エラスチン由来ペプチドダイマーの自己集合特性および立体構造の解析
キーワード：エラスチン ペプチド コアセルベーション
2013.03～2017.03.
| 巣山 慶太郎（すやま けいたろう） | データ更新日：2023.09.27 |
主な研究テーマ
光学活性なアルミニウム錯体を触媒とする不斉合成
キーワード：不斉触媒反応 アルミニウムサラレン錯体
2006.04～2009.03.
キーワード：不斉触媒反応 アルミニウムサラレン錯体
2006.04～2009.03.
核内受容体結合試験の新規プローブの開発
キーワード：核内受容体 受容体結合試験 蛍光トレーサー ビスフェノール
2009.04.
キーワード：核内受容体 受容体結合試験 蛍光トレーサー ビスフェノール
2009.04.
従事しているプロジェクト研究
【AMED橋渡し研究プログラム】九州大学拠点2022年度 異分野融合型研究シーズ(シーズH)
2022.09～2024.03, 代表者：森 健, 九州大学工学研究院応用化学部門.
2022.09～2024.03, 代表者：森 健, 九州大学工学研究院応用化学部門.
研究業績
主要原著論文
| 1. | Daiki Tatsubo, Keitaro Suyama, Naoki Sakamoto, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose, Determining the sequence-dependency of self-assembly of elastin-like peptides using short peptide analogs with shuffled repetitive sequences , Biochemistry, https://doi.org/10.1021/acs.biochem.3c00146, 62, 17, 2559-2570, 2023.08. |
| 2. | Kohei Yoshida, Keitaro Suyama, Shin Matsushita, Iori Maeda, Takeru Nose, Development of the efficient preparation method for thermoresponsive elastin‐like peptides using liquid‐phase synthesis combined with fragment condensation strategy, Journal of Peptide Science, 10.1002/psc.3528, e3528, 2023.06. |
| 3. | Shogo Sumiyoshi, Keitaro Suyama, Naoki Tanaka, Takumi Andoh, Akihiko Nagata, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose, Development of truncated elastin-like peptide analogues with improved temperature-response and self-assembling properties, Scientific Reports, 10.1038/s41598-022-23940-0, 12, 1, 2022.11, Abstract Functional peptides, which are composed of proteinogenic natural amino acids, are expected to be used as biomaterials with minimal environmental impact. Synthesizing a functional peptide with a shorter amino acid sequence while retaining its function is a easy and economical strategy. Furthermore, shortening functional peptides helps to elucidate the mechanism of their functional core region. Truncated elastin-like peptides (ELPs) are peptides consisting of repetitive sequences, derived from the elastic protein tropoelastin, that show the thermosensitive formation of coacervates. In this study, to obtain shortened ELP analogues, we synthesized several (Phe-Pro-Gly-Val-Gly)n (FPGVG)n analogues with one or two amino acid residues deleted from each repeat sequence, such as the peptide analogues consisting of FPGV and/or FPG sequences. Among the novel truncated ELP analogues, the 16-mer (FPGV)4 exhibited a stronger coacervation ability than the 25-mer (FPGVG)5. These results indicated that the coacervation ability of truncated ELPs was affected by the amino acid sequence and not by the peptide chain length. Based on this finding, we prepared Cd2+-binding sequence-conjugated ELP analogue, AADAAC-(FPGV)4, and found that it could capture Cd2+. These results indicated that the 16-mer (FPGV)4 only composed of proteinogenic amino acids could be a new biomaterial with low environmental impact.. |
| 4. | Keitaro Suyama, Marin Shimizu, Iori Maeda, Takeru Nose, Flexible customization of the self-assembling abilities of short elastin-like peptide Fn analogs by substituting N-terminal amino acids, BIOPOLYMERS, 10.1002/bip.23521, 2022.07, Elastin-like peptides (ELPs) are thermoresponsive biopolymers inspired by the characteristic repetitive sequences of natural elastin. As ELPs exhibit temperature-dependent reversible self-assembly, they are expected to be biocompatible thermoresponsive materials for drug delivery carriers. One of the most widely studied ELPs in this field is the repetitive pentapeptide, (VPGXG)(n). We previously reported that phenylalanine-containing ELP (Fn) analogs, in which the former Val residue of the repetitive sequence (VPGVG)(n) is replaced by Phe, show coacervation with a short chain length (n = 5). Owing to their short sequences, Fn analogs are easily modified in amino acid sequences via simple chemical synthesis, and are useful for investigating the relationship between peptide sequences and temperature responsiveness. In this study, we developed Fn analogs by replacing Phe residue(s) with other amino acids or introducing another amino acid at the N-terminus. The temperature responsiveness of the Fn analogs changed drastically with the substitution of a single Phe residue, suggesting that aromatic amino acids play an important role in their self-assembly. In addition, the self-assembling ability of Fn was enhanced by increasing the bulkiness of the N-terminal amino acids. Therefore, the N-terminal residue was considered to be important for hydrophobicity-induced intermolecular interactions between the peptides during coacervation.. |
| 5. | Shogo Sumiyoshi, Keitaro Suyama, Daiki Tatsubo, Naoki Tanaka, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose, Metal ion scavenging activity of elastin-like peptide analogues containing a cadmium ion binding sequence, SCIENTIFIC REPORTS, 10.1038/s41598-022-05695-w, 12, 1, 2022.02, The development of simple and safe methods for recovering environmental pollutants, such as heavy metals, is needed for sustainable environmental management. Short elastin-like peptide (ELP) analogues conjugated with metal chelating agents are considered to be useful as metal sequestering agents as they are readily produced, environment friendly, and the metal binding domain can be selected based on any target metal of interest. Due to the temperature dependent self-assembly of ELP, the peptide-based sequestering agents can be transformed from the solution state into the particles that chelate metal ions, which can then be collected as precipitates. In this study, we developed a peptide-based sequestering agent, AADAAC-(FPGVG)(4), by introducing the metal-binding sequence AADAAC on the N-terminus of a short ELP, (FPGVG)(4). In turbidity measurements, AADAAC-(FPGVG)(4) revealed strong self-assembling ability in the presence of metal ions such as Cd2+ and Zn2+. The results from colorimetric analysis indicated that AADAAC-(FPGVG)(4) could capture Cd2+ and Zn2+. Furthermore, AADAAC-(FPGVG)(4) that bound to metal ions could be readily recycled by treatment with acidic solution without compromising its metal binding affinity. The present study indicates that the fusion of the metal-binding sequence and ELP is a useful and powerful strategy to develop cost-effective heavy metal scavenging agents with low environmental impacts.. |
| 6. | Xiaohui Liu, Keitaro Suyama, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi, Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding, PLoS ONE, https://doi.org/ 10.1371/journal.pone.0246583, 16, 2, e0246583, 2021.02. |
| 7. | Keitaro Suyama, Mika Mawatari, Daiki Tatsubo, Iori Maeda, Takeru Nose., Simple Regulation of the Self-Assembling Ability by Multimerization of Elastin-Derived Peptide (FPGVG)n Using Nitrilotriacetic Acid as a Building Block., ACS Omega, 10.1021/acsomega.0c06140. , 6, 8, 5705-5716, 2021.02. |
| 8. | Keitaro Suyama, Shuhei Kaneko, Hitoshi Kesamaru, Xiaohui Liu, Ayami Matsushima, Yoshimitsu Kakuta, Takashi Okubo, Kazumi Kasatani, Takeru Nose, Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ, Chemical Research in Toxicology, 10.1021/acs.chemrestox.9b00379, 33, 4, 889-902, 2020.04, [URL], Halogenation of organic compounds is one the most important transformations in chemical synthesis and is used for the production of various industrial products. A variety of halogenated bisphenol analogs have recently been developed and are used as alternatives to bisphenol A (BPA), which is a raw material of polycarbonate that has adverse effects in animals. However, limited information is available on the potential toxicity of the halogenated BPA analogs. In the present study, to assess the latent toxicity of halogenated BPA analogs, we evaluated the binding and transcriptional activities of halogenated BPA analogs to the estrogen-related receptor γ(ERRγ), a nuclear receptor that contributes to the growth of nerves and sexual glands. Fluorinated BPA analogs demonstrated strong ERRγbinding potency, and inverse antagonistic activity, similar to BPA. X-ray crystallography and fragment molecular orbital (FMO) calculation revealed that a fluorine-substituted BPA analog could interact with several amino acid residues of ERRγ-LBD, strengthening the binding affinity of the analogs. The ERRγbinding affinity and transcriptional activity of the halogenated BPAs decreased with the increase in the size and number of halogen atom(s). The IC50 values, determined by the competitive binding assay, correlated well with the binding energy obtained from the docking calculation, suggesting that the docking calculation could correctly estimate the ERRγbinding potency of the BPA analogs. These results confirmed that ERRγhas a ligand binding pocket that fits very well to BPA. Furthermore, this study showed that the binding affinity of the BPA analogs can be predicted by the docking calculation, indicating the importance of the calculation method in the risk assessment of halogenated compounds.. |
| 9. | Xiaohui Liu, Keitaro Suyama, Junichi Shiki, Kohei Torikai, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi, Bisphenol AF Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities, Bioorganic and Medicinal Chemistry, 10.1016/j.bmc.2019.115274, 28, 3, 2020.02, [URL], 17β-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs) ERα and ERβ. We recently observed that CF3-containing bisphenol AF (BPAF) works as an agonist for ERα but as an antagonist for ERβ. Similar results were also observed for the CCl3-containing bisphenol designated as HPTE. Both BPAF and HPTE are comprised of a tri-halogenated methyl group in the central alkyl moiety of their bisphenol structures, which strongly suggests that halogens contribute directly to the agonist/antagonist dual biological functions. We conducted this study to investigate the structure-activity relationships by assessing together newly synthesized CF3- and CBr3-containing bisphenol E analogs (BPE-X). We first tested bisphenols for their receptor binding ability and then for their transcriptional activities. Halogen-containing bisphenols were found to be fully active for ERα, but almost completely inactive for ERβ. When we examined these bisphenols for their inhibitory activities for E2 in ERβ, we observed that they worked as distinct antagonists. The ascending order of agonist/antagonist dual biological functions was BPE-F |
| 10. | Xiaohui Liu, Hiroki Sakai, Mitsuhiro Nishigori, Keitaro Suyama, Tasuku Nawaji, Shin Ikeda, Makoto Nishigouchi, Hiroyuki Okada, Ayami Matsushima, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi, Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors, Toxicology and Applied Pharmacology, 10.1016/j.taap.2019.114610, 377, 2019.08, [URL], An endocrine-disrupting chemical Bisphenol A (BPA) binds specifically to a nuclear receptor (NR) named ERRγ. Although the importance of receptor-binding evaluation for human NRs is often stressed, the binding characteristics of so-called next-generation (NextGen) bisphenol compounds are still poorly understood. The ultimate objective of this investigation was to evaluate BPA and its NextGen analogs for their abilities to bind to 21 human NRs, the greatest members of NRs for which tritium-labeled specific ligands were available. After establishing the detailed assay conditions for each NR, the receptor binding affinities of total 11 bisphenols were evaluated in competitive binding assays. The results clearly revealed that BPA and the NextGen bisphenols of BPAF, BPAP, BPB, BPC, BPE, and BPZ were highly potent against one or more of NRs such as CAR, ERα, ERβ, ERRγ, and GR, with IC50 values of 3.3–73 nM. These bisphenols were suggested strongly to be disruptive to these NRs. BPM and BPP also appeared to be disruptive, but less potently. BPF exhibited only weak effects and only against estrogen-related NRs. Surprisingly, most doubtful bisphenol BPS was supposed not to be disruptive. The NRs to which BPA and NextGen bisphenols did not bind were RARα, RARβ, RARγ, and VDR. PPARγ, RORα, RORβ, RORγ, RXRα, RXRβ, and RXRγ, exhibited very weak interaction with these bisphenols. The ten remaining NRs, namely, ERRγ, ERβ, ERα, CAR, GR, PXR, PR, AR, LXRβ, and LXRα, showed distinctly strong binding to some bisphenols in this order, being likely to have consequential endocrine-disruption effects.. |
| 11. | Xiaohui Liu, Hiroki Sakai, Mitsuhiro Nishigori, Keitaro Suyama, Tasuku Nawaji, Shin Ikeda, Makoto Nishigouchi, Hiroyuki Okada, Ayami Matsushima, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi , Receptor-binding Affinities of Bisphenol A and Its Next-generation Analogs for Human Nuclear Receptors, Toxicology and Applied Pharmacology, https://doi.org/10.1016/j.taap.2019.114610, in press, 2019.06, An endocrine-disrupting chemical Bisphenol A (BPA) binds specifically to a nuclear receptor (NR) named ERRγ. Although the importance of receptor-binding evaluation for human NRs is often stressed, the binding characteristics of so-called next-generation (NextGen) bisphenol compounds are still poorly understood. The ultimate objective of this investigation was to evaluate BPA and its NextGen analogs for their abilities to bind to 21 human NRs, the greatest members of NRs for which tritium-labeled specific ligands were available. After establishing the detailed assay conditions for each NR, the receptor binding affinities of total 11 bisphenols were evaluated in competitive binding assays. The results clearly revealed that BPA and the NextGen bisphenols of BPAF, BPAP, BPB, BPC, BPE, and BPZ were highly potent against one or more of NRs such as CAR, ERα, ERβ, ERRγ, and GR, with IC50 values of 3.3–73 nM. These bisphenols were suggested strongly to be disruptive to these NRs. BPM and BPP also appeared to be disruptive, but less potently. BPF exhibited only weak effects and only against estrogen-related NRs. Surprisingly, most doubtful bisphenol BPS was supposed not to be disruptive. The NRs to which BPA and NextGen bisphenols did not bind were RARα, RARβ, RARγ, and VDR. PPARγ, RORα, RORβ, RORγ, RXRα, RXRβ, and RXRγ, exhibited very weak interaction with these bisphenols. The ten remaining NRs, namely, ERRγ, ERβ, ERα, CAR, GR, PXR, PR, AR, LXRβ, and LXRα, showed distinctly strong binding to some bisphenols in this order, being likely to have consequential endocrine-disruption effects.. |
| 12. | Keitaro Suyama, Daiki Tatsubo, Wataru Iwasaki, Masaya Miyazaki, Yuhei Kiyota, Ichiro Takahashi, Iori Maeda, Takeru Nose, Enhancement of self-aggregation properties of linear elastin-derived short peptides by simple cyclization strong self-aggregation properties of cyclo[FPGVG]n, consisting only of natural amino acids, Biomacromolecules, 10.1021/acs.biomac.8b00353, 19, 8, 3201-3211, 2018.06, [URL], Elastin-like peptides (ELP) consist of distinctive repetitive sequences, such as (VPGVG)n, exhibit temperature-dependent reversible self-assembly (coacervation), and have been considered to be useful for the development of thermo-responsive materials. Further fundamental studies evaluating coacervative properties of novel nonlinear ELPs could present design concepts for new thermo-responsive materials. In this study, we prepared novel ELPs, cyclic (FPGVG)n (cyclo[FPGVG]n, n = 1-5), and analyzed its self-assembly properties and structural characteristics. Cyclo[FPGVG]n (n = 3-5) demonstrated stronger coacervation capacity than the corresponding linear peptides. The coacervate of cyclo[FPGVG]5 was able to retain water-soluble dye molecules at 40°C, which implied that cyclo[FPGVG]5 could be employed as a base material of DDS (Drug Delivery System) matrices and other biomaterials. The results of molecular dynamics simulations and circular dichroism measurements suggested that a certain chain length was required for cyclo[FPGVG]n to demonstrate alterations in molecular structure that were critical to the exhibition of coacervation.. |
| 13. | Keitaro Suyama, Daiki Tatsubo, Hitoshi Kesamaru, Iori Maeda, Takeru Nose, Coacervation Property and Structural Analysis of Cyclic Analogs of Elastin-derived Peptide (FPGVG)n, Peptide Science 2016, 101-102, 2017.03, The elastin-derived peptide analog, (FPGVG)5, demonstrates a temperature- dependent self-association (coacervation) property. In this study, we prepared cyclic (FPGVG)n (n=1-5) analogs and investigated their coacervation and structural properties to assess their potential for use as a biomaterial. We found that the cyclic (FPGVG)n (n=3-5) analogs exhibited high coacervation ability. The results from the molecular dynamics simulation suggest that turn structures were important for coacervation of elastin-derived cyclic peptide analogs.. |
| 14. | Keitaro Suyama, Hitoshi Kesamaru, Daiki Tatsubo, Takeru Nose, Coacervation Properties and Structural Analysis of Aminobenzoyl-labeled Fluorescent Elastin-derived Peptides, Peptide Science 2015, 293-294, 2016.03, The elastin-derived peptide analog, (FPGVG)5, demonstrates a temperature- dependent self-association (coacervation) property. In this study, we prepared fluorescent-labeled (FPGVG)5 analogs, and evaluated their coacervation and fluorescent properties in order to assess their potential for use as a base material for fluorescent thermometers. We found that the fluorescent-labeled (FPGVG)5 analogs exhibited high coacervation ability. Results from the molecular dynamics calculation suggest that the fluorescent group is exposed on the surface of the molecule.. |
| 15. | Daiki Tatsubo, Keitaro Suyama, Takeru Nose, Fluorescence Analysis Using a Molecular Probe 1,8-ANS for Elucidation of the Molecular Mechanisms Underlying Coacervation of a Tryptophan-containing Elastin derived Dimeric Peptide, Peptide Science 2015, 95-96, 2016.03, A tryptophan-containing elastin-derived dimeric peptide (C(WPGVG)3)2 shows potent self-assembly activity. To elucidate the underlying coacervation mechanisms, we measured the fluorescence of (C(WPGVG)3)2 by using 1,8-ANS as a fluorescent probe. The results revealed that the peptide forms microaggregates at temperature and concentration lower than those at which visible coacervation occurs. These findings suggest that microaggregate formation is unrelated to the maturation of the coacervate drop, which is temperature-dependent.. |
| 16. | Keitaro Suyama, Suguru Taniguchi, Daiki Tatsubo, Iori Maeda, Takeru Nose, Dimerization effects on coacervation property of an elastin-derived synthetic peptide (FPGVG)5, Journal of Peptide Science, 10.1002/psc.2876, in press, 2016.03, A series of elastin-derived peptide (Phe-Pro-Gly-Val-Gly)5 dimers possessing high coacervation potential were synthesized. The new dimeric peptides showed significantly high coacervation ability compared to known elastin-derived peptide analogs. The molecular dynamics calculation results reveal that the dimeric peptides contain characteristic sheet-turnsheet motif involving a type II β-turn-like structure and form globular conformation.. |
| 17. | 巣山 慶太郎, 田坪大来, 谷口 卓, 袈裟丸仁志, 前田衣織, 野瀬 健, Coacervation property and structural analysis of synthetic dimer peptides of aromatic amino acid containing elastin-derived peptides., Peptide Science 2014, 323-324, 2015.03, It has been shown that elastin-derived peptides containing aromatic amino acids, (FPGVG)n and (WPGVG)n, demonstrate coacervation at small repetition numbers (n = 3–5). In this study, we prepared dimer peptides of (FPGVG)5 and (WPGVG)3 and evaluated their coacervation properties. The coacervation ability of the peptides was significantly enhanced by the dimerization. The results of molecular dynamics calculation suggest that the sheet-turn-sheet motif is important for the self-assembly of FPGVG-related peptides.. |
| 18. | 巣山 慶太郎, 谷口 卓, 前田衣織, 田坪大来, 野瀬 健, Coacervation Property and Secondary Structure of Synthetic Dimer Peptides of Elastin-derived Pentapeptide Repeats , Peptide Science 2013, 277-278, 2014.03, Elastin is the core protein of elastic fibers in the elastic tissues, such as arterial walls, lungs, and skin, and plays an essential role in tissue biomechanics, providing the extensibility and condensability. Elastin shows self-association, which is referred as coacervation, under physiological conditions. Coacervation property of elastin characterized by reversible association/dissociation phenomena is considered to be important for its elasticity. Tropoelastin, the precursor protein of elastin, contains characteristic repetitive sequences in its hydrophobic regions. The pentapeptide sequence, Val-Pro-Gly-Val-Gly (VPGVG), is one of the repeating sequences, and presents in almost all mammal species analyzed so far. To clarify the mechanism of elastin’s elasticity, many studies about coacervation properties of elastin-derived peptide-analogs have been conducted. Many previous studies reported that large molecular size was needed for coacervation of elastin-derived peptides. For instance, (VPGVG)n demonstrated the coacervation property only when they had large numbers of repetition (n>40). Recently, we developed the synthetic hydrophobic oligomers (IPGVG)n and (FPGVG)n, and reported that they demonstrate coacervation at significantly smaller repetition numbers (n=5~7). Because of their low molecular size, these analogs are expected to be useful as model peptides for structure analysis and base materials for developing various biomedical products, skin substitutes, synthetic vascular grafts, and drug delivery systems. In this study, to obtain more short coacervatable peptides, we synthesized dimers of pentapeptide (FPGVG)5 and investigated their coacervation property and secondary structures. To produce dimer peptides, cysteine-conjugated pentapeptide Cys-(FPGVG)5 and (FPGVG)5-Cys were synthesized by the solid-phase method using Fmoc strategy. By aerobic oxidation reaction of each Cys-peptide, homodimers, linked by disulfide bond, were obtained. Synthesized peptides were purified by HPLC and analyzed by MALDI-TOF- MS. The dimer peptides clearly showed coacervation around 15˚C in the condition at 10 mg/ml, whereas (FPGVG)5 required rather higher temperature and at least 20 mg/ml of peptide to demonstrate coacervation. These results indicated that the dimerization of elastin-derived peptide-analogs significantly enhanced the coacervation ability of (FPGVG)5. Furthermore, these dimer peptides showed reversible temperature-dependent conformation change in CD measurement.. |
| 19. | Kanako Nishio, Hirokazu Nishimura, Keitaro Suyama, Takeru Nose, Yasuyuki Shimohigashi, Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities, Peptide Science 2012, in press, 2013.03. |
| 20. | Yumi Kramitsu, Hirokazu Nishimura, Ryo Nakamura, Keitaro Suyama, Kazuhiro Matsumoto, Takeru Nose, Yasuyuki Shimohigashi, High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent substance P analogs, Peptide Science 2012, in press, 2013.03. |
| 21. | Ryo Nakamura, Hirokazu Nishimura, Keitaro Suyama, Takeru Nose, Yasuyuki Shimohigashi, The Effect of Halogenation of Phe-Phenyl Group of Two Consecutive Phe Residues Present in Neuropeptide Substance P on Its Specific Receptor Interaction, Peptide Science 2011, 157-158, 2012.03. |
| 22. | Kanako Nishio, Hirokazu Nishimura, Keitaro Suyama, Yoshinori Abe, Takeru Nose, Ayami Matsushima, Yasuyuki Shimohigashi, Effects of the Halogenation of Phe-Phenyl Group of Two Consecutive Residues in Endomorphin-2 on the Interaction with the μ-Opioid Receptors, Peptide Science 2011, 171-172, 2012.03. |
| 23. | Keitaro Suyama, Yoshifumi Sakai, Kazuhiro Matsumoto, Tsutomu Katsuki, Highly Enantioselective Hydrophosphonylation of Aldehydes: Base-Enhanced Aluminum-salalen Catalysis, Angewante Chemie, International Edition, 10.1002/anie.200905158, 49, 797-799, 2010.01. |
| 24. | Keitaro Suyama, Kazuhiro Matsumoto, Tsutomu Katsuki, Asymmetric Lewis Acid Catalysis of Aluminum(salalen) Complexes: Friedel-Crafts Reaction of Indole, Heterocycles, 10.3987/COM-08-S(F)93, 77, 817-824, 2009.02. |
主要総説, 論評, 解説, 書評, 報告書等
主要学会発表等
学会活動
学会大会・会議・シンポジウム等における役割
2021.06.12～2021.06.12, 令和3年度日本生化学会九州支部例会, 座長（Chairmanship）.
2019.09.10～2019.09.10, 第19回泉屋コロキウム, 世話人補佐・会計.
2018.09.12～2018.09.12, 第18回泉屋コロキウム, 世話人補佐・会計.
2015.05.16～2015.05.17, 平成27年度日本生化学会九州支部例会, 座長（Chairmanship）.
2015.08.08～2015.08.08, 平成27年度理学部前期特別談話会, 座長（Chairmanship）.
2016.02.18～2016.02.19, 平成27年度修士論文講演会, 座長（Chairmanship）.
2014.03.10～2014.03.10, リスクサイエンス研究フォーラム2014, 会場設営・備品搬入および搬出の監督.
2013.09.02～2013.09.03, 第13回泉屋コロキウム, 世話人補佐・会計.
受賞
令和3年度 日本生化学会九州支部 学術奨励賞, 日本生化学会九州支部, 2021.06.
優秀ポスター発表賞, 泉屋コロキウム, 2011.09.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2022年度～2024年度, 基盤研究(C), 代表, 光照射により薬物包含・放出を制御可能な光線力学療法用ペプチド性薬物送達担体の開発.
2020年度～2024年度, 挑戦的研究（開拓）, 分担, 天然タンパク質資源の有効活用を目指した機能性マイクロ粒子捕集素材の開発.
2020年度～2021年度, 若手研究, 代表, 光に応答して可逆的自己凝集を示すペプチドを用いた光線力学療法の薬物送達担体の開発.
2019年度～2021年度, 基盤研究(B), 分担, 自己凝集性ペプチドの可逆コアセルベーションによる環境汚染物質吸着システムの開発.
2015年度～2018年度, 基盤研究(B), 分担, ビスフェノールＡの化学修飾が引き起こす核内受容体結合力増強機構の解明.
2014年度～2015年度, 挑戦的萌芽研究, 分担, 自己凝集性ペプチドを基材とした金属イオン回収材の開発.
共同研究、受託研究(競争的資金を除く)の受入状況
2022.09～2024.03, 分担, ペプチド医薬の超長期滞留性DDSの開発.
2013.09～2014.03, 代表, 温度依存性自己集合性を有する繰り返し構造を持つペプチドの微細構造解析.
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