九州大学-研究者情報 [岸村顕広 (准教授) 工学研究院応用化学部門]

生体分子凝縮体に基づく人工オルガネラ構築と物質生産超越分子システムへの活用
キーワード：人工オルガネラ, 生体分子凝縮体, コアセルベート, 人工細胞, 酵素反応, タンパク質集積, 核酸
2022.04～2024.03.

生体分子凝縮体に基づく人工オルガネラ構築と物質生産超越分子システムへの活用
キーワード：人工オルガネラ, 生体分子凝縮体, 人工細胞, 酵素反応
2024.04.

生体高分子を含む過渡的濃縮相からの相分離制御に基づく階層的集合構造の合理的構築
キーワード：ベシクル、コアセルベート、階層構造、人工オルガネラ、生体高分子
2022.04.

タンパク質濃縮カプセルとしてのyolk-shell構造体の開発と高効率カスケード反応への応用
キーワード：酵素、タンパク質、ポリイオンコンプレックス、yolk-shell構造体、濃厚環境、液液相分離、カスケード反応
2020.06～2020.03.

人工細胞質設計に向けた液液相分離モデル系の構築と濃厚環境の機能的理解
キーワード：コアセルベート、細胞内相分離、タンパク質
2019.06～2021.03.

生体内での自律駆動を目指した自発光型ナノシステム創製とその応用
キーワード：光源フリー、ナノメディシン、ベシクル
2017.04～2019.07.

ナノ構造化コアセルベートを用いた新規ソフトマテリアル基盤の確立
キーワード：コアセルベート、ブロック共重合体、ポリイオンコンプレックス、ハイブリッド材料、タンパク質
2015.04.

分子集合体型薬物ナノカプセルの内部物性制御に基づく体内動態制御
キーワード：ドラッグデリバリーシステム、ナノメディシン、薬物動態学、ナノ生理学
2018.04～2022.03.

高分子ナノカプセルを用いた生体内における新規酵素利用基盤の構築
キーワード：酵素、ナノメディシン、タンパク質デリバリー、ベシクル、ナノリアクター
2014.04～2017.03.

クラウディング・ナノコンパートメントの創製とナノリアクターとしての開発
キーワード：ナノコンパートメント、ベシクル、分子クラウディング、酵素反応
2013.04～2015.03.

主要著書

全てを見る→

1.	岸村顕広（高分子学会・編）, 高分子科学の事典, 朝倉書店、東京, ポリイオンコンプレックスナノ粒子、2-14 pp. 168-169（2022年11月1日、総ページ数648） ISBN: 978-4-254-25272-9, 2022.11.
2.	多数, 相分離生物学の全貌　（第37節・高分子科学から見る生物学的相分離を執筆）, 東京化学同人, 2020.11.
3.	多数（103名）, 生体吸収性材料の開発と安全性評価高分子ベシクルを用いた新しいDDS材料の開発（４章第７節）, 技術情報協会、東京, 2017.12.
4.	Akihiro Kishimura, Kazunori Mtsuura, Akira Kakugo, Akinori Saeki, Takeoka Yukikazu, Masanobu Naito, Takashi Nakanishi, Masahiro Funahashi, Shiki Yagai, 有機機能材料　基礎から応用まで, 講談社, 第10章、第12章を分担執筆, 2014.03.

主要原著論文

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1.	Fadlina Aulia, Hiroaki Matsuba, Shoya Adachi, Takumi Yamada, Ikuhiko Nakase, Teruki Nii, Takeshi Mori, Yoshiki Katayama, and Akihiro Kishimura, Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths., J. Mater. Chem B., 10.1039/D3TB02049E, 12, 1826-1836, 2024.02, In nanomedicine, PEGylation of nanomaterials poses a dilemma since it inhibits their interaction with target cells and enables their retention in target tissues despite its biocompatibility and nonspecific internalisation suppression. PEGylated polypeptide-based polyion complexes (PICs) are fabricated via the self-assembly of PEGylated aniomers and homocatiomers based on electrostatic interactions. We propose that various parameters like block copolymer design and PIC domain characteristics can enhance the cell–PEGylated PIC interactions. Remarkably, the properties of the PIC domain were tuned by the matched/mismatched ionomer chain lengths, PIC domain crosslinking degree, chemical modification of cationic species after crosslinking, PIC morphologies (vesicles/micelles) and polyethylene glycol (PEG) chain lengths. Cellular internalisation of the prepared PICs was evaluated using HeLa cells. Consequently, mismatched ionomer chain lengths and vesicle morphology enhanced cell–PIC interactions, and the states of ion pairing, particularly cationic residues, affected the internalisation behaviours of PICs via acetylation or guanidinylation of amino groups on catiomers. This treatment attenuated the cell–PIC interactions, possibly because of reduced interaction of PICs with negatively charged species on the cell-surface, glycosaminoglycans. Moreover, morphology and PEG length were correlated with PIC internalisation, in which PICs with longer and denser PEG were internalised less effectively. Cell line dependency was tested using RAW 264.7 macrophage cells; PIC recognition could be maintained after capping amino groups on catiomers, indicating that the remaining anionic groups were still effectively recognised by the scavenger receptors of macrophages. Our strategy for tuning the physicochemical properties of the PEGylated PIC nanocarriers is promising for overcoming the PEG issue..
2.	Biplab K C, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Dynamic frustrated charge hotspots created by charge density modulation sequester globular proteins into complex coacervates, Chemical Science, 10.1039/d3sc00993a, 14, 24, 6608-6620, 2023.05, This study presents a simple strategy for the sequestration of globular proteins as clients into synthetic polypeptide-based complex coacervates as a scaffold, thereby recapitulating the scaffold-client interaction found in biological condensates. Considering the low net charges of scaffold proteins participating in biological condensates, the linear charge density (s) on the polyanion, polyethylene glycol-b-poly(aspartic acids), was reduced by introducing hydroxypropyl or butyl moieties as a charge- neutral pendant group. Complex coacervate prepared from the series of reduced-s polyanions and the polycation, homo-poly-L-lysine, could act as a scaffold that sequestered various globular proteins with high encapsulation efficiency (>80%), which sometimes involved further agglomerations in the coacervates. The sequestration of proteins was basically driven by electrostatic interaction, and therefore depended on the ionic strength and charges of the proteins. However, based on the results of polymer partitioning in the coacervate in the presence or absence of proteins, charge ratios between cationic and anionic polymers were maintained at the charge ratio of unity. Therefore, the origin of the electrostatic interaction with proteins is considered to be dynamic frustrated charges in the complex coacervates created by non-neutralized charges on polymer chains. Furthermore, fluorescence recovery after photobleaching (FRAP) measurements showed that the interaction of side-chains and proteins changed the dynamic property of coacervates. It also suggested that the physical properties of the condensate are tunable before and after the sequestration of globular proteins. The present rational design approach of the scaffold-client interaction is helpful for basic life-science research and the applied frontier of artificial organelles..
3.	Akinori Goto, Yasutaka Anraku, Shigeto Fukushima and Akihiro Kishimura, Increased Enzyme Loading in PICsomes Via Controlling Membrane Permeability Improves Enzyme Prodrug Cancer Therapy Outcome, Polymers, https://doi.org/10.3390/polym15061368, 15, 6, 1368, 2023.03.
4.	Asmariah Ahmad, Tomoki Maruyama, Teruki Nii, Takeshi Mori, Yoshiki Katayama, and Akihiro Kishimura, Facile preparation of hexagonal nanosheets via polyion complex formation from α-helical polypeptides and polyphosphate-based molecules, Chemical Communications, 10.1039/d2cc05137k, 59, 12, 1657-1660, 2023.01.
5.	Asmariah Ahmad, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Masanori Toyofuku, Akihiro Kishimura, Nanostructure Control of an Antibiotic-Based Polyion Complex Using a Series of Polycations with Different Side-Chain Modification Rates., Macromolecular rapid communications, 10.1002/marc.202200316, e2200316, 2022.06, Developing nanovehicles for delivering antibiotics is a promising approach to overcome the issue of antibiotic resistance. This study aims to utilize a polyion complex (PICs) system for developing novel nanovehicles for polymyxin-type antibiotics, which are known as last resort drugs. The formation of antibiotic-based PIC nanostructures is investigated using colistimethate sodium (CMS), an anionic cyclic short peptide, and a series of block catiomers bearing different amounts of guanidinium moieties on their side chains. In addition, only the modified catiomer, and not the unmodified catiomer, self-assembles with CMS, implying the importance of the guanidine moieties for enhancing the interaction between the catiomer and CMS via the formation of multivalent hydrogen bonding. Moreover, micellar and vesicular PIC nanostructures are selectively formed depending on the ratio of the guanidine residues. Size-exclusion chromatography reveals that the encapsulation efficiency of CMS is dependent on the guanidinium modification ratio. The antimicrobial activity of the PIC nanostructures is also confirmed, indicating that the complexation of CMS in the PICs and further release from the PICs successfully occurs..
6.	Yiwei Liu, Tomoki Maruyama, K. C. Biplab, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Inducible Dynamic Behavior of Polyion Complex Vesicles by Disrupting Charge Balance, CHEMISTRY LETTERS, 10.1246/cl.210037, 50, 5, 1034-1037, 2021.05, The formation and dynamic behavior of polyion complex-based vesicles (PICsomes) were examined under charge-balance disrupting conditions, using homo-catiomer and pegylated-aniomer. Under catiomer-rich conditions, an unusual increase in the PICsome size was observed, which was primarily attributed to Ostwald ripening. This growth was triggered by the addition of a homo-catiomer to switch the composition of the PIC membrane. The results provide insight into the design of smart PIC-based systems for functional nanocapsules..
7.	Beob Soo Kim, Mitsuru Naito, Hiroyuki Chaya, Mao Hori, Kotaro Hayashi, Hyun Su Min, Yu Yi, Hyun Jin Kim, Tetsuya Nagata, Yasutaka Anraku, Akihiro Kishimura, Kazunori Kataoka, and Kanjiro Miyata, Noncovalent Stabilization of Vesicular Polyion Complexes with Chemically Modified/Single-Stranded Oligonucleotides and PEG-b-guanidinylated Polypeptides for Intracavity Encapsulation of Effector Enzymes Aimed at Cooperative Gene Knockdown, Biomacromolecules, 10.1021/acs.biomac.0c01192, 21, 10, 4365-4376, 2020.09, For the simultaneous delivery of antisense oligonucleotides and their effector enzymes into cells, nanosized vesicular polyion complexes (PICs) were fabricated from oppositely charged polyion pairs of oligonucleotides and poly(ethylene glycol) (PEG)-b-polypeptides. First, the polyion component structures were carefully designed to facilitate a multimolecular (or secondary) association of unit PICs for noncovalent (or chemical cross-linking-free) stabilization of vesicular PICs. Chemically modified, single-stranded oligonucleotides (SSOs) dramatically stabilized the multimolecular associates under physiological conditions, compared to control SSOs without chemical modifications and duplex oligonucleotides. In addition, a high degree of guanidino groups in the polypeptide segment was also crucial for the high stability of multimolecular associates. Dynamic light scattering and transmission electron microscopy revealed the stabilized multimolecular associates to have a 100 nm sized vesicular architecture with a narrow size distribution. The loading number of SSOs per nanovesicle was determined to be ∼2500 using fluorescence correlation spectroscopic analyses with fluorescently labeled SSOs. Furthermore, the nanovesicle stably encapsulated ribonuclease H (RNase H) as an effector enzyme at ∼10 per nanovesicle through simple vortex-mixing with preformed nanovesicles. Ultimately, the RNase H-encapsulated nanovesicle efficiently delivered SSOs with RNase H into cultured cancer cells, thereby eliciting the significantly higher gene knockdown compared with empty nanovesicles (without RNase H) or a mixture of nanovesicles with RNase H without encapsulation. These results demonstrate the great potential of noncovalently stabilized nanovesicles for the codelivery of two varying bio-macromolecule payloads for ensuring their cooperative biological activity..
8.	Beob Soo Kim, Mitsuru Naito, Rimpei Kamegawa, Hyun Jin Kim, Ryo Iizuka, Takashi Funatsu, Shingo Ueno, Takanori Ichiki, Akihiro Kishimura and Kanjiro Miyata, Photo-reactive oligodeoxynucleotide-embedded nanovesicles (PROsomes) with switchable stability for efficient cellular uptake and gene knockdown, CHEMICAL COMMUNICATIONS, 10.1039/d0cc01750g, 56, 66, 9477-9480, 2020.08.
9.	岸村顕広 Akihiro Kishimura, 科学コミュニケーションを通じた地域社会と科学の関わり─「双方向コミュニケーション」「共創」の実装に向けて Engagement of 'science ' in local communities through science communication: Towards implementation of 'interactive science communication' and 'co-creation', 学術の動向 Trends in the Sciences, 25, 8, 8-21-8-27, 2020.08.
10.	岸村顕広 Akihiro Kishimura, 国際的議論を通じて “市民のエンパワメントを支える科学者” のあり方を考える Roles of Scientists to Empower Citizens: Some Thoughts Obtained Through the International Discussion, 学術の動向 Trends in the Sciences, 10.5363/tits.25.4_31, 25, 4, 4-31-4-37, 2020.04, [URL].
11.	岸村顕広, 国際的議論を通じて”市民のエンパワメントを支える科学者”のあり方を考える, 2020.04, 最近の若手アカデミーのシチズンサイエンスに関わる活動や国際会議における議論の内容を交えながら、社会における科学者のあり方について、次世代を担う若手・中堅科学者の立場から論考を行った。.
12.	新福洋子, 岸村顕広 Yoko Shimpuku, Akihiro Kishimura, 若手アカデミーから見た科学的助言 Significance of Science Advices from the Viewpoint of Young Academy, 学術の動向 TRENDS IN THE SCIENCES, 10.5363/tits.24.3_52, 24, 3, 3-52-3-55, 2019.03, [URL].
13.	岸村顕広 Akihiro Kishimura, SDGsから考える学術研究の社会貢献─若手アカデミーの視点から SDGs and Social Contribution of Academic Research: From the Viewpoint of Young Academy, 学術の動向 TRENDS IN THE SCIENCES, 10.5363/tits.23.8_16, 23, 8, 8-16-8-21, 2018.08, [URL].
14.	Omer F. Mutaf, Yasutaka Anraku, Akihiro Kishimura, Kazunori Kataoka, Unilamellar polyion complex vesicles (PICsomes) with tunable permeabilities for macromolecular solutes with different shapes and sizes, POLYMER, 10.1016/j.polymer.2017.10.062, 133, 1-7, 2017.12, [URL], Polyion complex vesicles (PICsomes) are characterized by their unique three-layered semipermeable nanomembrane structures, in which a unilamellar PIC layer is sandwiched by poly(ethylene glycol) layers, and have gathered much attention as nano-scaled drug vehicles. Herein, the crosslinking degree of the nanomembrane in the PICsome was controlled systematically for the first time. Permeability of the PICsome nanomembrane was evaluated through a kinetic study of the release of macromolecular cargoes from the PICsome. The degree of crosslinking in the nanomembrane successfully regulated the release behavior. Moreover, the shape and size of the macromolecular solutes were found to be critical factors determining their transport from the inner aqueous phase of the PICsome to the external environment. The results indicate that the unique three-layered structure of PICsome membranes plays a key role in modulating solute transport. These findings will provide a rational strategy for the development of nanomembrane-based controlled-release systems. (C) 2017 Elsevier Ltd. All rights reserved..
15.	Akinori Goto, Hui Chi Yen, Yasutaka Anraku, Shigeto Fukushima, Ping-Shan Lai, Masaru Kato, Akihiro Kishimura, Kazunori Kataoka, Facile Preparation of Delivery Platform of Water-Soluble Low-Molecular-Weight Drugs Based on Polyion Complex Vesicle (PlCsome) Encapsulating Mesoporous Silica Nanoparticle, ACS BIOMATERIALS SCIENCE & ENGINEERING, 10.1021/acsbiomaterials.6b00562, 3, 5, 807-815, 2017.05, Polyion complex vesicles (PlCsomes) are polymeric hollow capsules composed of a unique semipermeable membrane, which may represent a versatile platform for constructing drug-loaded nanoformulation. However, it is difficult to retain water-soluble low-molecular weight compounds (LMWCs) in the inner space of PlCsome because of the high permeability of PIC membrane for LMWCs. Herein, we selected mesoporous silica nanoparticle (MSN) as a drug-retaining nanomatrix, and we demonstrated successful encapsulation of MSN into the PlCsome to obtain MSN@PlCsome. The efficacy of MSN loading, a ratio of the amount of MSN encapsulated in the PICsome to the amount of feed MSN, was at most 83%, and the diameter of resulting product was approximately 100 nm. The obtained MSN@PlCsome was stably dispersed under the physiological condition, and showed considerable longevity in blood circulation of mice. Furthermore, the surface of MSN in MSN@PlCsome can be modified without any deterioration of the vesicle structure, obtaining amino-functionalized and sulfonate-functionalized MSN@PlCsomes (A-MSN@PlCsome and S-MSN@PICsome, respectively). Both surface-modified MSN@PlCsomes were successfully loaded with charged water-soluble low-molecular-weight compounds (LMWCs). Particularly, S-MSN@PICsome kept 8 wt % gemcitabine (GEM) per S-MSN, and released it in a sustained manner. GEM-loaded S-MSN@PlCsome demonstrated marked cytotoxicity against cultured tumor cells, and achieved significant in vivo efficacy to suppress the growth of subcutaneously implanted lung tumor via intravenous administration..
16.	Kenshiro Naoyama, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Fabrication of Dendrimer-Based Polyion Complex Submicrometer-Scaled Structures with Enhanced Stability under Physiological Conditions, MACROMOLECULAR RAPID COMMUNICATIONS, 10.1002/marc.201600171, 37, 13, 1087-1093, 2016.07, Submicrometer-scaled (sub-) self-assembled materials have been developed based on polyion complex (PIC) formation, in particular for biomedical-applications. However, sufficient stability under physiological conditions is required for their practical use. In this study, PIC formation behavior is examined using a block aniomer, poly(ethylene glycol)-b-poly(aspartic acid), and homocatiomers, poly(l-lysine) (LPK) and dendritic poly(l-lysine) (DPK) with different generations, to elucidate the contribution of the dendritic architecture to stability enhancement. LPK-based PIC shows a sub-vesicular structure only at 25 degrees C in the absence of NaCl; in contrast, DPK-based PIC forms a sub-structure under physiological salt concentration and temperature conditions, even when the number of charges of a single molecule is much smaller than that of LPK. Moreover, the formation of sub-vesicular and -spherical micellar structures is dependent on DPK generation. Thus, the molecular backbone architecture of the PIC component plays an important role not only in expanding the preparation conditions and enhancing stability, but also in controlling the self-assembled structures, mainly due to the spatially restricted structures of dendrimers..
17.	Ryosuke Taniguchi, Yutaka Miura, Hiroyuki Koyama, Tsukasa Chida, Yasutaka Anraku, Akihiro Kishimura, Kunihiro Shigematsu, Kazunori Kataoka, Toshiaki Watanabe, Adequately-Sized Nanocarriers Allow Sustained Targeted Drug Delivery to Neointimal Lesions in Rat Arteries, MOLECULAR PHARMACEUTICS, 10.1021/acs.molpharmaceut.6b00219, 13, 6, 2108-2116, 2016.06, In atherosclerotic lesions, the endothelial barrier against the bloodstream can become compromised, resulting in the exposure of the extracellular matrix (ECM) and intimal cells beneath. In theory, this allows adequately sized nanocarriers in circulation to infiltrate into the intimal lesion intravascularly. We sought to evaluate this possibility using rat carotid arteries with induced neointima. Cy5-labeled polyethylene glycol-conjugated polyion complex (PIC) micelles and vesicles, with diameters of 40, 100, or 200 nm (PICs-40, PICs-100, and PICs-200, respectively) were intravenously administered to rats after injury to the carotid artery using a balloon catheter. High accumulation and long retention of PICs-40 in the induced neointima was confirmed by in vivo imaging, while the accumulation of PICs-100 and PICs-200 was limited, indicating that the size of nanocarriers is a crucial factor for efficient delivery. Furthermore, epirubicin-incorporated polymeric micelles with a diameter similar to that of PICs-40 showed significant curative effects in rats with induced neointima, in terms of lesion size and cell number. Specific and effective drug delivery to pre-existing neointimal lesions was demonstrated with adequate size control of the nanocarriers. We consider that this nanocarrier-based drug delivery system could be utilized for the treatment of atherosclerosis..
18.	Yasutaka Anraku, Akihiro Kishimura, Mako Kamiya, Sayaka Tanaka, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Shigeto Fukushima, Daiki Sueyoshi, Mitsunobu R. Kano, Yasuteru Urano, Nobuhiro Nishiyama, Kazunori Kataoka, Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 10.1002/anie.201508339, 55, 2, 560-565, 2016.01, The design and construction of nanoreactors are important for biomedical applications of enzymes, but lipid-and polymeric-vesicle-based nanoreactors have some practical limitations. We have succeeded in preparing enzyme-loaded polyion complex vesicles (PICsomes) through a facile protein-loading method. The preservation of enzyme activity was confirmed even after cross-linking of the PICsomes. The crosslinked beta-galactosidase-loaded PICsomes (beta-gal@PICsomes) selectively accumulated in the tumor tissue of mice. Moreover, a model prodrug, HMDER-beta Gal, was successfully converted into a highly fluorescent product, HMDER, at the tumor site, even 4 days after administration of the beta-gal@PICsomes. Intravital confocal microscopy showed continuous production of HMDER and its distribution throughout the tumor tissues. Thus, enzyme-loaded PICsomes are useful for prodrug activation at the tumor site and could be a versatile platform for enzyme delivery in enzyme prodrug therapy..
19.	Akihiro Kishimura, An emerging material “PICsome” A hot zone between “PEG” and “PEG”, Drug Delivery System, 10.2745/dds.31.308, 31, 4, 308-319, 2016.01, [URL], Recently, nanomaterials constructed by molecular self-assembly have gathered much attention to develop nano-devices incorporated with many types of drugs. Particularly, hollow capsules are one of promising materials, and recently, we have developed polyion complex vesicles, PICsomes, as novel polymeric vesicles. The most advantageous feature of PICsomes is its simple preparation process: Typically, they can be prepared by simple mixing of oppositely charged block copolymers consisting of poly(ethylene glycol) (PEG) and charged poly(amino acid)s in an aqueous medium. Moreover, many other unique properties of PICsomes have been reported, such as facile tuning of vesicle sizes ranging from 100-400 nm while keeping monodispersed size distribution, semipermeable vesicle membrane, facile loading of various water-dispersed materials, long blood circulation after crosslinking, excellent tumor accumulation based on the enhanced permeability and retention (EPR) effect, and so on. The present review article describes basic design and synthetic strategy of PICsomes, fundamental properties of PICsomes, and recent applications of PICsomes to drug delivery system..
20.	Omer F. Mutaf, Akihiro Kishimura, Yuki Mochida, Ahram Kim, Kazunori Kataoka, Induction of Secondary Structure through Micellization of an Oppositely Charged Pair of Homochiral Block-and Homopolypeptides in an Aqueous Medium, MACROMOLECULAR RAPID COMMUNICATIONS, 10.1002/marc.201500368, 36, 22, 1958-1964, 2015.11, Polyion complex (PIC) formation is an attractive method for obtaining molecular assemblies owing to their facile fabrication process in aqueous media, but more insights are required in order to control the higher-dimensional structures of polypeptide-based PICs. Herein, the PIC formation behavior of oppositely charged homochiral polypeptides, poly-L-lysine and poly(ethylene glycol)-b-poly(L-glutamate) (PEG-PLG), and their secondary structures are carefully studied in water. PIC formation takes place in a polymer concentration-dependent manner, and clear beta-sheet formation is observed at polymer concentrations >= 0.3 mg mL(-1). The results also confirm that multimolecular aggregation is a prerequisite for beta-sheet formation, which indicates that the inner hydrophobic environment of PICs is favorable for beta-sheet formation. Furthermore, the PEG weight fraction, stereoregularity of the polypeptide, and ionic strength of the solutions are found to be key factors for generating a secondary structure, presumably because these factors can contribute to the tuning of the inner environment of PICs. This method of producing water-soluble nanoassemblies from oppositely charged polypeptides may expedite self-assembly studies in biological systems and be incorporated into various molecular systems to exploit protein-mimicking features..
21.	D. Sueyoshi, A. Kishimura, H. Oana, Y. Anraku, M. Takai, M. Washizu, K. Kataoka, Microchannel-assisted preparation of polyion complex vesicles and real-time observation of their dynamic responses to external electric fields, MicroTAS, 3, 1882-1884, 2014.08.
22.	國領大介, 安楽泰孝, 岸村顕広, 田中さやか, 狩野光伸, 西山伸宏, 佐賀恒夫, 青木伊知男, 片岡一則, 微小腫瘍検出のための高緩和能を有する新規造影剤SPIO‐Cy5‐PICsomeの開発, 日本磁気共鳴医学会雑誌, 34, 3, 92-95, 2014.08.
23.	Sayan Chuanoi, Yasutaka Anraku, Mao Hori, Akihiro Kishimura, Kazunori Kataoka, Fabrication of Polyion Complex Vesicles with Enhanced Salt and Temperature Resistance and Their Potential Applications as Enzymatic Nanoreactors, BIOMACROMOLECULES, 10.1021/bm500127g, 15, 7, 2389-2397, 2014, 2014.07, Integrating catalytic functions into polymeric vesicles through enzyme entrapment is appealing for bioreactor fabrication, yet there are critical issues regarding the regulation of solute transport through membranes and enzyme loading without denaturation. Polyion complex vesicles (PICsomes) with semipermeable membranes and the propensity to form in water can overcome these issues; however, cross-linking is required for sufficient physiological stability. Herein, we report the first successful fabrication of non-cross-linked PICsomes with sufficient stability at physiological salinity and temperature by tuning the hydrophobicity of the aliphatic side chains in the pendant group of the constituent polyelectrolytes. Dynamic light scattering and transmission electron microscopy revealed that the intervesicular fusion and disintegration of the PICsomes was prevented and a narrow distribution was maintained at physiological salinity and temperatures. Furthermore, their application as enzymatic nanoreactors was verified even in the presence of proteases. As such, the potential utility of the PICsomes in biomedical fields was established..
24.	Horacio Cabral, Kanjiro Miyata, Akihiro Kishimura, Nanodevices for studying nano-pathophysiology, ADVANCED DRUG DELIVERY REVIEWS, 10.1016/j.addr.2014.06.003, 74, 35-52, 2014.07, [URL], Nano-scaled devices are a promising platform for specific detection of pathological targets, facilitating the analysis of biological tissues in real-time, while improving the diagnostic approaches and the efficacy of therapies. Herein, we review nanodevice approaches, including liposomes, nanoparticles and polymeric nanoassemblies, such as polymeric micelles and vesicles, which can precisely control their structure and functions for specifically interacting with cells and tissues. These systems have been successfully used for the selective delivery of reporter and therapeutic agents to specific tissues with controlled cellular and subcellular targeting of biomolecules and programmed operation inside the body, suggesting a high potential for developing the analysis for nano-pathophysiology. (C) 2014 Elsevier B.V. All rights reserved..
25.	Arie Wibowo, Kensuke Osada, Hiroyuki Matsuda, Yasutaka Anraku, Haruko Hirose, Akihiro Kishimura, Kazunori Kataoka, Morphology Control in Water of Polyion Complex Nanoarchitectures of Double-Hydrophilic Charged Block Copolymers through Composition Tuning and Thermal Treatment, MACROMOLECULES, 10.1021/ma500314d, 47, 9, 3086-3092, 2014.05, [URL], Polyion complexes (PICs) are attractive as eco-friendly materials, because they offer simple and fast preparation methods to exert various functionalities in aqueous medium. However, control of nanoarchitectures in PIC materials has not been fully realized, except for the case of micelles and unilamellar vesicles formed from block ionomers. Here, the procedure to control PIC nanoarchitectures with various morphologies was established for the first time by careful tuning in the composition of PICs made from PEG-based block-ionomers with a varying amount of homoionomers as additive to modulate the PEG weight fraction (f(PEG)) in the obtained PICs. Accordingly, the variation in f(PEG) from 12.1% to 6.5% induced vigorous transition in the microphase separated structures of PICs basically from micelle to lamella via cylindrical network. Notably, uniformed lamella with alternative layers of PEG and PIG domains was found at elevated temperature (70 degrees C), which, by lowering temperature, reversibly transformed to cylindrical P1C network apparently with connected aqueous channel in mesoscopic scale..
26.	Akihiro Kishimura, Morphology Control in Water of Polyion Complex Nanoarchitectures of Double-Hydrophilic Charged Block Copolymers through Composition Tuning and Thermal Treatment. , American Chemical Society, 10.1021/ma500314d , 47, 9, 3086-3092, 2014, 2014.04.
27.	Daisuke Kokuryo, Yasutaka Anraku, Akihiro Kishimura, Sayaka Tanaka, Mitsunobu R. Kano, Jeff Kershaw, Nobuhiro Nishiyama, Tsuneo Saga, Ichio Aoki, Kazunori Kataoka, SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes) (vol 169, pg 220, 2013), JOURNAL OF CONTROLLED RELEASE, 10.1016/j.jconrel.2014.01.021, 178, 125-125, 2014.03, [URL].
28.	Sayan Chuanoi, Akihiro Kishimura, Wen-Fei Dong, Yasutaka Anraku, Yuichi Yamasaki, Kazunori Kataoka, Structural factors directing nanosized polyion complex vesicles (Nano-PICsomes) to form a pair of block aniomer/homo catiomers: studies on the aniomer segment length and the catiomer side-chain structure, POLYMER JOURNAL, 10.1038/pj.2013.82, 46, 2, 130-135, 2014.02, [URL], Much attention has been devoted to precise control of the size and morphology in nanosized molecular assemblies for a wide range of materials applications. Recently, we reported observing submicron/nanosized polyion complex vesicles (Nano-PICsomes) with a narrow size distribution, synthesized using specific types of homocatiomers and polyethylene glycol (PEG)-based block aniomers. However, only one example of Nano-PICsomes has been reported to date. Here, the role of the chemical composition of PEG-based block aniomers and the chemical structures of the side chains of homocatiomers were carefully examined to better understand the formation of Nano-PICsomes. Transmission electron microscopy and dynamic light scattering analyses of Nano-PICsomes revealed that a longer length of ionic segments in the block aniomers or a PEG weight fraction (f(PEG)) 10% produced spherical micelles. In addition, the homocatiomers containing longer aliphatic side chains (e. g., five or six carbon atoms) favored the formation of Nano-PICsomes, whereas those containing shorter aliphatic side chains produced irregularly shaped PIC micelles. Accordingly, f(PEG) and the length of the side chain were found to be the key factors that control the morphologies of Nano-PICsomes. Insights gained from this study can broaden the spectrum of the design of Nano-PICsomes for use in a diverse range of material applications..
29.	Huabing Chen, Ling Xiao, Yasutaka Anraku, Peng Mi, Xueying Liu, Horacio Cabral, Aki Inoue, Takahiro Nomoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka, Polyion Complex Vesicles for Photoinduced Intracellular Delivery of Amphiphilic Photosensitizer, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 10.1021/ja406992w, 136, 1, 157-163, 2014, 2014.01, Polymer vesicles formed by a pair of oppositely charged poly(ethylene glycol) (PEG)-based block aniomer and homocatiomer, termed "PICsomes", have tunable size, and are characterized by unique semipermeable property due to the flexible and tunable hydrophilicity of polyion complex (PIC) membranes. The PICsomes can encapsulate a variety of molecules in an inner aqueous phase just by a simple vortex mixing of solution, expecting their utility as nanocontainers of substances with biomedical interests. Here, we report on a new functionality of the PICsomes: photoinduced release of photoactive agents for intracellular drug delivery. A potent photosensitizer, Al(III) phthalocyanine chloride disulfonic acid (AlPcS2a), was efficiently incorporated into the PICsomes (11%(w/w)), and its quick release was induced by photoirracliation possibly due to the photochemical damage of the PIG membranes. The combination of a high-resolution fluorescent confocal microscopy and a lysosome membrane-specific staining method revealed that such photoinduced release of AlPcS2a occurred even in the lysosomes of living cells after endocytic internalization. Simultaneously, the released AlPcS2a photochemically affected the integrity of the lysosomal membranes, leading to the translocation of AlPcS2a and PICsomes themselves to the cytoplasm. Consequently, the AlPcS2a-encapsulated PICsomes (AIPcS2a-PICsomes) exhibited appreciably stronger photocytotoxicity compared with free AlPcS2a alone. Thus, the AlPcS2a-PICsomes have promising feasibility for the photodynamic therapy or the photoinduced cytoplasmic delivery of therapeutic molecules..
30.	Akihiro Kishimura, Development of polyion complex vesicles (PICsomes) from block copolymers for biomedical applications, POLYMER JOURNAL, 10.1038/pj.2013.33, 45, 9, 892-897, 2013.09, [URL], Polyion complex (PIC) formation is one of the most powerful techniques for obtaining molecular self-assemblies in aqueous media. The simple preparation process based on multiple electrostatic interactions is quite attractive for material syntheses, as well as biomedical applications. Therefore, it is desirable to control PIC architectures at the nanoscale in order to expand the scope of PIC materials. In this review article, recent progress on PIC vesicles (PICsomes) is summarized. PICsomes were first developed by my research group, and we recently succeeded in controlling the sizes and structural uniformity of the vesicles. Furthermore, the characteristic dynamic nature of PICs was revealed: PICs were found to exhibit reversible association/dissociation and structural transformation. We demonstrated that crosslinking the PIC layers of PICsomes is a powerful method for tuning properties such as stability and permeability. Finally, the potential utility of PICsomes for drug delivery nanocarriers was examined, and their future biomedical application is discussed..
31.	Daisuke Kokuryo, Yasutaka Anraku, Akihiro Kishimura, Sayaka Tanaka, Mitsunobu R. Kano, Jeff Kershaw, Nobuhiro Nishiyama, Tsuneo Saga, Ichio Aoki, Kazunori Kataoka, SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes), JOURNAL OF CONTROLLED RELEASE, 10.1016/j.jconrel.2013.03.016, 169, 3, 220-227, 2013.08, [URL], Size controllable polyion complex vesicles (PICsomes), composed of biocompatible poly(ethylene glycol) (PEG) and poly(amino acid) s, have an extremely prolonged lifetime in the bloodstream that enables them to accumulate effectively in tumors via the enhanced permeability and retention (EPR) effect. The purpose of this study was to use PICsomes to synthesize a highly sensitive MRI contrast agent for more precise tumor detection. We synthesized SPIO-Cy5-PICsomes (superparamagnetic iron oxide nanoparticle-loaded Cy5-cross-linked Nano-PICsomes) and characterized them using dynamic light scattering and transmission electron microscopy in vitro and evaluated their ability to detect subcutaneously grafted tumors in vivo with MRI. The transverse relaxivity (r(2)) of the SPIO-Cy5-PICsomes (r(2) = 663 +/- 28 mM(-1) s(-1)) was 2.54 times higher than that of bare clinically-used SPIO. In in vivo MRI experiments on mice subcutaneously grafted with colon-26 tumor cells, the tumor signal was significantly altered at 3 h after SPIO-Cy5-PICsome administration and persisted for at least 24 h. Small and early-stage in vivo tumors (3 days after grafting, approximately 4 mm(3)) were also clearly detected with MRI. SPIO-loaded PICsomes are sensitive MRI contrast agents that can act as a powerful nanocarrier to detect small tumors for early diagnosis. (C) 2013 Elsevier B. V. All rights reserved..
32.	N. Sasaki, M. Tatanou, Y. Anraku, A. Kishimura, K. Kataoka, K. Sato, Characterization of nanoparticle permeability on a membrane-integrated microfluidic device, MicroTAS, 3, 1818-1820, 2013.08.
33.	Hidehiro Oana, Mutsuki Morinaga, Akihiro Kishimura, Kazunori Kataoka, Masao Washizu, Direct formation of giant unilamellar vesicles from microparticles of polyion complexes and investigation of their properties using a microfluidic chamber, Soft Matter, 10.1039/c3sm00089c, 9, 22, 5448-5458, 2013.06, [URL], Although hollow microscopic capsules have a variety of potential biomedical applications, reports of organic-solvent-free methods for their preparation are rather limited. Herein, a novel approach is demonstrated for organic-solvent-free preparation of giant unilamellar vesicles utilizing the unique response of polyion complexes (PICs) to changes in additive salt concentration. A microfluidic device consisting of a main channel bearing side pockets that work as microscale reaction chambers is designed for facilitating the preparation process under an optical microscope. With this device, real-time observation of morphological transformation of individual PIC microparticles is carried out during rapid reduction of the additive salt concentration and direct formation of giant vesicles from PIC microparticles is shown. There is a quasilinear relationship between the surface areas of the formed vesicles and the volumes of the PIC microparticles, and the thickness of the vesicle membrane estimated by the relationship is indicative of the formation of a uniform unilamellar structure of the PIC membrane. Furthermore, detailed properties of the formed PIC vesicles with regard to salt response, loading of guest molecules, and permeability of the PIC membrane with/without modification of the PIC membrane by cross-linking are investigated using the microfluidic chamber. Thus, the usefulness of the microfluidic chamber for visualization and investigation of dynamic responses of microscale soft materials during changes in surrounding conditions is also demonstrated..
34.	Yasutaka Anraku, Akihiro Kishimura, Yuichi Yamasaki, Kazunori Kataoka, Living Unimodal Growth of Polyion Complex Vesicles via Two-Dimensional Supramolecular Polymerization, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 10.1021/ja3096587, 135, 4, 1423-1429, 2013.01, [URL], Understanding the dynamic behavior of molecular self-assemblies with higher-dimensional structures remains a key challenge to obtaining well-controlled and monodispersed structures. Nonetheless, there exist few systems capable of realizing the mechanism of supramolecular polymerization at higher dimensions. Herein, we report the unique self-assembling behavior of polyion complexes (PICs) consisting of poly(ethylene glycol)-polyelectrolyte block copolymer as an example of two-dimensional supramolecular living polymerization. Monodispersed and submicrometer unilamellar PIC vesicles (nano-PICsomes) displayed time-dependent growth while maintaining a narrow size distribution and a unilamellar structure. Detailed analysis of the system revealed that vesicle growth proceeded through the consumption of unit PICs (uPICs) composed of a single polycation/polyanion pair and was able to restart upon the further addition of isolated uPICs. Interestingly, the resulting vesicles underwent dissociation into uPICs in response to mechanical stress. These results clearly frame the growth as a two-dimensional supramolecular living polymerization of uPICs..
35.	Kensuke Osada, Horacio Cabral, Yuki Mochida, Sangeun Lee, Kazuya Nagata, Tetsuya Matsuura, Megumi Yamamoto, Yasutaka Anraku, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka, Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer-Metal Complexation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 10.1021/ja304615y, 134, 32, 13172-13175, 2012.08, [URL], Spontaneous formation of polymeric metallosomes with uniform size (similar to 100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of omega-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular dichroism spectrum measurements revealed that the PLGA segment forms an alpha-helix structure within the metallosomes, suggesting that secondary-structure formation of metallocomplexed PLGA segment may drive the self-assembly of the system into vesicular structure. These metallosomes can encapsulate water-soluble fluorescent macromolecules into their inner aqueous phase and eventually deliver them selectively into tumor tissues in mice, owing to the prolonged blood circulation. Accordingly, fluorescent imaging of the tumor was successfully demonstrated along with an appreciable antitumor activity by DACHPt moieties retained in the vesicular wall of the metallosomes, indicating the potential of metallosomes as multifunctional drug carriers..
36.	岸村顕広, 超分子集合体を用いた生体材料設計とナノDDS,ナノ生理学への応用(ヘッドライン:未来を拓く超分子化学の世界), 化学と教育, 10.20665/kakyoshi.59.11_550, 59, 11, 550-553, 2011.11.
37.	Yasutaka Anraku, Akihiro Kishimura, Atsushi Kobayashi, Makoto Oba, Kazunori Kataoka, Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues, Chemical Communications, 10.1039/c1cc11465d, 47, 21, 6054-6056, 2011.06, [URL], Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (∼150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler..
38.	Yasutaka Anraku, Akihiro Kishimura, Makoto Oba, Yuichi Yamasaki, Kazunori Kataoka, Spontaneous Formation of Nanosized Unilamellar Polyion Complex Vesicles with Tunable Size and Properties, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 10.1021/ja908350e, 132, 5, 1631-1636, 2010.02, [URL], Fabrication of monodispersed, submicrometer-sized vesicles (nanosomes) that form through self-assembly possessing a thin and permeable membrane remains a significant challenge. Conventional fabrication of nanosomes through self-assembly of amphiphilic molecules often requires cumbersome processes using organic solvents combined with physical procedures (e.g., sonication, thermal treatment, and membrane filtration) to obtain unilamellar structures with a controlled size distribution. Herein, we report the first example of spontaneously formed submicrometer-sized unilamellar polyion complex vesicles (Nano-PICsomes) via self-assembly of a pair of oppositely charged PEG block aniomer and homocatiomer in an aqueous medium. Detailed dynamic light scattering and transmission electron microscopic analysis revealed that vesicle sizes can be controlled in the range of 100-400 nm with a narrow size distribution, simply by changing the total polymer concentration. Also, each Nano-PICsome was composed of a uniform single PIC membrane, the thickness of which is around 10-15 nm, regardless of its size. Fluorescence correlation spectroscopy measurement verified that Nano-PICsomes were able to encapsulate water-soluble fluorescent macromolecules in the inner water phase and release them slowly into the exterior. Moreover, cross-linking of the vesicle membrane allows tuning of permeability, enhancement in stability under physiological conditions, and preservation of size and structure even after freeze-drying and centrifugation treatment. Finally, Nano-PICsomes showed a long circulation time in the bloodstream of mice. Precise control of the particle size and structure of hollow capsules through simple aqueous self-assembly and easy modification of their properties by cross-linking is quite novel and fascinating in terms of ecological, low-cost, and low-energy fabrication processes as well as the potential utility in the biomedical arena..
39.	Hidehiro Oana, Akihiro Kishimura, Kei Yonehara, Yuichi Yamasaki, Masao Washizu, Kazunori Kataoka, Spontaneous formation of giant unilamellar vesicles from microdroplets of a polyion complex by thermally induced phase separation, Angewandte Chemie - International Edition, 10.1002/anie.200900721, 48, 25, 4613-4616, 2009.06, [URL], Water pump: Polyion complex (PIC) vesicles are spontaneously formed from PIC microdroplets, which are formed by mixing cationic and anionic polymers (see picture). The formation process can be reversibly controlled by local heating with a focused infrared laser that triggers microphase separation and subsequent water influx. The size of the resulting giant unilamellar vesicles is determined by the initial size of the PIC droplets..
40.	Wen-Fei Dong, Akihiro Kishimura, Yasutaka Anraku, Sayan Chuanoi, Kazunori Kataoka, Monodispersed Polymeric Nanocapsules: Spontaneous Evolution and Morphology Transition from Reducible Hetero-PEG PICmicelles by Controlled Degradation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 10.1021/ja808419b, 131, 11, 3804-+, 2009.03, [URL], In this communication, a novel "self-templating" strategy was used to prepare uniform and biocompatible nanocapsules by the addition of a reduction agent (i.e., DTT) into a solution of highly monodispersed PICmicelles bearing a heterodetachable PEG Corona. PEG chains were released from PICmicelle shells following disulfide reduction which leads a spontaneous and drastic morphology evolution from micelles to vesicles induced by the decrease of the PEG weight fraction. Formation of uniform nanocapsules with controllable capsule size was achieved by careful control of the micelle composition and molecular weight of homo-P[Asp(DET)]..
41.	Akihiro Kishimura, Sittipong Liamsuwan, Hiroyuki Matsuda, Wen Fei Dong, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka, PH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media, Soft Matter, 10.1039/b815884c, 5, 3, 529-532, 2008.11, [URL], The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment..
42.	Akihiro Kishimura, Aya Koide, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka, Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers A physiologically available oxygen carrier, Angewandte Chemie - International Edition, 10.1002/anie.200701776, 46, 32, 6085-6088, 2007.08, [URL], (Figure Presented) Take your PIC: Biologically active polyion complex vesicles (PICsomes) with encapsulated myoglobin (Mb) can be prepared by the self-assembly of a pair of oppositely charged block ionomers with polyethylene glycol (PEG) segments (see picture; metMb: metmyoglobin). The loaded Mb maintains reversible oxygenation even in the presence of trypsin..
43.	A Koide, A Kishimura, K Osada, WD Jang, Y Yamasaki, K Kataoka, Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: Physiologically stable micro-/nanocontainers of water-soluble macromolecules, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 10.1021/ja057993r, 128, 18, 5988-5989, 2006.05, [URL].
44.	Akihiro Kishimura, Takashi Yamashita, Kentaro Yamaguchi, Takuzo Aida, “Rewritable phosphorescent paper” by the control of competing kinetic and thermodynamic self–assembling events., Nature Materials, 10.1038/nmat1401, 4, 7, 546-549, 2005.07, [URL].
45.	Akihiro Kishimura, Takashi Yamashita, Takuzo Aida, Phosphorescent Organogels via 'Metallophilic' Interactions for Reversible RGB–Color Switching, Journal of the American Chemical Society, 10.1021/ja0441007, 127, 1, 179-183, 2005.01, [URL].

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1.	岸村顕広, 好奇心に基づく科学の担い手について考える –シチズンサイエンスの視点から, 学術の動向, 10.5363/tits.28.5_62, 2023.07, [URL], 「持続可能な発展のための科学」を発展させるには、その担い手である研究者そのものを持続させることが肝要である。学問の民主化が進む中、いかにして社会に科学の営みそのものを浸透させていくかが大切だが、その中で科学者コミュニティが考えるべきことを「シチズンサイエンス」をキーワードとして掘り下げ、現役科学者が幅広い視点で次世代育成のためにできることを筆者の関わった事例を紹介しつつ論考した。.
2.	岸村　顕広, 第24期若手アカデミー活動総括 ──未来に向けてアクションできる組織にするために, 学術の動向, https://doi.org/10.5363/tits.27.6_46, 2022.06, 日本学術会議若手アカデミーの第24期の活動を振り返りつつ総括する。そこから未来へ向けて学術コミュニティに求められる態度について考えるとともに、第25期の活動への展望と期待を述べる。.
3.	岸村顕広, コロイドナノ材料を組み込むプラットフォームとしてのポリイオンコンプレックスナノ構造体〜コアセルベートを中心に, Colloid & Interface Communication, Colloid & Interface Communication, 2021, 46 (1), 26-29, 2021.03.
4.	岸村顕広、樋口ゆり子, 世代医工薬学に基づく“細胞編集” ―バイオマテリアルを活かした細胞機能制御―, YAKUGAKU ZASSHI, https://doi.org/10.1248/yakushi.20-00219-F, 2021.05.
5.	岸村顕広, 細胞機能編集に向けた人工オルガネラ創製へのチャレンジ, YAKUGAKU ZASSHI, https://doi.org/10.1248/yakushi.20-00219-1, 2021.05.
6.	福田幸二, 馬奈木俊介, 岸村顕広, 松中学, 田中和哉, AIを活用した政策提言, 学術の動向、2020、25 (2)、68-96., https://doi.org/10.5363/tits.25.2_66, 2020.02, 『日本学術会議第179回総会特別企画・AIを活用した政策提言』内で行われた、講演とパネルディスカッションにおける発言の記録である。.
7.	本庶佑, 日本学術会議第178回総会特別講演・本庶佑「獲得免疫の驚くべき幸運」, 学術の動向、2019、24 (9)、80-89., https://doi.org/10.5363/tits.24.9_80, 2019.09, 本庶先生の特別講演後のパネルディスカッションの発言記録である。（本庶先生に加え、山極壽一先生、小谷元子先生、小林傳司先生と岸村がパネリストとして参加。）.
8.	岸村顕広, 「好き」で科学者になれる社会をつくるために, 化学、2019, 74 (5), 11., 2019.05.
9.	新福洋子、岸村顕広, 若手アカデミーから見た科学的助言, 学術の動向、2019、24 (3)、52–55., 2019.03.
10.	加藤千尋、岸村顕広、新福洋子、住井英二郎、中西和嘉、西嶋一欽、松中学、安田仁奈、狩野光伸、, 若手科学者による座談会 –ブダペスト宣言の精神は、今後どう展開するのか, 学術の動向、2019、24 (1)、42–57., https://doi.org/10.5363/tits.24.1_42, 2019.01, [URL].
11.	岸村顕広, SDGsから考える学術の社会貢献 –若手アカデミーの視点から, https://doi.org/10.5363/tits.23.8_16, 2018.08, [URL].
12.	岸村顕広, 若手アカデミーの国際的活動を通じて思う「日本の国際的プレゼンス拡大」、学術の動向, 学術の動向、2018、23 (10)、64-70., https://doi.org/10.5363/tits.23.10_64, 2018.10, [URL].
13.	岸村顕広, ポリイオンコンプレックス形成による簡便なポリマーナノ構造形成技術の開発と機能材料への応用, 化学工業, 2018.05.
14.	岸村顕広, エマージングマテリアル・PICsome 〜PEGとPEGのはざまで〜, Drug Delivery System, 2016.09.
15.	岸村顕広, 静電相互作用を利用したポリアミノ酸由来高分子電解質のユニークな自己組織化とその生体材料応用, 自己組織化マテリアルのフロンティア（フロンティア出版）, 2015.12.
16.	岸村顕広, 高分子中空ナノカプセルPICsomeの作製法とその活用, DDSキャリア作製プロトコル集、株式会社シーエムシー出版：東京, 2015.08.
17.	Akihiro Kishimura, Horacio Cabral, Kanjiro MIyata, Nanodevices for studying nano-pathophysiology, Advanced Drug Delivery reviews, DOI: 10.1016/j.addr.2014.06.003, 2014.06, Nano-scaled devices are a promising platform for specific detection of pathological targets, facilitating the anal- ysis of biological tissues in real-time, while improving the diagnostic approaches and the efficacy of therapies. Herein, we review nanodevice approaches, including liposomes, nanoparticles and polymeric nanoassemblies, such as polymeric micelles and vesicles, which can precisely control their structure and functions for specifically interacting with cells and tissues. These systems have been successfully used for the selective delivery of reporter and therapeutic agents to specific tissues with controlled cellular and subcellular targeting of biomolecules and programmed operation inside the body, suggesting a high potential for developing the analysis for nano- pathophysiology..
18.	Akihiro Kishimura, Development of polyion complex vesicles (PICsomes) from block copolymers for biomedical applications, Polymer Journal, 2013.04, Polyion complex (PIC) formation is one of the most powerful techniques for obtaining molecular self-assemblies in aqueous media. The simple preparation process based on multiple electrostatic interactions is quite attractive for material syntheses, as well as biomedical applications. Therefore, it is desirable to control PIC architectures at the nanoscale in order to expand the scope of PIC materials. In this review article, recent progress on PIC vesicles (PICsomes) is summarized. PICsomes were first developed by my research group, and we recently succeeded in controlling the sizes and structural uniformity of the vesicles. Furthermore, the characteristic dynamic nature of PICs was revealed: PICs were found to exhibit reversible association/ dissociation and structural transformation. We demonstrated that crosslinking the PIC layers of PICsomes is a powerful method for tuning properties such as stability and permeability. Finally, the potential utility of PICsomes for drug delivery nanocarriers was examined, and their future biomedical application is discussed..
19.	Akihiro Kishimura, ポリイオンコンプレックス型透過膜を有する中空カプセルPICsomeの開発とその応用, 膜, 2014.09.

主要学会発表等

全てを見る→

1.	○神澤大志、山田拓実、吉川洋史、宮田完二郎、新居輝樹、森健、片山佳樹、岸村顕広, 固-液多相分離を活用することでコアセルベート液滴の形状を制御しタンパク質の相選択的集積を実現する, 第23回フロンティア生命化学研究会, 2024.01.
2.	○岸村顕広、神澤大志、中本妃那乃、大前諒真、新居輝樹、森健、片山佳樹, Frustrated charge hotspot 仮説に基づき人工的に生体分子凝縮体をデザインし機能場や階層構造を構築する, 第23回フロンティア生命化学研究会, 2024.01.
3.	○Ziwei Ma, Hiroshi Kamizawa, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Development of temperature-sensitive polyion complex microparticles capable of sustained release of oligonucleotide-based polymeric micelles, MRM2023/IUMRS-ICA2023, 2023.12.
4.	○Akihiro Kishimura, Biplab KC, Yiwei Liu, Teruki Nii,Takeshi Mori, Yoshiki Katayama, Development of Artificial Client-scaffold Model and Cell-like Structures Based on Rational Design of Synthetic-polymer-based Biomolecular Condensates, MRM2023/IUMRS-ICA2023, 2023.12.
5.	◯Fadlina Aulia, Hiroaki Matsuba, Shoya Adachi, Ikuhiko Nakase, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Effective design for PEGylated polyion complex (PIC) nanoparticles to enhance cell-PIC interaction, 第18回ナノバイオメディカル学会, 2023.11.
6.	○Ryoma Omae, K C Biplab, Teruki Nii, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura, Charge density modulation in complex coacervate for protein sequestration to mimic biomolecular condensates　（コンプレックスコアセルベートの電荷密度調節によるタンパク質内包機能をもつ人工生体分子凝縮体の設計）, 第61回日本生物物理学会年会, 2023.11.
7.	〇Hiroshi Kamizawa, Yiwei Liu, Takumi Yamada, Kanjiro Miyata, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, 合成ポリペプチド鎖とオリゴ核酸の設計に基づく固-液多相分離階層構造の開発 Development of the solid-liquid multiphase hierarchical structures based on chemically-designed synthetic polypeptides and oligonucleotides, 第61回日本生物物理学会年会, 2023.11.
8.	○岸村顕広, 合理的に設計された合成コアセルベートに基づくタンパク質取り込み活性を有する人工非膜オルガネラの開発Development of artificial membraneless organelle with protein sequestrarion activity based on rationally designed synthetic coacervates, 第61回日本生物物理学会年会, 2023.11.
9.	○岸村顕広、KC BIPLAB、Liu Yiwei、Ahmad Asmariah、新居輝樹、森健、片山佳樹, 生体分子凝縮体をヒントにしたバイオ高分子材料の開発, 第72回高分子討論会, 2023.09.
10.	○岸村顕広, Frustrated charge hotspot仮説に基づくスポンジ型人工非膜オルガネラの構築, 「細胞を創る」研究会16.0, 2023.09.
11.	〇神澤大志, Biplab K C, 山田拓実, 新居輝樹, 森健, 片山佳樹, 岸村顕広, 固-液多相分離を駆使したコアセルベート液滴の形態制御とタンパク質の相選択的内包, 学術変革A 「超越分子システム」第2回若手会, 2023.09.
12.	〇中本妃那乃、山田拓実、Biplab KC、神澤大志、新居輝樹、森健、片山佳樹、岸村顕広, ポリマー設計に基づくコアセルベートの構造制御と刺激応答性の付与, 学術変革A 「超越分子システム」第2回若手会, 2023.09.
13.	○山田拓実、丸山朋輝、Biplab KC、新居輝樹、森健、片山佳樹、岸村顕広, 高機能な人工細胞の構築に向けた階層構造を有する新規PIC構造体の開発, 学術変革A 「超越分子システム」第2回若手会, 2023.09.
14.	○H. Kamizawa, T. Yamada, Y. Liu, T. Nii, K. Miyata, T. Mori, Y. Katayama, A. Kishimura, Development of multiphase hierarchical structures via polymer condensate formation, ISP2023, 2023.08.
15.	○岸村顕広, Designer coacervates as a protein sequestration scaffold based on the strategy of the dynamic frustrated charge hotspots, ISP2023, 2023.08.
16.	○岸村顕広, Designer coacervates as a protein sequestration scaffold, IUPAC CHAINS 2023, 2023.08.
17.	◯井上満里奈、神澤大志、K C Biplab、谷戸謙太、新居輝樹、森健、片山佳樹、岸村顕広, 生体分子凝縮体制御に向けたブロックコポリマーの設計と凝縮体形成挙動の評価, 第60回化学関連支部合同九州大会, 2023.07.
18.	◯中本妃那乃、山田拓実、Biplab KC、神澤大志、新居輝樹、森健、片山佳樹、岸村顕広 , ポリマー設計に基づく多相コアセルベートの構造制御と構造スイッチング手法の開発, 第60回化学関連支部合同九州大会, 2023.07.
19.	○岸村顕広、安達翔哉、Aulia Fadlina、新居輝樹、森健、片山佳樹, 人工オルガネラ創製に向けた二枚膜ポリイオンコンプレックスベシクルの物性評価とその活用, 第72回高分子学会年次大会, 2023.05.
20.	○岸村顕広、天見雄大、KC Biplab、新居輝樹、森健、片山佳樹, 合成ポリペプチドの設計に基づく複合コアセルベートの物性制御, 第72回高分子学会年次大会, 2023.05.
21.	○Ziwei Ma, Hiroshi Kamizawa, Rento Ota, Teruki Nii, Takeshi Mori,Yoshiki Katayama,　Akihiro Kishimura, Development of temperature-responsive polyion complexes capableof sustained release of micelles containing oligonucleotides, 日本薬学会第143年会, 2023.03.
22.	○Haya Kadan, Biplab K C, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Protein encapsulation in polypeptide-based cyto-mimetic complex coacervates via polymer charge-density tuning, 日本薬学会第143年会, 2023.03.
23.	〇Fadlina Aulia, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Kishimura Akihiro, Application of sulfobetaine-type zwitterionic polymer for drug absorption enhancer in transmucosal drug delivery, 日本薬学会第143年会, 2023.03.
24.	○神澤大志, 江頭巧, 太田廉人, 新居輝樹, 森健, 片山佳樹, 岸村顕広, バイオ医薬品内包型ミセルの徐放を目指した温度応答性ポリイオンコンプレックス構造体の開発, 日本薬学会第143年会, 2023.03.
25.	○岸村　顕広, 高分子科学から見る生物学的相分離〜静電相互作用を中心に〜, 高分子と水･分離に関する研究会 2022年度界面動電現象研究会主題＝生物、生体分子の凝集現象（意味と特徴）, 2023.03.
26.	○岸村　顕広, 合成ポリペプチドのデザインに基づく相分離制御, 「相分離マテリアルの創製」プロジェクト全体会議, 2023.01.
27.	○岸村　顕広, 生体分子凝縮系のデザインと動的機能制御：人工細胞創製に向けて, 第３回発動分子科学サロン「発動分子と合成分子」 , 2023.01.
28.	○岸村　顕広, GYA 総会兼学会 2022:「感性と理性のリバランス」に向けて多様な主体を「つなぐ」ための機会として, 第42回日本看護科学学会学術集会, 2022.12.
29.	◯Akihiro Kishimura, Development of Synthetic Polypeptide-based Biocondensates for Artificial Cells and Biomedical Materials, 3rd International Symposium of Chemistry Education Center for Sustainability: Frontiers in Chemical Biology for Sustainable Future, 2022.11.
30.	○岸村　顕広, ボトムアップポリマーナノテクノロジーを用いたミクロレベル・マクロレベルの液液相分離制御, 第60回日本生物物理学会年会, 2022.09.
31.	○岸村　顕広, 超越分子システムとしての機能共生型人工オルガネラ創製と実用化に向けた機能実証, 学術変革領域研究（A）「超越分子システム」第2回領域会議, 2022.09.
32.	○岸村顕広、Asmad Asmariah、リースヨン、新居輝樹、森健、片山佳樹, ポリリン酸含有生体分子により誘起されるポリーL-リシン鎖のα-helix形成に基づくヘキサゴン名のシートの作製, 第16回バイオ関連化学シンポジウム, 2022.09.
33.	○神澤大志･太田廉人・馬シエ・新居輝樹・森健・片山佳樹・岸村顕広, 核酸を構成因子とする高分子ミセルを徐放可能な温度応答性ポリイオンコンプレックス構造体の開発, 第71回高分子討論会, 2022.09.
34.	〇Fadlina Aulia, Hiroaki Matsuba, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Development of polypeptide-based polyion complex (PIC) nanoparticles with tunable physicochemical nature for selective cellular interaction and manipulation of cellular function, 第71回高分子討論会, 2022.09.
35.	アーマドアスマリア･リースヨン･新居輝樹･森健･片山佳樹･○岸村顕広, PEG–ポリ-L-リシンブロック共重合体を用いたポリイオンコンプレックスヘキサゴンナノシートの作製, 第71回高分子討論会, 2022.09.
36.	◯Akihiro Kishimura, Chemistry for Medicine: a Common Language Based on the “World of Molecules”~Toward Artificial Viruses and Cells~, Kick-off Symposium of the Kyushu University Stockholm Liaison Offic: Finding a Common Language for Well-Being and Inclusive Growth: Connecting Medicine, Chemistry, and Sustainability Science, 2022.08.
37.	○T. Yamada, T. Maruyama, Biplab KC, T. Nii, T. Mori, Y. Katayama, A. Kishimura, Development of a novel polyion complex with a hierarchical structure formed utilizing phase separation from a condensate, IUMRA-ICYRAM 2022, 2022.08.
38.	〇H. Kamizawa, T. Maruyama, Y. Liu, T. Nii, K. Miyata, T. Mori, Y. Katayama, A. Kishimura, Development of novel higher order structures of polyion complexes obtained via polymer condensate formation, IUMRA-ICYRAM 2022, 2022.08.
39.	○Fadlina Aulia, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Tuning of polyion complex(PIC) properties for effective modulation of cellular uptake behaviors of PIC-based nanoparticles having different block copolymer compositions and chemical modifications on charges functionality, IUMRA-ICYRAM 2022, 2022.08.
40.	○劉　一イ、片山佳樹、森　健、岸村　顕広, Formation and structure control of a protein-loaded yolk-shell polyion complex, IUMRA-ICYRAM 2022, 2022.08.
41.	〇山田拓実、丸山朋輝、Biplab KC、新居輝樹、森健、片山佳樹、岸村顕広, ポリマー間相互作用に基づいた相分離による新規ポリイオンコンプレックス構造体の開発, 第59回化学関連支部合同九州大会, 2022.07.
42.	◯神澤大志、丸山朋輝、劉一イ、新居輝樹、宮田完二郎、森健、片山佳樹、岸村顕広, 高分子濃厚相形成を基点とするポリイオンコンプレックス新規高次構造体の構築と解析, 第71回高分子学会年次大会, 2022.05.
43.	○岸村顕広、Beob Soo KIM、内藤瑞、茶谷洋行、林光太朗、Kim Hyun Jin、片岡一則、宮田完二郎, アンチセンス核酸送達に向けた機能性核酸型ベシクルの開発, 日本薬学会第141年会, 2021.03.
44.	○岸村顕広, 分子濃縮系としての生命現象を扱う分子集合体科学への挑戦, 第30回格子欠陥フォーラム, 2020.12.
45.	○丸山朋輝･劉一イ･森健･片山佳樹･岸村顕広, ポリイオンコンプレックスベシクルの多重膜化とその形成挙動の解析, 令和二年度九州地区高分子若手研究会・冬の講演会, 2020.12.
46.	○丸山朋輝、劉一イ、森健、片山佳樹、岸村顕広, 一重膜ポリイオンコンプレックスベシクルの多重膜構造への変形, 第30回日本MRS年次大会, 2020.12.
47.	○岸村　顕広, Development of novel polyioncomplex systems for protein delivery and encapsulation, VANJ Conference 2020, 2020.11.
48.	○丸山朋輝、劉一イ、森健、片山佳樹、岸村顕広, 浸透圧ショックによる多重膜ポリイオンコンプレックスベシクルの形成, 2020年日本化学会九州支部秋期研究発表会, 2020.11.
49.	○太田廉人、森健、片山佳樹、岸村顕広, 生体高分子の0次放出へ向けたシリンダーナノアレイ構造を有する新規デポ剤の開発, 第69回高分子討論会, 2020.09.
50.	○丸山朋輝、劉一イ、森健、片山佳樹、岸村顕広, 浸透圧ショックにより誘起されるポリイオンコンプレックスベシクルの多重膜化, 第69回高分子討論会, 2020.09.
51.	◯岸村顕広, キムボブス, 内藤瑞,茶谷洋行, 林光太朗, キムヒョンジン片岡一則, 宮田完二郎, アンチセンス核酸送達を通じて考えるポリイオンコンプレックス材料の設計戦略, 第69回高分子討論会, 2020.09.
52.	○岸村顕広、江頭巧、KC Biplab、太田廉人、森健、片山佳樹, ポリマーナノ構造体の階層的構造化に基づくナノ製剤放出の時間制御, 第69回高分子討論会, 2020.09.
53.	○丸山朋輝、劉一イ、森健、片山佳樹、岸村顕広, タンパク質内包自己組織化Yolk-shell型構造体の多重膜化, 第14回バイオ関連化学シンポジウム2020, 2020.09.
54.	○岸村顕広、劉一イ、丸山朋輝、神澤大志、森健、片山佳樹, ベシクル型コンパートメント内へのタンパク質集積に基づくyolk-shell型構造体の形成, 第14回バイオ関連化学シンポジウム2020, 2020.09.
55.	○太田廉人、江頭巧、KC Biplab、森健、片山佳樹、岸村顕広, ポリマーナノ製剤の徐放速度制御に向けた『ナノ金太郎飴』の開発, 第36回日本DDS学会学術集会, 2020.08.
56.	○Fadlina Aulia、森本展行、山本雅哉、森健、片山佳樹、岸村顕広, 経粘膜薬物送達に向けたスルホベタインポリマーの浸透能力評価, 第36回日本DDS学会学術集会, 2020.08.
57.	○岸村顕広、KC Biplab、太田廉人、森健、片山佳樹, 高分子電解質の荷電密度制御に基づくコアセルベート(液滴)へのタンパク質集積化手法の開発, 第36回日本DDS学会学術集会, 2020.08.
58.	○岸村顕広、劉一イ、丸山朋輝、森健、片山佳樹 , ユニークなタンパク質カプセル化手法としてのPIC yolk-shell構造体の開発, 第36回日本DDS学会学術集会, 2020.08.
59.	岸村顕広, The Trust Bridge between Societies and Scientists, Implementation of Novel Technologies to Our Society, webinar lectures collaborating with NRC in Egypt and JSPS Research Station, 2020.08.
60.	○Buplab K.C Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Rational Design Of An Artificial Liquid-liquid Phase Separation System Via Side-chain Modification Of Synthetic Polypeptide As IDP Mimic For Effective Protein Sequestration, 第20回日本蛋白質科学会年会, 2020.07.
61.	○丸山朋輝、劉一イ、森健、片山佳樹、岸村顕広, Osmotic Pressure-induced Multilamellar Structure Formation Based On Protein-Encapsulated Yolk-shell Structure , 第20回日本蛋白質科学会年会, 2020.07.
62.	○丸山朋輝、劉一イ、森健、片山佳樹、岸村顕広, ポリイオンコンプレックス形成に基づくタンパク質内包自己組織化Yolk-shell構造体のサイズ制御, 第69回高分子学会年次大会, 2020.05.
63.	○太田廉人、ケーシービプラブ、江頭巧、森健、片山佳樹、岸村顕広, ABA型ブロック共重合体から形成されるナノ構造化コアセルベートへのタンパク質内包手法の確立 , 第69回高分子学会年次大会, 2020.05.
64.	アウリアファドリナ、森健、片山佳樹、岸村顕広、森本展行、山本雅哉, 経粘膜薬物送達に向けたスルホベタインポリマーの浸透能力評価, 日本薬学会第140年会（京都）, 2020.03.
65.	○岸村　顕広, 細胞機能編集に向けた人工オルガネラ創製へのチャレンジ, 日本薬学会第140年会（京都）, 2020.03.
66.	◯岸村顕広, ポリイオンコンプレックスの設計に基づく生体材料・生体環境模倣材料の開発, 高分子学会九州支部女性研究者創発フォーラム, 2020.01.
67.	○MengJu Chan, Kanjiro Miyata, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Facile Fabrication of Silica-Hybrid Polyion Complex Nano-Vesicles and Its Function Enhancement, the 18th Asian Chemical Congres, 2019.12.
68.	○Biplab K C, Takeshi Mori、Akihiro Kishimura、Yoshiki Katayama, Protein Sequestration in Synthetic Di-block-copolymer-based Complex Coacervate by Mimicking Intracellular Phase Separation, the 18th Asian Chemical Congres, 2019.12.
69.	○江頭巧、森　健、片山佳樹、岸村　顕広, ミクロ相分離構造体を基盤とした高分子ミセルの制御放出が可能な温度応答性徐放性担体の設計 Design of thermo-responsive sustained release carrier capable of controlled release of polymeric micelles based on well-ordered microphase-separated structure, 第29回日本MRS年次大会, 2019.11.
70.	○チャンメンル、宮田完二郎、森健、片山佳樹、岸村顕広, ポリイオンコンプレックスナノカプセルに基づくアミノ基の促進した機能強化シリカハイブリッドの開発 Development of amino-group-promoted silica hybrid based on polyion complex nano-vesicles for function enhancement, 第29回日本MRS年次大会, 2019.11.
71.	○Biplab K C, Takeshi Mori、Akihiro kishimura、Yoshiki Katayama, Polypeptide based complex coacervate as biomimetic material to sequester biomolecules via rational design of polymeric sidechain, Okinawa Colloids 2019, 2019.11.
72.	○Fadlina Aulia, 松葉弘顕、中瀬生彦、森　健、岸村顕広、片山佳樹, Control of cellular uptake behavior based on tuning of structure and physical properties of PEGylated polyion complex and its application, Okinawa Colloids 2019, 2019.11.
73.	○劉　一イ、森　健、片山佳樹、岸村　顕広, Formation of yolk-shell structure based on self-assembly of polyions and proteins, Okinawa Colloids 2019, 2019.11.
74.	○T. Egashira, T. Mori, Y. Katayama and A. Kishimura, Release of Metal Nanoparticles as Micelles from Complex Coacervates Nano-Architectures, Okinawa Colloids 2019, 2019.11.
75.	○Akihiro Kishimura, Block-copolymer-based polyion complex nanostrucctures as a platform for incorporation of colloidal nanomaterials, Okinawa Colloids 2019, 2019.11.
76.	○江頭巧、濱田裕次郎、森　健、片山佳樹、岸村　顕広, ナノ構造化コアセルベートへの部位特異的な金属ナノ粒子の内包と機能評価, 第9回 CSJ化学フェスタ 2019, 2019.10.
77.	○岸村顕広, デザインできる細胞質模倣溶媒の開発と人工細胞への挑戦, 第19回発動分子科学セミナー, 2019.10.
78.	○劉　一イ、森　健、片山佳樹、岸村　顕広, ポリイオンコンプレックス形成を活用したタンパク質捕捉基盤としてのyolk-shell構造の開発とその形成メカニズム解明, 第68回高分子討論会, 2019.09.
79.	○岸村顕広、KC Biplab、劉一イ、江頭巧、森健、片山佳樹, 細胞内濃厚環境超越に向けた高分子デザインとタンパク質濃縮, 第68回高分子討論会, 2019.09.
80.	○江頭巧、濱田裕次郎、森　健、片山佳樹、岸村　顕広, ナノ構造化コンプレックスコアセルベートを基盤とした金属ナノ粒子の空間配置制御, 第68回高分子討論会, 2019.09.
81.	○Akihiro Kishimura, Control of the Formation Process of Polypeptide Self-assemblies for Understanding Complex Biological Systems:From Nano-physiology to Artificial Cells, Japan-Britain Joint Symposiumu, 2019.09.
82.	劉一イ、森健、片山佳樹、○岸村顕広, タンパク質を内部に集積可能な高分子中空カプセルの開発, 第13回バイオ関連化学シンポジウム, 2019.09.
83.	○岸村顕広、KC Biplab、太田廉人、江頭巧、森健、片山佳樹, ポリペプチド由来コンプレックスコアセルベートを用いたタンパク質の液滴内集積, 第13回バイオ関連化学シンポジウム, 2019.09.
84.	○Fadlina Aulia, Morimoto Nobuyuki, Mori Takeshi, Katayama Yoshiki, Kishimura Akihiro, Development of cell penetrating materials for transmucosal drug delivery, 第56回化学関連支部合同九州大会, 2019.07.
85.	○詹孟儒, 岸村顕広, 森健, 片山佳樹, 宮田完二郎, Development of silica hybrid polyion complex nanocarrier for functional enrichment, 第56回化学関連支部合同九州大会, 2019.07.
86.	○岸村　顕広, コアセルベートを用いた新たなタンパク質濃縮担体の開発, 第25回次世代医工学研究会, 2019.07.
87.	○Biplab K C, Takeshi Mori、Akihiro Kishimura、Yoshiki Katayama, Synthetic complex coacervate to sequester functional proteins: A synthetic model for intracellular phase separation, 第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会, 2019.06.
88.	○岸村　顕広, Block-copolymer-based polyion complex nanotechnology as a platform for biomedical appliactions, China-Japan-Singapore Joint Symposium on Supramolecular Systems and Optoelectronic Functions, 2019.06.
89.	○Biplab.K.C, T.Mori, Y.Katayama, A.Kishimura, Introduction of Charge Heterogeneity in Di-block Copolymer for Effective Protein Sequestration in Coacervates, 第24回日本化学会九州支部・韓国化学会釜山支部合同セミナー, 2019.06.
90.	○江頭巧、森健、片山佳樹、岸村顕広, Incorporation of Metal Nanoparticles into Complex Coacervates Nano-Architectures and Their Release via Structural Transformation, 第24回日本化学会九州支部・韓国化学会釜山支部合同セミナー, 2019.06.
91.	○Akihiro Kishimura, Development of biomedical and biomimetic materials utilizing polyion-complex-based nanofabrication techniques, 2019.05.
92.	○Akihiro Kishimura, Development of biomedical and biomimetic materials utilizing polyion-complex-based nanofabrication techniques, 2019.05.
93.	○Akihiro Kishimura, Block-copolymer-based polyion complex nanotechnology as a platform for biomedical applications, 2019.05.
94.	○Akihiro Kishimura, Block-copolymer-based polyion complex nanotechnology as a platform for biomedical applications, 2019.05.
95.	○Y. Liu, T. Mori, Y. Katayama, A. Kishimura, Yolk-Shell assembly formation based on polyion complex of proteins, ACS National Meetin & Expo, 2019.04.
96.	○Y. Liu, T. Mori, Y. Katayama, A. Kishimura, Yolk-Shell assembly formation based on polyion complex of proteins, ACS National Meetin & Expo, 2019.04.
97.	○Akihiro Kishimura, Yiwei Liu, Biplab KC, Takumi Egashira, Takeshi Mori, Yoshiki Katayama, , Block-copolymer-based polyion complexes for utilization of proteins and inorganic nanoparticles, 257th ACS National Meeting, Division of Polymer Chemistry, Polymer-Based Gene & Drug Delivery Systems,, 2019.03.
98.	○岸村顕広, 江頭巧, 森健, 片山佳樹, コアセルヘベートを基盤とする薬物担体開発(1):シリンダー型ナノ構造を有するポリマー徐放基材の開発, 日本薬学会第139年会（千葉）, 2019.03.
99.	○ケーシービプラブ, 森健, 片山佳樹, 岸村顕広, コアセルベートを基盤とする薬物担体開発(2):タンパク質を取り込む液状ポリマー基材の開発, 日本薬学会第139年会（千葉）, 2019.03.
100.	松葉弘晃 , ○ファドリナアウリア , 中瀬生彦 , 森健, 片山佳樹, 岸村顕広, PEG 化ナノメディシン基材の物性と細胞取り込み挙動の相関, 日本薬学会第139年会（千葉）, 2019.03.
101.	○B. S. Kim, S. Chuanoi, Y. Anraku, K. Miyata, A. Kishimura, K. Kataoka, , siRNAsome: A self-assembled vesicular architecture formed from siRNAs and PEGylated block catiomers, 6th International Conference on Multifunctional, Hybrid and Nanomaterials 2019,, 2019.03.
102.	○江頭巧、森　健、片山佳樹、岸村　顕広, 温度上昇によるポリイオンコンプレックスネットワークの構築とミクロ相分離構造の発現 Construction of polyion complex network by thermal treatment and, 第28回日本MRS年次大会, 2018.12.
103.	○江頭巧、森　健、片山佳樹、岸村　顕広, 温度応答的な構造変換に基づいたポリイオンコンプレックス材料への金属ナノ粒子取り込みと放出 Spontaneous incorporation of metal nanoparticles into polyion complex nano-architectures, 第28回日本MRS年次大会, 2018.12.
104.	○Biplab K C, Takeshi Mori、Akihiro Kishimura、Yoshiki Katayama, Functionalization of polyelectrolyte side chains via chemical modification for effective sequestration of biomolecules into diblock-copolymer-based complex coacervate, 第28回日本MRS年次大会, 2018.12.
105.	○劉　一イ、森　健、片山佳樹、岸村　顕広, タンパク質を中空カプセル内に蓄積するyolk-shell型ポリイオンコンプレックスの開発 Development of Protein-loaded Yolk-shell Polyion Complexes for Accumulation of Proteins in Hollow Capsules, 第28回日本MRS年次大会, 2018.12.
106.	○宮田完二郎, キムボブス, チュアノイサヤン, 須磨知也, 安楽泰孝, 内藤瑞, キムヒョンジン, 岸村顕広, 片岡一則,, siRNAを膜成分として含有するベシクル型ポリイオンコンプレックス(siRNAsome)の構築とsiRNAデリバリーへの展開, 第40回日本バイマテリアル学会大会, 2018.12.
107.	○岸村顕広, ナノ材料を接着して組み上げる高分子テクノロジー, 日本接着学会東北支部講演会2018, 2018.12.
108.	○Takumi Egashira・Takeshi Mori・Yoshiki Katayama・Akihiro Kishimura, Thermo-responsive structural transition of nano-structured polyion complexes using, IPC2018, 2018.12.
109.	○松葉弘晃、中瀬生彦、森　健、片山佳樹、岸村　顕広, Utilization of dynamic response of polyion complex for enhancing cell-communication function of nanomedicine, IPC2018, 2018.12.
110.	○Biplab K.C, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Sequestration of biomolecules into diblock-copolymer-based coacervate through chemical modification of polyelectrolyte sidechain, IPC2018, 2018.12.
111.	○B. S. Kim, K. Miyata, A. Kishimura, K. Kataoka, Vesicular self-assemblies from siRNAs and PEGylated block catiomers (siRNAsomes): Their structural, physicochemical, and biological characteristics,, IPC2018, 2018.12.
112.	Akihiro Kishimura, Development of therapeutic nanosystems based on well-designed nano-scaled formulations, 国立中興大学・短期訪問学者セミナー, 2018.10.
113.	Akihiro Kishimura, Polymer nanotechnology for advanced materials: self-assembly and integration of macromolecules and colloidal nanoparticles, 国立中興大学・短期訪問学者セミナー, 2018.10.
114.	Wararu Hatanaka, Hiroki Takeuchi, Akihiro Kishimra, Yoshiki Katayama, ○Takeshi Mori, Modification of Transmembrane Protein Mimics on Living Cells, The 79th Okazaki Conference, 2018.09.
115.	○江頭巧、濱田裕次朗、」森　健、片山佳樹、岸村　顕広, ポリイオンコンプレックスの温度応答的ネットワーク化とその可逆性を利用した磁性ナノ粒子の取り込み・放出制御, 第55回化学関連支部合同九州大会, 2018.06.
116.	○Akihiro Kishimura, Polymer-nanobiotechnology for Utilization of Proteins Towards Biomedical Application, 第35回国際フォトポリマーコンファレンス　ICPST-35(2018), 2018.06.
117.	○岸村顕広, 自己組織化中空高分子カプセル PICsome の作製とその応用, 第34回日本DDS学会学術集会, 2018.06.
118.	○劉　一イ、森　健、片山佳樹、岸村　顕広, 高効率にタンパク質内包が可能なポリイオンコンプレックスyolk-shell構造体の開発, 第34回日本DDS学会学術集会, 2018.06.
119.	○松葉弘晃、中瀬生彦、森　健、片山佳樹、岸村顕広, 標的組織送達後の機能発現に向けたPEG化ポリイオンコンプレックスナノ粒子の細胞吸着・取り込み原理の解明とその積極的活用, 第34回日本DDS学会学術集会, 2018.06.
120.	○江頭巧、森　健、片山佳樹、岸村　顕広, 高分子ミセルの放出が可能な温度応答性徐放担体設計の新手法, 第34回日本DDS学会学術集会, 2018.06, 薬物徐放担体の一つとして、高分子を基材とするデポ剤があるが、特に環境応答性の制御により内包薬物の制御を放出する系はこれまでも盛んに研究されてきた。本研究では、水中で簡便に作製できるポリイオンコンプレックス（PIC）ナノ相分離構造体をもとに、生体高分子などのキャリアとして活用できるPICミセルが連続的に放出可能なデポ剤の開発を試みた。特に、非常に規則性の高いPICナノ相分離構造体からの均一なナノ構造体の放出を狙った。アニオン性のトリブロックコポリマー（ポリアスパラギン酸(PAsp)-PEG- PAsp）とジブロックコポリマーのPEG-PAspの混合物、及びカチオン性のポリ-L-リシンを用いることで、PICヘキサゴナルシリンダー構造を持つマイクロ粒子を得るとともに、PEG-PAspとPAsp-PEG-PAspの混合割合を変えることでマイクロ粒子がPICミセルへと崩壊する温度を制御することが可能であった。.
121.	濱田祐次朗、○江頭巧、檜垣勇次、小椎尾謙、高原淳、森健、片山佳樹、岸村顕広, ABAトリブロック共重合体を用いたナノ構造化ポリイオンコンプレックス(PIC)材料への金属ナノ粒子内包と粘弾性評価・・・, 第67回高分子学会年次大会, 2018.06.
122.	○劉　一イ、濱田　祐次朗、森　健、片山佳樹、岸村　顕広, ポリイオンコンプレックス形成に基づくタンパク質内包自己組織化yolk-shell構造の開発, 第67回高分子学会年次大会, 2018.05.
123.	○江頭巧、濱田祐次朗、森健、片山佳樹、岸村顕広, ABAおよびAB型ブロック共重合体混合系を用いたナノ構造化コアセルベートの作製とナノ構造の温度依存性評価・・・, 第67回高分子学会年次大会, 2018.05.
124.	○小川敦嗣、唐蘅敏、森健、片山佳樹、岸村顕広, Development of functionalized PEGylated polymer vesicles for overcoming the mucosal barrier, ISBC2017, 2017.12.
125.	Mikio Terauchi1, ○Biplab KC, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura, Study on functional biomolecule incorporation in complex coacervates using PEG-based block copolymers, ISBC2017, 2017.12.
126.	Akihiro Kishimura, Development of Polyion Complex Vesicle (PICsome) for Biomedical Applications, 理研セミナー, 2017.12.
127.	濱田　祐次朗、尚山　堅士郎、森　健、片山　佳樹、○岸村　顕広, 双親水性ブロック共重合体を用いたいナノ構造化コアセルベートへの機能性ナノ粒子の部位選択的導入, 第27回日本MRS年次大会, 2017.12.
128.	寺内　幹雄、Biplab KC、森　健、片山　佳樹、 ○岸村　顕広, 高分子電解質との複合コアセルベート形成に基づくタンパク質の特異な自己組織化挙動, 第27回日本MRS年次大会, 2017.12.
129.	○濱田祐次朗、檜垣勇次、小椎尾　謙、高原　淳、森　健、片山佳樹、岸村顕広, ブロック共重合体を用いたナノ構造化コアセルベートの設計とミクロな構造とマクロな物性の相関関係の解明, 第27回日本MRS年次大会, 2017.12.
130.	○小川敦嗣、唐蘅敏、森健、片山佳樹、岸村顕広, 粘膜バリア突破を目指した膜機能強化型PEG化ポリマーベシクルの開発, 第27回日本MRS年次大会, 2017.12.
131.	〇松葉弘晃、小川敦嗣、唐蘅敏、山崎北斗、森健、片山佳樹、岸村顕広, 標的組織送達後の機能発現を指向したPEG化ポリイオンコンプレックスナノ粒子の細胞取り込み挙動制御：その粒子形態とPEG鎖長への依存性評価, 第27回日本MRS年次大会, 2017.12.
132.	○松葉弘晃、唐蘅敏、小川敦嗣、森健、片山佳樹、岸村顕広, 標的組織送達後の機能発現に向けたPEG化ポリイオンコンプレックスナノ粒子の細胞取り込み挙動制御：その粒子形態・PEG鎖長依存性, 平成２９年度高分子学会九州支部特別講演会, 2017.11.
133.	濱田祐次朗・檜垣勇次・小椎尾謙・高原淳・森健・片山佳樹・岸村顕広, コンプレックスコアセルベートにおけるナノ構造の構築および物性との相関関係の解明, 第66回高分子討論会, 2017.09.
134.	寺内幹雄・KC Biplab・森健・片山佳樹・○岸村顕広, 内部でタンパク質の超分子構造体形成が可能なコアセルベートの開発, 第11回バイオ関連化学シンポジウム, 2017.09.
135.	岸村顕広, 人工ポリペプチドを用いて天然ポリペプチドを活かす, 第49回若手ペプチド夏の勉強会, 2017.08.
136.	○松葉弘晃、小川敦嗣、唐蘅敏、森健、片山佳樹、岸村顕広, 標的組織送達後の機能発現に向けたPEG化ポリイオンコンプレックスナノ粒子の細胞取り込み挙動制御：その粒子形態・PEG鎖長依存性, 第54回化学関連支部合同九州大会, 2017.07.
137.	○Akihiro Kishimura, Facile Synthesis of Nano-structured Materials Based on Block Copolymer Technology and their Biomedical Applications, 2017International Conference on smart Science, 2017.04.
138.	唐ヘンミン、森健、片山佳樹、田中智之、○岸村顕広, 酵素封入型ナノリアクターによる生理活性物質の除去に基づく病態制御法開発：生体内ヒスタミン分解・除去機能の評価, 日本薬学会第137年会（仙台）, 2017.03.
139.	Akihiro Kishimura, Development of Polymer-Based Supramolecular Nanosystems for Therapeutic Applications, The 50th CMS International Seminar, 2017.03.
140.	○Akihiro Kishimura, Kenshiro Naoyama, Yujiro Hamada, Takeshi Mori, Yoshiki Katayama, Development of nanostructured coacervates based on double hydrophilic block copolymers and the behavior of site-selective incorporation of functional nanoparticles, 日本化学会第97春季年会, 2017.03.
141.	◯寺内幹雄、森健、片山佳樹、岸村顕広, コアセルベートを基盤としたタンパク質複合化材料の開発, 日本化学会第97春季年会, 2017.03.
142.	○Yiwei Liu, Hengmin Tang, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura, Enhanced Protein Encapsulation by Polyion Complex Vesicle Induction on Protein-Polyion Complex Particle, The 11th SPSJ International Polymer Conference (IPC2016), 2016.12.
143.	○Yujiro Hamada, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura, Design of nano-structured PICs using all-hydrophilic block copolymers and their site-specific incorporation of functional nanomaterials, The 11th SPSJ International Polymer Conference (IPC2016), 2016.12.
144.	○岸村顕広, 親水－親水相分離によるナノ構造創製とその機能化, 日本化学会新領域研究グループ「エキゾチック自己組織化材料」・「金属と分子集合」第１回合同シンポジウム, 2016.11.
145.	○小川敦嗣、唐蘅敏、森健、片山佳樹、岸村顕広, 粘膜上皮突破に向けた膜機能強化型PEG化ポリマーベシクルの開発とその機能評価, 日本バイオマテリアル学会シンポジウム2016, 2016.11.
146.	○濱田祐次朗、森健、片山佳樹、岸村顕広, ABA型ブロック共重合体を用いたナノ構造化コアセルベートの設計と金ナノ粒子の空間配置制御, 九州地区高分子若手研究会・冬の講演会, 2016.11.
147.	○岸村顕広, Development of Self-assembled Nano-structured Materials for Biomedical Applications, MRS-id Meeting 2016, 2016.10.
148.	Akihiro Kishimura, Development of nanostructured soft materials based on all-hydrophilic block copolymers: From basics to biomedical applications,, 2016.10.
149.	○岸村顕広, Development of Novel Supramolecular Hollow Capsules "Picsomes" for Biomedical Applications, ChinaNanomedicine 2016, 2016.10.
150.	○小川敦嗣、唐蘅敏、森健、片山佳樹、岸村顕広, 粘膜上皮細胞層透過に向けたPEG 化ポリマーベシクルの膜機能強化とその評価, 日本バイオマテリアル学会九州講演会2016, 2016.09.
151.	○濱田祐次朗、森健、片山佳樹、岸村顕広, ABA型ブロック共重合体を用いたナノ構造コアセルベートの設計と機能性素材の内包挙動解明, 第65回高分子討論会, 2016.09.
152.	○岸村顕広、寺内幹雄、濱田祐次朗、尚山堅士郎、劉一イ、森健、片山佳樹, ミクロ構造を持つコアセルベートを用いた生体関連材料開発, 第10回バイオ関連化学シンポジウム, 2016.09.
153.	○岸村顕広, Development of polyion complex nanostructures based on all-hydrophilic block copolymers, Ostwald Colloquium 2016, 2016.09.
154.	Akihiro Kishimura, Development of polymeric nano-vesicles for advanced drug delivery system, 2016.08.
155.	○劉　一イ、唐　衡敏、森　健、片山佳樹、岸村　顕広, ポリカチオンリッチ条件下におけるポリイオンコンプレックスベシクル形成とその物性評価, 第53回化学関連支部合同九州大会, 2016.07.
156.	○濱田祐次朗，尚山堅士郎、森健、片山佳樹、岸村顕広, トリブロックコポリマーを用いたナノ構造化コアセルベート形成と金ナノ粒子の空間配置制御, 第53回化学関連支部合同九州大会, 2016.07.
157.	○小川敦嗣、唐蘅敏、森健、片山佳樹、岸村顕広, 粘膜上皮突破に向けた膜機能強化型PEG化ポリマーベシクルの開発とその機能評価, 第53回化学関連支部合同九州大会, 2016.07.
158.	○岸村顕広, 物質透過性ナノ膜を利⽤した⽣体⾼分⼦送達カプセルの設計と開発, 第32回日本DDS学会学術集会, 2016.06.
159.	○岸村顕広、秦智貴、唐蘅敏、劉一葳、森健、片山佳樹, 生体分子の効率的捕捉・送達のための高分子ナノカプセルの開発, 第32回日本DDS学会学術集会, 2016.06.
160.	○唐蘅敏、森　健、田中智之、片山佳樹、岸村　顕広, 酵素封入型ナノリアクターの開発とヒスタミン分解・除去機能の評価, 第32回日本DDS学会学術集会, 2016.06.
161.	Akihiro KISHIMURA, Engineering of Enzyme Nano-capsules for Biomedical Applications, CIMTEC2016, 2016.06.
162.	○唐　衡敏、坂村　有紀、森　健、片山佳樹、岸村　顕広, 酵素封入型ナノリアクターの機能強化に向けた検討～ナノコンパートメントへの格納および非荷電高分子共存による酵素反応挙動の評価～, 第65回高分子学会年次大会, 2016.05.
163.	尚山堅士郎、濱田祐次朗、森健、片山佳樹、○岸村顕広, AB型ブロック共重合体を用いたナノ構造化コアセルベートの調整と部位特異的な酸化鉄ナノ粒子包含挙動, 第65回高分子学会年次大会, 2016.05.
164.	○濱田祐次朗、尚山堅士郎、森健、片山佳樹、岸村顕広, ABA型ブロックコポリマーを用いたナノ構造化コアセルベートの設計と機能性素材の空間配置制御, 第65回高分子学会年次大会, 2016.05.
165.	尚山堅士郎、黒木奏子、森健、片山佳樹、○岸村顕広, ポリアミノ酸デンドリマー型ポリカチオンを用いたポリイオンコンプレックス形成とその特異な自己組織化挙動, 第65回高分子学会年次大会, 2016.05.
166.	○劉　一イ、唐　衡敏、森　健、片山佳樹、岸村　顕広, ブロックポリアニオン/ホモポリカチオンの混合比率がポリイオンコンプレックスベシクルの性質に与える影響, 第65回高分子学会年次大会, 2016.05.
167.	Akihiro Kishimura, Development of polymeric nanomedicine for novel therapy and pathophysiologic study, 2016.05.
168.	岸村顕広, 分子運動の制御による超分子カプセルの作製とその応用, 日本化学会第９６春季年会・特別企画「ミクロな分子運動」を活用する機能性材料の新展開, 2016.03.
169.	Yuki Sakamura , Hengmin Tang , Takeshi Mori , Yoshiki Katayama , ○Akihiro Kishimura, Development of enzyme-loaded polymeric nanocapsules as a versatile platform for enzyme applications: Effect of co-encapsulation of neutral macromolecules, THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015, 2015.12.
170.	○Kenshiro Naoyama, Takeshi Mori , Yoshiki Katayama , Akihiro Kishimura, Site-selective incorporation of nanoparticles into the complex coacervate utilizing self-assembly of block copolymers in aqueous solution, THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015, 2015.12.
171.	○Akihiro Kishimura, Development of polyion complex vesicle “PICsomes” and their unique self-assembling behavior, THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015, 2015.12.
172.	○Hengmin Tang, Yuki Sakamura , Satoshi Tanaka , Takeshi Mori , Yoshiki Katayama , Akihiro Kishimura, Development of a novel enzymatic nano-reactors as biodetoxification nanomedicine, THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015, 2015.12.
173.	○秦智貴、唐蘅敏、森健、片山佳樹、岸村顕広, ：腫瘍環境制御に向けた生理活性物質を捕捉可能なヘパリン包含ナノデバイスの開発, 第25回日本MRS年次大会, 2015.12.
174.	岸村顕広, 高分子透過膜からなるベシクルの創製と次世代DDSへの応用生体膜, 第37回生体膜と薬物の相互作用シンポジウム, 2015.11.
175.	Akihiro Kishimura, Rational design of polyion complex nano-architectures for development of functional materials, 2015 Pusan-Gyeongnam/Kyushu-Seibu Joint Symposium on High Polymers (17th) and Fibers (15th), 2015.11.
176.	Akihiro Kishimura, ポリイオンコンプレックスナノ構造体の創製とそのユニークな物性, 日本化学会新領域研究グループ「エキゾチック自己組織化材料(ExOM)」全体講演会, 2015.11.
177.	○尚山堅士郎, Study on site-selective incorporation of Fe2O3-nanoparticle into the block copolymer based coacervate, 日本化学会新領域研究グループ「エキゾチック自己組織化材料(ExOM)」全体講演会, 2015.11.
178.	Akihiro Kishimura, Development of polyion complex nano-vesicles for biomedical applications, Polymers in Medicine and Biology:2015, 2015.09.
179.	坂村有紀、唐蘅敏、山﨑北斗、森健、片山佳樹、○岸村顕広, 酵素封入型ナノリアクターの機能開発・酵素のナノコンパートメントへの格納と非荷電水溶性高分子共存の効果, 第9回バイオ関連化学シンポジウム, 2015.09.
180.	○唐　衡敏、森　健、田中　智之、片山佳樹、岸村　顕広, Development of a novel enzymatic nano-reactor for the application of biodetoxification, 42nd CRS Annual Meeting & Exposition, 2015.07.
181.	○寺内　幹雄、尚山　堅士郎、森　健、片山佳樹、岸村　顕広, 糖タンパク質をビルディングブロックとした分子集合体の構造制御, 日本化学会九州支部設立100周年記念国際シンポジウム第52回化学関連支部合同九州大会, 2015.06.
182.	○山﨑北斗、唐衡敏、森健、片山佳樹、岸村顕広, Development of novel polymeric vesicles with light-responsive properties for switching their in vivo functions, 日本化学会九州支部設立100周年記念国際シンポジウム第52回化学関連支部合同九州大会, 2015.06.
183.	◯尚山堅士郎、森健、片山佳樹、岸村顕広, PEG-ポリペプチドブロック共重合体から形成されるコアセルベートへの部位選択的な無機微粒子内包挙動, 第64回高分子学会年次大会, 2015.05.
184.	○山﨑　北斗、坂村　有紀、唐　衡敏、森　健、片山佳樹、岸村　顕広, 光刺激による生体内機能スイッチングを可能とする新規ポリマーベシクルの開発, 第64回高分子学会年次大会, 2015.05.
185.	○唐　衡敏、森　健、田中　智之、片山佳樹、岸村　顕広, Development of enzymatic nano-reactor for removing physiological active substance, 第64回高分子学会年次大会, 2015.05.
186.	岸村　顕広, ポリイオンコンプレックスを基盤とする高分子ナノ構造材料の開発と応用, 第151回東海高分子研究会講演会, 2015.04.
187.	岸村　顕広, タンパク質を生かす高分子材料学, 第２回九州バイオ若手の会, 2014.09.
188.	岸村　顕広, 物性制御可能なナノカプセルの開発と新しい生理学の可能性, 第二回生体分子サイエンスセミナー, 2014.09.
189.	岸村　顕広, 高分子中空ナノカプセルPICsomeを用いた新しいDDSのアプローチ, 第３０回日本DDS学会学術集会, 2014.07.
190.	Akihiro Kishimura, Development of Polyion Complex Vesicles “PICsomes” with Semipermeable Properties As a Novel Platform for Nano-medicine, The 5th International Conference on the Development of Biomedical Engineering in Vietnam, 2014.06.
191.	岸村　顕広, ポリイオンコンプレックスを用いた水中での簡便なポリマーナノ構造形成と生体材料応用, 第86回千葉地域活動高分子研究交流講演会, 2014.06.
192.	岸村　顕広, ポリイオンコンプレックス型透過膜を有する中空カプセルPICsomeの開発とDDSへの応用, 日本膜学会第36年会, 2014.05.
193.	Akihiro Kishimura, ポリイオンコンプレックス形成を利用した簡便なナノ構造形成とその応用, 第14回リング・チューブ超分子研究会, 2014.03.
194.	Akihiro Kishimura, スマートライフケアを実現する万能ナノコンテナシステムの開発, COINSスマートライフケア社会への変革を先導するものづくりオープンイノベーション拠点」キックオフシンポジウム, 2014.03.
195.	Akihiro Kishimura, ブロック共重合体を用いたポリイオンコンプレックス形成に基づくナノ構造制御とその応用, 日本接着学会東北支部講演会2013, 2014.03.
196.	Akihiro Kishimura, ポリイオンコンプレックス型ベシクルPICsomeの開発と薬物送達への応用, 第23回日本MRS年次大会セッションN, 2013.12.
197.	Akihiro Kishimura, ポリイオンコンプレックス型ベシクルPICsomeを用いた新規薬物送達システム開発, バイオマテリアル学会九州講演会2013, 2013.09.
198.	Akihiro Kishimura, Novel method to load high amount of drugs and macromolecules into polyion complex vesicles (PICsomes), 40th Annual Meeting & Exposition of the Controlled Release Society, 2013.07.

特許出願・取得

特許出願件数 1件

特許登録件数 0件

その他の優れた研究業績

2018.06, 高分子ミセルの放出が可能な温度応答性徐放担体設計の新手法.

2018.11, siRNAを膜成分として含有するベシクル型ポリイオンコンプレックス(siRNAsome)の構築とsiRNAデリバリーへの展開.

2017.03, 酵素封入型ナノリアクターによる生理活性物質の除去に基づく病態制御法開発：生体内ヒスタミン分解・除去機能の評価.

所属学会名

「細胞を創る」研究会

日本科学振興協会

日本疫学会

日本生物物理学会

日本蛋白質科学会

日本バイオマテリアル学会

日本DDS学会

Controlled Release Society

American Chemical Society

一般社団法人　日本MRS

公益社団法人　高分子学会

公益社団法人日本化学会

公益社団法人日本薬学会

学協会役員等への就任

2022.02～2022.06, 日本科学振興協会, 監事.

2022.04, 日本バイオマテリアル学会, 評議員.

2019.03～2020.02, 日本化学会九州支部, 幹事.

2017.12～2020.09, 第２４期日本学術会議若手アカデミー, 代表.

2017.02～2022.05, the Global Young Academy (GYA), Member.

学会大会・会議・シンポジウム等における役割

2023.11.15～2023.11.15, 第61回日本生物物理学会年会シンポジウム「シン・合成生物学：既存生命のみに依拠しないシステム創成に向けた化学者からの提案」, シンポジウムオーガナイザー.

2022.12.05～2022.12.07, 第32回日本MRS年次大会, シンポジウムオーガナイザー.

2021.12.13～2021.12.15, 第31回日本MRS年次大会, シンポジウムオーガナイザー.

2022.06.29～2022.06.30, 第３８回日本DDS学会学術集会, 実行委員.

2022.06.12～2022.06.17, The Global Young Academy年次総会兼学会2022, local organizing comitte 副委員長.

2020.12.09～2020.12.11, 第30回日本MRS年次大会, シンポジウムオーガナイザー.

2019.11.28～2019.11.29, 第29回日本MRS年次大会, シンポジウムオーガナイザー.

2020.03.26～2020.03.26, 日本薬学会第１４０年会, シンポジウムオーガナイザー.

2015.12.09～2015.12.10, 第25回日本MRS年次大会, シンポジウムオーガナイザー.

2016.12.19～2016.12.20, 第26回日本MRS年次大会, シンポジウムオーガナイザー.

2017.12.05～2017.12.06, 第27 回日本MRS年次大会, シンポジウムオーガナイザー.

2018.12.18～2018.12.20, 第28 回日本MRS年次大会 , シンポジウムオーガナイザー.

2017.12.14～2017.12.16, The 2nd International Symposium on Biofunctional Chemistry (ISBC2017), Scientific Program Committee .

2017.08.20～2017.08.24, Biomaterials International 2017 (BMI2017), Organizing Committee.

2017.03.16～2017.03.16, 日本化学会第97春季年会・特別企画9「生命化学が先導する分子機能創成の最先端：生体機能・生体分子を超えるためのアプローチ」, 企画責任者、セッションオーガナイザー.

2017.01.17～2017.01.17, 日本化学会エキゾチック自己組織化材料 (ExOM) & 九大分子システム科学センター (CMS) 第1回合同シンポジウム, 企画責任者・世話人.

2016.11.21～2016.11.22, 日本バイオマテリアル学会シンポジウム2016, 実行委員.

2015.09.18～2015.09.18, 第５回日本バイオマテリアル学会九州ブロック講演会, 実行委員.

2014.06.13～2014.06.14, 第７回NanoBio若手ネットワーキングシンポジウム, 世話人.

2014.08.01～2014.08.01, 第1回ソフト界面研究会, 組織委員.

2014.08～2013.08, IUMRS-ICA2014, セッションオーガンナイザー.

2014.09.24～2014.09.26, 第６３回高分子討論会　特定テーマ14．“動き”のある自己組織化材料：動的応答・変化を示す材料の設計・機能・応用の最前線, セッションオーガナイザー.

2015.01.20～2015.01.20, The 2nd CMS International Symposium, シンポジウムオーガナイザー.

学会誌・雑誌・著書の編集への参加状況

2017.10～2018.07, Nanomaterials, 国際, 特集号・編集委員.

学術論文等の審査

年度	外国語雑誌査読論文数	合計
2023年度	3	3
2018年度	7	7
2017年度	15	15
2016年度	9	9
2013年度	6	6
2014年度	10	10
2015年度	18	18

海外渡航状況, 海外での教育研究歴

Johannes Gutenberg Universitat Mainz, Germany, 2019.05～2019.05.

Twente大学, Netherlands, 2019.05～2019.05.

華中科技大学, China, 2016.05～2016.05.

国立中興大学, 中央研究院, Taiwan, 2018.10～2018.10.

Insitut Teknologi Bandung (ITB), Indonesia, 2016.10～2016.10.

Westfälische Wilhelms-Universität Münster, RWTH Aachen University, Germany, 2016.08～2016.09.

西北農林科技大学, China, 2016.10～2016.10.

中南民族大学, 華中科技大学, China, 2016.05～2016.05.

Bristol大学, UnitedKingdom, 2015.07～2015.07.

外国人研究者等の受入れ状況

2018.07～2018.08, 2週間以上1ヶ月未満, Department of Material Engineering, Faculty of Mechanical and Aerospace Engineering (FMAE), Institute of Technology, Bandung (ITB); Research Center for Nanoscience and Nanotechnology (RCNN), ITB, Indonesia, 外国政府・外国研究機関・国際機関.

2015.06～2015.08, 1ヶ月以上, 延世大学大学院理学部化学科, Japan, 外国政府・外国研究機関・国際機関.

科学研究費補助金の採択状況(文部科学省、日本学術振興会)

2024年度～2025年度, 学術変革領域研究(A), 代表, 生体分子凝縮体に基づく人工オルガネラ構築と物質生産超越分子システムへの活用.

2023年度～2025年度, 基盤研究(C), 分担, 非腫瘍細胞を有するマイクロ腫瘍組織モデルの構築（代表・佐々木直樹）.

2022年度～2023年度, 学術変革領域研究(A), 代表, 超越分子システムとしての機能共生型人工オルガネラ創製と実用化に向けた機能実証.

2022年度～2025年度, 基盤研究(B), 代表, 生体高分子を含む過渡的濃縮相からの相分離制御に基づく階層的集合構造の合理的構築.

2019年度～2019年度, 基盤研究(C), 分担, ナノ薬剤評価用マイクロ腫瘍組織モデルの開発.

2018年度～2019年度, 挑戦的研究（萌芽）, 分担, RNA膜で構成される人工エクソソームの創製と高機能生理活性メディエーターへの展開.

2018年度～2021年度, 基盤研究(B), 代表, 分子集合体型薬物ナノカプセルの内部物性制御に基づく体内動態制御.

2017年度～2018年度, 挑戦的研究（萌芽）, 代表, 生体内での自律駆動を目指した自発光型ナノシステムの創製とその応用.

2011年度～2013年度, 基盤研究(B), 分担, 超分子デバイスと光技術を駆使した微小がんの一期的な診断・治療システムの開発.

2014年度～2016年度, 基盤研究(B), 代表, 高分子ナノカプセルを用いた生体内における新規酵素利用基盤の構築.

2011年度～2013年度, 若手研究(A), 代表, 高分子ベシクルを用いた人工オルガネラの創製と細胞内配置技術の開発.

2013年度～2015年度, 新学術領域研究, 代表, ポリイオンコンプレックスナノ構造を中心とする融合マテリアル創出法の開発.

2013年度～2015年度, 挑戦的萌芽研究, 代表, クラウディング・ナノコンパートメントの創製とナノリアクターとしての開発.

共同研究、受託研究(競争的資金を除く)の受入状況

2023.08～2024.03, 分担, 課題名：「いとしま免疫村」づくりに関する研究
（目的・目標）
1) 糸島市内の事業所等で働く人を対象にした実態調査及びその分析を通して、市民の健康増進・健康寿命の延伸・QOLの向上につながる施策の提言。
2) 「いとしま免疫村」づくりの取り組みを生かして、フレイルに関する既存の研究・事業の成果・データを市民に還元するとともに、各分野の専門職がそのデータを活用し、フレイル予防のための指導を行うことができる評価の仕組みを構築。
3) 「いとしま免疫村」づくりに繋がる市民の行動変容の促進・機運醸成。
岸村はこの中の1)のテーマを分担し、共同研究を推進した。特に、「目的・目標」の1)について、糸島市内の企業に勤務する働く世代を対象にした健康意識調査「職場における健康づくりアンケート」を計画し、糸島市健康づくり課と議論を交わしながら事業所向けのものと個別の従業員向けのアンケートをそれぞれ作成した。九州大学病院における適切な倫理審査を経た後、10月初旬からアンケート（紙の質問票）の配布を開始し、糸島市内の約200の事業所、約2,000名の従業員へ配布を行うことにより調査を実施した。１１月上旬に回収を終え、アンケートへの同意のあった有効回答数は、事業所からは207、従業員からは729であった。その後、回収した質問票を外部業者（株式会社FCCテクノ）に委託のもとでデジタルデータ化し、１２月上旬より九州大学にてデータ解析を実施し、糸島市役所の担当者と綿密に議論を行い、市の施策の策定に資する成果を得た。.

2020.08～2021.03, 代表, 静電相互作用型高分子中空微粒子によるタンパク質内封DDS製剤の開発.

寄附金の受入状況

2020年度, 公益財団法人池谷科学技術振興財団
, 公益財団法人池谷科学技術振興財団 2020年度研究助成
課題名「タンパク質濃縮カプセルとしてのyolk-shell構造体の開発と高効率カスケード反応への応用」.

2015年度, 公益財団法人・持田記念医学薬学振興財団 , 平成２７年度持田記念研究助成金
NO発生ナノデバイスの開発と疾患治療への応用.

学内資金・基金等への採択状況

2019年度～2020年度, 平成31年度工学研究新分野開拓助成, 代表, 人工細胞質設計に向けた液液相分離モデル系の構築と濃厚環境の機能的理解.

2016年度～2016年度, 研究活動基礎支援制度「国際学会派遣支援」(第1回), 代表, 医療応用に向けた酵素ナノカプセルの工学的開拓.


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