Kyushu University Academic Staff Educational and Research Activities Database
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TOSHIYUKI HAYAKAWA Last modified date:2019.05.23

Associate Professor / Division for Arts and Science, Faculty of Arts and Science
Division for Experimental Natural Science
Faculty of Arts and Science


Graduate School


Phone
092-802-5827
Academic Degree
Ph.D.
Field of Specialization
Evolutionary biology, Glycobiology, Evolutionary medicine
Total Priod of education and research career in the foreign country
03years00months
Research
Research Interests
  • Evolution of the genes involved in mental activity
    keyword : mental activity, social activity, evolution
    2012.07.
  • Evolution of Siglec-11 and Siglec-16 in primates
    keyword : Microglia, Mental diseases, Brain
    2010.04.
  • Human-specific inactivation of CMP-N-acetylneuraminic acid hydroxylase
    keyword : Malaria, Co-evolution
    2006.01.
Academic Activities
Books
1. TOSHIYUKI HAYAKAWA, Ajit Varki, Human-specific Changes in Sialic Acid Biology. Post-Genome Biology of Primates, Primatology Monographs , Springer, 123-148, 2012.03.
Papers
1. Naoko T. Fujito, Yoko Satta, Masaya Hane, Atsushi Matsui, Kenta Yashima, Ken Kitajima, Chihiro Sato, Naoyuki Takahata, Toshiyuki Hayakawa, Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia, PLoS ONE, 13, 7, e0200278, 2018.07.
2. Toshiyuki Hayakawa, Zahra Khedri, Flavio Schwarz, Corinna Landing, Suh-Yuen Liang, Hai Yu, Xi Chen, Naoko T. Fujito, Yoko Satta, Ajit Varki, Takashi Angata, Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates, BMC Evolutionary Biology, 2017.11.
3. X. Wang, N. Mitra, P. Cruz, L. Deng, NISC Comparative Sequencing Program, N. Varki, T. Angata, E.D. Green, J. Mullikin, TOSHIYUKI HAYAKAWA, A. Varki, Evolution of Siglec-11 and Siglec-16 genes in Hominins, Mol. Biol. Evol. , 29, 8, 2073-2086, 2012.08.
4. TOSHIYUKI HAYAKAWA, S.-I. Tachibana, K. Hikosaka, N. Arisue, A. Matsui, T. Horii, K. Tanabe, Age of the last common ancestor of extant Plasmodium parasite lineages, Gene , 502, 1, 36-39, 2012.07.
5. TOSHIYUKI HAYAKAWA, N. Arisue, T. Udono, H. Hirai, J. Sattabongkot, T. Toyama, T. Tsuboi, T. Horii, K. Tanabe, Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees, PLoS ONE , 4, 10, e7412, 2009.10.
6. TOSHIYUKI HAYAKAWA, R. Culleton, H. Otani, T. Horii, K. Tanabe, Big bang in the evolution of extant malaria parasites, Mol. Biol. Evol. , 25, 10, 2233-2239, 2008.10.
7. TOSHIYUKI HAYAKAWA, I. Aki, A. Varki, Y. Satta, N. Takahata, Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution, Genetics , 172, 2, 1139-1146, 2006.02.
8. T. Angata, TOSHIYUKI HAYAKAWA, M. Yamanaka, A. Varki, M. Nakamura, Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates, FASEB J. , 20, 12, 1964-1973, 2006.10.
9. T. K. Altheide, TOSHIYUKI HAYAKAWA, T. S. Mikkelsen, S. Diaz, N. Varki, A. Varki, System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution, J. Biol. Chem. , 281, 35, 25689-25702, 2006.09.
10. TOSHIYUKI HAYAKAWA, T. Angata, A. L. Lewis, T. S. Mikkelsen, N. M. Varki, A. Varki, A human-specific gene in microglia, Science , 309, 5741, 1693, 2005.09.
11. The Chimpanzee Sequencing and Analysis Consortium, Initial sequence of the chimpanzee genome and comparison with the human genome, Nature, 437, 7055, 69-87, 2005.09.
12. TOSHIYUKI HAYAKAWA, T. K. Altheide, A. Varki, Genetic basis of human brain evolution: accelerating along the primate speedway, Dev. Cell , 8, 1, 2-4, 2005.01.
13. H.-H. Chou, TOSHIYUKI HAYAKAWA, S. Diaz, M. Krings, E. Indriati, M. Leakey, S. Paabo, Y. Satta, N. Takahata, A. Varki, Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution, Proc. Natl. Acad. Sci. USA , 99, 18, 11736-11741, 2002.09.
14. TOSHIYUKI HAYAKAWA, Y. Satta, P. Gagneux, A. Varki, N. Takahata, Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene, Proc. Natl. Acad. Sci. USA , 98, 20, 11399-11404, 2001.09.
Presentations
1. Fujito, N., Y. Satta, M. Hane, A. Matsui, K. Yashima, K. Kitajima, C. Sato, N. Takahata, T. Hayakawa, Adaptive evolution of mental activity-related STX gene in the out-of-Africa migration., International Symposium on Evolutionary Genomics and Bioinformatics, 2017.11.
2. Fujito, N., Y. Satta, M. Hane, A. Matsui, K. Yashima, K. Kitajima, C. Sato, N. Takahata, T. Hayakawa, Adaptive evolution of mental activity-related STX gene in the out-of-Africa migration., Society for Molecular Biology and Evolution Meeting, 2017.07.
3. TOSHIYUKI HAYAKAWA, Evolution of sialic acid biology in the primate lineage, International Primatological Society XXIII Congress Kyoto 2010, 2010.09.
4. TOSHIYUKI HAYAKAWA, Evolution of sialic acid biology in primates, Hominization conference 2009 Primate Genomics for Globalization of Collaboration Program: Post-genome biology of primates as the hub-research for understanding our species and neighbors, 2010.03.