Kyushu University Academic Staff Educational and Research Activities Database
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Shintaro Nakao Last modified date:2020.01.07

Administration Post

Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Research Interests
  • Investigation of Retinal/Choroidal Vascular Diseases
    keyword : Diabetic retinopathy, Diabetic macular edema, Age-related macular degeneration, Vitrectomy, Angiogenesis, Lymphangiogenesis, Inflammation, Macrophage, Robotic Surgery
Academic Activities
1. Shintaro Nakao, Yasuaki Hata, An Overview on Diabetes and Ocular Health , Elsevier, 2012.01.
1. Nakao S, Yoshida S, Kaizu Y, Wada I, Sonoda KH, Detection Capability of OCT Angiography for Nonperfused Areas in Diabetic Retinopathy, 10th Joint Meeting of Korea-China-Japan Ophthalmologists, 2017.11.
2. 中尾 新太郎, Evaluation of hyperreflective foci in diabetic macular edema by ultra-high resolution en face optical coherence tomography, ARVO, 2017.05.
3. 中尾 新太郎, Impact of Anti-VEGF Therapy on Photoreceptor in Patients with Exudative Age-Related Macular Degeneration, 1st Japan-Taiwan Vitreoretinal Joint Meeting, 2016.10.
4. 中尾 新太郎, Impact of Anti-VEGF Therapy on Photoreceptor in Patients with Exudative Age-Related Macular Degeneration, 49th Annual Retina Society Meeting, 2016.09.
5. Shintaro Nakao, Evaluation of Vascular Lesion Before and After Anti-VEGF Therapy for Age-Related Macular Degeneration by OCT Angiography, The 54th Annual Meeting of Japanese Retina and Vitreous Society, 2015.12.
6. Shintaro Nakao, ROCK as a therapeutic target in diabetic retinopathy. Molecular Mechanisms in Diabetic Retinopathy, Asia ARVO 2015, 2015.02.
7. Shintaro Nakao, Rhoichi Arita, Muneo Yamaguchi, Tatsuro Ishibashi, Characterization of Microaneurysm in Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy, ARVO.
8. Shintaro Nakao, Rhoichi Arita, Tomoyuki Isobe, Yoshio Kaneko, Tatsuro Ishibashi, Therapeutic potential of topical ROCK inhibitor K-115 in retinal neovascularization, World Ophthalmology Congress 2014, 2014.04.
9. Shintaro Nakao, Souska Zandi, Riichiro Kohno, Dawei Sun, Lack of Lymphatics and Lymph Node-mediated Immunity in Choroidal Neovascularization , The Sixth Joint Meeting of Chinese-Korean-Japanese Ophthalmologists, 2013.09, Purpose. Inflammation and immune cells regulate choroidal neovascularization (CNV) and could become therapeutic targets in age-related macular degeneration (AMD). Lymphangiogenesis is a key component of various inflammatory diseases. Whether lymphangiogenesis and lymph node-mediated immunity are involved in the pathogenesis of AMD is not understood.
Methods. To investigate lymphangiogenesis in AMD, we generated choroidal neovascularization (CNV) in animals by laser and studied surgically removed CNV membranes from uveitis and AMD patients. Immunohistochemistry was performed with LYVE-1 and podoplanin antibodies. VEGF-C and VEGFR-3 expressions were examined with immunohistochemistry and western blotting. To examine the role of lymph node in CNV, we lasered lymphotoxin alpha deficient mice (LTα-/-) and measured the CNV volume.
Results. Immunohistochemistry showed that LYVE-1(+) macrophages infiltrated in acutely induced CNV, however, lymphatic tubes did not form. CNV membranes from patients did not show LYVE-1(+)podoplanin(+) vessels, suggesting lack of lymphangiogenesis in AMD and uveitis. Western blots and immunostaining revealed VEGF-C and VEGFR-3 expression in CNV lesions, mainly in macrophages and angiogenic endothelial cells. Using fluorescent microsphere tracers, we show a path for cellular migration from the eye to the cervical lymph nodes (LN) during CNV. However, CNV injury did not cause LN swelling. CNV volume did not differ between WT and LN deficient mice, suggesting that LN is not a key component of early CNV formation.
Conclusion. Laser-induced CNV is not primarily dependent on acquired immunity, nor does the fundus injury affect peripheral LNs. Our results reveal a previously unknown cellular connection between the ocular fundus and the cervical LNs. This connection that in function resembles lymphatics is actively utilized in CNV.
10. 中尾 新太郎, Altred Vascular Microenvironment by anti-VEGF therapy in Diabetic Fibrovascular Membrane, EuroLam Retina, 2013.05.
Membership in Academic Society
  • The Retina Society
  • Japanese Ophthalmological Society
  • Japan Ophthalmologist Association
  • The Japan Diabetes Society
  • The Japanse Society of Ophthalmic Diabetology
  • Japanese Society for Ocular Circulation
  • Japanese Ocular Inflammation Society
  • Japanese Retina and Vitreous Society
  • The Japanese Vascular Biology and Medicine Organization
  • The Association for Research in Vision and Ophthalmology
  • Impact of Anti-VEGF Therapy on The Cellular Microenvironment in Retinal Angiogenesis
Educational Activities