||Honda M., Nakashima K., and Katada S., PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells, J Neurochem, 10.1111/jnc.14123., 142, 901-907, 2017.07, Arginine methylation is a post-translational modification which is catalyzed by protein arginine methyltransferases (PRMTs). Here, we report that PRMT1 is highly expressed in neural stem/precursor cells (NS/PCs) of mouse embryos, and knockdown of PRMT1 in NS/PCs suppresses the generation of astrocytes. The luciferase assay demonstrated that knockdown of PRMT1 inhibits activation of the promoter of a typical astrocytic marker gene, glial fibrillary acidic protein (Gfap), in NS/PCs. The transcription factor signal transducer and activator of transcription 3 (STAT3) is known to generally be critical for astrocytic differentiation of NS/PCs. We found that PRMT1 methylates arginine residue(s) of STAT3 to regulate its activity positively, resulting in the promotion of astrocytic differentiation of NS/PCs..
||Kawamura Y., Katada S., Noguchi H., Yamamoto H., Sanosaka T, Iihara K., and Nakashima K, Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain, FEBS Letters, 10.1002/1873-3468.12881, 591, 22, 3709-3720, 2017.11.
||Aguilar-Arnal, Lorena, Katada, Sayako, Orozco-Solis, Ricardo, Sassone-Corsi, Paolo, NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 10.1038/nsmb.2990, 22, 4, 312-U60, 2015.04.