Kyushu University Academic Staff Educational and Research Activities Database
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LIU XIAOHUI Last modified date:2018.07.19

Assistant Professor / Laboratory of Molecular and Cellular Biochemistry
Department of Chemistry
Faculty of Sciences


Graduate School
Undergraduate School
Other Organization
Other
Administration Post
Other


E-Mail
Phone
092-802-4157
Fax
092-802-4126
Academic Degree
Doctor
Field of Specialization
Biochemistry
Research
Research Interests
  • The molecular mechanism of estrogen-like activities of bisphenol A: Activity reinforcement of bisphenol A-bound estrogen receptors (ER) by estrogen-related receptors (ERR)

    keyword : bisphenol A, estrogen-related receptor, estrogen receptor, estrogen-like activities, activity reinforcement
    2012.04.
  • Specific transcription activity of halogen-containing bisphenols for estrogen receptor subtypes
    keyword : bisphenol, estrogen receptor, halogen bond, transfection activity
    2008.04.
  • Structural requirements of the human nuclear receptor ERRγ in its specific binding of bisphenol A
    keyword : bisphenol A, estrogen-related receptor, endocrine disruptor, nuclear receptor, low does effects
    2006.10.
Academic Activities
Reports
1. Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. Shimohigashi, M., and Shimohigashi, Y., α-Helix-peptides composing the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization. — Bisphenol A receptor ERRγ physiologically functions as homodimer., Biomedical Advances, ep-20178-10, 2017.08.
Papers
1. Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A., and Shimohigashi, Y., Mutual co-work between nuclear receptor ERα and ERRα requires their homodimerization, Peptide Science  2017, 198-199, 2018.03.
2. Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y., Homodimer function of human nuclear receptor ERRα evidenced using α-helix peptides in the dimer interface, Peptide Science  2017, 190-191, 2018.03.
3. Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M., Shimohigashi, Y., α-Helix-peptides composing the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization., Biopolymers–Peptide Science, 10.1002/bip.22795, 4, 547-554, 2016.06, ERRγがそのリガンド結合ドメインでダイマー化したX線結晶構造が報告されていることから、まず、このダイマー構造のインターフェイスに存在するα-ヘリックスペプチドをERRγと一緒に共発現するレポーター遺伝子アセイ系をデザイン・確立した。そして、α-ヘリックスペプチドはERRγに結合し細胞核内に移行すること、そして、転写活性化を阻害することを実験的に、それぞれ免疫組織学、及びレポーターアッセイで実証し、「ERRγはホモダイマーとして機能する」ことの証明に成功した。.
4. Sakito, S., Liu, X., Fujiyama, A., Matsushima, A., Shimohigashi, Y., Do the estrogen receptors function as a homodimer? Experrimental validation of homodimerization by inhibitory peptides.
, Peptide Science 2015, 335-336, 2016.03.
5. Liu, X., Shimohigashi, M., Matsushima, A., Shimohigashi, Y., Protein constitutive peptide fragments to inhibit protein-protein interaction: Inhibitory peptides as molecular probe for clarification of human nuclear receptor activation mechanism., Peptide Science 2015, 319-320, 2016.03.
6. LIU, X., MATSUSHIMA, A., SHIMOHIGASHI, Y., A novel method to identify and quantify the coactivator proteins that couple with human nuclear receptor: The use of interacting interface α-helix peptide for quantitative inhibition, Peptide Science 2014, 2014, 349-350, 2015.03.
7. LIU, X., MATSUSHIMA, A., SHIMOHIGASHI, M., SHIMOHIGASHI, Y., A Characteristic Back Support Structure in the Bisphenol A-Binding Pocket in the Human Nuclear Receptor ERRgamma, PLoS ONE, 10.1371/journal.pone.0101252, 9(6): e101252. , 2014.06.
8. Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, Y., Constitutive α-helix-peptides required for functional dimerization of estrogen-related receptor γ (ERRγ), Peptide Science 2013, 429-430, 2014.03.
Presentations
1. Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, Y., Constitutive α-helix-peptides required for functional dimerization of estrogen-related receptor γ (ERRγ), 4th Asis-Pacific International Peptide Symposium-50th Japanese Peptide Symposium (APIPS 2013), 2013.11.
2. Xiaohui Liu, Ayami Matsushima, Naoto Shirasu, Yoshiya Tominaga, Miki Shimohigashi, Yasuyuki Shimohigashi, Structural characteristic of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands, 1stAsia-Pacific International Peptide Symposium, 2004.11.
3. Xiaohui Liu, Ayami Matsushima, Naoto Shirasu, Yoshiya Tominaga, Miki Shimohigashi, Yasuyuki Shimohigashi, Expression and binding assay of Drosophila estrogen-related receptor, International Assembly in Neurobiology(IAN 2004), 2004.03.
4. Xiaohui Liu, Ayami Matsushima, Yoshiya Tominaga, Miki Shimohigashi, Yasuyuki Shimohigashi, cDNA cloning and expression of estrogen-related receptor in the fruit fly Drosophila, 第76回日本生化学会大会, 2003.10.
Membership in Academic Society
  • The Japanese Biochemical Society
  • The Chemical Society of Japan
  • The Japanese Peptide Society
  • Japan Society of Endocrine Disrupters Research
Awards
  • Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ)