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Tomohiro Ohgomori Last modified date:2019.06.24

Assistant Professor / Department of Developmental Molecular Anatomy
Department of Basic Medicine
Faculty of Medical Sciences


Graduate School
Undergraduate School


E-Mail
Phone
092-642-6051
Fax
092-642-6202
Academic Degree
Science
Country of degree conferring institution (Overseas)
No
Field of Specialization
Biochemistry, Molecular Biology, Glycobiology
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • The therapeutic effects of phytoestrogens in schizophrenia
    keyword : estrogen、schizophrenia
    2017.04~2020.03.
  • The role of glycans regulating neuronal plasticity
    The role of glycans in neuro-glial association
    keyword : perineuronal net, microglia, astrocyte, neuronal plasticity, glycan
    2013.10~2018.09.
Current and Past Project
  • Amyotrophic lateral sclerosis (ALS) is a motoneuron-degenerative disease, the pathogenesis of which requires both cell autonomous and non-cell autonomous processes. Although many important proteins and gene mutations involved in the pathogenesis have been identified, sugar chains have been poorly studied in this process, and their biological significance remains largely unknown. Here, we investigate the role of keratan sulfate (KS) in ALS pathogenesis. KS expression was observed in a subpopulation of microglia in SOD1G93A mice, and became detectable around motoneurons in the ventral horn during the presymptomatic phase. In addition, we have employed ALS model SOD1G93A mice and GlcNAc6ST-1-/- mice, which are KS-deficient in the central nervous system. Surprisingly, SOD1G93AGlcNAc6ST-1-/- mice exhibited a significantly shorter lifespan than SOD1G93A mice and an accelerated disease onset. This study suggests that KS plays an indispensable, suppressive role in the early phase pathogenesis of ALS.
Academic Activities
Papers
1. Tomohiro Ohgomori, Shozo Jinno, The expression of keratan sulfate reveals a unique subset of microglia in the mouse hippocampus after pilocarpine-induced status epileptics, The Journal of Comparative Neurology , In press, 2019.06.
2. Tomohiro Ohgomori, Shozo Jinno, Cuprizone-induced demyelination in the mouse hippocampus is alleviated by phytoestrogen genistein., Toxicol Appl Pharmacol., 2018.11.
3. Tomohiro Ohgomori, Ryo Yamasaki, Jun-ichi Kira, Shozo Jinno, Upregulation of Vesicular Glutamate Transporter 2 and STAT3 Activation in the Spinal Cord of Mice Receiving 3,3'-Iminodipropionitrile., Neurotox Res., 10.1007/s12640-017-9822-x, 33, 4, 768-780, 2018.05.
4. Tomohiro Ohgomori, Ryo Yamasaki, Hideyuki Takeuchi, Kenji Kadomatsu, Jun-ichi Kira, Shozo Jinno, Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1G93A mouse model of amyotrophic lateral sclerosis., Eur J Neurosci. , doi: 10.1111/ejn.13650. , 46, 4, 2001-2014, 2017.08.
5. Tomohiro Ohgomori, Ryo Yamasaki, Hideyuki Takeuchi, Kenji Kadomatsu, Jun-ichi Kira, Shozo Jinno, Differential involvement of vesicular and glial glutamate transporters around spinal α-motoneurons in the pathogenesis of SOD1G93A mouse model of amyotrophic lateral sclerosis., Neuroscience, 356, 114-124, 2017.05.
6. Tomohiro Ohgomori, Jun Yamada, Hideyuki Takeuchi, Kenji Kadomatsu, Shozo Jinno, Comparative morphometric analysis of microglia in the spinal cord of SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis., Eur J Neurosci., 10.1111/ejn.13227, 43, 10, 1340-1351, 2016.05.
7. Hiroki Matsui, Tomohiro Ohgomori, Takamitsu Natori, Katsuichi Miyamoto, Susumu Kusunoki, Kazuma Sakamoto, Naoki Ishiguro, Shiro Imagama, Kenji Kadomatsu, Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis, Cell Death Dis., 4, e946, 2013.12.
8. Kenichi Hirano, Tomohiro Ohgomori, Kazuyoshi Kobayashi, Fumiaki Tanaka, Tomohiro Matsumoto, Takamitsu Natori, Yukihiro Matsuyama, Kenji Uchimura, Kazuma Sakamoto, Hideyuki Takeuchi, Akihiro Hirakawa, Akio Suzumura, Gen Sobue, Naoki Ishiguro, Kenji Kadomatsu, Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS, PLoS One, 8, e66969, 2013.06.
9. Kazuyoshi Kobayashi, Shiro Imagama, Tomohiro Ohgomori, Kenichi Hirano, Kenji Uchimura, Kazuma Sakamoto, Akihiro Hirakawa, Hideyuki Takeuchi, Akio Suzumura, Naoki Ishiguro, Kenji Kadomatsu, Minocycline selectively inhibits M1 polarization of microglia., Cell Death Dis., 4, e525, 2013.03.
10. Ryoji Tauchi, Shiro Imagama, Tomohiro Ohgomori, Takamitsu Natori, Ryuichi Shinjo, Naoki Ishiguro, Kenji Kadomatsu, ADAMTS-13 is produced by glial cells and upregulated after spinal cord injury., Neurosci Lett., 1, 517, 1-6, 2012.05.
11. Tomohiro Ohgomori, Osamu Funatsu, Syuichi Nakaya, Akinori Morita, Masahiko Ikekita, Structural study of the N-glycans of intercellular adhesion molecule-5 (telencephalin)., Biochimica Biophysica Acta –General Subjects-, 12, 1790, 1611-1623, 2009.12.
12. Tomohiro Ohgomori, Tomohisa Nanao, Akinori Morita, Masahiko Ikekita, Asn54-linked glycan is critical for functional folding of intercellular adhesion molecule-5., Glycoconj J., 1, 29, 47-55, 2012.01.
Works, Software and Database
1. .
Presentations
1. Tomohiro Ohgomori, Shozo Jinno, Molecular heterogeneity of perineuronal nets in the thalamic reticular nucleus of mice, with reference to the topographic organization, JSCR SFG joint meeting , 2014.11.