九州大学 研究者情報
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基本情報 研究活動 教育活動 社会活動
廣政 恭明(ひろまさ やすあき) データ更新日:2018.06.13



主な研究テーマ
植物と昆虫のプロテオミクス研究
キーワード:プロテオミクス
2006.07~2014.03.
ピルビン酸デヒドロゲナーゼ複合体の構造と機能制御の解明
キーワード:超分子複合体、機能制御、分子間相互作用、アロステリック効果
1998.10.
研究業績
主要著書
主要原著論文
1. Jiang, Jiansen; Baiesc, Flavius L.; Hiromasa, Yasuaki; Yu, Xuekui; Hui, Wong Hoi; Dai, Xinghong; Roche, Thomas E.; Zhou, Z. Hong, Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex, BIOCHEMISTRY, 10.1021/acs.biochem.8b00357, 57, 16, 2325-2334, 2018.04.
2. Wei Wang, Huaien Dai, Yi Zhang, Raman Chandrasekar, Lan Luo, Yasuaki Hiromasa, Changzhong Sheng, Gongxin Peng, Shaoliang Chen, John M. Tomich, John Reese, Owain Edwards, Le Kang, Gerald Reeck, Feng Cui, Armet is an effector protein mediating aphid-plant interactions, FASEB Journal, 10.1096/fj, 29, 5, 2032-2045, 2015.02.
3. Takahashi, D, Dai, H, Yasuaki Hiromasa, Krishnamoorthi R, Kanost, MR, Self-association of an insect β-1,3-glucan recognition protein upon binding laminarin stimulates prophenoloxidase activation as an innate immune response., Journal of Biological Chemistry, 10.1074/jbc.M114.583971, 289, 41, 28399-28410, 2014.08.
4. G. Bousfield, V. Butnev, V. Butnev, Yasuaki Hiromasa, D. Harvey, J. May, Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24)), MOLECULAR AND CELLULAR ENDOCRINOLOGY, 10.1016/j.mce.2013.11.008, 382, 2, 989-997, 2014.02.
5. D. Takahashi, Yasuaki Hiromasa, Y. Kim, A. Anbanandam, X. Yao, KO. Chang, O. Prakash, Structural and dynamics characterization of norovirus protease, PROTEIN SCIENCE, 10.1002/pro.2215, 22, 3, 347-357, 2013.03.
6. H. Dai, Yasuaki Hiromasa, D. Takahashi, D. VanderVelde, J. Fabrick, MR. Kanost, R. Krishnamoorthi, An Initial Event in the Insect Innate Immune Response: Structural and Biological Studies of Interactions between beta-1,3-Glucan and the N-Terminal Domain of beta-1,3-Glucan Recognition Protein, BIOCHEMISTRY, 10.1021/bi301440p, 52, 1, 161-170, 2013.01.
7. JM. Christen, Yasuaki Hiromasa, C. An, MR. Kanost, Identification of plasma proteinase complexes with serpin-3 in Manduca sexta, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 10.1016/j.ibmb.2012.09.008, 42, 12, 946-955, 2012.12.
8. C. An, Yasuaki Hiromasa, X. Zhang, S. Lovell, M. Zolkiewski, JM Tomich, MR. Kanost, Biochemical Characterization of Anopheles gambiae SRPN6, a Malaria Parasite Invasion Marker in Mosquitoes, PLOS ONE, 10.1371/journal.pone.0048689, 7, 11, 2012.11.
9. M. Tomasi, Yasuaki Hiromasa, MR. Pope, S. Gudlur, JM. Tomich, SD. Fleming, Human beta 2-glycoprotein I attenuates mouse intestinal ischemia/reperfusion induced injury and inflammation, MOLECULAR IMMUNOLOGY, 10.1016/j.molimm.2012.05.018, 52, 3-4, 207-216, 2012.10.
10. N. Dittmer, Yasuaki Hiromasa, JM. Tomich, N. Lu, RW. Beeman, KJ. Kramer, MR. Kanost, Proteomic and Transcriptomic Analyses of Rigid and Membranous Cuticles and Epidermis from the Elytra and Hindwings of the Red Flour Beetle, Tribolium castaneum, JOURNAL OF PROTEOME RESEARCH, 10.1021/pr2009803, 11, 1, 269-278, 2012.01.
11. VC. Thomas, Yasuaki Hiromasa, N. Harms, L. Thulow, J. Tomich, LE. Hancock, A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis, MOLECULAR MICROBIOLOGY, 10.1111/j.1365-2958.2009.06703.x, 72, 4, 1022-1036, 2009.05.
12. X. Mo, Yasuaki Hiromasa, M. Warner, AN. Al-Rawi, T. Iwamoto, TS. Rahman, X. Sun, JM. Tomich, Design of 11-residue peptides with unusual biophysical properties: Induced secondary structure in the absence of water, BIOPHYSICAL JOURNAL, 10.1529/hiophysj.107.118299, 94, 5, 1807-1817, 2008.03.
13. Yasuaki Hiromasa, X. Yan, TE. Roche, Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r, BIOCHEMISTRY, 10.1021/bi7014772, 47, 8, 2312-2324, 2008.02.
14. Yasuaki Hiromasa, TE. Roche, Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2, BIOCHEMISTRY, 10.1021/bi701475f, 47, 8, 2298-2311, 2008.02.
15. X. Yu, Yasuaki Hiromasa, H. Tsen, JK. Stoops, TE. Roche, ZH, Hong, Structures of the human pyruvate dehydrogenase complex cores: A highly conserved catalytic center with flexible N-terminal domains, STRUCTURE, 10.1016/j.str.2007.10.024, 16, 1, 104-114, 2008.01.
16. Yasuaki Hiromasa, LY. Hu, TE. Roche, Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2, JOURNAL OF BIOLOGICAL CHEMISTRY, 10.1074/jbc.M513514200, 281, 18, 12568-12579, 2006.05.
主要総説, 論評, 解説, 書評, 報告書等
1. 廣政 恭明, ピルビン酸デヒドロゲナーゼ複合体制御の構造生物学, 化学と生物 48(3), 170-175 , 2010.03.
2. TE. Roche, Yasuaki Hiromasa, Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. , Cell Mol Life Sci. (2007) 64, 830-49, 2007.04.
主要学会発表等
特許出願・取得
特許出願件数  0件
特許登録件数  1件
学会活動
所属学会名
日本農芸化学会
学協会役員等への就任
2017.03~2019.02, 日本農芸化学会, 広報委員.
2015.03~2018.02, 日本農芸化学会, 参与.
2015.03~2017.02, 日本農芸化学会, 広報委員.
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2017年度      
その他の研究活動
海外渡航状況, 海外での教育研究歴
Northern Arizona University, UnitedStatesofAmerica, 2018.03~2018.03.
U.C.Davis, UnitedStatesofAmerica, 2018.03~2018.03.
香港城市大学, Hong Kong , 2018.02~2018.02.
University of British Columbia, Canada, 2018.02~2018.02.
Kansas State University, UnitedStatesofAmerica, 2018.02~2018.02.
University of New South Wales, Australia, 2017.12~2017.12.
台湾大学, Taiwan, 2017.10~2017.10.
La Trobe University, Australia, 2017.12~2017.12.
University of New South Wales, Australia, 2017.04~2017.04.
香港城市大学, Hong Kong , 2017.04~2017.04.
Northern Arizona University, UnitedStatesofAmerica, 2017.03~2017.03.
Kansas State University, UnitedStatesofAmerica, 2017.02~2017.03.
U.C.Davis, UnitedStatesofAmerica, 2017.02~2017.02.
ニューサウスウェールズ大学, Australia, 2016.11~2016.11.
Vietnam National University of Agriculture, Vietnam, 2016.09~2016.09.
University of New South Wales, Australia, 2016.08~2016.09.
キングモンクット工科大学, Thailand, 2016.08~2016.08.
Kansas State University, UnitedStatesofAmerica, 2016.05~2016.05.
Northern Arizona University, UnitedStatesofAmerica, 2016.05~2016.05.
香港城市大学, Hong Kong , 2016.11~2016.11.
Kansas State University, UnitedStatesofAmerica, 2016.02~2016.03.
Kansas State University, UnitedStatesofAmerica, 2015.02~2015.03.
University of New South Wales, Australia, 2015.08~2015.09.
University of New South Wales, Australia, 2015.07~2015.07.
City University of Hong Kong, China, 2015.04~2015.04.
University of Sydney, Australia, 2015.11~2015.11.
University of New South Wales, Australia, 2014.02~2014.03.
University of New South Wales, Australia, 2014.07~2014.07.
University of New South Wales, Australia, 2014.08~2014.09.
Kansas State University, UnitedStatesofAmerica, 2014.10~2014.11.
Kansas State University, UnitedStatesofAmerica, 1998.10~2013.09.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2014年度~2017年度, 基盤研究(C), 代表, ピルビン酸デヒドロゲナーゼキナーゼの制御機構の解明.

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pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。
 
 
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