Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Jun Hata Last modified date:2019.06.26

Associate Professor / Department of Epidemiology and Public Health / Department of Basic Medicine / Faculty of Medical Sciences


Papers
1. Tanaka M, Honda T, Yamakage H, Hata J, Yoshida D, Hirakawa Y, Shibata M, Inoue T, Kusakabe T, Satoh-Asahara N, Ninomiya T., A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: The Hisayama study., Diabetes Res Clin Pract, 146, 225-232, 2018.12.
2. Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, Hata J, Hozawa A, Iwasaki M, Matsuda K, Minegishi N, Satoh M, Tanno K, Yamaji T, Wakai K, Hitomi J, Kiyohara Y, Kubo M, Tanaka H, Tsugane S, Yamamoto M, Sobue K, Shimizu A, Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols, PLoS One, 11, 1, e0147519, 2016.01.
3. Wakisaka Y, Matsuo R, Hata J, Kuroda J, Kitazono T, Kamouchi M, Ago T; Fukuoka Stroke Registry Investigators, Adverse influence of pre-stroke dementia on short-term functional outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry., Cerebrovasc Dis, 43, 82-89, 2017.04.
4. Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T, Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study., J Am Heart Assoc , 7, e006693, 2018.01.
5. Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T, Alternative measures of hyperglycemia and risk of alzheimer's disease in the community: the Hisayama Study., J Clin Endocrinol Metab, 102, 3002-3010, 2017.08.
6. Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y, Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: the Hisayama Study, J Atheroscler Thromb, 22, 4, 390-403, 2015.04.
7. Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T., Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community., J Am Geriatr Soc, 66, 1911-1918, 2018.10.
8. Inaishi J, Hirakawa Y, Horikoshi M, Akiyama M, Higashioka M, Yoshinari M, Hata J, Mukai N, Kamatani Y, Momozawa Y, Kubo M, Ninomiya T., Association Between Genetic Risk and Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study., J Clin Endocrinol Metab, 1, 3213-3222, 2019.08.
9. Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T, Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study, Diabetes Care, 39, 9, 1543-1549, 2016.09.
10. Shibata M, Ohara T, Yoshida D, Hata J, Mukai N, Kawano H, Kanba S, Kitazono T, Ninomiya T, Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study., J Affect Disord, 237, 73-79, 2018.04.
11. Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T, Association between serum vitamin D and all-cause and cause-specific death in a general Japanese population - the Hisayama Study., Circ J, 81, 1315-1321, 2017.08.
12. Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators, Association between onset-to-door time and clinical outcomes after ischemic stroke., Stroke, 48, 3049-3056, 2017.11.
13. Kiyuna F, Sato N, Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.., Association of Embolic Sources With Cause-Specific Functional Outcomes Among Adults With Cryptogenic Stroke., JAMA Netw Open, 1, e182953, 2018.09.
14. Kudo K, Hata J, Matsumoto K, Shundo Y, Fukuyama S, Inoue H, Kitazono T, Kiyohara Y, Ninomiya T, Nakanishi Y, Association of airflow limitation with carotid atherosclerosis in a Japanese community - the Hisayama Study., Circ J, 81, 1846-1853, 2017.11.
15. Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y, Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study, Cardiovasc Diabetol, 14, 84, 2015.06.
16. Delcourt C, Zheng D, Chen X, Hackett M, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Woodward M, Huang Y, Robinson T, Lavados PM, Lindley RI, Stapf C, Davies L, Chalmers J, Anderson CS, Sato S; INTERACT Investigators, Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies, J Neurol Neurosurg Psychiatry, 88, 1, 70-75, 2017.01.
17. Hata J, Yubi T, Ninomiya T., Author response: Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community., Neurol Clin Pract, 8, 464-465, 2018.12.
18. Peters SAE, Wang X, Lam TH, Kim HC, Ho S, Ninomiya T, Knuiman M, Vaartjes I, Bots ML, Woodward M; Asia Pacific Cohort Studies Collaboration.., Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration., BMJ Open, 8, e019335, 2018.03.
19. Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T, Combination of helicobacter pylori antibody and serum pepsinogen as a good predictive tool of gastric cancer incidence: 20-year prospective data from the Hisayama Study, J Epidemiol, 26, 12, 629-639, 2016.12.
20. Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y, Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama Study, Cerebrovasc Dis, 31, 5, 477-484, 2011.05.
21. Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T., Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study., Am J Clin Nutr, 109, 1664-1671, 2019.06.
22. Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T; FSR Investigators, Day-by-day blood pressure variability and functional outcome after acute ischemic stroke: Fukuoka Stroke Registry, Stroke, 46, 7, 1832-1839, 2015.07.
23. Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T, Day-to-day blood pressure variability and risk of dementia in a general Japanese elderly population: the Hisayama Study., Circulation, 136, 516-525, 2017.08, The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged 40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988–2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n ¼ 17; age-adjusted hazard ratio ¼ 4.56, 95% confidence interval: 2.42, 8.60) and women (n ¼ 6; age-adjusted hazard ratio ¼ 5.84, 95% confidence interval: 2.00, 17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n ¼ 23; age-adjusted hazard ratio ¼ 3.91, 95% confidence interval: 2.23, 6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori–negative and –positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection..
24. Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T, Development and validation of a risk assessment tool for gastric cancer in a general Japanese population., Gastric Cancer, 21, 383-390, 2018.05.
25. Honda T, Yoshida D, Hata J, Hirakawa Y, Ishida Y, Shibata M, Sakata S, Kitazono T, Ninomiya T., Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: The Hisayama Study., Atherosclerosis, 279, 38-44, 2018.12.
26. Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T, Dietary protein intake and stroke risk in a general Japanese population: the Hisayama Study, Stroke, 48, 6, 1478-1486, 2017.06.
27. Nakane H, Kamouchi M, Hata J, Ibayashi S, Kusuda K, Omae T, Nagao T, Ago T, Kitazono T; EMINENT Study Investigators, Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: the EMINENT Study, Intern Med, 54, 6, 573-577, 2015.03.
28. Hata J, Arima H, Zoungas S, Fulcher G, Pollock C, Adams M, Watson J, Joshi R, Kengne AP, Ninomiya T, Anderson C, Woodward M, Patel A, Mancia G, Poulter N, MacMahon S, Chalmers J, Neal B; ADVANCE Collaborative Group, Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE tria, PLoS One, 8, 2, e55807, 2013.02.
29. Hata J, Arima H, Rothwell PM, Woodward M, Zoungas S, Anderson C, Patel A, Neal B, Glasziou P, Hamet P, Mancia G, Poulter N, Williams B, MacMahon S, Chalmers J; ADVANCE Collaborative Group, Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial, Circulation, 128, 12, 1325-1334, 2013.09.
30. Hashimoto S, Yasuda M, Ninomiya T, Hata J, Yoshida D, Tahara-Asakuma T, Hirakawa Y, Arakawa S, Fujiwara K, Kiyohara Y, Ishibashi T, Foveal and macular thickness in a Japanese population: the Hisayama Study, Ophthalmic Epidemiol, 23, 3, 202-208, 2016.06.
31. Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M, Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction, Hum Mol Genet, 16, 6, 630-639, 2007.03.
32. Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A, Genetic predisposition to ischemic stroke: a polygenic risk score, Stroke, 48, 2, 253-258, 2017.02.
33. Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y, Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study, Atherosclerosis, 242, 1, 199-204, 2015.09.
34. Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.., Insulin resistance and clinical outcomes after acute ischemic stroke., Neurology, 90, e1470-e1477, 2018.04.
35. Fujiwara K, Yasuda M, Ninomiya T, Hata J, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T, Insulin resistance is a risk factor for increased intraocular pressure: the Hisayama Study, Invest Ophthalmol Vis Sci, 56, 13, 7983-7987, 2015.12.
36. Delcourt C, Sato S, Zhang S, Sandset EC, Zheng D, Chen X, Hackett ML, Arima H, Hata J, Heeley E, Salman RA, Robinson T, Davies L, Lavados PM, Lindley RI, Stapf C, Chalmers J, Anderson CS; INTERACT2 Investigators, Intracerebral hemorrhage location and outcome among INTERACT2 participants, Neurology, 88, 15, 1408-1414, 2017.04.
37. Ogata T, Matsuo R, Kiyuna F, Hata J, Ago T, Tsuboi Y, Kitazono T, Kamouchi M; FSR Investigators, Left atrial size and long-term risk of recurrent stroke after acute ischemic stroke in patients with nonvalvular atrial fibrillation., J Am Heart Assoc, 6, e006402, 2017.08.
38. Yonemoto K, Honda T, Kishimoto H, Yoshida D, Hata J, Mukai N, Shibata M, Hirakawa Y, Ninomiya T, Kumagai S., Longitudinal Changes of Physical Activity and Sedentary Time in the Middle-Aged and Older Japanese Population: The Hisayama Study., J Phys Act Health, 16, 165-171, 2019.02.
39. Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study, J Am Geriatr Soc, 63, 11, 2332-2339, 2015.11.
40. Sakata S, Hata J, Fukuhara M, Yonemoto K, Mukai N, Yoshida D, Kishimoto H, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T, Morning and evening blood pressures are associated with intima-media thickness in a general population - the Hisayama Study., Circ J, 81, 1647-1653, 2017.10.
41. Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Parテゥ G, O'Donnell M, Ago T, et al., Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis., Circulation, 139, 295-298, 2019.01.
42. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, et al., Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes., Nat Genet, 50, 524-537, 2018.04.
43. Honda T, Kishimoto H, Mukai N, Hata J, Yoshida D, Hirakawa Y, Shibata M, Ohara T, Kumagai S, Ninomiya T., Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study., J Diabetes Investig, 10, 809-816, 2019.05.
44. Chen T, Kishimoto H, Honda T, Hata J, Yoshida D, Mukai N, Shibata M, Ninomiya T, Kumagai S, Patterns and Levels of Sedentary Behavior and Physical Activity in a General Japanese Population: The Hisayama Study., J Epidemiol, 28, 260-265, 2018.05.
45. Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y., Periodontal status and lung function decline in the community: the Hisayama study., Sci Rep, 8, 13354, 2018.09.
46. Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y., Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease., J Dent Res, 98, 534-540, 2019.05.
47. Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.., Poor glycemic control and posterior circulation ischemic stroke., Neurol Clin Pract, 9, 129-139, 2019.04.
48. Fujiwara K, Yasuda M, Hata J, Oshima Y, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T, Ninomiya T, Sonoda KH., Prevalence and Risk Factors for Polypoidal Choroidal Vasculopathy in a General Japanese Population: The Hisayama Study., Semin Ophthalmol, 33, 813-819, 2018.08.
49. Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T., Prevalence of adult epilepsy in a general Japanese population: The Hisayama study., Epilepsia Open, 4, 182-186, 2019.01.
50. Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T., Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community., Neurol Clin Pract, 8, 223-231, 2018.06.
51. Ohkuma T, Woodward M, Jun M, Muntner P, Hata J, Colagiuri S, Harrap S, Mancia G, Poulter N, Williams B, Rothwell P, Chalmers J; ADVANCE Collaborative Group, Prognostic value of variability in systolic blood pressure related to vascular events and premature death in type 2 diabetes mellitus: the ADVANCE-ON study., Hypertension, 70, 461-468, 2017.08.
52. NCD Risk Factor Collaborationツ(NCD-RisC).., Rising rural body-mass index is the main driver of the global obesity epidemic in adults., Nature, 569, 260-264, 2019.05.
53. Hata J, Nagai A, Hirata M, Kamatani Y, Tamakoshi A, Yamagata Z, Muto K, Matsuda K, Kubo M, Nakamura Y; Biobank Japan Cooperative Hospital Group, Kiyohara Y, Ninomiya T; Collaborator, Risk prediction models for mortality in patients with cardiovascular disease: the BioBank Japan project, J Epidemiol, 27, 3S, S71-S76, 2017.03.
54. Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y, Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009), Circulation, 128, 11, 1198-1205, 2013.09.
55. Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y, Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population, Circulation, 118, 25, 2672-2678, 2008.12.
56. Furuta Y, Hata J, Mukai N, Hirakawa Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T, Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: The Hisayama Study., Atherosclerosis, 273, 84-90, 2018.06.
57. Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T., Serum Ethylamine Levels as an Indicator of l-Theanine Consumption and the Risk of Type 2 Diabetes in a General Japanese Population: The Hisayama Study., Diabetes Care, 42, 1234-1240, 2019.07.
58. Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T., Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study., Ann Neurol, 85, 47-58, 2019.01.
59. Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T, Serum angiopoietin-like protein 2 is a novel risk factor for cardiovascular disease in the community: the Hisayama Study, Arterioscler Thromb Vasc Biol, 36, 8, 1686-1691, 2016.08, Objective—Angiopoietin-like protein 2 (ANGPTL2), a proinflammatory mediator, has been reported to accelerate the development of insulin resistance, endothelial dysfunction, and atherosclerosis in mice. However, no cohort studies have examined the relationship between serum ANGPTL2 levels and the development of cardiovascular disease (CVD) in a general population.
Approach and Results—A total of 3005 community-dwelling Japanese aged ≥40 years without a history of CVD were divided into 4 groups according to the quartiles of serum ANGPTL2 concentrations (Q1, lowest and Q4, highest) and followed up for 10 years. The hazards ratios and their 95% confidence intervals for the development of CVD (coronary heart disease or stroke) were estimated using a Cox proportional hazards model. During the follow-up, 219 first-ever CVD events were observed. The risk of CVD increased significantly with elevating ANGPTL2 levels after adjustment for age, sex, serum total cholesterol, use of lipid-lowering agents, ECG abnormalities, smoking habits, alcohol intake, and regular exercise (hazards ratios [95% confidence interval], Q1, 1.00 [reference]; Q2, 1.27 [0.80–2.04]; Q3, 1.48 [0.95–2.32]; and Q4, 1.85 [1.20–2.85]; P=0.003 for trend). After additional adjustment for metabolic syndrome components and serum high-sensitivity C-reactive protein levels as an inflammatory marker, the association was attenuated but remained significant (hazards ratios [95% confidence interval], Q1, 1.00 [reference]; Q2, 1.21 [0.76–1.94]; Q3, 1.38 [0.87–2.17]; and Q4, 1.66 [1.05–2.60]; P=0.02 for trend).
Conclusions—Our findings suggest that elevated serum ANGPTL2 levels are a novel risk factor for the development of CVD in the general population. This association is partially mediated by metabolic disorders and inflammation..
60. Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T, Serum non-high-density lipoprotein cholesterol and risk of cardiovascular disease in community dwellers with chronic kidney disease: the Hisayama Study., J Atheroscler Thromb, 24, 706-715, 2017.07.
61. Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T, Serum uric acid as a risk factor for chronic kidney disease in a Japanese community: the Hisayama Study, Circ J, 80, 8, 1857-1862, 2016.07.
62. Irie F, Kamouchi M, Hata J, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators, Sex differences in short-term outcomes after acute ischemic stroke: the Fukuoka Stroke Registry, Stroke, 46, 2, 471-476, 2015.02.
63. Hata J, Tanizaki Y, Kiyohara Y, Kato I, Kubo M, Tanaka K, Okubo K, Nakamura H, Oishi Y, Ibayashi S, Iida M, Ten year recurrence after first ever stroke in a Japanese community: the Hisayama Study, J Neurol Neurosurg Psychiatry, 76, 3, 368-372, 2005.03.
64. Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuhara M, Kubo M, Kitazono T, Iida M, Kiyohara Y, The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population, Atherosclerosis , 210, 1, 249-255, 2010.05.
65. Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, Kanba S, Kitazono T, Kiyohara Y, The long-term association between physical activity and risk of dementia in the community: the Hisayama Study, Eur J Epidemiol, 31, 3, 267-274, 2016.03.
66. Takeuchi K, Ohara T, Furuta M, Takeshita T, Shibata Y, Hata J, Yoshida D, Yamashita Y, Ninomiya T, Tooth loss and risk of dementia in the community: the Hisayama Study, J Am Geriatr Soc, 65, 5, e95-e100, 2017.05.
67. Nagata M, Hata J, Hirakawa Y, Mukai N, Yoshida D, Ohara T, Kishimoto H, Kawano H, Kitazono T, Kiyohara Y, Ninomiya T, The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community: the Hisayama Study., J Epidemiol, 27, 578-583, 2017.12.
68. Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y., Tongue Microbiota and Oral Health Status in Community-Dwelling Elderly Adults., mSphere, 3, e00332-18, 2018.08.
69. Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T, Trends in dementia prevalence, incidence, and survival rate in a Japanese community, Neurology, 88, 20, 1925-1932, 2017.05.
70. Ogata H, Hirakawa Y, Matsumoto K, Hata J, Yoshida D, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y., Trends in the prevalence of airflow limitation in a general Japanese population: two serial cross-sectional surveys from the Hisayama Study., BMJ Open, 9, e023673, 2019.03.
71. Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T, White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study., Hypertens Res, 40, 937-943, 2017.11.