Kyushu University Academic Staff Educational and Research Activities Database
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Akiko Mizokami Last modified date:2019.06.27

Associate Professor / Division of Oral Biological Sciences
Department of Dental Science
Faculty of Dental Science


Graduate School


E-Mail
Phone
092-642-6319
Fax
092-642-6322
Academic Degree
Ph.D (dental science)
Country of degree conferring institution (Overseas)
No
Field of Specialization
Biochemistry, molecular biology, cellular biology
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Role of osteocalcin in protection from sarcopenia obesity.

    keyword : Sarcopenic obesity, osteocalcin
    2018.04~2021.03.
  • Osteocalcin as a new preventive agent for metabolic syndrome
    keyword : Osteocalcin, Metabolic syndrome, Bone
    2015.01~2016.01.
  • Roles of bone derived hormone osteocalcin in energy metabolism
    keyword : Osteocalcin, incretin, glucose metabolism
    2013.08.
  • A role of GABA signal-regulating molecule in feeding regulation
    keyword : PRIP, energy metabolism
    2010.04~2014.03.
Academic Activities
Papers
1. Yu Yasutake, Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Ichiro Takahashi, Hiroshi Takeuchi, Hirata Masato, Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 10.1152/ajpendo.00334.2015, 310, 8, E662-E675, 2016.04.
2. Akiko Mizokami, Yu Yasutake, Sen Higashi, Tomoyo Kawakubo-Yasukochi, Sakura Chishaki, Ichiro Takahashi, Hiroshi Takeuchi, Masato Hirata, Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion, BONE, 10.1016/j.bone.2014.09.006, 69, 68-79, 2014.12, Uncarboxylated osteocalcin (GluOC), a bone-derived hormone, regulates energy metabolism by stimulating insulin secretion and pancreatic β-cell proliferation. We previously showed that the effect of GluOC on insulin secretion is mediated largely by glucagon-like peptide-1 (GLP-1) secreted from the intestine in response to GluOC exposure. We have now examined the effect of oral administration of GluOC on glucose utilization as well as the fate of such administered GluOC in mice. Long-term intermittent or daily oral administration of GluOC reduced the fasting blood glucose level and improved glucose tolerance in mice without affecting insulin sensitivity. It also increased the fasting serum insulin concentration as well as the β-cell area in the pancreas. A small proportion of orally administered GluOC reached the small intestine and remained there for at least 24 h. GluOC also entered the general circulation, and the serum GLP-1 concentration was increased in association with the presence of GluOC in the intestine and systemic circulation. The putative GluOC receptor, GPRC6A was detected in intestinal cells, and was colocalized with GLP-1 in some of these cells. Our results suggest that orally administered GluOC improved glucose handling likely by acting from both the intestinal lumen and the general circulation, with this effect being mediated in part by stimulation of GLP-1 secretion. Oral administration of GluOC warrants further study as a safe and convenient option for the treatment or prevention of metabolic disorders..
Presentations
1. 溝上 顕子, 安武 雄, 竹内 弘, 高 靖, 平田 雅人, Osteocalcin induces release of glucagon-like peptide-1 and improves metabolic state in mice, The 8th Japan-Korea Conference on Cellular Signaling for Young Scientists, 2013.11.
Membership in Academic Society
  • The Japanese Biochemical Society