Kyushu University Academic Staff Educational and Research Activities Database
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Kazumasa Yoshida Last modified date:2019.05.28



Graduate School
Undergraduate School


E-Mail
Homepage
http://tansaku.phar.kyushu-u.ac.jp/saito/ENGLISH_PAGE.html
Phone
092-642-6639
Fax
092-642-6635
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Molecular biology, Cell biology
Total Priod of education and research career in the foreign country
03years00months
Research
Research Interests
  • Regulation of eukaryotic DNA replication and its relevance to chromosome instability/tumorigenesis.
    keyword : DNA replication, Chromosome, Genome integrity
    2016.05~2019.04.
  • Study of coorporation between regulation of chromatin and DNA replication by genome-wide analysis
    keyword : DNA replication, Chromosome, Genome integrity
    2013.05~2016.04.
  • Genome-wide study of histone deacetylases as key regulators of DNA replication timing
    keyword : histone deacetylase, replication timing
    2010.05~2014.04.
  • Role of CDC6 Interaction with ATR in Activation of DNA Replication Checkpoint
    keyword : CDC6, ATR, replication stress
    2006.04~2010.04.
  • Preventing re-replication of genome: Control of DNA replication licensing
    keyword : geminin, Cdt1, DNA replication
    2000.04~2006.03.
Academic Activities
Reports
1. Mitsunori Higa, Masatoshi Fujita, Kazumasa Yoshida, DNA Replication Origins and Fork Progression at Mammalian Telomeres, Genes, 2017.03, [URL].
2. Kazumasa Yoshida, Armelle Lengronne, Philippe Pasero, The replication timing program in the hands of two HDACs., Microbial Cell, 2014.08, [URL].
3. , [URL].
4. Kazumasa Yoshida, Ana POVEDA, Philippe PASERO, Time to Be Versatile: Regulation of the Replication Timing Program in Budding Yeast., Journal of Molecular Biology, 2013.11, [URL].
5. Marcel Méchali, Kazumasa Yoshida, Philippe Coulombe, Philippe Pasero, Genetic and epigenetic determinants of replication origin position and activation, Current Opinion in Genetics & Development, 2013.04, [URL].
Papers
1. Issay Morii, Yukiko Iwabuchi, Sumiko Mori, Masaki Suekuni, Toyoaki Natsume, Kazumasa Yoshida, Nozomi Sugimoto, Masato T Kanemaki, Masatoshi Fujita, Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib, Cancer Science, 10.1111/cas.13941, 2019.01, [URL].
2. Shinya Watanabe, Hiroki Fujiyama, Takuya Takafuji, Kota Kayama, Masaki Matsumoto, Keiichi Nakayama, Kazumasa Yoshida, Nozomi Sugimoto, Masatoshi Fujita, Glutamate-rich WD40 repeat containing 1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system, Journal of Cell Science, 10.1242/jcs.213009., 2018.07, [URL].
3. Nozomi Sugimoto, Kazumitsu Maehara, Kazumasa Yoshida, Yasuyuki Ohkawa, Masatoshi Fujita, Genome-wide analysis of the spatiotemporal regulation of firing and dormant origins in human cells, Nucleic Acids Research, 10.1093/nar/gky476, 46, 6683-6696, 2018.06, [URL].
4. Mitsunori Higa, Tatsunori Kushiyama, Seiichiro Kurashige, Daisuke Kohmon, Kouki Enokitani, Satoko Iwahori, Nozomi Sugimoto, Kazumasa Yoshida, Masatoshi Fujita, TRF2 recruits ORC through TRFH domain dimerization., Biochimica et Biophysica Acta - Molecular Cell Research, 10.1016/j.bbamcr.2016.11.004., 1864, 191-201, 2017.01, [URL].
5. Kota Kayama, Shinya Watanabe, Takuya Takafuji, Takahiro Tsuji, Kensuke Hironaka, Masaki Matsumoto, Keiichi Nakayama, Masato Enari, Takashi Kohno, Kouya Shiraishi, Tohru Kiyono, Kazumasa Yoshida, Nozomi Sugimoto, Masatoshi Fujita, GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis, EMBO Reports, 10.15252/embr.201642444 | Published online 17.11.2016, 18, 123-137, 2017.01, [URL].
6. Masahiro Aizawa, Nozomi Sugimoto, Shinya Watanabe, Kazumasa Yoshida, Masatoshi Fujita, Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation., Biochimica et Biophysica Acta, 10.1016/j.bbamcr.2016.08.008, 1863, 11, 2739-2748, 2016.11, [URL].
7. Makoto Ohira, Yuka Iwasaki, Chika Tanaka, Michitaka Kuroki, Naoki Matsuo, Tatsuhiko Kitamura, Masaki Yukuhiro, Hiroyuki Morimoto, Nisha Pang, Bei Liu, Tohru Kiyono, Masahide Amemiya, Kozo Tanaka, Kazumasa Yoshida, Nozomi Sugimoto, Takashi Ohshima, Masatoshi Fujita, A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo., Biochimica et Biophysica Acta, 1850, 9, 1676-1684, 2015.09, [URL].
8. Nozomi Sugimoto, Kazumitsu Maehara, Kazumasa Yoshida, Shuhei Yasukouchi, Satoko Osano, Shinya Watanabe, Masahiro Aizawa, Takashi Yugawa, Tohru Kiyono, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Masatoshi Fujita, Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture., Nucleic Acids Research, 43, 12, 5898-5911, 2015.07, [URL].
9. Kazumasa Yoshida, Julien Bacal, Damien Desmarais, Ismael Padioleau, Olga Tsaponina, Andrei Chabes, Veronique Pantesco, Emeric Dubois, Hugues Parrinello, Magdalena Skrzypczak, Krysztof Ginalski, Armelle Lengronne, Philippe Pasero, The Histone Deacetylases Sir2 and Rpd3 Act on Ribosomal DNA to Control the Replication Program in Budding Yeast., Molecular Cell, 54, 691-697, 2014.05, [URL], 出芽酵母をモデル系として全ゲノム領域のDNA複製開始活性について解析を行い、rDNAリピートの複製活性がそれ以外の一般的ゲノム領域のDNA複製開始と競合的関係にあることを示した。さらにクロマチン構造制御を行うヒストン修飾酵素Rpd3とSir2が、rDNAの複製活性をそれぞれ正と負に制御することにより、ゲノム全体の複製プログラムを制御していることを発見した。.
10. Julien N. Bianco, Jérome Poli, Julie Saksouk, Julien Bacal, Maria Joao Silva, Kazumasa Yoshida, Yea-Lih Lin, Hélène Tourrière, Armelle Lengronne, Philippe Pasero, Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing, Methods, 57, 149-157, 2012.06, [URL].
11. Kazumasa Yoshida, Nozomi Sugimoto, Satoko Iwahori, Takashi Yugawa, Mako Narisawa-Saito, Tohru Kiyono, Masatoshi Fujita, CDC6 Interaction with ATR Regulates Activation of a Replication Checkpoint in Higher Eukaryotic Cells, Journal of Cell Science, 123, 225-235, 2010.01, [URL].
12. Nozomi Sugimoto, Kazumasa Yoshida, Yasutoshi Tatsumi, Takashi Yugawa, Mako Narisawa-Saito, Shou Waga, Tohru Kiyono, Masatoshi Fujita, Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells, Journal of Cell Science, 122, 1184-1191, 2009.04, [URL].
13. Yasutoshi Tatsumi, Kai Ezura, Kazumasa Yoshida, Takashi Yugawa, Mako Narisawa-Saito, Tohru Kiyono, Satoshi Ohta, Chikashi Obuse, Masatoshi Fujita, Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres, Genes to Cells, 13, 1045-1059, 2008.10, [URL].
14. Kazumasa Yoshida, Haruhiko Takisawa, Yumiko Kubota, Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs, Genes to Cells, 10, 63-73, 2005.01, [URL].
Presentations
1. Mitsunori Higa, Kazumasa Yoshida, Daisuke Kohmon, Nozomi Sugimoto, Masatoshi Fujita, TRF2 recruits ORC through the dimerized TRFH domain, Cold Spring Harbor Laboratory Meeting on “Eukaryotic DNA Replication & Genome Maintenance”, 2015.09.
2. 吉田 和真, Damien DESMARAIS, Armelle LENGRONNE, Philippe PASERO, The HDACs Rpd3 and Sir2 control replication timing in budding yeast by regulating the activity of rDNA origins, The CSHL meeting on EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE, 2013.09.
Membership in Academic Society
  • The Japanese Cancer Association
  • The Pharmaceutical Society of Japan
  • The Molecular Biology Society of Japan