| 1. |
Mhd Fouad Zakaria, Soichiro Sonoda, Hiroki Kato, Lan Ma, Norihisa Uehara, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Lisha Dai, Erika Yamauchi-Tomoda, Reona Aijima, Haruyoshi Yamaza, Fusanori Nishimura, Takayoshi Yamaza, Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease, Scientific Reports, 10.1038/s41598-024-57361-y., 6719, 14, 2024.03, Alveolar bone loss caused by periodontal disease eventually leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are the tissue-specific cells for maintaining and repairing the periodontal ligament, cementum, and alveolar bone. Here, we investigated the role of erythropoietin receptor (EPOR), which regulates the microenvironment-modulating function of mesenchymal stem cells, in PDLSC-based periodontal therapy. We isolated PDLSCs from patients with chronic periodontal disease and healthy donors, referred to as PD-PDLSCs and Cont-PDLSCs, respectively. PD-PDLSCs exhibited reduced potency of periodontal tissue regeneration and lower expression of EPOR compared to Cont-PDLSCs. EPOR-silencing suppressed the potency of Cont-PDLSCs mimicking PD-PDLSCs, whereas EPO-mediated EPOR activation rejuvenated the reduced potency of PD-PDLSCs. Furthermore, we locally transplanted EPOR-silenced and EPOR-activated PDLSCs into the gingiva around the teeth of ligament-induced periodontitis model mice and demonstrated that EPOR in PDLSCs participated in the regeneration of the periodontal ligament, cementum, and alveolar bone in the ligated teeth. The EPOR-mediated paracrine function of PDLSCs maintains periodontal immune suppression and bone metabolic balance via osteoclasts and osteoblasts in the periodontitis model mice. Taken together, these results suggest that EPOR signaling is crucial for PDLSC-based periodontal regeneration and paves the way for the development of novel options for periodontal therapy.. |
| 2. |
Norihisa Uehara, Nobuhide Shibusawa, Yoshikazu Mikami, Yukari Kyumoto-Nakamura, Soichiro Sonoda, Hiroki Kato, Takayoshi Yamaza, Toshio Kukita, Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling, Archives of Biochemistry and Biophysics, 10.1016/j.abb.2023.109821, 750, 2023.12. |
| 3. |
Norihisa Uehara, Yukari Kyumoto-Nakamura, Yoshikazu Mikami, Manabu Hayatsu, Soichiro Sonoda, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita, miR-92a-3p encapsulated in bone metastatic mammary tumor cell-derived extracellular vesicles modulates mature osteoclast longevity, Cancer Science, 10.1111/cas.15557, 113, 12, 4219-4229, 2022.12. |
| 4. |
Jing-Qi Zhang, Akira Takahashi, Jiong-Yan Gu, Xiaoxu Zhang, Yukari Kyumoto-Nakamura, Akiko Kukita, Norihisa Uehara, Hidenobu Hiura, Takayoshi Yamaza, and Toshio Kukita, In vitro and in vivo detection of tunneling nanotubes in normal and pathological osteoclastogenesis involving osteoclast fusion, Laboratory Investigation, 101, 12, 1571-1584, 2021.04. |
| 5. |
Soichiro Sonoda, Sara Murata, Hiroki Kato, Fouad Zakaria, Yukari Kyumoto-Nakamura, Norihisa Uehara, Haruyoshi Yamaza, Toshio Kukita, Takayoshi Yamaza, Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus, The Journal of Immunology, 206, 12, 3053-3063, 2021.04. |
| 6. |
Mizuki Ogawa, Miyako Udono, Kiichiro Teruya, Norihisa Uehara, Yoshinori Katakura, Exosomes Derived from Fisetin-treated Keratinocytes Mediate Hair Growth Promotion, Nutrients, 13, 6, 2087, 2021.06. |
| 7. |
Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza, Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model, Stem Cell Research and Therapy, 10.1186/s13287-020-01818-0, 11, 1, 296, 2020.07. |
| 8. |
Chisato Kubo,
Mizuki Ogawa,
Norihisa Uehara,
Yoshinori Katakura, Fisetin Promotes Hair Growth by Augmenting TERT Expression, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2020.566617, 8, 2020.10. |
| 9. |
Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza, Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model, Stem Cell Research and Therapy, 10.1186/s13287-020-01818-0, 11, 1, 2020.07. |
| 10. |
Badawy, T.
Kyumoto-Nakamura, Y.
Uehara, N.
Zhang, J.
Sonoda, S.
Hiura, H.
Yamaza, T.
Kukita, A.
Kukita, T., Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling, Laboratory Investigation, 10.1038/s41374-018-0179-4, 99, 6, 866-884, 2019.06. |
| 11. |
Yosuke Tanaka, Soichiro Sonoda, Haruyoshi Yamaza, Sara Murata, Kento Nishida, Yukari Kyumoto-Nakamura, Norihisa Uehara, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza, Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla, Journal of Endodontics, 10.1016/j.joen.2019.01.016, 45, 5, 591-598.e6, 2019.05. |
| 12. |
Tanaka, Y.
Sonoda, S.
Yamaza, H.
Murata, S.
Nishida, K.
Hama, S.
Kyumoto-Nakamura, Y.
Uehara, N.
Nonaka, K.
Kukita, T.
Yamaza, T., Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla, Stem Cell Res Ther, 10.1186/s13287-018-1077-9, 9, 1, 334, 2018.11. |
| 13. |
Badawy, T.
Kyumoto-Nakamura, Y.
Uehara, N.
Zhang, J.
Hiura, H.
Sonoda, S.
Yamaza, T.
Kukita, A.
Kukita, T., Unique Osteoblast-Specific Cell-Surface Antigen Useful for Odontoblast Ontology and Dentin Regeneration, Oral Health & Dental Science, 10.1038/s41374-018-0179-4, 2018.11. |
| 14. |
Soichiro Sonoda, Yu Feng Mei, Atsuta Ikiru, Atsushi Danjo, Haruyoshi Yamaza, Shion Hama, Kento Nishida, Ronghao Tang, Yukari Kyumoto, Norihisa Uehara, Toshio Kukita, Fusanori Nishimura, Takayoshi Yamaza, Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells, Scientific Reports, 10.1038/s41598-018-21183-6, 8, 1, 2018.02. |
| 15. |
Takuma Shiratori, Yukari Kyumoto, Akiko Kukita, Norihisa Uehara, Jingqi Zhang, Kinuko Koda, Mako Kamiya, Tamer Badawy, Erika Tomoda, Xianghe Xu, Takayoshi Yamaza, Yasuteru Urano, Kiyoshi Koyano, Toshio Kukita, IL-1β induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity
A possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and Talin-1, Journal of Immunology, 10.4049/jimmunol.1602035, 200, 1, 218-228, 2018.01. |
| 16. |
Norihisa Uehara, Akiko Kukita, Yukari Kyumoto, Takayoshi Yamaza, Hisataka Yasuda, Toshio Kukita, Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments, Laboratory Investigation, 10.1038/labinvest.2017.55, 97, 10, 1235-1244, 2017.10. |
| 17. |
Ombretta Melaiu, Justin Stebbing, Ylenia Lombardo, Elisa Bracci, Norihisa Uehara, Alessandra Bonotti, Alfonso Cristaudo, Rudy Foddis, Luciano Mutti, Roberto Barale, Federica Gemignani, Georgios Giamas, Stefano Landi, Correction
MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma (PLoS ONE (2017) 12:6 (e0180317) DOI: 10.1371/journal.pone.0085935), PLoS One, 10.1371/journal.pone.0180317, 12, 6, 2017.06. |
| 18. |
Toshio Takano, Yin Ji Li, Akiko Kukita, Takayoshi Yamaza, Yasunori Ayukawa, Kanako Moriyama, Norihisa Uehara, Hisayuki Nomiyama, Kiyoshi Koyano, Toshio Kukita, Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis, Laboratory Investigation, 10.1038/labinvest.2013.152, 94, 3, 286-296, 2014.03. |
| 19. |
Ombretta Melaiu, Justin Stebbing, Ylenia Lombardo, Elisa Bracci, Norihisa Uehara, Alessandra Bonotti, Alfonso Cristaudo, Rudy Foddis, Luciano Mutti, Roberto Barale, Federica Gemignani, Georgios Giamas, Stefano Landi, MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma, PLoS One, 10.1371/journal.pone.0085935, 9, 1, 2014.01. |
| 20. |
Kanako Moriyama, Akiko Kukita, Yin Ji Li, Norihisa Uehara, Jing Qi Zhang, Ichiro Takahashi, Toshio Kukita, Regulation of osteoclastogenesis through Tim-3
Possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction, Laboratory Investigation, 10.1038/labinvest.2014.107, 94, 11, 1200-1211, 2014.01. |
| 21. |
Yuko Emoto, Katsuhiko Yoshizawa, Norihisa Uehara, Yuichi Kinoshita, Takashi Yuri, Nobuaki Shikata, Airo Tsubura, Curcumin suppresses n-methyl-n-nitrosourea-induced photoreceptor apoptosis in sprague-dawley rats, In Vivo, 27, 5, 583-590, 2013.09. |
| 22. |
Katsuhiko Yoshizawa, Yuichi Kinoshita, Yuko Emoto, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Airo Tsubura, N-Methyl-N-nitrosourea-induced renal tumors in rats
Immunohistochemical comparison to human Wilms tumors, Journal of Toxicologic Pathology, 10.1293/tox.26.141, 26, 2, 141-148, 2013.07. |
| 23. |
Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Airo Tsubura, Histopathological and immunohistochemical characterization of spontaneously occurring uterine deciduomas in young adult rats, Journal of Toxicologic Pathology, 10.1293/tox.26.61, 26, 1, 61-66, 2013.06. |
| 24. |
Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Tomohito Hamazaki, Airo Tsubura, Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal Preneoplastic lesions in young Lewis rats, Oncology Letters, 10.3892/ol.2013.1162, 5, 4, 1112-1116, 2013.04. |
| 25. |
Katsuhiko Yoshizawa, Tomo Sasaki, Maki Kuro, Norihisa Uehara, Hideho Takada, Akiko Harauma, Naoki Ohara, Toru Moriguchi, Airo Tsubura, Arachidonic acid supplementation during gestational, lactational and post-weaning periods prevents retinal degeneration induced in a rodent model, British Journal of Nutrition, 10.1017/S0007114512003327, 109, 8, 1424-1432, 2013.04. |
| 26. |
Yuichi Kinoshita, Kosho Takasu, Takashi Yuri, Katsuhiko Yoshizawa, Norihisa Uehara, Ayako Kimura, Hisanori Miki, Airo Tsubura, Nobuaki Shikata, Two cases of malignant peritoneal mesothelioma without asbestos exposure
Cytologic and immunohistochemical features, Annals of Diagnostic Pathology, 10.1016/j.anndiagpath.2012.05.007, 17, 1, 99-103, 2013.02. |
| 27. |
Katsuhiko Yoshizawa, Norihisa Uehara, Ayako Kimura, Yuko Emoto, Yuichi Kinoshita, Takashi Yuri, Hideho Takada, Toru Moriguchi, Tomohito Hamazaki, Airo Tsubura, Promoting effect of arachidonic acid supplementation on N-methyl-N-nitrosourea--induced pancreatic acinar cell hyperplasia in young Lewis rats, Oncology Letters, 10.3892/ol.2012.1009, 5, 1, 76-82, 2013.01. |
| 28. |
Ayako Kimura, Katsuhiko Yoshizawa, Tomo Sasaki, Norihisa Uehara, Yuichi Kinoshita, Hisanori Miki, Takashi Yuri, Takashi Uchida, Airo Tsubura, N-methyl-N-nitrosourea-induced changes in epithelial rests of Malassez and the development of odontomas in rats, Experimental and Therapeutic Medicine, 10.3892/etm.2012.559, 4, 1, 15-20, 2012.07. |
| 29. |
Tomo Sasaki, Katsuhiko Yoshizawa, Yuichi Kinoshita, Hisanori Miki, Ayako Kimura, Takashi Yuri, Norihisa Uehara, Airo Tsubura, Spontaneously occurring intracranial lipomatous hamartoma in a young BALB/c mouse and a literature review, Journal of Toxicologic Pathology, 10.1293/tox.25.179, 25, 2, 179-182, 2012.07. |
| 30. |
Norihisa Uehara, Katsuhiko Yoshizawa, Airo Tsubura, Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells, Oncology Reports, 10.3892/or.2012.1758, 28, 1, 105-110, 2012.07. |
| 31. |
Hisanori Miki, Norihisa Uehara, Ayako Kimura, Tomo Sasaki, Takashi Yuri, Katsuhiko Yoshizawa, Airo Tsubura, Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells, International Journal of Oncology, 10.3892/ijo.2012.1325, 40, 4, 1020-1028, 2012.04. |
| 32. |
Katsuhiko Yoshizawa, Tomo Sasaki, Norihisa Uehara, Maki Kuro, Ayako Kimura, Yuichi Kinoshita, Hisanori Miki, Takashi Yuri, Airo Tsubura, N-ethyl-N-nitrosourea induces retinal photoreceptor damage in adult rats, Journal of Toxicologic Pathology, 10.1293/tox.25.27, 25, 1, 27-35, 2012.03. |
| 33. |
Norihisa Uehara, Sayaka Kanematsu, Hisanori Miki, Katsuhiko Yoshizawa, Airo Tsubura, Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells, Cancer Letters, 10.1016/j.canlet.2011.07.032, 315, 2, 112-121, 2012.02. |
| 34. |
Sayaka Kanematsu, Katsuhiko Yoshizawa, Norihisa Uehara, Hisanori Miki, Tomo Sasaki, Maki Kuro, Yen Chang Lai, Ayako Kimura, Takashi Yuri, Airo Tsubura, Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice, Oncology Reports, 10.3892/or.2011.1311, 26, 3, 603-608, 2011.09. |
| 35. |
Maki Kuro, Katsuhiko Yoshizawa, Norihisa Uehara, Hisanori Miki, Kanji Takahashi, Airo Tsubura, Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice, In Vivo, 25, 4, 617-623, 2011.07. |
| 36. |
Katsuhiko Yoshizawa, Tomo Sasaki, Maki Kuro, Hisanori Miki, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Airo Tsubura, Corneal damage induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea, In Vivo, 25, 4, 609-615, 2011.07. |
| 37. |
Katsuhiko Yoshizawa, Maki Kuro-Kuwata, Tomo Sasaki, Yen Chang Clark Lai, Sayaka Kanematsu, Hisanori Miki, Ayako Kimura-Kawanaka, Norihisa Uehara, Takashi Yuri, Airo Tsubura, Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-Ethyl-N-nitrosourea, Toxicologic Pathology, 10.1177/0192623311402221, 39, 4, 606-613, 2011.06. |
| 38. |
Airo Tsubura, Yen Chang Lai, Maki Kuwata, Norihisa Uehara, Katsuhiko Yoshizawa, Anticancer effects of garlic and garlic-derived compounds for breast cancer control, Anti-Cancer Agents in Medicinal Chemistry, 11, 3, 249-253, 2011.03. |
| 39. |
Airo Tsubura, Yen Chang Lai, Hisanori Miki, Tomo Sasaki, Norihisa Uehara, Takashi Yuri, Katsuhiko Yoshizawa, Animal models of N-methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials, In Vivo, 25, 1, 11-22, 2011.01. |
| 40. |
Katsuhiko Yoshizawa, Kazuko Nakao, Mayu Habiro, Kazuko Hayashi, Maki Kuwata, Norihisa Uehara, Takashi Yuri, Kae Nakamura, Airo Tsubura, Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque (Macaca fuscata)., Toxicologic Pathology, 10.1177/0192623310382561, 38, 7, 1058-1063, 2010.12. |
| 41. |
Sayaka Kanematsu, Norihisa Uehara, Hisanori Miki, Katsuhiko Yoshizawa, Ayako Kawanaka, Takashi Yuri, Airo Tsubura, Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells, Anticancer Research, 30, 9, 3381-3390, 2010.09. |
| 42. |
A. Tsubura, K. Yoshizawa, M. Kuwata, Norihisa Uehara, Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials, Histology and Histopathology, 25, 7, 933-944, 2010.07. |
| 43. |
Katsuhiko Yoshizawa, Maki Kuwata, Ayako Kawanaka, Norihisa Uehara, Takashi Yuri, Airo Tsubura, N-methyl-N-nitrosourea-induced retinal degeneration in mice is independent of the p53 gene., Molecular Vision, 15, 2919-2925, 2009.12. |
| 44. |
Yen Chang Lai, Takashi Yuri, Norihisa Uehara, Yoichiro Matsuoka, Sayaka Kanematsu, Airo Tsubura, Biphasic effect of short-term pregnancy hormone treatment on N-methyl-N-nitrosourea-induced mammary carcinogenesis in young and old rats, Molecular Medicine Reports, 10.3892/mmr-00000086, 2, 2, 213-220, 2009.03. |
| 45. |
Airo Tsubura, T. Yuri, K. Yoshizawa, Norihisa Uehara, H. Takada, Role of fatty acids in malignancy and visual impairment
Epidemiological evidence and experimental studies, Histology and Histopathology, 24, 2, 223-234, 2009.02. |
| 46. |
Airo Tsubura, Norihisa Uehara, Yoichiro Matsuoka, Katsuhiko Yoshizawa, Takashi Yuri, Estrogen and progesterone treatment mimicking pregnancy for protection from breast cancer, In Vivo, 22, 2, 191-202, 2008.03. |
| 47. |
Yoichiro Matsuoka, Norihisa Uehara, Airo Tsubura, hnRNP U interacts with the c-Myc-Max complex on the E-box promoter region inducing the ornithine decarboxylase gene, Oncology Reports, 10.3892/or_00000431, 22, 2, 249-255, 2008.02. |
| 48. |
Yoichiro Matsuoka, Katsumi Fukamachi, Norihisa Uehara, Hiroyuki Tsuda, Airo Tsubura, Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis, Cancer Science, 10.1111/j.1349-7006.2007.00689.x, 99, 2, 309-315, 2008.02. |
| 49. |
Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura, Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells, Molecular Cancer Research, 10.1158/1541-7786.MCR-07-0254, 6, 2, 186-193, 2008.02. |
| 50. |
Naoto Shimano, Norihisa Uehara, Yasuhiko Kiyozuka, Nobuaki Shikata, Airo Tsubura, Effects of prepubertal indole-3-carbinol treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Sprague-Dawley rats, In Vivo, 21, 6, 983-988, 2007.11. |
| 51. |
Katsuaki Miki, Katsuhiko Yoshizawa, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka, Airo Tsubura, PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats, In Vivo, 21, 5, 739-744, 2007.09. |
| 52. |
Reiko Tsukamoto, Takako Mikami, Katsuaki Miki, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka, Kazuichi Okazaki, Airo Tsubura, N-methyl-N-nitrosourea-induced mammary carcinogenesis is promoted by short-term treatment with estrogen and progesterone mimicking pregnancy in aged female Lewis rats, Oncology Reports, 18, 2, 337-342, 2007.08. |
| 53. |
T. Fujiki, T. Miura, M. Maura, H. Shiraishi, S. Nishimura, Y. Imada, Norihisa Uehara, Kosuke Tashiro, S. Shirahata, Yoshinori Katakura, TAK1 represses transcription of the human telomerase reverse transcriptase gene, Oncogene, 10.1038/sj.onc.1210331, 26, 36, 5258-5266, 2007.08. |
| 54. |
Airo Tsubura, Katsuhiko Yoshizawa, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka, Multistep mouse mammary tumorigenesis through preneoplasia to neoplasia and acquisition of metastatic potential, Medical Molecular Morphology, 10.1007/s00795-006-0351-6, 40, 1, 9-17, 2007.03. |
| 55. |
Katsuaki Miki, Norihisa Uehara, Nobuaki Shikata, Miyo Matsumura, Airo Tsubura, Poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide rescues N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats through preservation of nuclear factor-κB activity, Experimental Eye Research, 10.1016/j.exer.2006.09.023, 84, 2, 285-292, 2007.02. |
| 56. |
Takashi Yuri, Reiko Tsukamoto, Katsuaki Miki, Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura, Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells, Oncology Reports, 16, 6, 1307-1312, 2006.12. |
| 57. |
Takashi Yuri, Reiko Tsukamoto, Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura, Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats, In Vivo, 20, 6 B, 829-836, 2006.11. |
| 58. |
Norihisa Uehara, Akira Unami, Yasuhiko Kiyozuka, Nobuaki Shikata, Yuji Oishi, Airo Tsubura, Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats, Oncology Reports, 15, 4, 903-911, 2006.04. |
| 59. |
Norihisa Uehara, Katsuaki Miki, Reiko Tsukamoto, Yoichiro Matsuoka, Airo Tsubura, Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition, Experimental Eye Research, 10.1016/j.exer.2005.08.006, 82, 3, 488-495, 2006.03. |
| 60. |
Miki Tsujita-Kyutoku, Norihisa Uehara, Yoichiro Matsuoka, Shigeo Kyutoku, Yutaka Ogawa, Airo Tsubura, Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions, In Vivo, 19, 6, 959-964, 2005.11. |
| 61. |
Yoshinori Katakura, Kaichi Yoshizaki, Tomoharu Yasuda, Takahiro Tsunematsu, Norihisa Uehara, Takumi Miura, Tsukasa Fujiki, Sanetaka Shirahata, Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress, Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2005.06.109, 334, 2, 450-459, 2005.08. |
| 62. |
Yasuyoshi Nikaido, Naoyuki Danbara, Miki Tsujita-Kyutoku, Takashi Yuri, Norihisa Uehara, Airo Tsubura, Effects of prepubertal exposure to xenoestrogen on development of estrogen target organs in female CD-1 mice, In Vivo, 19, 3, 487-494, 2005.05. |
| 63. |
Naoyuki Danbara, Takashi Yuri, Miki Tsujita-Kyutoku, Reiko Tsukamoto, Norihisa Uehara, Airo Tsubura, Enterolactone induces apoptosis and inhibits growth of colo 201 human colon cancer cells both in vitro and in vivo, Anticancer Research, 25, 3 B, 2269-2276, 2005.05. |
| 64. |
Airo Tsubura, Norihisa Uehara, Yasuhiko Kiyozuka, Nobuaki Shikata, Dietary factors modifying breast cancer risk and relation to time of intake, Journal of Mammary Gland Biology and Neoplasia, 10.1007/s10911-005-2543-4, 10, 1, 87-100, 2005.01. |
| 65. |
Naoyuki Danbara, Norihisa Uehara, Nobuaki Shikata, Hideho Takada, Takahiko Hada, Airo Tsubura, Dietary effects of conjugated docosahexaenoic acid on N-methyl-N- nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats, Oncology Reports, 12, 5, 1079-1085, 2004.11. |
| 66. |
Takashi Yuri, Yasuyoshi Nikaido, Naoto Shimano, Norihisa Uehara, Nobuaki Shikata, Airo Tsubura, Effects of prepubertal zeranol exposure on estrogen target organs and N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats, In Vivo, 18, 6, 755-762, 2004.11. |
| 67. |
Yasuyoshi Nikaido, Katsuhiko Yoshizawa, Naoyuki Danbara, Miki Tsujita-Kyutoku, Takashi Yuri, Norihisa Uehara, Airo Tsubura, Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring, Reproductive Toxicology, 10.1016/j.reprotox.2004.05.002, 18, 6, 803-811, 2004.08. |
| 68. |
Miki Tsujita-Kyutoku, Takashi Yuri, Naoyuki Danbara, Hideto Senzaki, Yasuhiko Kiyozuka, Norihisa Uehara, Hideho Takada, Takahiko Hada, Teruo Miyazawa, Yutaka Ogawa, Airo Tsubura, Conjugated docosahexaenoic acid suppresses KPL-1 human breast cancer cell growth in vitro and in vivo
potential mechanisms of action., Breast Cancer Research, 6, 4, 2004.04. |
| 69. |
Norihisa Uehara, Yu Chien Chou, Jose J. Galvez, Paola de-Candia, Robert D. Cardiff, Robert Benezra, Gopalan Shyamala, Id-1 is not expressed in the luminal epithelial cells of mammary glands, Breast Cancer Research, 10.1186/bcr560, 5, 2, 2003.04. |
| 70. |
Yu Chien Chou, Norihisa Uehara, Jason R. Lowry, G. Shyamala, Mammary epithelial cells of PR-A transgenic mice exhibit distinct alterations in gene expression and growth potential associated with transformation, Carcinogenesis, 10.1093/carcin/24.3.403, 24, 3, 403-409, 2003.03. |
| 71. |
Takumi Miura, Yoshinori Katakura, Katsuhiko Yamamoto, Norihisa Uehara, Toshie Tsuchiya, Eun Ho Kim, Sanetaka Shirahata, Neural stem cells lose telomerase activity upon differentiating into astrocytes, Cytotechnology, 10.1023/A:1014016315003, 36, 1-3, 137-144, 2001.12. |
| 72. |
Norihisa Uehara, Yoshinori Katakura, Takumi Miura, Sanetaka Shirahata, Subtractive screening of genes involved in cellular senescence, Cytotechnology, 10.1023/A:1008103230335, 35, 1, 35-42, 2001.01. |
| 73. |
Uehara, N.
Katakura, Y.
Nishimoto, S.
Teruya, K.
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