasukawa, T., Marjavaara, S. K., Jacobs, H. T., Holt, I. J., Watanabe, K., Suzuki, T., Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect, Hum. Mol. Genet., 15, 897-904, 2006.03.
18. Yasukawa, T., Yang, M. Y., Jacobs, H. T., Holt, I. J., A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA, Mol. Cell, 18, 651-662, 2005.06.
19. Yasukawa, T., Kirino, Y., Ishii, N., Holt, I. J., Jacobs, H. T., Makifuchi, T., Fukuhara, N., Ohta, S., Suzuki, T., Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases, FEBS Lett., 579, 2948-2952, 2005.05.
20. Kirino, Y., Yasukawa, T., Ohta, S., Akira, S., Ishihara, K., Watanabe, K., Suzuki, T., Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease, Proc. Natl. Acad. Sci. USA., 101, 15070-15075, 2004.10.
21. Hino, N., Suzuki, T., Yasukawa, T., Seio, K., Watanabe, K., Ueda, T., The pathogenic A4269G mutation in human mitochondrial tRNA(Ile) alters the T-stem structure and decreases the binding affinity for elongation factor Tu, Genes Cells, 9, 243-252, 2004.03.
22. Bowmaker, M., Yang, M. Y., Yasukawa, T., Reyes, A., Jacobs, H. T., Huberman, J. A., Holt, I. J., Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone, J. Biol. Chem., 278, 50961-50969, 2003.12.
23. Toompuu, M., Yasukawa, T., Suzuki, T., Hakkinen, T., Spelbrink, J. N., Watanabe, K., Jacobs, H. T., The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover, J. Biol. Chem., 277, 22240-22250, 2002.06.
24. Yasukawa, T., Suzuki, T., Ishii, N., Ohta, S., Watanabe, K., Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease, EMBO J., 20, 4794-4802, 2001.09.
25. Yasukawa, T., Suzuki, T., Ishii, N., Ueda, T., Ohta, S., Watanabe, K., Defect in modification at the anticodon wobble nucleotide of mitochondrial tRNA(Lys) with the MERRF encephalomyopathy pathogenic mutation, FEBS Lett., 467, 175-178, 2000.02.
26. Yasukawa, T., Hino, N., Suzuki, T., Watanabe, K., Ueda, T., Ohta, S., A pathogenic point mutation reduces stability of mitochondrial mutant tRNA(Ile), Nucleic Acids Res., 28, 3779-3784, 2000.10.
27. Yasukawa, T., Suzuki, T., Suzuki, T., Ueda, T., Ohta, S., Watanabe, K., Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, J. Biol. Chem., 275, 4251-4257, 2000.02.